JP2008541730A5 - - Google Patents

Info

Publication number

JP2008541730A5

JP2008541730A5 JP2008513739A JP2008513739A JP2008541730A5 JP 2008541730 A5 JP2008541730 A5 JP 2008541730A5 JP 2008513739 A JP2008513739 A JP 2008513739A JP 2008513739 A JP2008513739 A JP 2008513739A JP 2008541730 A5 JP2008541730 A5 JP 2008541730A5

Authority

JP

Japan

Prior art keywords

adenoviral

influenza

recombinant

gene

plasmid

Prior art date

2006-05-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000013612 plasmid Substances 0.000 claims 36
• 241000701161 unidentified adenovirus Species 0.000 claims 32
• 206010022000 influenza Diseases 0.000 claims 25
• 108090000623 proteins and genes Proteins 0.000 claims 22
• 239000013598 vector Substances 0.000 claims 19
• 238000000034 method Methods 0.000 claims 17
• 210000004027 cell Anatomy 0.000 claims 12
• 108020004707 nucleic acids Proteins 0.000 claims 11
• 150000007523 nucleic acids Chemical class 0.000 claims 11
• 102000039446 nucleic acids Human genes 0.000 claims 11
• 108700026220 vif Genes Proteins 0.000 claims 10
• 210000001236 prokaryotic cell Anatomy 0.000 claims 9
• 230000003115 biocidal effect Effects 0.000 claims 8
• 230000010076 replication Effects 0.000 claims 8
• 241000588724 Escherichia coli Species 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 6
• 238000004806 packaging method and process Methods 0.000 claims 5
• 101710154606 Hemagglutinin Proteins 0.000 claims 3
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 claims 3
• 108010006232 Neuraminidase Proteins 0.000 claims 3
• 108010061100 Nucleoproteins Proteins 0.000 claims 3
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 3
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 3
• 101710176177 Protein A56 Proteins 0.000 claims 3
• 230000001580 bacterial effect Effects 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 230000006801 homologous recombination Effects 0.000 claims 3
• 238000002744 homologous recombination Methods 0.000 claims 3
• 208000037797 influenza A Diseases 0.000 claims 3
• 208000037798 influenza B Diseases 0.000 claims 3
• 208000037799 influenza C Diseases 0.000 claims 3
• 239000011159 matrix material Substances 0.000 claims 3
• 238000002360 preparation method Methods 0.000 claims 3
• 230000035897 transcription Effects 0.000 claims 3
• 238000013518 transcription Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 241000701022 Cytomegalovirus Species 0.000 claims 2
• YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 claims 2
• 239000004098 Tetracycline Substances 0.000 claims 2
• 108010084455 Zeocin Proteins 0.000 claims 2
• 229960000723 ampicillin Drugs 0.000 claims 2
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229960005091 chloramphenicol Drugs 0.000 claims 2
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 2
• 229930027917 kanamycin Natural products 0.000 claims 2
• 229960000318 kanamycin Drugs 0.000 claims 2
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 2
• 229930182823 kanamycin A Natural products 0.000 claims 2
• CWCMIVBLVUHDHK-ZSNHEYEWSA-N phleomycin D1 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC[C@@H](N=1)C=1SC=C(N=1)C(=O)NCCCCNC(N)=N)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C CWCMIVBLVUHDHK-ZSNHEYEWSA-N 0.000 claims 2
• 230000008488 polyadenylation Effects 0.000 claims 2
• 108091008146 restriction endonucleases Proteins 0.000 claims 2
• 229960002180 tetracycline Drugs 0.000 claims 2
• 229930101283 tetracycline Natural products 0.000 claims 2
• 235000019364 tetracycline Nutrition 0.000 claims 2
• 150000003522 tetracyclines Chemical class 0.000 claims 2
• 102000007469 Actins Human genes 0.000 claims 1
• 108010085238 Actins Proteins 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 1
• 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000002163 immunogen Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1