JP2004508064A5 - - Google Patents
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- Publication number
- JP2004508064A5 JP2004508064A5 JP2002526335A JP2002526335A JP2004508064A5 JP 2004508064 A5 JP2004508064 A5 JP 2004508064A5 JP 2002526335 A JP2002526335 A JP 2002526335A JP 2002526335 A JP2002526335 A JP 2002526335A JP 2004508064 A5 JP2004508064 A5 JP 2004508064A5
- Authority
- JP
- Japan
- Prior art keywords
- adenovirus
- adenoviral
- adenoviral vector
- vector
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013598 vector Substances 0.000 claims 89
- 241000701161 unidentified adenovirus Species 0.000 claims 51
- 229960005486 vaccine Drugs 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 230000002950 deficient Effects 0.000 claims 21
- 230000005030 transcription termination Effects 0.000 claims 21
- 230000014509 gene expression Effects 0.000 claims 20
- 230000010076 replication Effects 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 229940033330 HIV vaccine Drugs 0.000 claims 12
- 229940021704 adenovirus vaccine Drugs 0.000 claims 10
- 230000004927 fusion Effects 0.000 claims 10
- 238000004806 packaging method and process Methods 0.000 claims 10
- 230000000295 complement effect Effects 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 8
- 238000012986 modification Methods 0.000 claims 8
- 239000013612 plasmid Substances 0.000 claims 8
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108010057360 Adenovirus E1 Proteins Proteins 0.000 claims 6
- 241000701022 Cytomegalovirus Species 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000008488 polyadenylation Effects 0.000 claims 5
- 230000024932 T cell mediated immunity Effects 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 108010006025 bovine growth hormone Proteins 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000001890 transfection Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 108700026244 Open Reading Frames Proteins 0.000 claims 3
- 108700019146 Transgenes Proteins 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 108010084873 Human Immunodeficiency Virus nef Gene Products Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 101710177291 Gag polyprotein Proteins 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 101710125418 Major capsid protein Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 108010089520 pol Gene Products Proteins 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23318000P | 2000-09-15 | 2000-09-15 | |
| PCT/US2001/028861 WO2002022080A2 (en) | 2000-09-15 | 2001-09-14 | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508064A JP2004508064A (ja) | 2004-03-18 |
| JP2004508064A5 true JP2004508064A5 (enExample) | 2005-08-04 |
Family
ID=22876220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526335A Withdrawn JP2004508064A (ja) | 2000-09-15 | 2001-09-14 | コドン最適化ｈｉｖ１−ｇａｇ、ｐｏｌ、ｎｅｆおよび修飾体を発現する増強された第１世代アデノウイルスワクチン |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1320621A4 (enExample) |
| JP (1) | JP2004508064A (enExample) |
| AU (2) | AU2001294562B2 (enExample) |
| CA (1) | CA2422882A1 (enExample) |
| WO (1) | WO2002022080A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1242441A4 (en) * | 1999-12-17 | 2004-04-14 | Merck & Co Inc | CODON OPTIMIZED HIV-1 NEF AND MODIFIED HIV-1 NEF EXPRESSING POLYNUCLEOTID VACCINE |
| ATE467680T1 (de) | 2001-10-11 | 2010-05-15 | Merck Sharp & Dohme | Hepatitis-c-virus-impfstoff |
| CN1606625A (zh) | 2001-10-31 | 2005-04-13 | 南非医学研究会 | Hiv－1亚型分离株调节/附加基因及其修饰物和衍生物 |
| US20060165664A1 (en) * | 2002-03-13 | 2006-07-27 | Emini Emilio A | Method of inducing an enhanced immune response against hiv |
| ATE386824T1 (de) | 2002-03-29 | 2008-03-15 | Merck & Co Inc | Verfahren zur virusproduktion |
| WO2003097797A2 (en) | 2002-05-14 | 2003-11-27 | Merck & Co., Inc. | Methods of adenovirus purification |
| CN1490056A (zh) * | 2002-10-18 | 2004-04-21 | ��¡���ɵ°��̲��о����� | 针对hiv-1的免疫方法和组合物 |
| US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
| EP1553983A2 (en) | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| EP1573012B1 (en) | 2002-12-17 | 2011-11-30 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
| AU2003294023B2 (en) | 2003-01-03 | 2008-01-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Rhesus HER2/neu, nucleotides encoding same, and uses thereof |
| EP1649020B1 (en) | 2003-07-21 | 2017-01-11 | MSD Italia S.r.l. | Synthetic gene encoding human epidermal growth factor 2/neu antigen and uses thereof |
| GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
| EP1716173B8 (en) | 2004-02-11 | 2012-06-27 | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. | Carcinoembryonic antigen fusion protein and uses thereof |
| EP1780269B1 (en) | 2004-02-23 | 2009-07-08 | Crucell Holland B.V. | Virus purification methods |
| JP2007532656A (ja) * | 2004-04-12 | 2007-11-15 | アメリカ合衆国 | アデノウイルスベクターを用いて免疫応答を誘導するための方法 |
| GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
| AP2351A (en) | 2004-10-13 | 2012-01-25 | Crucell Holland Bv | Improved adenoviral vectors and uses thereof. |
