CN101460054B - 成熟的树突细胞组合物和用于培养其的方法 - Google Patents

成熟的树突细胞组合物和用于培养其的方法 Download PDF

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CN101460054B
CN101460054B CN200780020901.5A CN200780020901A CN101460054B CN 101460054 B CN101460054 B CN 101460054B CN 200780020901 A CN200780020901 A CN 200780020901A CN 101460054 B CN101460054 B CN 101460054B
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cells
cd40l
dcs
dendritic cells
seq
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CN101460054A (zh
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D·希利
A·希诺哈拉
M·亚当斯
M·德贝内德特
I·彻雷潘诺娃
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Merix Bioscience Inc
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Kirin Pharma KK
Merix Bioscience Inc
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CN200780020901.5A 2006-04-07 2007-04-06 成熟的树突细胞组合物和用于培养其的方法 Expired - Fee Related CN101460054B (zh)

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US11/400,774 US8513008B2 (en) 2004-10-07 2006-04-07 Mature dendritic cell compositions and methods for culturing same
US11/400,774 2006-04-07
PCT/US2007/008734 WO2007117682A2 (en) 2006-04-07 2007-04-06 Mature dendritic cell compositions and methods for culturing same

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
KR101243577B1 (ko) 2004-10-07 2013-03-20 아고스 쎄라퓨틱스, 인코포레이티드 성숙 수지상 세포 조성물 및 그의 배양 방법
JP5020935B2 (ja) 2005-04-08 2012-09-05 アルゴス セラピューティクス,インコーポレイティド 樹状細胞組成物および方法
ES2520026T3 (es) 2006-09-18 2014-11-11 The Board Of Trustees Of The University Of Arkansas Composiciones y métodos para potenciar respuestas inmunitarias
WO2009039198A2 (en) * 2007-09-17 2009-03-26 The Trustees Of The University Of Pennsylvania Generation of hyperstable mrnas
BRPI0818736A2 (pt) * 2007-10-30 2017-06-13 Univ Arkansas composições e métodos para intensificar imunorrepostas à bactéria flagelada
CN101969990B (zh) 2007-11-01 2014-07-09 阿肯色大学评议会 增强针对艾美球虫属的免疫反应的组合物和方法
EP2072617A1 (en) * 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
EP2254998B1 (en) * 2008-02-28 2015-12-23 Argos Therapeutics, Inc. Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection
CN102811734B (zh) 2010-01-21 2016-02-10 阿肯色大学评议会 增强免疫应答的疫苗载体和方法
CN102971008B (zh) 2010-06-09 2015-11-25 阿肯色大学评议会 降低弯曲菌属感染的疫苗和方法
WO2012041635A1 (en) * 2010-09-29 2012-04-05 Universite De Liege Combination of an agonistic anti-cd40 monoclonal antibody or a cd40 ligand and inactivated or attenuated bacteria for use in the treatment and/or prevention of mastitis
CN109536446B (zh) * 2012-02-10 2022-08-02 医疗法人社团博心厚生会 单核细胞增殖剂、单核细胞增殖用培养基、及单核细胞的制造方法
US9603915B2 (en) 2013-02-14 2017-03-28 The Board of Trustees of the University of Akansas Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection
BR112015023024B1 (pt) 2013-03-15 2022-04-19 The Board Of Trustees Of The University Of Arkansas Vetor de vacina e composições farmacêuticas compreendendo o mesmo
AU2015218865B2 (en) * 2014-02-21 2021-06-10 Coimmune, Inc. TSCM cells and methods for use
EP3316897A4 (en) 2015-07-02 2019-03-13 Primevax Immuno-Oncology, Inc. COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS
JP2018535191A (ja) * 2015-09-26 2018-11-29 プライムヴァックス イミュノ−オンコロジー,インク. 樹状細胞を産生するための組成物及び方法
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
WO2017123242A1 (en) * 2016-01-15 2017-07-20 Ding Enyu A universal nucleic acid drug vector enhancing mrna stability and translatability
KR102767638B1 (ko) 2016-05-03 2025-02-20 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법
JP2020500847A (ja) 2016-11-16 2020-01-16 プライムヴァックス イミュノ−オンコロジー,インク. 癌の処置のための併用免疫療法
CA3049225A1 (en) 2017-01-04 2018-07-12 PrimeVax Immuno-Oncology, Inc. Compositions and methods for therapy with dengue virus
US11779599B2 (en) 2017-11-07 2023-10-10 Coimmune, Inc. Methods and uses for dendritic cell therapy
CN111166876B (zh) * 2018-11-13 2022-10-11 北京启辰生生物科技有限公司 一种免疫增强剂组合和编码核酸及其应用
KR102698871B1 (ko) * 2021-09-10 2024-08-28 이종균 수지상 세포, 자연 살해 세포 및 세포 독성 t 세포를 포함하는 암의 예방 또는 치료용 생물학적 조성물
WO2024231621A1 (fr) * 2023-05-05 2024-11-14 Centre National De La Recherche Scientifique Acide nucleique synthetique et ses utilisations therapeutiques

