JP2002516662A5 - - Google Patents
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- Publication number
- JP2002516662A5 JP2002516662A5 JP2000541960A JP2000541960A JP2002516662A5 JP 2002516662 A5 JP2002516662 A5 JP 2002516662A5 JP 2000541960 A JP2000541960 A JP 2000541960A JP 2000541960 A JP2000541960 A JP 2000541960A JP 2002516662 A5 JP2002516662 A5 JP 2002516662A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- variant
- nucleic acid
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 34
- 102000004196 processed proteins & peptides Human genes 0.000 description 34
- 108090000765 processed proteins & peptides Proteins 0.000 description 34
- 102000039446 nucleic acids Human genes 0.000 description 22
- 108020004707 nucleic acids Proteins 0.000 description 22
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 125000003275 alpha amino acid group Chemical group 0.000 description 20
- 239000012634 fragment Substances 0.000 description 13
- 229960005486 vaccine Drugs 0.000 description 9
- 101710164918 Choline-binding protein Proteins 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 208000035109 Pneumococcal Infections Diseases 0.000 description 3
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- 210000001106 artificial yeast chromosome Anatomy 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8087898P | 1998-04-07 | 1998-04-07 | |
| US09/056,019 | 1998-04-07 | ||
| US09/056,019 US6858706B2 (en) | 1998-04-07 | 1998-04-07 | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| US60/080,878 | 1998-04-07 | ||
| PCT/US1999/007669 WO1999051188A2 (en) | 1998-04-07 | 1999-04-07 | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002516662A JP2002516662A (ja) | 2002-06-11 |
| JP2002516662A5 true JP2002516662A5 (enExample) | 2006-06-01 |
| JP4739521B2 JP4739521B2 (ja) | 2011-08-03 |
Family
ID=26734874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000541960A Expired - Fee Related JP4739521B2 (ja) | 1998-04-07 | 1999-04-07 | Ｎ−末端コリン結合プロテインａ切端形のアミノ酸を含むポリペプチド、それに由来するワクチンおよびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP4739521B2 (enExample) |
| KR (1) | KR100638503B1 (enExample) |
| CN (1) | CN1191851C (enExample) |
| AU (2) | AU3479699A (enExample) |
| BR (1) | BR9909910A (enExample) |
| CA (1) | CA2326388C (enExample) |
| HU (1) | HUP0102306A3 (enExample) |
| IL (1) | IL138939A0 (enExample) |
| MX (1) | MXPA00009899A (enExample) |
| NO (1) | NO20005081L (enExample) |
| NZ (1) | NZ507983A (enExample) |
| PL (1) | PL193132B1 (enExample) |
| TR (1) | TR200003498T2 (enExample) |
| WO (1) | WO1999051188A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CN103251940A (zh) | 2005-12-22 | 2013-08-21 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| MX2009013949A (es) | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
| MX2010011412A (es) | 2008-04-16 | 2010-11-12 | Glaxosmithkline Biolog Sa | Vacuna. |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| US20140072622A1 (en) | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| EP0912608B1 (en) * | 1996-05-01 | 2006-04-19 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| PT942983E (pt) * | 1996-10-31 | 2007-02-28 | Human Genome Sciences Inc | Antigénios e vacinas de streptococcus pneumoniae |
| EP0942984A2 (en) * | 1996-11-12 | 1999-09-22 | Regents Of The University Of Minnesota | C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE) |
| US6503511B1 (en) * | 1998-04-07 | 2003-01-07 | Medimmune, Inc. | Derivatives of choline binding proteins for vaccines |
| US6858706B2 (en) * | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
-
1999
- 1999-04-07 IL IL13893999A patent/IL138939A0/xx unknown
- 1999-04-07 AU AU34796/99A patent/AU3479699A/en not_active Withdrawn
- 1999-04-07 MX MXPA00009899A patent/MXPA00009899A/es unknown
- 1999-04-07 KR KR1020007011206A patent/KR100638503B1/ko not_active Expired - Fee Related
- 1999-04-07 WO PCT/US1999/007669 patent/WO1999051188A2/en not_active Ceased
- 1999-04-07 HU HU0102306A patent/HUP0102306A3/hu unknown
- 1999-04-07 PL PL347946A patent/PL193132B1/pl unknown
- 1999-04-07 BR BR9909910-1A patent/BR9909910A/pt not_active Application Discontinuation
- 1999-04-07 NZ NZ507983A patent/NZ507983A/xx not_active IP Right Cessation
- 1999-04-07 TR TR2000/03498T patent/TR200003498T2/xx unknown
- 1999-04-07 CN CNB998108545A patent/CN1191851C/zh not_active Expired - Fee Related
- 1999-04-07 AU AU34797/99A patent/AU764811B2/en not_active Ceased
- 1999-04-07 JP JP2000541960A patent/JP4739521B2/ja not_active Expired - Fee Related
- 1999-04-07 CA CA2326388A patent/CA2326388C/en not_active Expired - Fee Related
-
2000
- 2000-10-09 NO NO20005081A patent/NO20005081L/no not_active Application Discontinuation
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