JP2008515439A5 - - Google Patents
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- JP2008515439A5 JP2008515439A5 JP2007535869A JP2007535869A JP2008515439A5 JP 2008515439 A5 JP2008515439 A5 JP 2008515439A5 JP 2007535869 A JP2007535869 A JP 2007535869A JP 2007535869 A JP2007535869 A JP 2007535869A JP 2008515439 A5 JP2008515439 A5 JP 2008515439A5
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- 238000000034 method Methods 0.000 claims description 47
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims description 14
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 108010029697 CD40 Ligand Proteins 0.000 claims description 11
- 102100032937 CD40 ligand Human genes 0.000 claims description 11
- 108020004999 messenger RNA Proteins 0.000 claims description 9
- 230000011664 signaling Effects 0.000 claims description 9
- 102100035793 CD83 antigen Human genes 0.000 claims description 7
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 7
- 210000000581 natural killer T-cell Anatomy 0.000 claims description 7
- 238000004520 electroporation Methods 0.000 claims description 6
- 102100037850 Interferon gamma Human genes 0.000 claims description 5
- 108010074328 Interferon-gamma Proteins 0.000 claims description 5
- 230000028993 immune response Effects 0.000 claims description 4
- VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- 210000004443 dendritic cell Anatomy 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 20
- 125000000539 amino acid group Chemical group 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 239000000556 agonist Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229940123189 CD40 agonist Drugs 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 108010085650 interferon gamma receptor Proteins 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 101150013553 CD40 gene Proteins 0.000 claims 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000012642 immune effector Substances 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 108091027963 non-coding RNA Proteins 0.000 claims 2
- 102000042567 non-coding RNA Human genes 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 230000001270 agonistic effect Effects 0.000 claims 1
- MYYARUCLXARAEE-ZATZPJRKSA-N alpha-C-GalCer Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCCCCC MYYARUCLXARAEE-ZATZPJRKSA-N 0.000 claims 1
- 125000003550 alpha-D-galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 229960002986 dinoprostone Drugs 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- -1 β-arabinosylceramide Chemical compound 0.000 claims 1
- 230000035800 maturation Effects 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102000001398 Granzyme Human genes 0.000 description 1
- 108060005986 Granzyme Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52251204P | 2004-10-07 | 2004-10-07 | |
| US60/522,512 | 2004-10-07 | ||
| PCT/US2005/036304 WO2006042177A2 (en) | 2004-10-07 | 2005-10-07 | Mature dendritic cell compositions and methods for culturing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013003939A Division JP2013121352A (ja) | 2004-10-07 | 2013-01-11 | 成熟樹状細胞組成物およびその培養方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515439A JP2008515439A (ja) | 2008-05-15 |
| JP2008515439A5 true JP2008515439A5 (enExample) | 2012-03-29 |
| JP5269412B2 JP5269412B2 (ja) | 2013-08-21 |
Family
ID=36148973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535869A Expired - Fee Related JP5269412B2 (ja) | 2004-10-07 | 2005-10-07 | 成熟樹状細胞組成物およびその培養方法 |
| JP2013003939A Pending JP2013121352A (ja) | 2004-10-07 | 2013-01-11 | 成熟樹状細胞組成物およびその培養方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013003939A Pending JP2013121352A (ja) | 2004-10-07 | 2013-01-11 | 成熟樹状細胞組成物およびその培養方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20080145931A1 (enExample) |
| EP (2) | EP2251418B1 (enExample) |
| JP (2) | JP5269412B2 (enExample) |
| KR (1) | KR101243577B1 (enExample) |
| CN (1) | CN101080487B (enExample) |
| AT (1) | ATE489455T1 (enExample) |
| AU (1) | AU2005294150B2 (enExample) |
| CA (1) | CA2577125C (enExample) |
| DE (1) | DE602005025005D1 (enExample) |
| DK (1) | DK1809737T3 (enExample) |
| ES (1) | ES2861199T3 (enExample) |
| TW (1) | TWI382843B (enExample) |
| WO (1) | WO2006042177A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101243577B1 (ko) * | 2004-10-07 | 2013-03-20 | 아고스 쎄라퓨틱스, 인코포레이티드 | 성숙 수지상 세포 조성물 및 그의 배양 방법 |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| JP5020935B2 (ja) | 2005-04-08 | 2012-09-05 | アルゴス セラピューティクス，インコーポレイティド | 樹状細胞組成物および方法 |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
| US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US9249423B2 (en) * | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| DE102007006736B4 (de) | 2007-02-07 | 2012-01-12 | Dagmar Briechle | In-vitro Testkit zur tierversuchsfreien Bestimmung des sensibilisierenden Potentials einer Substanz |
| WO2008133983A1 (en) * | 2007-04-25 | 2008-11-06 | Immurx, Inc. | Adjuvant combinations of nkt activator, cd40 agonist, and optional antigen, the use through inducing synergistic cellular immunity |
| HUE029164T2 (hu) | 2007-09-14 | 2017-02-28 | Univ Brussel Vrije | Humán antigén-prezentáló sejtek T-sejteket stimuláló képességének fokozása és azok alkalmazása vakcinázásra |
| US9408909B2 (en) | 2007-09-14 | 2016-08-09 | Vrije Universiteit Brussel | Enhancing the T-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and its use in vaccination |
| EP2201100B1 (en) * | 2007-09-14 | 2016-03-16 | Vrije Universiteit Brussel | Enhancing the t-cells stimulatory capacity of human antigen presenting cells and their use in vaccination |
| BRPI0818736A2 (pt) | 2007-10-30 | 2017-06-13 | Univ Arkansas | composições e métodos para intensificar imunorrepostas à bactéria flagelada |
| CN101969990B (zh) | 2007-11-01 | 2014-07-09 | 阿肯色大学评议会 | 增强针对艾美球虫属的免疫反应的组合物和方法 |
| EP2072617A1 (en) * | 2007-12-12 | 2009-06-24 | Trimed Biotech GmbH | Method for producing dendritic cells |
| US20090263828A1 (en) * | 2008-04-16 | 2009-10-22 | Franco Lori | Novel assay for precursor T-cells having high proliferative capacity (PHPC-asay) |
| US8741639B2 (en) | 2008-11-14 | 2014-06-03 | Dnavec Corporation | Method for producing dendritic cells |
| CN102325790A (zh) | 2008-12-03 | 2012-01-18 | 西马生物医学计划公司 | 应用酚可溶性调控蛋白研制疫苗 |
| CN102753700A (zh) * | 2009-09-04 | 2012-10-24 | 先正达参股股份有限公司 | 增加植物中多肽表达的翻译增强子元件堆叠 |
| RU2012127811A (ru) * | 2009-12-04 | 2014-01-10 | Стем Селл Энд Ридженерэйтив Медсин Интернэшнл, Инк. | Способ получения клеток-натуральных киллеров и дендритных клеток из человеческих эмбриональных гемангиобластов, полученных из стволовых клеток |
| CN102811734B (zh) | 2010-01-21 | 2016-02-10 | 阿肯色大学评议会 | 增强免疫应答的疫苗载体和方法 |