| CA2602944C (en) | 2005-04-11 | 2015-08-11 | Crucell Holland B.V. | Virus purification using ultrafiltration |
| JP5175178B2 (ja) * | 2005-05-12 | 2013-04-03 | グラクソ グループ リミテッド | ワクチン組成物 |
| AU2012201827B2 (en) * | 2005-05-12 | 2014-09-04 | Glaxo Group Limited | Vaccine composition |
| ES2370040T3 (es) | 2005-10-07 | 2011-12-12 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | Vacuna de metaloproteinasa 11 de la matriz. |
| US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
| EA021391B1 (ru) * | 2007-03-02 | 2015-06-30 | Глаксосмитклайн Байолоджикалс С.А. | Способ индукции иммунного ответа, вакцинная композиция, ее применение и набор |
| EP2185192B1 (en) | 2007-08-03 | 2018-10-31 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
| EP2047861B1 (en) * | 2007-10-12 | 2019-07-31 | Institut Pasteur | Lentiviral gene transfer vectors suitable for iterative administration and their medicinal applications |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| US9017691B2 (en) * | 2008-11-18 | 2015-04-28 | Beth Israel Deaconess Medical Center | Antiviral vaccines with improved cellular immunogenicity |
| KR101814857B1 (ko) | 2011-04-06 | 2018-01-04 | 바이오백심 리미티드 | 인간에서의 hiv 질환의 예방 및/또는 치료를 위한 제약 조성물 |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| PL2825640T3 (pl) | 2012-03-12 | 2016-10-31 | Partie rekombinowanych adenowirusów o zmienionych końcach | |
| SG11201503864TA (en) | 2012-11-16 | 2015-06-29 | Beth Israel Hospital | Recombinant adenoviruses and use thereof |
| ES2836432T3 (es) | 2015-03-18 | 2021-06-25 | Janssen Vaccines & Prevention Bv | Ensayos para sistemas de expresión recombinante |
| SI3283634T1 (sl) | 2015-04-14 | 2019-08-30 | Janssen Vaccines & Prevention B.V. | Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjem |
| EP3472327B1 (en) | 2016-06-20 | 2020-08-19 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| KR20200077559A (ko) | 2017-10-31 | 2020-06-30 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| US11236361B2 (en) | 2017-10-31 | 2022-02-01 | Janssen Vaccines & Prevention B.V. | Adenovirus and uses thereof |
| EA202091104A1 (ru) | 2017-10-31 | 2020-08-12 | Янссен Вэксинс Энд Превеншн Б.В. | Аденовирус и пути его применения |
| SG11202003398SA (en) | 2017-10-31 | 2020-05-28 | Janssen Vaccines & Prevention Bv | Adenovirus vectors and uses thereof |
| WO2019118480A1 (en) | 2017-12-11 | 2019-06-20 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and uses thereof |
| CN111057716B (zh) * | 2019-07-27 | 2022-04-15 | 中国人民解放军军事科学院军事医学研究院 | 用于包装重组人4型腺病毒的单质粒载体系统及其应用 |
| EP4038088A1 (en) | 2019-10-03 | 2022-08-10 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| CN112522276B (zh) * | 2020-12-15 | 2022-07-15 | 武汉纽福斯生物科技有限公司 | 一种emc1核苷酸序列及其应用 |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
| CN120464596A (zh) * | 2024-10-14 | 2025-08-12 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643579A (en) * | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| AU3551195A (en) * | 1994-09-23 | 1996-04-09 | Somatix Therapy Corporation | Chimeric adenovirus for gene delivery |
| US5872005A (en) * | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| US6019978A (en) * | 1995-06-05 | 2000-02-01 | The Wistar Institute Of Anatomy And Biology | Replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| WO1996039178A1 (en) * | 1995-06-05 | 1996-12-12 | The Wistar Institute Of Anatomy And Biology | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| EP1003895A2 (de) * | 1997-07-10 | 2000-05-31 | Hepavec AG fur Gentherapie | Klonierungsvektoren für die herstellung von adenoviralen minimalviren |
| GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| WO2000015819A1 (en) * | 1998-09-11 | 2000-03-23 | The Children's Medical Center Corporation | Packaging cell lines for hiv-derived retroviral vector particles |
| CA2360347C (en) * | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| GB9906177D0 (en) * | 1999-03-17 | 1999-05-12 | Oxford Biomedica Ltd | Anti-viral vectors |
| GB9912965D0 (en) * | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
| EP1242124A4 (en) * | 1999-12-22 | 2004-07-14 | Merck & Co Inc | POLYNUCLEOTIDE VACCINES EXPRESSING CODONE-OPTIMIZED HIV-1 POL AND MODIFIED HIV-1 POL |
| ATE318908T1 (de) * | 2000-05-18 | 2006-03-15 | Geneart Gmbh | Synthetische gene für gagpol und deren verwendungen |
| AU2001284999B2 (en) * | 2000-08-14 | 2006-09-21 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of HIV Env, Gag and Pol enhance immunogenicity for genetic immunization |
-
2001
- 2001-09-14 CA CA002422882A patent/CA2422882A1/en not_active Abandoned
- 2001-09-14 AU AU2001294562A patent/AU2001294562B2/en not_active Ceased
- 2001-09-14 JP JP2002526335A patent/JP2004508064A/ja not_active Withdrawn
- 2001-09-14 WO PCT/US2001/028861 patent/WO2002022080A2/en not_active Ceased
- 2001-09-14 AU AU9456201A patent/AU9456201A/xx active Pending
- 2001-09-14 EP EP01975214A patent/EP1320621A4/en not_active Withdrawn
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