CA2326388C - Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations - Google Patents

Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations Download PDF

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Publication number
CA2326388C
CA2326388C CA2326388A CA2326388A CA2326388C CA 2326388 C CA2326388 C CA 2326388C CA 2326388 A CA2326388 A CA 2326388A CA 2326388 A CA2326388 A CA 2326388A CA 2326388 C CA2326388 C CA 2326388C
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CA
Canada
Prior art keywords
polypeptide
lys
glu
ala
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2326388A
Other languages
English (en)
Other versions
CA2326388A1 (fr
Inventor
Elaine I. Tuomanen
H. Robert Masure
Theresa M. Wizemann
Leslie Sydnor Johnson
Scott Koenig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Jude Childrens Research Hospital
MedImmune LLC
Original Assignee
St Jude Childrens Research Hospital
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/056,019 external-priority patent/US6858706B2/en
Application filed by St Jude Childrens Research Hospital, MedImmune LLC filed Critical St Jude Childrens Research Hospital
Publication of CA2326388A1 publication Critical patent/CA2326388A1/fr
Application granted granted Critical
Publication of CA2326388C publication Critical patent/CA2326388C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, laquelle séquence apparaît dans SEQ ID NOS: 1, 3-7 ou 9-11, y compris les fragments, mutants, variants, analogues ou dérivés de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où l'acide aminé apparaît dans SEQ ID NO 2, où le polypeptide conserve sa structure tertiaire d'origine. L'invention concerne également les méthodes d'élaboration de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où le polypeptide présente une activité de lectine et ne fixe pas la choline. L'invention concerne également un polypeptide isolé immunogène comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. L'invention concerne également un acide nucléique isolé codant un polypeptide comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. Enfin, l'invention concerne des compositions pharmaceutiques, des vaccins et des méthodes diagnostiques et thérapeutiques d'utilisation de ces compositions et de ces vaccins.
CA2326388A 1998-04-07 1999-04-07 Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations Expired - Fee Related CA2326388C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8087898P 1998-04-07 1998-04-07
US09/056,019 1998-04-07
US60/080,878 1998-04-07
US09/056,019 US6858706B2 (en) 1998-04-07 1998-04-07 Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
PCT/US1999/007669 WO1999051188A2 (fr) 1998-04-07 1999-04-07 Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations

Publications (2)

Publication Number Publication Date
CA2326388A1 CA2326388A1 (fr) 1999-10-14
CA2326388C true CA2326388C (fr) 2014-02-04

Family

ID=26734874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2326388A Expired - Fee Related CA2326388C (fr) 1998-04-07 1999-04-07 Polypeptide comprenant l'acide amine d'un produit tronque de la proteine a n-terminale fixant la choline, vaccin derive de ce polypeptide et ses utilisations

Country Status (14)

Country Link
JP (1) JP4739521B2 (fr)
KR (1) KR100638503B1 (fr)
CN (1) CN1191851C (fr)
AU (2) AU3479699A (fr)
BR (1) BR9909910A (fr)
CA (1) CA2326388C (fr)
HU (1) HUP0102306A3 (fr)
IL (1) IL138939A0 (fr)
MX (1) MXPA00009899A (fr)
NO (1) NO20005081L (fr)
NZ (1) NZ507983A (fr)
PL (1) PL193132B1 (fr)
TR (1) TR200003498T2 (fr)
WO (1) WO1999051188A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
NO346529B1 (no) 2005-12-22 2022-09-26 Glaxosmithkline Biologicals Sa Bruk av et immunogenpreparat for småbarn, omfattende 22F sakkaridkonjugat
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CN101883583B (zh) 2007-06-26 2017-05-17 葛兰素史密丝克莱恩生物有限公司 含有肺炎链球菌荚膜多糖缀合物的疫苗
WO2009127676A1 (fr) 2008-04-16 2009-10-22 Glaxosmithkline Biologicals S.A. Vaccin
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
EA201391456A1 (ru) 2011-05-17 2014-05-30 Глаксосмитклайн Байолоджикалс С.А. ВАКЦИНА ПРОТИВ Streptococcus pneumoniae
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592876B1 (en) * 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
AU732520B2 (en) * 1996-05-01 2001-04-26 Rockefeller University, The Choline binding proteins for anti-pneumococcal vaccines
AU5194598A (en) * 1996-10-31 1998-05-22 Human Genome Sciences, Inc. (streptococcus pneumoniae) antigens and vaccines
US6291654B1 (en) * 1996-11-12 2001-09-18 Regents Of The University Of Minnesota Method for isolating a C3 binding protein of streptococcus pneumoniae
BR9909483A (pt) * 1998-04-07 2001-10-09 Medimmune Inc Derivados de proteìnas ligantes pneumococcal colina para vacinas
US6858706B2 (en) * 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof

Also Published As

Publication number Publication date
AU3479699A (en) 1999-10-25
NO20005081D0 (no) 2000-10-09
NO20005081L (no) 2000-12-06
CN1191851C (zh) 2005-03-09
AU764811B2 (en) 2003-08-28
KR20010052244A (ko) 2001-06-25
CA2326388A1 (fr) 1999-10-14
TR200003498T2 (tr) 2001-10-22
MXPA00009899A (es) 2002-05-08
WO1999051188A3 (fr) 2001-04-19
NZ507983A (en) 2004-03-26
JP2002516662A (ja) 2002-06-11
PL347946A1 (en) 2002-04-22
KR100638503B1 (ko) 2006-10-26
PL193132B1 (pl) 2007-01-31
HUP0102306A1 (hu) 2001-09-28
WO1999051188A9 (fr) 2000-10-12
JP4739521B2 (ja) 2011-08-03
BR9909910A (pt) 2002-01-15
IL138939A0 (en) 2001-11-25
WO1999051188A2 (fr) 1999-10-14
AU3479799A (en) 1999-10-25
HUP0102306A3 (en) 2008-04-28
CN1342088A (zh) 2002-03-27

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Legal Events

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FZDC Discontinued application reinstated
EEER Examination request
MKLA Lapsed

Effective date: 20180409