BR9909910A - Polipeptìdeo compreendendo o aminoácido de um truncado de proteìna a de ligação à colina de terminal n, vacina derivada dele e seus empregos - Google Patents
Polipeptìdeo compreendendo o aminoácido de um truncado de proteìna a de ligação à colina de terminal n, vacina derivada dele e seus empregosInfo
- Publication number
- BR9909910A BR9909910A BR9909910-1A BR9909910A BR9909910A BR 9909910 A BR9909910 A BR 9909910A BR 9909910 A BR9909910 A BR 9909910A BR 9909910 A BR9909910 A BR 9909910A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- polypeptide
- choline
- truncate
- acid sequence
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 229960001231 choline Drugs 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 150000001413 amino acids Chemical class 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 150000003248 quinolines Chemical group 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 6
- 102000004856 Lectins Human genes 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: "POLIPEPTìDEO COMPREENDENDO O AMINOáCIDO DE UM TRUNCADO DE PROTEìNA A DE LIGAçãO à COLINA DE TéRMINO N, VACINA DERIVADA DELE E SEUS EMPREGOS". Esta invenção fornece um polipeptídeo isolado compreendendo uma seq³ência de aminoácido de um truncado de proteína A de ligação à colina de término N, no qual a seq³ência de aminoácido é mencionada em qualquer das SEQ ID NN<0>s 1, 3 a 7, ou 9 a 11, incluindo fragmentos, mutantes, variantes, análogos, ou derivados destes. Além disso, esta invenção fornece polipeptídeos isolados compreendendo uma seq³ência de aminoácido de um truncado de proteína A de ligação à colina de término N, onde o aminoácido é mencionado na SEQ ID NN<0> 24, em que o polipeptídeo retém sua estrutura terciária nativa e métodos de preparação. Esta invenção fornece um polipeptídeo isolado compreendendo uma seq³ência de aminoácido de um truncado de proteína A de ligação à colina de término N, onde o polipeptídeo tem atividade de lectina e não liga-se à colina. Esta invenção fornece um polipeptídeo imunogênico isolado compreendendo uma seq³ência de aminoácido de um truncado de proteína A de ligação à colina de término N. Esta invenção fornece um ácido nucléico isolado codificando um polipeptídeo compreendendo uma seq³ência de aminoácido de truncado de proteína A de ligação à colina de término N. Finalmente, esta invenção fornece composições farmacêuticas, vacinas, e métodos diagnósticos e terapêuticos de uso.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8087898P | 1998-04-07 | 1998-04-07 | |
| US09/056,019 US6858706B2 (en) | 1998-04-07 | 1998-04-07 | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| PCT/US1999/007669 WO1999051188A2 (en) | 1998-04-07 | 1999-04-07 | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9909910A true BR9909910A (pt) | 2002-01-15 |
Family
ID=26734874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9909910-1A BR9909910A (pt) | 1998-04-07 | 1999-04-07 | Polipeptìdeo compreendendo o aminoácido de um truncado de proteìna a de ligação à colina de terminal n, vacina derivada dele e seus empregos |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP4739521B2 (pt) |
| KR (1) | KR100638503B1 (pt) |
| CN (1) | CN1191851C (pt) |
| AU (2) | AU764811B2 (pt) |
| BR (1) | BR9909910A (pt) |
| CA (1) | CA2326388C (pt) |
| HU (1) | HUP0102306A3 (pt) |
| IL (1) | IL138939A0 (pt) |
| MX (1) | MXPA00009899A (pt) |
| NO (1) | NO20005081L (pt) |
| NZ (1) | NZ507983A (pt) |
| PL (1) | PL193132B1 (pt) |
| TR (1) | TR200003498T2 (pt) |
| WO (1) | WO1999051188A2 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| EP3020411A1 (en) | 2005-12-22 | 2016-05-18 | GlaxoSmithKline Biologicals s.a. | Vaccine |
| WO2009000825A2 (en) | 2007-06-26 | 2008-12-31 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| EA201001479A1 (ru) | 2008-04-16 | 2011-06-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| ATE323721T1 (de) * | 1996-05-01 | 2006-05-15 | Univ Rockefeller | Cholin-bindendes protein, welches als gegen pneumokokken gerichtetes vakzin verwendet wird |
| DE69737125T3 (de) * | 1996-10-31 | 2015-02-26 | Human Genome Sciences, Inc. | Streptococcus pneumoniae-Antigene und Impfstoffe |
| CA2269636A1 (en) * | 1996-11-12 | 1998-05-22 | The Regents Of The University Of Minnesota | C3 binding protein of streptococcus pneumoniae |
| US6858706B2 (en) * | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| BR9909483A (pt) * | 1998-04-07 | 2001-10-09 | Medimmune Inc | Derivados de proteìnas ligantes pneumococcal colina para vacinas |
-
1999
- 1999-04-07 PL PL347946A patent/PL193132B1/pl unknown
- 1999-04-07 AU AU34797/99A patent/AU764811B2/en not_active Ceased
