JP2012504959A5 - - Google Patents
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- JP2012504959A5 JP2012504959A5 JP2011531018A JP2011531018A JP2012504959A5 JP 2012504959 A5 JP2012504959 A5 JP 2012504959A5 JP 2011531018 A JP2011531018 A JP 2011531018A JP 2011531018 A JP2011531018 A JP 2011531018A JP 2012504959 A5 JP2012504959 A5 JP 2012504959A5
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- 108090000623 proteins and genes Proteins 0.000 claims 45
- 102000004169 proteins and genes Human genes 0.000 claims 30
- 108091023040 Transcription factor Proteins 0.000 claims 21
- 102000040945 Transcription factor Human genes 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 19
- 108091033319 polynucleotide Proteins 0.000 claims 19
- 239000002157 polynucleotide Substances 0.000 claims 19
- 210000002865 immune cell Anatomy 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 239000003446 ligand Substances 0.000 claims 8
- 230000001419 dependent effect Effects 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 108010057988 ecdysone receptor Proteins 0.000 claims 5
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 4
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 4
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims 4
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 4
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 4
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 4
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 4
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 4
- 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 claims 4
- 102100035304 Lymphotactin Human genes 0.000 claims 4
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- -1 IFN-α1 Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 108010082808 4-1BB Ligand Proteins 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 2
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 2
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
- 101710098275 C-X-C motif chemokine 10 Proteins 0.000 claims 2
- 101710085500 C-X-C motif chemokine 9 Proteins 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100025221 CD70 antigen Human genes 0.000 claims 2
- 108010083702 Chemokine CCL21 Proteins 0.000 claims 2
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 2
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 2
- 108700010013 HMGB1 Proteins 0.000 claims 2
- 101150021904 HMGB1 gene Proteins 0.000 claims 2
- 102100037907 High mobility group protein B1 Human genes 0.000 claims 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims 2
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 2
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 2
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 2
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 2
- 101000804764 Homo sapiens Lymphotactin Proteins 0.000 claims 2
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 2
- 102100034980 ICOS ligand Human genes 0.000 claims 2
- 102100026720 Interferon beta Human genes 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108010002352 Interleukin-1 Proteins 0.000 claims 2
- 102000000589 Interleukin-1 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108010065637 Interleukin-23 Proteins 0.000 claims 2
- 108010066979 Interleukin-27 Proteins 0.000 claims 2
- 108010002386 Interleukin-3 Proteins 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 108010002616 Interleukin-5 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 108010002335 Interleukin-9 Proteins 0.000 claims 2
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 2
- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 108091030071 RNAI Proteins 0.000 claims 2
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 108040006870 interleukin-10 receptor activity proteins Proteins 0.000 claims 2
- 108010074108 interleukin-21 Proteins 0.000 claims 2
- 102000003898 interleukin-24 Human genes 0.000 claims 2
- 108090000237 interleukin-24 Proteins 0.000 claims 2
- 108010019677 lymphotactin Proteins 0.000 claims 2
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 2
- 102100030703 Interleukin-22 Human genes 0.000 claims 1
- 102000013264 Interleukin-23 Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100031789 Myeloid-derived growth factor Human genes 0.000 claims 1
- 102100033125 Transcription factor 24 Human genes 0.000 claims 1
- 101710119682 Transcription factor 24 Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10381008P | 2008-10-08 | 2008-10-08 | |
| US61/103,810 | 2008-10-08 | ||
| PCT/US2009/005510 WO2010042189A2 (en) | 2008-10-08 | 2009-10-08 | Engineered cells expressing multiple immunomodulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015157352A Division JP2016025858A (ja) | 2008-10-08 | 2015-08-07 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504959A JP2012504959A (ja) | 2012-03-01 |
| JP2012504959A5 true JP2012504959A5 (enExample) | 2012-11-29 |
Family
ID=42101134
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011531018A Withdrawn JP2012504959A (ja) | 2008-10-08 | 2009-10-08 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
| JP2015157352A Withdrawn JP2016025858A (ja) | 2008-10-08 | 2015-08-07 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
| JP2018166324A Withdrawn JP2019000118A (ja) | 2008-10-08 | 2018-09-05 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015157352A Withdrawn JP2016025858A (ja) | 2008-10-08 | 2015-08-07 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
| JP2018166324A Withdrawn JP2019000118A (ja) | 2008-10-08 | 2018-09-05 | 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9492482B2 (enExample) |
| EP (1) | EP2356219A4 (enExample) |
| JP (3) | JP2012504959A (enExample) |
| KR (2) | KR101361416B1 (enExample) |
| CN (1) | CN102575227A (enExample) |
| AU (3) | AU2009302804B2 (enExample) |
| BR (1) | BRPI0920679A2 (enExample) |
| CA (1) | CA2739902A1 (enExample) |
| IL (3) | IL212184A (enExample) |
| MX (1) | MX340972B (enExample) |
| RU (1) | RU2573912C2 (enExample) |
| WO (1) | WO2010042189A2 (enExample) |
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| WO2009045370A2 (en) | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| US20130195800A1 (en) * | 2010-03-23 | 2013-08-01 | Intrexon Corporation | Vectors Conditionally Expressing Therapeutic Proteins, Host Cells Comprising the Vectors, and Uses Thereof |
| US9402919B2 (en) * | 2011-03-04 | 2016-08-02 | Intrexon Corporation | Vectors conditionally expressing protein |
| PH12014500528A1 (en) * | 2011-09-08 | 2014-04-21 | Intrexon Corp | Crystalline diacylhydrazine and the use thereof |
| EP2755487B1 (en) * | 2011-09-16 | 2018-12-19 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
| CA2850575C (en) * | 2011-10-11 | 2020-12-15 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
| CN102631671B (zh) * | 2012-04-05 | 2014-11-26 | 倪国颖 | 提高疫苗诱导的细胞毒性t细胞反应的治疗性疫苗 |
| US10426794B2 (en) * | 2013-04-11 | 2019-10-01 | The Brigham And Women's Hospital, Inc. | Methods and compositions of treating autoimmune diseases |
| DK3461491T3 (da) * | 2013-04-18 | 2025-02-03 | Tilt Biotherapeutics Oy | Forbedret adoptiv celleterapi |
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| JP6755465B2 (ja) * | 2014-12-03 | 2020-09-16 | 株式会社アネロファーマ・サイエンス | 共発現プラスミド |
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- 2009-10-08 CN CN200980150164XA patent/CN102575227A/zh active Pending
- 2009-10-08 EP EP09819559.7A patent/EP2356219A4/en not_active Withdrawn
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