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411228B1 (en) 1989-07-31 1995-11-08 International Business Machines Corporation Controlled fiber-optic switch
US5936076A (en) 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
US7405270B2 (en) 1991-10-25 2008-07-29 Immunex Corporation CD40-Ligand lacking native-pattern glycosylation
US5962406A (en) 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5981724A (en) 1991-10-25 1999-11-09 Immunex Corporation DNA encoding CD40 ligand, a cytokine that binds CD40
CA2121798C (en) 1991-10-25 2007-07-24 Richard J. Armitage Novel cytokine
TW261533B (enExample) 1992-07-16 1995-11-01 Kirin Brewery
KR100281264B1 (ko) 1992-10-22 2001-02-01 마나배 게이사꾸 신규한 스핀고당 지질 및 그의 사용
CN1045302C (zh) 1993-04-15 1999-09-29 麒麟麦酒株式会社 新型(神经)鞘糖脂、含有它们的药物组合物及其用途
PL181496B1 (pl) 1996-03-20 2001-07-31 Politechnika Slaska Im Wincent Sposób wytwarzania ß-naftolu PL
AU705647B2 (en) 1996-07-10 1999-05-27 Immunex Corporation Method of activating dendritic cells
US6017527A (en) 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
TW555562B (en) 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
ES2235324T3 (es) 1997-04-10 2005-07-01 Kirin Beer Kabushiki Kaisha Empleo de a-glicosilceramidas para la obtencion de un agente terapeutico para enfermedades autoinmunes.
TW575420B (en) 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
ATE428769T1 (de) 1997-10-27 2009-05-15 Univ Rockefeller Methode und zusammensetzung zur herstellung von reifen dendritischen zellen
CA2328604A1 (en) 1998-05-26 1999-12-02 Andrew Segal Compositions and methods of modulating an immune response to an antigen
EP1185627A2 (en) 1999-06-01 2002-03-13 Cornell Research Foundation, Inc. Activation of dendritic cells to enhance immunity
US20030077263A1 (en) 1999-10-29 2003-04-24 Immunex Corporation Method of activating dendritic cells
US20030059427A1 (en) 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
US7063845B2 (en) 2000-04-28 2006-06-20 Gemini Science, Inc. Human anti-CD40 antibodies
ES2389645T3 (es) 2000-06-19 2012-10-30 Beth Israel Deaconess Medical Center Composiciones y métodos de anticuerpos monoclonales y policlonales específicos para subpoblaciones de linfocitos T
AU2001268564A1 (en) 2000-06-22 2002-01-02 The Brigham And Women's Hospital, Inc. Alpha-glycosylceramides for treating bacterial and fungal infections
DE10041515A1 (de) 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
US20040247563A1 (en) 2000-11-02 2004-12-09 Lynch David H. Method of enhancing lymphocyte-mediated immune responses
AU2002224851A1 (en) 2000-11-14 2002-05-27 Universite Libre De Bruxelles Generation and use of dendritic cells
JP2004520033A (ja) 2001-01-15 2004-07-08 イ・デ・エム・イミュノ−デジネ・モレキュル 分化拘束された成熟樹状細胞の調製用補助組成物
WO2002074345A2 (en) 2001-03-16 2002-09-26 Johns Hopkins University School Of Medicine Immune modulation by transduced hematopoietic stem cells expressing antigens and antigen-presenting cell regulatory molecules
EP1270732A1 (en) 2001-06-21 2003-01-02 Schuler, Gerold Improved transfection of eukaryontic cells with linear polynucleotides by electroporation
