JP2012512915A5 - - Google Patents
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- JP2012512915A5 JP2012512915A5 JP2011542550A JP2011542550A JP2012512915A5 JP 2012512915 A5 JP2012512915 A5 JP 2012512915A5 JP 2011542550 A JP2011542550 A JP 2011542550A JP 2011542550 A JP2011542550 A JP 2011542550A JP 2012512915 A5 JP2012512915 A5 JP 2012512915A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- group
- acid selected
- peptide
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 235000001014 amino acid Nutrition 0.000 claims description 611
- 150000001413 amino acids Chemical class 0.000 claims description 585
- 229910052700 potassium Inorganic materials 0.000 claims description 398
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 290
- 229910052740 iodine Inorganic materials 0.000 claims description 279
- 229910052720 vanadium Inorganic materials 0.000 claims description 236
- 229910052727 yttrium Inorganic materials 0.000 claims description 221
- 229910052731 fluorine Inorganic materials 0.000 claims description 208
- 229910052739 hydrogen Inorganic materials 0.000 claims description 202
- 229910052721 tungsten Inorganic materials 0.000 claims description 201
- 229910052799 carbon Inorganic materials 0.000 claims description 171
- 229910052698 phosphorus Inorganic materials 0.000 claims description 112
- 229910052717 sulfur Inorganic materials 0.000 claims description 98
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims description 74
- 229910052757 nitrogen Inorganic materials 0.000 claims description 72
- 238000000034 method Methods 0.000 claims description 62
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 56
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims description 55
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims description 55
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims description 52
- 201000010099 disease Diseases 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 230000003993 interaction Effects 0.000 claims description 14
- SNDPXSYFESPGGJ-UHFFFAOYSA-N 2-aminopentanoic acid Chemical compound CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims description 12
- 238000002965 ELISA Methods 0.000 claims description 11
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 208000015294 blood coagulation disease Diseases 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 230000002860 competitive effect Effects 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 8
- 239000007850 fluorescent dye Substances 0.000 claims description 8
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims description 7
- 239000000975 dye Substances 0.000 claims description 7
- 108091023037 Aptamer Proteins 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 239000002254 cytotoxic agent Substances 0.000 claims description 6
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 239000003053 toxin Substances 0.000 claims description 6
- 231100000765 toxin Toxicity 0.000 claims description 6
- 108091027076 Spiegelmer Proteins 0.000 claims description 5
- -1 and X3021 is A Inorganic materials 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000002950 deficient Effects 0.000 claims description 5
- 230000005764 inhibitory process Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- XOYSDPUJMJWCBH-VKHMYHEASA-N (3s)-3,5-diamino-5-oxopentanoic acid Chemical compound NC(=O)C[C@H](N)CC(O)=O XOYSDPUJMJWCBH-VKHMYHEASA-N 0.000 claims description 4
