JP2010538649A5 - - Google Patents
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- Publication number
- JP2010538649A5 JP2010538649A5 JP2010524977A JP2010524977A JP2010538649A5 JP 2010538649 A5 JP2010538649 A5 JP 2010538649A5 JP 2010524977 A JP2010524977 A JP 2010524977A JP 2010524977 A JP2010524977 A JP 2010524977A JP 2010538649 A5 JP2010538649 A5 JP 2010538649A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- factors
- acid sequence
- inhibit
- genetically engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 30
- 241000894006 Bacteria Species 0.000 claims 26
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 24
- 230000010472 type I IFN response Effects 0.000 claims 24
- 238000000034 method Methods 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 15
- 210000001519 tissue Anatomy 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 230000001580 bacterial effect Effects 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 241000701806 Human papillomavirus Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 108010006510 Rotavirus NSP1 protein Proteins 0.000 claims 3
- 241000607768 Shigella Species 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 108700032552 influenza virus INS1 Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 239000002512 suppressor factor Substances 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 241000725630 Ectromelia virus Species 0.000 claims 2
- 241000186781 Listeria Species 0.000 claims 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 101710117545 C protein Proteins 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 101710199711 Early E1A protein Proteins 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010061192 Haemorrhagic fever Diseases 0.000 claims 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 claims 1
- 102000002227 Interferon Type I Human genes 0.000 claims 1
- 108010014726 Interferon Type I Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 241000714209 Norwalk virus Species 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 108700012707 hepatitis C virus NS3 Proteins 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 108091008819 oncoproteins Proteins 0.000 claims 1
- 102000027450 oncoproteins Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 102220201851 rs143406017 Human genes 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/854,027 | 2007-09-12 | ||
| US11/854,027 US7608256B2 (en) | 2007-09-12 | 2007-09-12 | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response |
| PCT/US2008/075972 WO2009036137A1 (en) | 2007-09-12 | 2008-09-11 | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type i interferon response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538649A JP2010538649A (ja) | 2010-12-16 |
| JP2010538649A5 true JP2010538649A5 (enExample) | 2011-10-13 |
| JP5665541B2 JP5665541B2 (ja) | 2015-02-04 |
Family
ID=40432101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524977A Expired - Fee Related JP5665541B2 (ja) | 2007-09-12 | 2008-09-11 | 真核生物ｉ型インタフェロン応答サプレッサー類の共発現による細菌ベースデリバリシステムからのトランスジーン発現の増強方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7608256B2 (enExample) |
| EP (1) | EP2188377A4 (enExample) |
| JP (1) | JP5665541B2 (enExample) |
| KR (1) | KR20100075884A (enExample) |
| CN (1) | CN101874114A (enExample) |
| WO (1) | WO2009036137A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608256B2 (en) | 2007-09-12 | 2009-10-27 | Aeras Global Tb Vaccine Foundation | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response |
| WO2010025016A2 (en) * | 2008-08-06 | 2010-03-04 | Aeras Global Tb Vaccine Foundation | Enhancement of transgene expression from virus-based vaccine vectors using suppressors of the type 1 interferon response |
| US20100273220A1 (en) | 2009-04-22 | 2010-10-28 | Massachusetts Institute Of Technology | Innate immune suppression enables repeated delivery of long rna molecules |
| MX365946B (es) | 2009-12-10 | 2019-06-19 | Turnstone Lp | Rabdovirus oncolitico. |
| RU2611187C2 (ru) * | 2010-01-04 | 2017-02-21 | Курна, Инк. | Лечение заболеваний, связанных с интерферон-регуляторным фактором 8 (irf8), путем ингибирования природного антисмыслового транскрипта к irf8 |
| US10363293B2 (en) | 2013-02-21 | 2019-07-30 | Turnstone Limited Partnership | Vaccine composition |
| WO2014198002A1 (en) * | 2013-06-14 | 2014-12-18 | Ottawa Hospital Research Institute | A bacterium producing an interferon binding protein and uses thereof |
| KR101550217B1 (ko) | 2014-03-26 | 2015-09-04 | 전남대학교산학협력단 | 숙주세포의 생체 회로 간섭 없이 외래 유전자를 발현하기 위한 재조합 벡터 및 이의 용도 |
| WO2017079936A1 (zh) * | 2015-11-12 | 2017-05-18 | 昕颖生医技术股份有限公司 | 表现异源基因的系统及其用途 |
| CN108159410A (zh) * | 2018-01-15 | 2018-06-15 | 重庆市卓诺科技发展有限公司 | 登革热病毒疫苗 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7016A (en) * | 1850-01-15 | Mill for grinding | ||
| US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
| AU1288099A (en) * | 1997-10-30 | 1999-05-24 | Cornell Research Foundation Inc. | A method of inhibiting an immune response to a recombinant vector |
| US7033781B1 (en) * | 1999-09-29 | 2006-04-25 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
| WO2007081447A2 (en) * | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| US7608256B2 (en) * | 2007-09-12 | 2009-10-27 | Aeras Global Tb Vaccine Foundation | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response |
-
2007
- 2007-09-12 US US11/854,027 patent/US7608256B2/en active Active
-
2008
- 2008-09-11 WO PCT/US2008/075972 patent/WO2009036137A1/en not_active Ceased
- 2008-09-11 KR KR1020107007191A patent/KR20100075884A/ko not_active Ceased
- 2008-09-11 EP EP08799449A patent/EP2188377A4/en not_active Withdrawn
- 2008-09-11 JP JP2010524977A patent/JP5665541B2/ja not_active Expired - Fee Related
- 2008-09-11 CN CN200880116402A patent/CN101874114A/zh active Pending
-
2009
- 2009-09-11 US US12/558,137 patent/US7883696B2/en active Active
-
2010
- 2010-12-10 US US12/964,830 patent/US8414884B2/en not_active Expired - Fee Related
-
2013
- 2013-04-08 US US13/858,289 patent/US8658136B2/en active Active
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