WO2003010301A1 (en) 2001-07-25 2003-02-06 I.D.M. Immuno-Designed Molecules New isolated dendritic cells, a process for preparing the same and their use in pharmaceutical compositions
CA2453880A1 (en) 2001-07-25 2003-02-06 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
DK1437358T3 (da) 2001-08-16 2007-02-05 Daiichi Asubio Pharma Co Ltd Hidtil ukendt glycolipid og medikament til autoimmune sygdomme indeholdende dette som det aktive stof
EP1444330A1 (en) 2001-11-07 2004-08-11 Kirin Beer Kabushiki Kaisha Expansion of t cells in vitro and expanded t cell populations
CA2493690C (en) 2002-06-13 2011-11-08 New York University Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases
EP1572228A4 (en) 2002-09-19 2009-03-04 Centocor Inc METHOD FOR THE INTRODUCTION OF THE TREATMENT OF DENDRITIC CELLS AND ITS USES
WO2004026318A1 (ja) 2002-09-20 2004-04-01 Kirin Beer Kabushiki Kaisha α-グリコシルセラミドを有効成分とするC型肝炎ウイルス抑制剤
US20040146948A1 (en) * 2002-10-18 2004-07-29 Centenary Institute Of Cancer Medicine And Cell Biology Compositions and methods for targeting antigen-presenting cells with antibody single-chain variable region fragments
WO2004053095A2 (en) * 2002-12-10 2004-06-24 Merix Bioscience, Inc. In situ maturation of dendritic cells
SE0301109D0 (sv) 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
US20050003533A1 (en) 2003-05-08 2005-01-06 Pawel Kalinski Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use
AU2004277376B2 (en) 2003-07-18 2011-06-02 Eastern Virginia Medical School Apparatus for generating electrical pulses and methods of using the same
CN1882603A (zh) 2003-11-25 2006-12-20 阿哥斯医疗公司 mRNA转染的抗原呈递细胞
US20050222048A1 (en) 2004-03-31 2005-10-06 The Research Foundation Of The City University Of New York Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
KR101243577B1 (ko) 2004-10-07 2013-03-20 아고스 쎄라퓨틱스, 인코포레이티드 성숙 수지상 세포 조성물 및 그의 배양 방법
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
JP5020935B2 (ja) * 2005-04-08 2012-09-05 アルゴス セラピューティクス,インコーポレイティド 樹状細胞組成物および方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Frank Blaeser et al..Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation.《Clinical Immunology》.2005,第117卷231-237. *
Irina Y Tcherepanova et al..Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion.《BMC Molecular Biology》.2008,第9卷90. *

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JP5425618B2 (ja) 2014-02-26
JP2009533025A (ja) 2009-09-17
EP2003969A4 (en) 2009-05-13
CN101460054A (zh) 2009-06-17
KR20090006078A (ko) 2009-01-14
EP2003969A2 (en) 2008-12-24
ATE510451T1 (de) 2011-06-15
WO2007117682A2 (en) 2007-10-18
AU2007235227B2 (en) 2012-10-04
US20120269832A1 (en) 2012-10-25
CA2648675C (en) 2015-03-10
US20170096639A1 (en) 2017-04-06
US10184108B2 (en) 2019-01-22
US9523077B2 (en) 2016-12-20
DK2003969T3 (da) 2011-09-12
AU2007235227A1 (en) 2007-10-18
US20140017788A1 (en) 2014-01-16
WO2007117682A3 (en) 2008-10-16
KR101425686B1 (ko) 2014-08-01
US8513008B2 (en) 2013-08-20
CA2648675A1 (en) 2007-10-18
US20070082400A1 (en) 2007-04-12
EP2003969B1 (en) 2011-05-25

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