JP2013517773A5 - - Google Patents
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- Publication number
- JP2013517773A5 JP2013517773A5 JP2012550162A JP2012550162A JP2013517773A5 JP 2013517773 A5 JP2013517773 A5 JP 2013517773A5 JP 2012550162 A JP2012550162 A JP 2012550162A JP 2012550162 A JP2012550162 A JP 2012550162A JP 2013517773 A5 JP2013517773 A5 JP 2013517773A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- chimeric protein
- heterologous antigen
- amino acids
- norovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000037865 fusion proteins Human genes 0.000 claims 24
- 108020001507 fusion proteins Proteins 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 235000001014 amino acid Nutrition 0.000 claims 16
- 229940024606 amino acid Drugs 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 108090000565 Capsid Proteins Proteins 0.000 claims 15
- 102100023321 Ceruloplasmin Human genes 0.000 claims 15
- 241001263478 Norovirus Species 0.000 claims 13
- 238000000034 method Methods 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000351643 Metapneumovirus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29710910P | 2010-01-21 | 2010-01-21 | |
| US61/297,109 | 2010-01-21 | ||
| PCT/US2011/022094 WO2011091279A2 (en) | 2010-01-21 | 2011-01-21 | Targeted heterologous antigen presentation on calicivirus virus-like particles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000115A Division JP2016106101A (ja) | 2010-01-21 | 2016-01-04 | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013517773A JP2013517773A (ja) | 2013-05-20 |
| JP2013517773A5 true JP2013517773A5 (enExample) | 2014-03-13 |
Family
ID=44307607
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550162A Pending JP2013517773A (ja) | 2010-01-21 | 2011-01-21 | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
| JP2016000115A Pending JP2016106101A (ja) | 2010-01-21 | 2016-01-04 | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000115A Pending JP2016106101A (ja) | 2010-01-21 | 2016-01-04 | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8980275B2 (enExample) |
| EP (1) | EP2525816A4 (enExample) |
| JP (2) | JP2013517773A (enExample) |
| KR (1) | KR20120125627A (enExample) |
| CN (1) | CN102791286B (enExample) |
| AU (1) | AU2011207355B2 (enExample) |
| CA (1) | CA2787666A1 (enExample) |
| SG (1) | SG182636A1 (enExample) |
| WO (1) | WO2011091279A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2601969B1 (en) | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| CA2683977C (en) * | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| CN104740624B (zh) | 2007-09-18 | 2018-04-24 | 武田疫苗股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| JP5852883B2 (ja) * | 2008-08-08 | 2016-02-03 | タケダ ワクチン，インコーポレイテッド | 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子 |
| JP2013517773A (ja) * | 2010-01-21 | 2013-05-20 | リゴサイト ファーマスーティカルズ，インコーポレイテッド | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
| PH12014500093A1 (en) | 2011-07-11 | 2014-03-17 | Takeda Vaccines Inc | Parenteral norovirus vaccine formulations |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| EP2970395A4 (en) * | 2013-03-15 | 2017-03-29 | The University of North Carolina At Chapel Hill | Methods and compositions for norovirus blockade epitopes |
| US9975923B2 (en) | 2013-03-15 | 2018-05-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for norovirus blockade epitopes |
| JP2015015931A (ja) * | 2013-07-12 | 2015-01-29 | 株式会社Ｕｍｎファーマ | ウイルス様粒子を含む培養物の製造方法 |
| EP3089755A1 (en) | 2014-01-03 | 2016-11-09 | Fundacion Biofisica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
| WO2016160166A1 (en) * | 2015-03-30 | 2016-10-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunogenic rsv polypeptides |
| JP6675185B2 (ja) * | 2015-11-30 | 2020-04-01 | 宏 半田 | 免疫誘導剤およびその製造方法 |
| EP4631970A3 (en) * | 2016-05-04 | 2026-01-07 | CureVac SE | Nucleic acid molecules and uses thereof |
| EP3601580A4 (en) | 2017-03-23 | 2021-01-06 | Medicago Inc. | NOROVIRUS FUSION PROTEINS AND VLPS WITH NOROVIRUS FUSION PROTEINS |
| CN107988240A (zh) * | 2017-12-20 | 2018-05-04 | 中国人民解放军南京军区南京总医院 | 鼠诺如病毒vp1蛋白病毒样颗粒表达、纯化及多克隆抗体制备 |
| AR117462A1 (es) * | 2018-12-20 | 2021-08-04 | Takeda Vaccines Inc | Vacuna contra norovirus, formulaciones y métodos |
| CN116438202A (zh) * | 2020-10-05 | 2023-07-14 | 勃林格殷格翰动物保健美国有限公司 | 包含圆环病毒科衣壳蛋白的融合蛋白及其构成的嵌合病毒样颗粒 |
| CN116063578A (zh) * | 2022-11-22 | 2023-05-05 | 中国医学科学院医学生物学研究所 | 一种以诺如病毒衍生的纳米颗粒作为疫苗平台的制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572862B1 (en) * | 1989-11-08 | 2003-06-03 | Baylor College Of Medicine | Methods and reagents to detect and characterize Norwalk and related viruses |
| WO1994005700A2 (en) * | 1992-09-07 | 1994-03-17 | Baylor College Of Medicine | Methods and reagents to detect and characterize norwalk and related viruses |
| CA2375337C (en) * | 1999-06-22 | 2012-09-25 | Naokazu Takeda | Srsv detection kit |
| US8277819B2 (en) | 2005-06-16 | 2012-10-02 | Children's Hospital Medical Center | Norovirus particle for use as an antiviral or vaccine |
| EP2601969B1 (en) * | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| AU2007304883B2 (en) * | 2006-10-04 | 2013-09-05 | The University Of Queensland | VLP based vaccine delivery system |
| CN107043408B (zh) * | 2009-06-09 | 2021-02-09 | 儿童医院医疗中心 | 抗原-诺罗病毒p-结构域单体和二聚体，抗原-诺罗病毒p-粒子分子，及其制备和应用方法 |
| JP2013517773A (ja) * | 2010-01-21 | 2013-05-20 | リゴサイト ファーマスーティカルズ，インコーポレイテッド | カリシウイルスウイルス様粒子上の標的化異種抗原提示 |
-
2011
- 2011-01-21 JP JP2012550162A patent/JP2013517773A/ja active Pending
- 2011-01-21 US US13/574,756 patent/US8980275B2/en not_active Expired - Fee Related
- 2011-01-21 SG SG2012053807A patent/SG182636A1/en unknown
- 2011-01-21 WO PCT/US2011/022094 patent/WO2011091279A2/en not_active Ceased
- 2011-01-21 AU AU2011207355A patent/AU2011207355B2/en not_active Ceased
- 2011-01-21 CN CN201180013873.0A patent/CN102791286B/zh not_active Expired - Fee Related
- 2011-01-21 KR KR1020127021082A patent/KR20120125627A/ko not_active Ceased
- 2011-01-21 EP EP11735244.3A patent/EP2525816A4/en not_active Withdrawn
- 2011-01-21 CA CA2787666A patent/CA2787666A1/en not_active Abandoned
-
2015
- 2015-02-09 US US14/617,576 patent/US20150252082A1/en not_active Abandoned
-
2016
- 2016-01-04 JP JP2016000115A patent/JP2016106101A/ja active Pending
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