CN101248186A - 不含腺病毒的重组腺病毒载体的快速生产 - Google Patents
不含腺病毒的重组腺病毒载体的快速生产 Download PDFInfo
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- CN101248186A CN101248186A CNA2006800269435A CN200680026943A CN101248186A CN 101248186 A CN101248186 A CN 101248186A CN A2006800269435 A CNA2006800269435 A CN A2006800269435A CN 200680026943 A CN200680026943 A CN 200680026943A CN 101248186 A CN101248186 A CN 101248186A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Manufacturing & Machinery (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68363805P | 2005-05-23 | 2005-05-23 | |
| US60/683,638 | 2005-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101248186A true CN101248186A (zh) | 2008-08-20 |
Family
ID=37452858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800269435A Pending CN101248186A (zh) | 2005-05-23 | 2006-05-23 | 不含腺病毒的重组腺病毒载体的快速生产 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090175897A1 (enExample) |
| EP (1) | EP1899470A4 (enExample) |
| JP (1) | JP2008541730A (enExample) |
| KR (1) | KR20080052512A (enExample) |
| CN (1) | CN101248186A (enExample) |
| AU (1) | AU2006249877A1 (enExample) |
| CA (1) | CA2609276A1 (enExample) |
| WO (1) | WO2006127956A2 (enExample) |
| ZA (1) | ZA200710860B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105112428A (zh) * | 2009-02-02 | 2015-12-02 | 葛兰素史密斯克莱生物公司 | 猿腺病毒核酸和氨基酸序列,包含其的载体及其用途 |
| CN110892064A (zh) * | 2017-07-25 | 2020-03-17 | 牛津遗传学有限公司 | 腺病毒载体 |
| CN116179604A (zh) * | 2022-08-31 | 2023-05-30 | 上海锦斯生物技术有限公司 | 一种降低回复突变频率的重组5型腺病毒载体及其构建方法 |
| CN119432919A (zh) * | 2024-11-12 | 2025-02-14 | 北京因美未来生物医药科技有限公司 | 减少复制型腺病毒污染的病毒载体及构建方法 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009936A1 (en) | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| JP2009512421A (ja) * | 2005-08-15 | 2009-03-26 | ヴァクシン インコーポレイテッド | 非複製性ベクターワクチン投与による鳥類への免疫方法 |
| CA2742474C (en) | 2008-11-03 | 2016-05-31 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
| US8865182B2 (en) * | 2009-07-31 | 2014-10-21 | Paxvax, Inc. | Adenoviral-based vectors |
| WO2012011955A2 (en) * | 2010-07-21 | 2012-01-26 | Duke University | Compositions and methods for production and screening of monoclonal antibodies |
| KR20200008014A (ko) | 2011-03-21 | 2020-01-22 | 알티뮨 인크. | 급속 및 지속적 면역학적제제-치료제 |
| US10183069B2 (en) | 2011-03-21 | 2019-01-22 | Altimmune Inc. | Rapid and prolonged immunologic-therapeutic |
| KR101557974B1 (ko) * | 2013-03-29 | 2015-10-08 | 주식회사 에스씨티 | 혈청형6 재조합 아데노바이러스 제조용 벡터 |
| WO2015035128A1 (en) * | 2013-09-06 | 2015-03-12 | Vaxin Inc. | Methods and compositions for viral vectored vaccines |
| WO2016037163A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20200208173A1 (en) * | 2015-10-30 | 2020-07-02 | Seracare Life Sciences, Inc. | Adenovirus control virus |
| CN106853247A (zh) * | 2015-12-08 | 2017-06-16 | 中国农业科学院兰州兽医研究所 | 一种制备狂犬病活载体疫苗的方法及其产品和用途 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR20190104194A (ko) | 2017-01-07 | 2019-09-06 | 셀렉타 바이오사이언시즈, 인크. | 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여 |
| BR112019019813A2 (pt) | 2017-03-30 | 2020-04-22 | Univ Queensland | moléculas quiméricas e usos das mesmas |
| EP4400174A3 (en) | 2017-09-01 | 2024-10-23 | The Francis Crick Institute Limited | Immunoregulatory molecules and uses therefor |