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims description 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 4
- 206010053567 Coagulopathies Diseases 0.000 claims description 4
- OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 claims description 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 4
- 230000023555 blood coagulation Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims description 2
- HOKKHZGPKSLGJE-VKHMYHEASA-N (2s)-2-(methylamino)butanedioic acid Chemical compound CN[C@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-VKHMYHEASA-N 0.000 claims description 2
- CNMAQBJBWQQZFZ-LURJTMIESA-N (2s)-2-(pyridin-2-ylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1=CC=CC=N1 CNMAQBJBWQQZFZ-LURJTMIESA-N 0.000 claims description 2
- AXDLCFOOGCNDST-VIFPVBQESA-N (2s)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid Chemical compound CN[C@H](C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-VIFPVBQESA-N 0.000 claims description 2
- XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 claims description 2
- BUZICZZQJDLXJN-GSVOUGTGSA-N (3R)-3-amino-4-hydroxybutanoic acid Chemical compound OC[C@H](N)CC(O)=O BUZICZZQJDLXJN-GSVOUGTGSA-N 0.000 claims description 2
- GLUJNGJDHCTUJY-RXMQYKEDSA-N (3R)-beta-leucine Chemical compound CC(C)[C@H]([NH3+])CC([O-])=O GLUJNGJDHCTUJY-RXMQYKEDSA-N 0.000 claims description 2
- PJDINCOFOROBQW-LURJTMIESA-N (3S)-3,7-diaminoheptanoic acid Chemical compound NCCCC[C@H](N)CC(O)=O PJDINCOFOROBQW-LURJTMIESA-N 0.000 claims description 2
- OFVBLKINTLPEGH-VIFPVBQESA-N (3S)-3-Amino-4-phenylbutanoic acid Chemical compound OC(=O)C[C@@H](N)CC1=CC=CC=C1 OFVBLKINTLPEGH-VIFPVBQESA-N 0.000 claims description 2
- IDNSGZOFDGAHTI-BYPYZUCNSA-N (3s)-3,6-diamino-6-oxohexanoic acid Chemical compound OC(=O)C[C@@H](N)CCC(N)=O IDNSGZOFDGAHTI-BYPYZUCNSA-N 0.000 claims description 2
- VNWXCGKMEWXYBP-YFKPBYRVSA-N (3s)-3-amino-6-(diaminomethylideneamino)hexanoic acid Chemical compound OC(=O)C[C@@H](N)CCCNC(N)=N VNWXCGKMEWXYBP-YFKPBYRVSA-N 0.000 claims description 2
- MLYMSIKVLAPCAK-LURJTMIESA-N (S)-3-Amino-5-methylhexanoic acid Chemical compound CC(C)C[C@H](N)CC(O)=O MLYMSIKVLAPCAK-LURJTMIESA-N 0.000 claims description 2
- XJODGRWDFZVTKW-UHFFFAOYSA-N -N-Methylleucine Natural products CNC(C(O)=O)CC(C)C XJODGRWDFZVTKW-UHFFFAOYSA-N 0.000 claims description 2
- XABCFXXGZPWJQP-UHFFFAOYSA-N 3-aminoadipic acid Chemical compound OC(=O)CC(N)CCC(O)=O XABCFXXGZPWJQP-UHFFFAOYSA-N 0.000 claims description 2
- 102100022641 Coagulation factor IX Human genes 0.000 claims description 2
- 150000008574 D-amino acids Chemical class 0.000 claims description 2
- 108010076282 Factor IX Proteins 0.000 claims description 2
- 108010054218 Factor VIII Proteins 0.000 claims description 2
- 102000001690 Factor VIII Human genes 0.000 claims description 2
- 230000005526 G1 to G0 transition Effects 0.000 claims description 2
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims description 2
- GDFAOVXKHJXLEI-UHFFFAOYSA-N L-N-Boc-N-methylalanine Natural products CNC(C)C(O)=O GDFAOVXKHJXLEI-UHFFFAOYSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 2
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 claims description 2
- VUNPIAMEJXBAFP-QMMMGPOBSA-N L-beta-Homotyrosine Chemical compound OC(=O)C[C@@H](N)CC1=CC=C(O)C=C1 VUNPIAMEJXBAFP-QMMMGPOBSA-N 0.000 claims description 2
- JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 claims description 2
