JP2012504959A5 - - Google Patents

Info

Publication number

JP2012504959A5

JP2012504959A5 JP2011531018A JP2011531018A JP2012504959A5 JP 2012504959 A5 JP2012504959 A5 JP 2012504959A5 JP 2011531018 A JP2011531018 A JP 2011531018A JP 2011531018 A JP2011531018 A JP 2011531018A JP 2012504959 A5 JP2012504959 A5 JP 2012504959A5

Authority

JP

Japan

Prior art keywords

transcription factor

vector

function

polynucleotide encoding

protein

Prior art date

2009-10-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 108090000623 proteins and genes Proteins 0.000 claims 45
• 102000004169 proteins and genes Human genes 0.000 claims 30
• 108091023040 Transcription factor Proteins 0.000 claims 21
• 102000040945 Transcription factor Human genes 0.000 claims 21
• 102000040430 polynucleotide Human genes 0.000 claims 19
• 108091033319 polynucleotide Proteins 0.000 claims 19
• 239000002157 polynucleotide Substances 0.000 claims 19
• 210000002865 immune cell Anatomy 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 239000003446 ligand Substances 0.000 claims 8
• 230000001419 dependent effect Effects 0.000 claims 6
• 238000000338 in vitro Methods 0.000 claims 6
• 108010057988 ecdysone receptor Proteins 0.000 claims 5
• 102000008096 B7-H1 Antigen Human genes 0.000 claims 4
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 4
• 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 4
• 102100036846 C-C motif chemokine 21 Human genes 0.000 claims 4
• 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 4
• 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 4
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 4
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 4
• 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 4
• 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 claims 4
• 102100035304 Lymphotactin Human genes 0.000 claims 4
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• -1 IFN-α1 Proteins 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 108010082808 4-1BB Ligand Proteins 0.000 claims 2
• 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 2
• 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 2
• 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
• 101710098275 C-X-C motif chemokine 10 Proteins 0.000 claims 2
• 101710085500 C-X-C motif chemokine 9 Proteins 0.000 claims 2
• 101150013553 CD40 gene Proteins 0.000 claims 2
• 102100025221 CD70 antigen Human genes 0.000 claims 2
• 108010083702 Chemokine CCL21 Proteins 0.000 claims 2
• 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
• 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 2
• 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
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• 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 2
• 108700010013 HMGB1 Proteins 0.000 claims 2
• 101150021904 HMGB1 gene Proteins 0.000 claims 2
• 102100037907 High mobility group protein B1 Human genes 0.000 claims 2
• 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
• 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims 2
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims 2
• 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 2
• 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 2
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 2
• 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 2
• 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 2
• 101000804764 Homo sapiens Lymphotactin Proteins 0.000 claims 2
• 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 2
• 102100034980 ICOS ligand Human genes 0.000 claims 2
• 102100026720 Interferon beta Human genes 0.000 claims 2
• 102100037850 Interferon gamma Human genes 0.000 claims 2
• 108010047761 Interferon-alpha Proteins 0.000 claims 2
• 102000006992 Interferon-alpha Human genes 0.000 claims 2
• 108090000467 Interferon-beta Proteins 0.000 claims 2
• 108010074328 Interferon-gamma Proteins 0.000 claims 2
• 108010002352 Interleukin-1 Proteins 0.000 claims 2
• 102000000589 Interleukin-1 Human genes 0.000 claims 2
• 108010002350 Interleukin-2 Proteins 0.000 claims 2
• 108010065637 Interleukin-23 Proteins 0.000 claims 2
• 108010066979 Interleukin-27 Proteins 0.000 claims 2
• 108010002386 Interleukin-3 Proteins 0.000 claims 2
• 108090000978 Interleukin-4 Proteins 0.000 claims 2
• 108010002616 Interleukin-5 Proteins 0.000 claims 2
• 108010002586 Interleukin-7 Proteins 0.000 claims 2
• 108090001007 Interleukin-8 Proteins 0.000 claims 2
• 108010002335 Interleukin-9 Proteins 0.000 claims 2
• 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 2
• 108010042215 OX40 Ligand Proteins 0.000 claims 2
• 108091030071 RNAI Proteins 0.000 claims 2
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 2
• 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 2
• 101800004564 Transforming growth factor alpha Proteins 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims 2
• 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 2
• 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
• 239000000074 antisense oligonucleotide Substances 0.000 claims 2
• 238000012230 antisense oligonucleotides Methods 0.000 claims 2
• 230000009368 gene silencing by RNA Effects 0.000 claims 2
• 108040006870 interleukin-10 receptor activity proteins Proteins 0.000 claims 2
• 108010074108 interleukin-21 Proteins 0.000 claims 2
• 102000003898 interleukin-24 Human genes 0.000 claims 2
• 108090000237 interleukin-24 Proteins 0.000 claims 2
• 108010019677 lymphotactin Proteins 0.000 claims 2
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 2
• 102100030703 Interleukin-22 Human genes 0.000 claims 1
• 102000013264 Interleukin-23 Human genes 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 102100031789 Myeloid-derived growth factor Human genes 0.000 claims 1
• 102100033125 Transcription factor 24 Human genes 0.000 claims 1
• 101710119682 Transcription factor 24 Proteins 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 241000701161 unidentified adenovirus Species 0.000 claims 1