JP2012513481A5 - - Google Patents
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- JP2012513481A5 JP2012513481A5 JP2011543689A JP2011543689A JP2012513481A5 JP 2012513481 A5 JP2012513481 A5 JP 2012513481A5 JP 2011543689 A JP2011543689 A JP 2011543689A JP 2011543689 A JP2011543689 A JP 2011543689A JP 2012513481 A5 JP2012513481 A5 JP 2012513481A5
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- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 239000012453 solvate Substances 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000037906 ischaemic injury Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000030833 cell death Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- -1 8-quinolyl Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 210000000713 mesentery Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 230000021597 necroptosis Effects 0.000 claims 1
- 230000016273 neuron death Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 CN(C(C(*)(**)N1*)=O)C1=S Chemical compound CN(C(C(*)(**)N1*)=O)C1=S 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14061508P | 2008-12-23 | 2008-12-23 | |
| US61/140,615 | 2008-12-23 | ||
| PCT/US2009/069483 WO2010075561A1 (en) | 2008-12-23 | 2009-12-23 | Small molecule inhibitors of necroptosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230271A Division JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012513481A JP2012513481A (ja) | 2012-06-14 |
| JP2012513481A5 true JP2012513481A5 (enExample) | 2013-02-14 |
Family
ID=42288162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543689A Pending JP2012513481A (ja) | 2008-12-23 | 2009-12-23 | ネクロトーシスの小分子阻害剤 |
| JP2014230271A Expired - Fee Related JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230271A Expired - Fee Related JP6178777B2 (ja) | 2008-12-23 | 2014-11-13 | ネクロトーシスの小分子阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20120122889A1 (enExample) |
| EP (2) | EP3000468A1 (enExample) |
| JP (2) | JP2012513481A (enExample) |
| CN (2) | CN102316735A (enExample) |
| AU (2) | AU2009329879A1 (enExample) |
| BR (1) | BRPI0923126A2 (enExample) |
| CA (1) | CA2772760A1 (enExample) |
| HK (2) | HK1212973A1 (enExample) |
| WO (1) | WO2010075561A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491743B2 (en) | 2003-08-29 | 2009-02-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
| CA2696349A1 (en) | 2007-08-15 | 2009-02-19 | President And Fellows Of Harvard College | Heterocyclic inhibitors of necroptosis |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| CA2772760A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
| BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
| IT1401146B1 (it) | 2010-07-27 | 2013-07-12 | Gnosis Spa | Composizione comprendente shellac e/o un suo sale e sodio amido glicolato |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
| KR101410332B1 (ko) | 2012-02-29 | 2014-06-24 | 코아스템(주) | 중간엽 기질세포 배양용 항산화 조성물 및 이의 용도 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| TWI648273B (zh) | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類（三） |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| US20160024098A1 (en) | 2013-03-15 | 2016-01-28 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
| CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
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| EP3229807A4 (en) | 2014-12-11 | 2018-10-17 | President and Fellows of Harvard College | Inhibitors of cellular necrosis and related methods |
| HK1244792B (en) | 2014-12-24 | 2019-07-12 | 北京生命科学研究所 | Necrosis inhibitors |
| CN115197098B (zh) * | 2014-12-24 | 2023-08-08 | 北京生命科学研究所 | 细胞坏死抑制剂 |
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| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
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| JP2018504430A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのキナゾリノン及びアザキナゾリノン |
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| TWI730959B (zh) | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
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| US20200062735A1 (en) | 2017-02-27 | 2020-02-27 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| WO2019023278A1 (en) | 2017-07-25 | 2019-01-31 | Crinetics Pharmaceuticals, Inc. | MODULATORS OF SOMATOSTATIN AND USES THEREOF |
| AU2018395543A1 (en) | 2017-12-31 | 2020-07-23 | Evergreen Biosciences | Compositions for cryopreservation and methods of use thereof |
| CN109078187B (zh) * | 2018-08-02 | 2021-04-20 | 中国人民解放军第四军医大学 | 胰腺GnIH受体功能调节剂制备治疗2型糖尿病药物的应用 |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| CN113302183A (zh) * | 2018-11-20 | 2021-08-24 | 圣瑞诺有限公司 | 环脲 |
| SG11202105264UA (en) | 2018-11-20 | 2021-06-29 | Sironax Ltd | RIP1 Inhibitors |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| BR112022010082A2 (pt) | 2019-11-26 | 2022-08-30 | Univ Texas | Composto de fórmula estrutural i ou sal do mesmo, composição farmacêutica, uso do composto e uso da composição farmacêutica |
| CN115697972B (zh) * | 2020-05-20 | 2024-11-22 | 维泰瑞隆有限公司 | 包括哌嗪杂环酰胺脲的受体-相互作用蛋白1抑制剂 |
| IL298188A (en) | 2020-05-20 | 2023-01-01 | Sironax Ltd | Circular structures of piperazine |
| WO2021252307A1 (en) * | 2020-06-12 | 2021-12-16 | Merck Sharp & Dohme Corp. | Ripk1 inhibitors and methods of use |
| EP4168401B1 (en) * | 2020-06-19 | 2026-01-07 | Anaxis Pharma Pty Ltd | Sulphonamide compounds |
| CN117304110A (zh) * | 2023-09-21 | 2023-12-29 | 宁夏医科大学 | 一种化合物及其制备方法和用途 |
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2009
- 2009-12-23 CA CA2772760A patent/CA2772760A1/en not_active Abandoned
- 2009-12-23 AU AU2009329879A patent/AU2009329879A1/en not_active Abandoned
- 2009-12-23 JP JP2011543689A patent/JP2012513481A/ja active Pending
- 2009-12-23 US US13/141,545 patent/US20120122889A1/en not_active Abandoned
- 2009-12-23 EP EP15001699.6A patent/EP3000468A1/en not_active Withdrawn
- 2009-12-23 CN CN2009801569144A patent/CN102316735A/zh active Pending
- 2009-12-23 CN CN201510081043.1A patent/CN104803986A/zh active Pending
- 2009-12-23 EP EP09835866A patent/EP2381775A4/en not_active Withdrawn
- 2009-12-23 WO PCT/US2009/069483 patent/WO2010075561A1/en not_active Ceased
- 2009-12-23 BR BRPI0923126-9A patent/BRPI0923126A2/pt not_active IP Right Cessation
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2013
- 2013-09-20 US US14/033,176 patent/US9586880B2/en active Active
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2014
- 2014-11-13 JP JP2014230271A patent/JP6178777B2/ja not_active Expired - Fee Related
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2016
- 2016-01-26 HK HK16100821.7A patent/HK1212973A1/zh unknown
- 2016-04-12 AU AU2016202262A patent/AU2016202262A1/en not_active Abandoned
- 2016-09-30 HK HK16111463.7A patent/HK1223272A1/en unknown
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2017
- 2017-02-08 US US15/427,699 patent/US20170305824A1/en not_active Abandoned
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2018
- 2018-08-06 US US16/055,898 patent/US20190135718A1/en not_active Abandoned