- MRAUNPAHJZDYCK-BYPYZUCNSA-N L-nitroarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O MRAUNPAHJZDYCK-BYPYZUCNSA-N 0.000 claims description 2
- DGYHPLMPMRKMPD-BYPYZUCNSA-N L-propargylglycine Chemical compound OC(=O)[C@@H](N)CC#C DGYHPLMPMRKMPD-BYPYZUCNSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- OLYPWXRMOFUVGH-LURJTMIESA-N N(2)-methyl-L-lysine Chemical compound CN[C@H](C(O)=O)CCCCN OLYPWXRMOFUVGH-LURJTMIESA-N 0.000 claims description 2
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims description 2
- PSFABYLDRXJYID-VKHMYHEASA-N N-Methylserine Chemical compound CN[C@@H](CO)C(O)=O PSFABYLDRXJYID-VKHMYHEASA-N 0.000 claims description 2
- HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 claims description 2
- PSFABYLDRXJYID-UHFFFAOYSA-N N-methyl-DL-serine Natural products CNC(CO)C(O)=O PSFABYLDRXJYID-UHFFFAOYSA-N 0.000 claims description 2
- AXDLCFOOGCNDST-UHFFFAOYSA-N N-methyl-DL-tyrosine Natural products CNC(C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-UHFFFAOYSA-N 0.000 claims description 2
- GDFAOVXKHJXLEI-VKHMYHEASA-N N-methyl-L-alanine Chemical compound C[NH2+][C@@H](C)C([O-])=O GDFAOVXKHJXLEI-VKHMYHEASA-N 0.000 claims description 2
- XLBVNMSMFQMKEY-BYPYZUCNSA-N N-methyl-L-glutamic acid Chemical compound CN[C@H](C(O)=O)CCC(O)=O XLBVNMSMFQMKEY-BYPYZUCNSA-N 0.000 claims description 2
- SCIFESDRCALIIM-VIFPVBQESA-N N-methyl-L-phenylalanine Chemical compound C[NH2+][C@H](C([O-])=O)CC1=CC=CC=C1 SCIFESDRCALIIM-VIFPVBQESA-N 0.000 claims description 2
- AKCRVYNORCOYQT-YFKPBYRVSA-N N-methyl-L-valine Chemical compound CN[C@@H](C(C)C)C(O)=O AKCRVYNORCOYQT-YFKPBYRVSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 2
- 108010077895 Sarcosine Proteins 0.000 claims description 2
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 2
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 claims description 2
- 238000001042 affinity chromatography Methods 0.000 claims description 2
- 229940000635 beta-alanine Drugs 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 229960002173 citrulline Drugs 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 229960004222 factor ix Drugs 0.000 claims description 2
- 229960000301 factor viii Drugs 0.000 claims description 2
- BBJIPMIXTXKYLZ-UHFFFAOYSA-N isoglutamic acid Chemical compound OC(=O)CC(N)CC(O)=O BBJIPMIXTXKYLZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960003104 ornithine Drugs 0.000 claims description 2
- 229950009215 phenylbutanoic acid Drugs 0.000 claims description 2
- 229960002718 selenomethionine Drugs 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 41
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- FMUMEWVNYMUECA-LURJTMIESA-N (2s)-2-azaniumyl-5-methylhexanoate Chemical compound CC(C)CC[C@H](N)C(O)=O FMUMEWVNYMUECA-LURJTMIESA-N 0.000 claims 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims 1
- FMUMEWVNYMUECA-UHFFFAOYSA-N L-homoleucine Natural products CC(C)CCC(N)C(O)=O FMUMEWVNYMUECA-UHFFFAOYSA-N 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 4
- 108090000190 Thrombin Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13927208P | 2008-12-19 | 2008-12-19 | |
| US61/139,272 | 2008-12-19 | ||
| PCT/US2009/069060 WO2010071894A2 (en) | 2008-12-19 | 2009-12-21 | Tfpi inhibitors and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015089324A Division JP6095717B2 (ja) | 2008-12-19 | 2015-04-24 | Ｔｆｐｉインヒビターおよび使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512915A JP2012512915A (ja) | 2012-06-07 |