- 1999-04-07 AU AU34796/99A patent/AU3479699A/en not_active Withdrawn
- 1999-04-07 TR TR2000/03498T patent/TR200003498T2/xx unknown
- 1999-04-07 JP JP2000541960A patent/JP4739521B2/ja not_active Expired - Fee Related
- 1999-04-07 MX MXPA00009899A patent/MXPA00009899A/es unknown
- 1999-04-07 CA CA2326388A patent/CA2326388C/en not_active Expired - Fee Related
- 1999-04-07 CN CNB998108545A patent/CN1191851C/zh not_active Expired - Fee Related
- 1999-04-07 BR BR9909910-1A patent/BR9909910A/pt not_active Application Discontinuation
- 1999-04-07 WO PCT/US1999/007669 patent/WO1999051188A2/en active IP Right Grant
- 1999-04-07 NZ NZ507983A patent/NZ507983A/xx not_active IP Right Cessation
- 1999-04-07 IL IL13893999A patent/IL138939A0/xx unknown
- 1999-04-07 HU HU0102306A patent/HUP0102306A3/hu unknown
- 1999-04-07 KR KR1020007011206A patent/KR100638503B1/ko not_active IP Right Cessation
-
2000
- 2000-10-09 NO NO20005081A patent/NO20005081L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999051188A9 (en) | 2000-10-12 |
| HUP0102306A3 (en) | 2008-04-28 |
| AU764811B2 (en) | 2003-08-28 |
| JP4739521B2 (ja) | 2011-08-03 |
| KR100638503B1 (ko) | 2006-10-26 |
| AU3479799A (en) | 1999-10-25 |
| WO1999051188A2 (en) | 1999-10-14 |
| NO20005081L (no) | 2000-12-06 |
| WO1999051188A3 (en) | 2001-04-19 |
| TR200003498T2 (tr) | 2001-10-22 |
| CN1342088A (zh) | 2002-03-27 |
| AU3479699A (en) | 1999-10-25 |
| JP2002516662A (ja) | 2002-06-11 |
| CN1191851C (zh) | 2005-03-09 |
| PL193132B1 (pl) | 2007-01-31 |
| HUP0102306A1 (hu) | 2001-09-28 |
| PL347946A1 (en) | 2002-04-22 |
| IL138939A0 (en) | 2001-11-25 |
| NZ507983A (en) | 2004-03-26 |
| CA2326388A1 (en) | 1999-10-14 |
| CA2326388C (en) | 2014-02-04 |
| MXPA00009899A (es) | 2002-05-08 |
| NO20005081D0 (no) | 2000-10-09 |
| KR20010052244A (ko) | 2001-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9801122A2 (hu) | Osteoprotegerin | |
| BR0207267A (pt) | Proteìnas artificiais com imunogenicidade reduzida | |
| ATE352559T1 (de) | Verfahren zur verminderung der immunogenität von proteinen | |
| ATE292685T1 (de) | Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffe | |
| ZA891067B (en) | Pox virus vectors | |
| BG103824A (en) | Osteoprotegerin binding proteins and receptors | |
| PT93910A (pt) | Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula | |
| AR245778A1 (es) | Secuencia de nucleotido que codifica una proteina de membrana exterior de neisseria meningitis y uso de dicha proteina en preparaciones de vacuna | |
| Solioz et al. | The protective capacities of histone H1 against experimental murine cutaneous leishmaniasis | |
| BR9909910A (pt) | Polipeptìdeo compreendendo o aminoácido de um truncado de proteìna a de ligação à colina de terminal n, vacina derivada dele e seus empregos | |
| BR0207016A (pt) | Fator neurotrófico derivado de cérebro humano modificado (bdnf) com imunogenicidade reduzida | |
| BR9803960A (pt) | Gene de desidrogenase de d-sorbitol. | |
| BR9812240A (pt) | Proteìna g alterada ou polipeptìdeo do rsv, uso da mesma, molécula de ácido nucleico codificando uma proteìna g alterada ou um polipeptìdeo do rsv, construção do ácido nucleico, célula hospedeira recombinante, processos de produção de uma proteìna g alterada ou polipeptìdeo do rsv composição imunogênica, de indução de uma resposta imune em um vertebrado, de inibir a indução do aumento da doença após a vacinação e subsequente infecção de um vertebrado com o rsv e de imunização de um vertebrado contra o rsv, composição de vacina, vacina, e, composição imunogênica | |
| WO2000029434A3 (en) | PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF | |
| BR0207014A (pt) | Antagonista de receptor de interleucina-1 modificada (il-1ra) com imunogenicidade reduzida. | |
| EP1208196A4 (en) | NEW SECRETINE FAMILY GPCR TYPE 15571 MOLECULE AND USES THEREOF | |
| NO915084L (no) | Fremgangsmaate ved fremstilling av human interleukin-5 receptor | |
| BR0207015A (pt) | Eritropoientina modificada (epo) com imunogenicidade reduzida | |
| BR0207704A (pt) | Alfa interferon modificado com imunogenicidade reduzida | |
| BR0207905A (pt) | Protamina modificada com imunogenicidade reduzida | |
| WO1996040909A1 (en) | Bone stimulating factor | |
| CA2002833A1 (en) | Interferon-gamma binding proteins | |
| IE890087L (en) | Recombinant human interleukin-1 alpha polypeptides | |
| EP0887410A3 (en) | DNA encoding a plasminogen activating protein | |
| NO20011263L (no) | Moraxella Catarrhalis BASBO34-polypeptider og anvendelser derav |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 10 (VIII E IX) E 25 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |