JP2016505538A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505538A5 JP2016505538A5 JP2015544208A JP2015544208A JP2016505538A5 JP 2016505538 A5 JP2016505538 A5 JP 2016505538A5 JP 2015544208 A JP2015544208 A JP 2015544208A JP 2015544208 A JP2015544208 A JP 2015544208A JP 2016505538 A5 JP2016505538 A5 JP 2016505538A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- residues
- influenza
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010022000 influenza Diseases 0.000 claims description 44
- 101710154606 Hemagglutinin Proteins 0.000 claims description 39
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 39
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 39
- 101710176177 Protein A56 Proteins 0.000 claims description 39
- 239000000185 hemagglutinin Substances 0.000 claims description 37
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 33
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 238000006467 substitution reaction Methods 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 102000005348 Neuraminidase Human genes 0.000 claims description 8
- 108010006232 Neuraminidase Proteins 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108020001507 fusion proteins Proteins 0.000 claims description 6
- 102000037865 fusion proteins Human genes 0.000 claims description 6
- 241000712461 unidentified influenza virus Species 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000003053 immunization Effects 0.000 claims description 3
- 108020004705 Codon Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000001890 transfection Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 9
- 239000003937 drug carrier Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730186P | 2012-11-27 | 2012-11-27 | |
| US61/730,186 | 2012-11-27 | ||
| PCT/US2013/072279 WO2014085616A1 (en) | 2012-11-27 | 2013-11-27 | Computationally optimized broadly reactive antigens for h1n1 influenza |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124432A Division JP2018183149A (ja) | 2012-11-27 | 2018-06-29 | Ｈ１ｎ１インフルエンザに対する計算で最適化した広い反応性を示す抗原 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505538A JP2016505538A (ja) | 2016-02-25 |
| JP2016505538A5 true JP2016505538A5 (enExample) | 2016-11-24 |
Family
ID=50773495
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544208A Pending JP2016505538A (ja) | 2012-11-27 | 2013-11-27 | Ｈ１ｎ１インフルエンザに対する計算で最適化した広い反応性を示す抗原 |
| JP2018124432A Withdrawn JP2018183149A (ja) | 2012-11-27 | 2018-06-29 | Ｈ１ｎ１インフルエンザに対する計算で最適化した広い反応性を示す抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124432A Withdrawn JP2018183149A (ja) | 2012-11-27 | 2018-06-29 | Ｈ１ｎ１インフルエンザに対する計算で最適化した広い反応性を示す抗原 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9309290B2 (enExample) |
| EP (1) | EP2925773B1 (enExample) |
| JP (2) | JP2016505538A (enExample) |
| KR (1) | KR20150089005A (enExample) |
| CN (1) | CN104797594A (enExample) |
| AU (2) | AU2013352179B2 (enExample) |
| CA (1) | CA2891682A1 (enExample) |
| HK (1) | HK1212708A1 (enExample) |
| IN (1) | IN2015DN03070A (enExample) |
| MX (1) | MX2015005056A (enExample) |
| RU (1) | RU2015124805A (enExample) |
| SG (1) | SG11201503989PA (enExample) |
| WO (1) | WO2014085616A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883171B2 (en) * | 2010-09-14 | 2014-11-11 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| JP6113155B2 (ja) * | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すｈ１ｎ１インフルエンザの抗原 |
| MY166953A (en) | 2012-03-30 | 2018-07-25 | Univ Pittsburgh Commonwealth Sys Higher Education | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
| JP6764408B2 (ja) * | 2014-12-19 | 2020-09-30 | オレゴン ヘルス アンド サイエンス ユニバーシティー | Ｈ１ｎ１インフルエンザに対するコンピュータ最適化広反応性抗原の相乗的併用投与 |
| US10927151B2 (en) | 2015-06-09 | 2021-02-23 | Sanofi Pasteur Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| EP3464327A1 (en) | 2016-06-03 | 2019-04-10 | Sanofi Pasteur Inc. | Modification of engineered influenza hemagglutinin polypeptides |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1294892T3 (da) | 2000-06-23 | 2008-01-28 | Wyeth Corp | Aggregering af vildtype- og kimære influenzaviruslignende partikler (VLP'er) |
| US20050181459A1 (en) | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| US7566454B2 (en) | 2005-02-24 | 2009-07-28 | University Of Massachusetts | Influenza nucleic acids, polypeptides, and uses thereof |
| CA2615658A1 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technolgies Inc. | Recombinant flu vaccines |
| US20090327170A1 (en) | 2005-12-19 | 2009-12-31 | Claudio Donati | Methods of Clustering Gene and Protein Sequences |