| WO2019075360A1 (en) | 2017-10-13 | 2019-04-18 | Selecta Biosciences, Inc. | METHODS AND COMPOSITIONS FOR MITIGATING ANTI-VECTOR VIRAL TRANSFER IGM RESPONSES |
| CA3092372A1 (en) | 2018-02-26 | 2019-08-29 | AnTolRx, Inc. | Tolerogenic liposomes and methods of use thereof |
| JP2022526632A (ja) * | 2019-04-06 | 2022-05-25 | アルティミューン インコーポレーティッド | 広範囲及び持続性のインフルエンザワクチン |
| WO2020223205A1 (en) | 2019-04-28 | 2020-11-05 | Selecta Biosciences, Inc. | Methods for treatment of subjects with preexisting immunity to viral transfer vectors |
| US20200390718A1 (en) | 2019-05-28 | 2020-12-17 | Selecta Biosciences, Inc. | Methods and compositions for attenuated anti-viral transfer vector immune response |
| US20230141563A1 (en) | 2021-10-12 | 2023-05-11 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| WO2023172624A1 (en) | 2022-03-09 | 2023-09-14 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976552A (en) * | 1995-04-28 | 1999-11-02 | Protein Sciences Corporation | Virus vaccines |
| US6019978A (en) * | 1995-06-05 | 2000-02-01 | The Wistar Institute Of Anatomy And Biology | Replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| US5922576A (en) * | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
| US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US7094398B1 (en) * | 1999-06-01 | 2006-08-22 | University Of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
| EP1104813A1 (en) * | 1999-12-01 | 2001-06-06 | Leids Universitair Medisch Centrum | Conditional replication of recombinant human adenovirus DNA carrying modified inverted terminal repeat sequences |
| WO2004001032A2 (en) * | 2002-04-25 | 2003-12-31 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
-
2006
- 2006-05-23 KR KR1020077030182A patent/KR20080052512A/ko not_active Ceased
- 2006-05-23 WO PCT/US2006/020350 patent/WO2006127956A2/en not_active Ceased
- 2006-05-23 CA CA002609276A patent/CA2609276A1/en not_active Abandoned
- 2006-05-23 AU AU2006249877A patent/AU2006249877A1/en not_active Abandoned
- 2006-05-23 JP JP2008513739A patent/JP2008541730A/ja active Pending
- 2006-05-23 EP EP06760400A patent/EP1899470A4/en not_active Withdrawn
- 2006-05-23 CN CNA2006800269435A patent/CN101248186A/zh active Pending
-
2007
- 2007-11-21 US US11/943,901 patent/US20090175897A1/en not_active Abandoned
- 2007-12-13 ZA ZA200710860A patent/ZA200710860B/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105112428A (zh) * | 2009-02-02 | 2015-12-02 | 葛兰素史密斯克莱生物公司 | 猿腺病毒核酸和氨基酸序列,包含其的载体及其用途 |
| CN105112428B (zh) * | 2009-02-02 | 2021-04-20 | 葛兰素史密斯克莱生物公司 | 猿腺病毒核酸和氨基酸序列,包含其的载体及其用途 |
| CN110892064A (zh) * | 2017-07-25 | 2020-03-17 | 牛津遗传学有限公司 | 腺病毒载体 |
| CN116179604A (zh) * | 2022-08-31 | 2023-05-30 | 上海锦斯生物技术有限公司 | 一种降低回复突变频率的重组5型腺病毒载体及其构建方法 |
| CN119432919A (zh) * | 2024-11-12 | 2025-02-14 | 北京因美未来生物医药科技有限公司 | 减少复制型腺病毒污染的病毒载体及构建方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2609276A1 (en) | 2006-11-30 |
| EP1899470A4 (en) | 2009-07-29 |
| US20090175897A1 (en) | 2009-07-09 |
| JP2008541730A (ja) | 2008-11-27 |
| WO2006127956A2 (en) | 2006-11-30 |
| WO2006127956A3 (en) | 2007-10-18 |
| EP1899470A2 (en) | 2008-03-19 |
| AU2006249877A1 (en) | 2006-11-30 |
| KR20080052512A (ko) | 2008-06-11 |
| ZA200710860B (en) | 2008-12-31 |
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