CA2326388C - A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof - Google Patents

Info

Publication number

CA2326388C

CA2326388C CA2326388A CA2326388A CA2326388C CA 2326388 C CA2326388 C CA 2326388C CA 2326388 A CA2326388 A CA 2326388A CA 2326388 A CA2326388 A CA 2326388A CA 2326388 C CA2326388 C CA 2326388C

Authority

CA

Canada

Prior art keywords

polypeptide

lys

glu

ala

amino acid

Prior art date

1998-04-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 311
• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 274
• 229920001184 polypeptide Polymers 0.000 title claims abstract description 260
• 150000001413 amino acids Chemical class 0.000 title claims abstract description 70
• 101710164918 Choline-binding protein Proteins 0.000 title claims abstract description 56
• 229960005486 vaccine Drugs 0.000 title claims abstract description 33
• 125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 91
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 54
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 54
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 54
• 238000000034 method Methods 0.000 claims abstract description 52
• 230000000694 effects Effects 0.000 claims abstract description 49
• 229960001231 choline Drugs 0.000 claims abstract description 42
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims abstract description 41
• 239000012634 fragment Substances 0.000 claims abstract description 33
• 108090001090 Lectins Proteins 0.000 claims abstract description 25
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• 239000002523 lectin Substances 0.000 claims abstract description 25
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 24
• 230000002163 immunogen Effects 0.000 claims abstract description 13
• 230000027455 binding Effects 0.000 claims description 48
• 239000013598 vector Substances 0.000 claims description 40
• 210000004027 cell Anatomy 0.000 claims description 39
• 241000193998 Streptococcus pneumoniae Species 0.000 claims description 32
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 32
• 108020004414 DNA Proteins 0.000 claims description 26
• 239000002671 adjuvant Substances 0.000 claims description 24
• 239000003814 drug Substances 0.000 claims description 20
• 239000002773 nucleotide Substances 0.000 claims description 18
• 125000003729 nucleotide group Chemical group 0.000 claims description 18
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• 238000004519 manufacturing process Methods 0.000 claims description 17
• 208000015181 infectious disease Diseases 0.000 claims description 15
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• 230000001681 protective effect Effects 0.000 claims description 9
• 210000003527 eukaryotic cell Anatomy 0.000 claims description 6
• 210000001989 nasopharynx Anatomy 0.000 claims description 6
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• 229920001223 polyethylene glycol Polymers 0.000 description 31
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• 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 25
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• 108010054155 lysyllysine Proteins 0.000 description 24
• QVFGXCVIXXBFHO-AVGNSLFASA-N Leu-Glu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O QVFGXCVIXXBFHO-AVGNSLFASA-N 0.000 description 23
• XGZBEGGGAUQBMB-KJEVXHAQSA-N Tyr-Pro-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=C(C=C2)O)N)O XGZBEGGGAUQBMB-KJEVXHAQSA-N 0.000 description 23
• IEQCXFNWPAHHQR-YKLSGRGUSA-N beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc Chemical compound O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O IEQCXFNWPAHHQR-YKLSGRGUSA-N 0.000 description 23
• IEQCXFNWPAHHQR-UHFFFAOYSA-N lacto-N-neotetraose Natural products OCC1OC(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)C(NC(=O)C)C(O)C1OC1OC(CO)C(O)C(O)C1O IEQCXFNWPAHHQR-UHFFFAOYSA-N 0.000 description 23
• JRHFQUPIZOYKQP-KBIXCLLPSA-N Ile-Ala-Glu Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCC(O)=O JRHFQUPIZOYKQP-KBIXCLLPSA-N 0.000 description 22
• RPWTZTBIFGENIA-VOAKCMCISA-N Lys-Thr-Leu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O RPWTZTBIFGENIA-VOAKCMCISA-N 0.000 description 22
• 108010025488 pinealon Proteins 0.000 description 22
• 108010051110 tyrosyl-lysine Proteins 0.000 description 22
• VWVPYNGMOCSSGK-GUBZILKMSA-N Arg-Arg-Asn Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O VWVPYNGMOCSSGK-GUBZILKMSA-N 0.000 description 21
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• QQPSCXKFDSORFT-IHRRRGAJSA-N Lys-Lys-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN QQPSCXKFDSORFT-IHRRRGAJSA-N 0.000 description 19
• 241001465754 Metazoa Species 0.000 description 19
• SWSRFJZZMNLMLY-ZKWXMUAHSA-N Ser-Asp-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O SWSRFJZZMNLMLY-ZKWXMUAHSA-N 0.000 description 19
• -1 9-fluorenylmethoxycarbonyl (Fmoc) amino Chemical class 0.000 description 18
• 239000000463 material Substances 0.000 description 18
• KZYSHAMXEBPJBD-JRQIVUDYSA-N Asn-Thr-Tyr Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O KZYSHAMXEBPJBD-JRQIVUDYSA-N 0.000 description 17
• IRXNJYPKBVERCW-DCAQKATOSA-N Glu-Leu-Glu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O IRXNJYPKBVERCW-DCAQKATOSA-N 0.000 description 17
• 108010065920 Insulin Lispro Proteins 0.000 description 17
• PBIPLDMFHAICIP-DCAQKATOSA-N Lys-Glu-Glu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O PBIPLDMFHAICIP-DCAQKATOSA-N 0.000 description 17
• 229920000642 polymer Polymers 0.000 description 17
• CGOHAEBMDSEKFB-FXQIFTODSA-N Glu-Glu-Ala Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O CGOHAEBMDSEKFB-FXQIFTODSA-N 0.000 description 16
• 239000000126 substance Substances 0.000 description 16
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• WKOBSJOZRJJVRZ-FXQIFTODSA-N Ala-Glu-Glu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O WKOBSJOZRJJVRZ-FXQIFTODSA-N 0.000 description 15
• HRBYTAIBKPNZKQ-AVGNSLFASA-N Glu-Lys-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O HRBYTAIBKPNZKQ-AVGNSLFASA-N 0.000 description 15
• CKRFDMPBSWYOBT-PPCPHDFISA-N Ile-Lys-Thr Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)N CKRFDMPBSWYOBT-PPCPHDFISA-N 0.000 description 15
• CNGOEHJCLVCJHN-SRVKXCTJSA-N Lys-Pro-Glu Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O CNGOEHJCLVCJHN-SRVKXCTJSA-N 0.000 description 15
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• VCSABYLVNWQYQE-SRVKXCTJSA-N Ala-Lys-Lys Chemical compound NCCCC[C@H](NC(=O)[C@@H](N)C)C(=O)N[C@@H](CCCCN)C(O)=O VCSABYLVNWQYQE-SRVKXCTJSA-N 0.000 description 14
• TWYFJOHWGCCRIR-DCAQKATOSA-N Glu-Pro-Arg Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O TWYFJOHWGCCRIR-DCAQKATOSA-N 0.000 description 14
• ZYRXTRTUCAVNBQ-GVXVVHGQSA-N Glu-Val-Lys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCC(=O)O)N ZYRXTRTUCAVNBQ-GVXVVHGQSA-N 0.000 description 14
• NYTDJEZBAAFLLG-IHRRRGAJSA-N Lys-Val-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O NYTDJEZBAAFLLG-IHRRRGAJSA-N 0.000 description 14
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• 125000000539 amino acid group Chemical group 0.000 description 9
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