JP2009533025A5 - - Google Patents

Info

Publication number

JP2009533025A5

JP2009533025A5 JP2009504346A JP2009504346A JP2009533025A5 JP 2009533025 A5 JP2009533025 A5 JP 2009533025A5 JP 2009504346 A JP2009504346 A JP 2009504346A JP 2009504346 A JP2009504346 A JP 2009504346A JP 2009533025 A5 JP2009533025 A5 JP 2009533025A5

Authority

JP

Japan

Prior art keywords

dendritic

dendritic cell

cells

dendritic cells

ifn

Prior art date

2007-04-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004443 dendritic cell Anatomy 0.000 claims 35
• 238000000034 method Methods 0.000 claims 15
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 9
• 108010029697 CD40 Ligand Proteins 0.000 claims 9
• 102100032937 CD40 ligand Human genes 0.000 claims 9
• 239000000556 agonist Substances 0.000 claims 6
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 108010085650 interferon gamma receptor Proteins 0.000 claims 5
• 229960005486 vaccine Drugs 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 230000011664 signaling Effects 0.000 claims 4
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 3
• 102100037850 Interferon gamma Human genes 0.000 claims 3
• 108010074328 Interferon-gamma Proteins 0.000 claims 3
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims 3
• VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical group CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
• 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 210000003162 effector t lymphocyte Anatomy 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 210000003071 memory t lymphocyte Anatomy 0.000 claims 2
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 claims 1
• 241001385733 Aesculus indica Species 0.000 claims 1
• 108020004705 Codon Proteins 0.000 claims 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
• 108090000978 Interleukin-4 Proteins 0.000 claims 1
• 241000269435 Rana <genus> Species 0.000 claims 1
• MYYARUCLXARAEE-ZATZPJRKSA-N alpha-C-GalCer Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCCCCC MYYARUCLXARAEE-ZATZPJRKSA-N 0.000 claims 1
• 230000003796 beauty Effects 0.000 claims 1
• 239000002299 complementary DNA Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• 230000001052 transient effect Effects 0.000 claims 1