| US20080045472A1 (en) | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| EP2059532B1 (en) | 2006-09-07 | 2012-12-26 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| KR101255419B1 (ko) | 2007-11-12 | 2013-04-17 | 이노비오 파마수티컬즈, 인크. | 인플루엔자 바이러스의 다중 아형에 대한 신규 백신 |
| SG187500A1 (en) * | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| US7981428B2 (en) | 2008-01-23 | 2011-07-19 | Academia Sinica | Flu vaccines and methods of use thereof |
| WO2010036970A2 (en) | 2008-09-25 | 2010-04-01 | Fraunhofer Usa, Inc. | Influenza vaccines, antigens, compositions, and methods |
| US20110177122A1 (en) | 2008-09-26 | 2011-07-21 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | Dna prime/activated vaccine boost immunization to influenza virus |
| CN103585643A (zh) | 2009-04-03 | 2014-02-19 | 梅里亚有限公司 | 运载新城疫病毒的禽疫苗 |
| SI2445928T1 (en) * | 2009-06-24 | 2018-05-31 | Medicago Inc. | HYPER PARTICULARS, SIMILAR VIRUSES OF GRIPE, WHICH HAVE EXPOSED HEMAGLUTININE |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| US20110184160A1 (en) * | 2010-01-26 | 2011-07-28 | Weiner David B | Nucleic acid molecule encoding consensus influenza a hemagglutinin h1 |
| CN102373184A (zh) * | 2010-08-09 | 2012-03-14 | 中山大学 | 禽流感和传染性支气管炎混合病毒样颗粒、制备方法和应用 |
| US8883171B2 (en) | 2010-09-14 | 2014-11-11 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| JP6113155B2 (ja) * | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すｈ１ｎ１インフルエンザの抗原 |
| US9234008B2 (en) | 2012-02-07 | 2016-01-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses |
| US9566327B2 (en) | 2012-02-13 | 2017-02-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian H5N1 influenza |
| MY166953A (en) | 2012-03-30 | 2018-07-25 | Univ Pittsburgh Commonwealth Sys Higher Education | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
-
2013
- 2013-11-27 SG SG11201503989PA patent/SG11201503989PA/en unknown
- 2013-11-27 US US14/092,371 patent/US9309290B2/en active Active
- 2013-11-27 AU AU2013352179A patent/AU2013352179B2/en not_active Ceased
- 2013-11-27 JP JP2015544208A patent/JP2016505538A/ja active Pending
- 2013-11-27 WO PCT/US2013/072279 patent/WO2014085616A1/en not_active Ceased
- 2013-11-27 EP EP13859229.0A patent/EP2925773B1/en not_active Not-in-force
- 2013-11-27 CA CA2891682A patent/CA2891682A1/en not_active Abandoned
- 2013-11-27 MX MX2015005056A patent/MX2015005056A/es unknown
- 2013-11-27 KR KR1020157012693A patent/KR20150089005A/ko not_active Withdrawn
- 2013-11-27 HK HK16100529.2A patent/HK1212708A1/zh unknown
- 2013-11-27 IN IN3070DEN2015 patent/IN2015DN03070A/en unknown
- 2013-11-27 CN CN201380060899.XA patent/CN104797594A/zh active Pending
- 2013-11-27 RU RU2015124805A patent/RU2015124805A/ru not_active Application Discontinuation
-
2016
- 2016-02-24 US US15/051,991 patent/US9566328B2/en active Active
- 2016-12-28 US US15/392,710 patent/US10017544B2/en active Active
-
2018
- 2018-03-15 AU AU2018201876A patent/AU2018201876A1/en not_active Abandoned
- 2018-06-29 JP JP2018124432A patent/JP2018183149A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015506705A5 (enExample) | ||
| RU2014101401A (ru) | Антигены вируса гриппа h1n1 с широким спектром активности, оптимизированные с применением вычислительных средств | |
| RU2018113521A (ru) | Рекомбинантный полипептид гемагглютинин (ha) вируса гриппа для вызова иммунного ответа в отношении вирусов гриппа h2n2 или b | |
| RU2019139064A (ru) | Композиции и способы для лечения цитомегаловируса | |
| RU2017113571A (ru) | Рекомбинантные вакцины от fmdv и их применение | |
| JP2014530010A5 (enExample) | ||
| HRP20171213T1 (hr) | Glikoproteinske čestice nalik virusu (vlp) bjesnoće | |
| JP2015119730A5 (enExample) | ||
| JP2012095652A5 (enExample) | ||
| JP2009544318A5 (enExample) | ||
| JP2012501959A5 (enExample) | ||
| JP2013216685A5 (enExample) | ||
| RU2015124805A (ru) | Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вируса гриппа h1n1 | |
| JP2015501840A5 (enExample) | ||
| JP2014519817A5 (enExample) | ||
| JP2017513502A5 (enExample) | ||
| JP2013517773A5 (enExample) | ||
| JP2010535026A5 (enExample) | ||
| JP2015524422A5 (enExample) | ||
| JP2009540801A5 (enExample) | ||
| CN103547676A (zh) | 颗粒形式的免疫原性组合物和用于产生其的方法 | |
| JP2014507146A5 (enExample) | ||
| WO2014205579A4 (en) | Modified matrix proteins of vesicular stomatitis virus | |
| Carter et al. | A unique protein self‐assembling nanoparticle with significant advantages in vaccine development and production | |
| JP2015521206A5 (enExample) |