| CN102971008B (zh) | 2010-06-09 | 2015-11-25 | 阿肯色大学评议会 | 降低弯曲菌属感染的疫苗和方法 |
| SG11201404677TA (en) * | 2011-12-12 | 2014-11-27 | Cell Medica Ltd | Process of expanding t cells |
| US9603915B2 (en) | 2013-02-14 | 2017-03-28 | The Board of Trustees of the University of Akansas | Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection |
| BR112015023024B1 (pt) | 2013-03-15 | 2022-04-19 | The Board Of Trustees Of The University Of Arkansas | Vetor de vacina e composições farmacêuticas compreendendo o mesmo |
| CN109342710A (zh) * | 2013-03-28 | 2019-02-15 | 英属哥伦比亚大学 | 微流控装置及其在多细胞分泌检测中的使用方法 |
| JP2016081562A (ja) | 2014-10-09 | 2016-05-16 | ソニー株式会社 | 表示装置、表示装置の製造方法および電子機器 |
| EP3268012A4 (en) * | 2015-03-12 | 2018-10-31 | Health Research, Inc. | Enrichment of cd16+ monocytes to improve dendritic cell vaccine quality |
| CN105670994A (zh) * | 2016-02-28 | 2016-06-15 | 深圳爱生再生医学科技有限公司 | Dc诱导剂及其应用 |
| WO2017186121A1 (zh) * | 2016-04-26 | 2017-11-02 | 科济生物医药（上海）有限公司 | 一种改善免疫应答细胞功能的方法 |
| KR102767638B1 (ko) | 2016-05-03 | 2025-02-20 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법 |
| US11779599B2 (en) | 2017-11-07 | 2023-10-10 | Coimmune, Inc. | Methods and uses for dendritic cell therapy |
| US20210277354A1 (en) * | 2018-06-19 | 2021-09-09 | Fondazione Telethon | Production of engineered dendritic cells and uses thereof |
| BR112021000620A2 (pt) * | 2018-07-15 | 2021-04-20 | Enochian BioPharma, Inc. | métodos e composições com uso de células dendríticas recombinantes para terapia contra câncer |
| CN109797209B (zh) * | 2019-01-04 | 2021-07-16 | 中国人民解放军第二军医大学 | 一种树突状细胞和/或趋化性树突状细胞和/或其趋化状态和功能的特异性生物标志物 |
| BR112021020411A2 (pt) * | 2019-04-11 | 2022-03-15 | Univ Arkansas | Aptâmeros de dna específicos para cd40 como adjuvantes de vacina |
| AU2020294700A1 (en) * | 2019-06-17 | 2022-02-03 | Renovaro Biosciences Inc. | Allogeneic T-cell-based HIV vaccine to induce cellular and humoral immunity |
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| US20250223554A1 (en) * | 2024-01-05 | 2025-07-10 | Renovaro Biopharma Inc. | Methods and compositions using recombinant dendritic cells for cancer therapy |
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-
2005
- 2005-10-07 KR KR1020077008070A patent/KR101243577B1/ko not_active Expired - Fee Related
- 2005-10-07 ES ES10174970T patent/ES2861199T3/es not_active Expired - Lifetime
- 2005-10-07 WO PCT/US2005/036304 patent/WO2006042177A2/en not_active Ceased
- 2005-10-07 EP EP10174970.3A patent/EP2251418B1/en not_active Expired - Lifetime
- 2005-10-07 AU AU2005294150A patent/AU2005294150B2/en not_active Ceased
- 2005-10-07 DE DE602005025005T patent/DE602005025005D1/de not_active Expired - Lifetime
- 2005-10-07 EP EP05804341A patent/EP1809737B9/en not_active Expired - Lifetime
- 2005-10-07 TW TW094135203A patent/TWI382843B/zh not_active IP Right Cessation
- 2005-10-07 US US11/664,899 patent/US20080145931A1/en not_active Abandoned
- 2005-10-07 CN CN2005800337404A patent/CN101080487B/zh not_active Expired - Fee Related
- 2005-10-07 DK DK05804341.5T patent/DK1809737T3/da active
- 2005-10-07 US US11/246,387 patent/US8822223B2/en active Active
- 2005-10-07 CA CA2577125A patent/CA2577125C/en not_active Expired - Lifetime
- 2005-10-07 AT AT05804341T patent/ATE489455T1/de active
- 2005-10-07 JP JP2007535869A patent/JP5269412B2/ja not_active Expired - Fee Related
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