| JP2012512915A5 true JP2012512915A5 (https=) | 2013-01-24 |
| JP5739816B2 JP5739816B2 (ja) | 2015-06-24 |
Family
ID=42269298
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542550A Active JP5739816B2 (ja) | 2008-12-19 | 2009-12-21 | Ｔｆｐｉインヒビターおよび使用法 |
| JP2015089324A Active JP6095717B2 (ja) | 2008-12-19 | 2015-04-24 | Ｔｆｐｉインヒビターおよび使用法 |
| JP2017024988A Active JP6567577B2 (ja) | 2008-12-19 | 2017-02-14 | Ｔｆｐｉインヒビターおよび使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015089324A Active JP6095717B2 (ja) | 2008-12-19 | 2015-04-24 | Ｔｆｐｉインヒビターおよび使用法 |
| JP2017024988A Active JP6567577B2 (ja) | 2008-12-19 | 2017-02-14 | Ｔｆｐｉインヒビターおよび使用法 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8466108B2 (https=) |
| EP (1) | EP2379096B1 (https=) |
| JP (3) | JP5739816B2 (https=) |
| KR (3) | KR101792032B1 (https=) |
| CN (2) | CN102348462B (https=) |
| AU (1) | AU2009327338B2 (https=) |
| BR (2) | BRPI0922344A2 (https=) |
| CA (1) | CA2747721C (https=) |
| DK (1) | DK2379096T3 (https=) |
| ES (1) | ES2773766T3 (https=) |
| HR (1) | HRP20192282T8 (https=) |
| HU (1) | HUE046951T2 (https=) |
| LT (1) | LT2379096T (https=) |
| NZ (2) | NZ593815A (https=) |
| SI (1) | SI2379096T1 (https=) |
| WO (1) | WO2010071894A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Ｔｆｐｉ 억제제 및 사용 방법 |
| WO2010072691A1 (en) | 2008-12-22 | 2010-07-01 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
| US20110223149A1 (en) * | 2009-10-14 | 2011-09-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| PT3345615T (pt) | 2010-03-01 | 2020-01-17 | Bayer Healthcare Llc | Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi) |
| DK2547355T3 (en) * | 2010-03-19 | 2017-03-20 | Baxalta GmbH | TFPI INHIBITORS AND METHODS OF USE |
| JP2013533871A (ja) | 2010-06-30 | 2013-08-29 | ノヴォ ノルディスク アー／エス | 組織因子経路インヒビターに特異的に結合することが可能な抗体 |
| US9228022B2 (en) | 2010-06-30 | 2016-01-05 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
| WO2012109675A1 (en) * | 2011-02-11 | 2012-08-16 | Baxter International Inc. | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| TWI483733B (zh) * | 2011-02-11 | 2015-05-11 | Baxter Int | Ｔｆｐｉ抑制劑及使用方法 |
| WO2012178063A1 (en) | 2011-06-23 | 2012-12-27 | The Regents Of The University Of Michigan | Compound and method for modulating opioid receptor activity |
| BR112014022435B1 (pt) * | 2012-03-21 | 2023-02-14 | Takeda Pharmaceutical Company Limited | Inibidores de tfpi e métodos de uso |
| CN104215707B (zh) * | 2014-09-02 | 2016-01-20 | 福建中医药大学 | 栝楼桂枝汤的质量检测方法 |
| MY178445A (en) | 2015-02-25 | 2020-10-13 | Mogam Inst Biomedical Res | Novel antibody binding to tfpi and composition comprising the same |
| KR102438650B1 (ko) * | 2015-08-19 | 2022-08-31 | 화이자 인코포레이티드 | 조직 인자 경로 억제제 항체 및 그의 용도 |
| FI3997103T3 (fi) | 2019-07-08 | 2025-02-03 | 3B Pharmaceuticals Gmbh | Fibroblastien aktivaatioproteiinin ligandia käsittäviä yhdisteitä ja niiden käyttö |
| JP7152084B1 (ja) * | 2022-02-22 | 2022-10-12 | 株式会社血栓トランスレーショナルリサーチラボ | 組織因子経路インヒビターの抗凝固活性の検査試薬、検査試薬セット、および検査方法 |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS607193B2 (ja) | 1978-01-10 | 1985-02-22 | トヨタ自動車株式会社 | 熱風循環型乾燥炉 |
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| JPS5733175A (en) | 1980-07-31 | 1982-02-23 | Mitsubishi Electric Corp | Transmitter for signal of elevator |
| US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
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