JP2006526393A5 - - Google Patents
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- Publication number
- JP2006526393A5 JP2006526393A5 JP2006508083A JP2006508083A JP2006526393A5 JP 2006526393 A5 JP2006526393 A5 JP 2006526393A5 JP 2006508083 A JP2006508083 A JP 2006508083A JP 2006508083 A JP2006508083 A JP 2006508083A JP 2006526393 A5 JP2006526393 A5 JP 2006526393A5
- Authority
- JP
- Japan
- Prior art keywords
- flavivirus
- packaging
- protein
- construct
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000710831 Flavivirus Species 0.000 claims description 27
- 101710172711 Structural protein Proteins 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 230000014509 gene expression Effects 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 15
- 239000004098 Tetracycline Substances 0.000 claims 6
- 229960002180 tetracycline Drugs 0.000 claims 6
- 229930101283 tetracycline Natural products 0.000 claims 6
- 235000019364 tetracycline Nutrition 0.000 claims 6
- 150000003522 tetracyclines Chemical class 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 101710117545 C protein Proteins 0.000 claims 3
- 101710204837 Envelope small membrane protein Proteins 0.000 claims 3
- 101710145006 Lysis protein Proteins 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 241000710912 Kunjin virus Species 0.000 claims 2
- 101710189818 Non-structural protein 2a Proteins 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000001024 immunotherapeutic effect Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 101800000512 Non-structural protein 1 Proteins 0.000 claims 1
- 101800000508 Non-structural protein 5 Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108010087302 Viral Structural Proteins Proteins 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical group N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 108091006106 transcriptional activators Proteins 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 3
- 239000002245 particle Substances 0.000 description 2
- 102000004961 Furin Human genes 0.000 description 1
- 108090001126 Furin Proteins 0.000 description 1
- 230000002424 anti-apoptotic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 108700041737 bcl-2 Genes Proteins 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000004186 co-expression Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003902842A AU2003902842A0 (en) | 2003-06-06 | 2003-06-06 | Flavivirus replicon packaging system |
| PCT/AU2004/000752 WO2004108936A1 (en) | 2003-06-06 | 2004-06-07 | Flavivirus replicon packaging system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006526393A JP2006526393A (ja) | 2006-11-24 |
| JP2006526393A5 true JP2006526393A5 (enExample) | 2007-06-28 |
Family
ID=31953883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508083A Pending JP2006526393A (ja) | 2003-06-06 | 2004-06-07 | フラビウイルスレプリコンパッケージング系 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060280757A1 (enExample) |
| EP (1) | EP1633877A4 (enExample) |
| JP (1) | JP2006526393A (enExample) |
| CN (1) | CN1798845A (enExample) |
| AU (1) | AU2003902842A0 (enExample) |
| CA (1) | CA2528046A1 (enExample) |
| NZ (1) | NZ543419A (enExample) |
| WO (1) | WO2004108936A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1986686A4 (en) * | 2006-02-13 | 2010-08-11 | Integral Molecular Inc | VIRUS REPORTER OF DENGUE AND METHODS OF MAKING AND USING SAME |
| CN101454022B (zh) | 2006-02-27 | 2013-09-04 | 得克萨斯系统大学评议会 | 假性感染性黄病毒及其用途 |
| CA2717499A1 (en) | 2008-03-14 | 2009-09-17 | Sanofi Pasteur Biologics Co. | Replication-defective flavivirus vaccines and vaccine vectors |
| ES2544702T3 (es) | 2008-07-17 | 2015-09-02 | Medigen, Inc. | Vacunas en forma de ADNi y métodos para utilizarlas |
| CN102363751A (zh) * | 2011-03-24 | 2012-02-29 | 中山大学 | 登革病毒样颗粒及其制备方法与应用 |
| WO2015118146A1 (en) | 2014-02-10 | 2015-08-13 | Univercells Nv | System, apparatus and method for biomolecules production |
| HK1243730A1 (zh) * | 2015-05-13 | 2018-07-20 | Csl贝林基因治疗股份有限公司 | 慢病毒载体的生物生产 |
| US10799575B2 (en) | 2015-06-25 | 2020-10-13 | Technovax, Inc. | Flavivirus and alphavirus virus-like particles (VLPS) |
| CN111343998B (zh) * | 2017-09-11 | 2024-08-13 | 天甲生物医药有限公司 | 哺乳动物特异性的生长缺陷的虫媒病毒 |
| CN113637697B (zh) * | 2021-07-13 | 2024-06-14 | 中山大学 | 一种denv-4全长感染性克隆及其构建方法 |
| CN114317563B (zh) * | 2021-12-17 | 2023-09-05 | 华南理工大学 | 提高基因表达的rna复制子及其应用 |
| CN119899808A (zh) * | 2024-12-05 | 2025-04-29 | 深圳湾实验室 | 登革减毒株及其应用 |
| CN120818539B (zh) * | 2025-09-16 | 2025-12-09 | 成都锦城学院 | 黄病毒的复制依赖的rna重组实验系统的建立和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893866B1 (en) * | 1997-11-28 | 2005-05-17 | The Crown In The Right Of The Queensland Department Of Health | Flavivirus expression and delivery system |
| JP2005510244A (ja) * | 2001-11-26 | 2005-04-21 | ザ・ユニヴァーシティ・オヴ・クイーンズランド | フラビウイルスワクチン送達系 |
| CN1909922B (zh) * | 2002-02-26 | 2013-08-21 | 阿尔特拉瓦克斯股份有限公司 | 新的黄病毒抗原 |
-
2003
- 2003-06-06 AU AU2003902842A patent/AU2003902842A0/en not_active Abandoned
-
2004
- 2004-06-07 WO PCT/AU2004/000752 patent/WO2004108936A1/en not_active Ceased
- 2004-06-07 CA CA002528046A patent/CA2528046A1/en not_active Abandoned
- 2004-06-07 US US10/559,146 patent/US20060280757A1/en not_active Abandoned
- 2004-06-07 NZ NZ543419A patent/NZ543419A/en unknown
- 2004-06-07 EP EP04736184A patent/EP1633877A4/en not_active Withdrawn
- 2004-06-07 JP JP2006508083A patent/JP2006526393A/ja active Pending
- 2004-06-07 CN CNA200480015488XA patent/CN1798845A/zh active Pending
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