JP2014532691A5 - - Google Patents
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- Publication number
- JP2014532691A5 JP2014532691A5 JP2014539428A JP2014539428A JP2014532691A5 JP 2014532691 A5 JP2014532691 A5 JP 2014532691A5 JP 2014539428 A JP2014539428 A JP 2014539428A JP 2014539428 A JP2014539428 A JP 2014539428A JP 2014532691 A5 JP2014532691 A5 JP 2014532691A5
- Authority
- JP
- Japan
- Prior art keywords
- human enterovirus
- polypeptide
- expression cassette
- human
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 229960005486 vaccine Drugs 0.000 claims 15
- 241001207270 Human enterovirus Species 0.000 claims 12
- 241000991587 Enterovirus C Species 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 108091005804 Peptidases Proteins 0.000 claims 8
- 239000004365 Protease Substances 0.000 claims 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 8
- 241000988559 Enterovirus A Species 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 6
- 241000710188 Encephalomyocarditis virus Species 0.000 claims 4
- 241001529459 Enterovirus A71 Species 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000988556 Enterovirus B Species 0.000 claims 2
- 241000991586 Enterovirus D Species 0.000 claims 2
- 206010014909 Enterovirus infection Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 241001429382 Coxsackievirus A16 Species 0.000 claims 1
- 241001466953 Echovirus Species 0.000 claims 1
- 241000709701 Human poliovirus 1 Species 0.000 claims 1
- 241000709704 Human poliovirus 2 Species 0.000 claims 1
- 241000709727 Human poliovirus 3 Species 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI2011005318 | 2011-11-03 | ||
| MYPI2011005318 | 2011-11-03 | ||
| PCT/IB2012/003114 WO2013098655A2 (en) | 2011-11-03 | 2012-11-01 | Antigens and vaccines directed against human enteroviruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149338A Division JP6419271B2 (ja) | 2011-11-03 | 2017-08-01 | ヒトエンテロウイルスに対する抗原及びワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532691A JP2014532691A (ja) | 2014-12-08 |
| JP2014532691A5 true JP2014532691A5 (enExample) | 2015-12-10 |
| JP6190378B2 JP6190378B2 (ja) | 2017-08-30 |
Family
ID=47215776
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539428A Expired - Fee Related JP6190378B2 (ja) | 2011-11-03 | 2012-11-01 | ヒトエンテロウイルスに対する抗原及びワクチン |
| JP2017149338A Expired - Fee Related JP6419271B2 (ja) | 2011-11-03 | 2017-08-01 | ヒトエンテロウイルスに対する抗原及びワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149338A Expired - Fee Related JP6419271B2 (ja) | 2011-11-03 | 2017-08-01 | ヒトエンテロウイルスに対する抗原及びワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9987350B2 (enExample) |
| EP (2) | EP3290050B1 (enExample) |
| JP (2) | JP6190378B2 (enExample) |
| KR (3) | KR101900460B1 (enExample) |
| CN (2) | CN107441484A (enExample) |
| AU (1) | AU2012360168C1 (enExample) |
| BR (1) | BR112014010658A2 (enExample) |
| CA (1) | CA2854594C (enExample) |
| CL (1) | CL2014001160A1 (enExample) |
| HK (2) | HK1245128A1 (enExample) |
| MX (2) | MX363409B (enExample) |
| MY (1) | MY172501A (enExample) |
| PH (2) | PH12014501041B1 (enExample) |
| SG (1) | SG11201401998VA (enExample) |
| TW (2) | TWI626308B (enExample) |
| WO (1) | WO2013098655A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI700295B (zh) * | 2013-12-16 | 2020-08-01 | 馬來西亞商Ｍａｂ探索私人有限公司 | 對會感染人類之腸病毒具有專一性之抗體 |
| PT3134131T (pt) | 2014-04-23 | 2022-03-24 | Modernatx Inc | Vacinas de ácidos nucleicos |
| WO2015167710A1 (en) * | 2014-04-29 | 2015-11-05 | National Health Research Institutes | Adenoviral vector-based vaccine against enterovirus infection |
| CN111925423B (zh) * | 2014-11-07 | 2022-08-19 | 普莱柯生物工程股份有限公司 | 一种抗o型口蹄疫的疫苗组合物及其制备方法和应用 |
| CN106554965B (zh) * | 2015-09-28 | 2019-08-27 | 斯澳生物科技（苏州）有限公司 | 用于制备ev71病毒样颗粒的核酸构建体和方法 |
| CN105348391B (zh) * | 2015-11-03 | 2019-06-28 | 李越希 | 埃可病毒6型vp1蛋白特异性抗原表位及其融合蛋白的制备、应用 |
| CN105802923B (zh) * | 2016-04-14 | 2019-07-16 | 中国科学院生物物理研究所 | 一种重组脊髓灰质炎病毒样颗粒及其制备方法与应用 |
| MY190078A (en) * | 2016-04-22 | 2022-03-24 | Integrated Res Associates Llc | Improved method for producing virus like particles |
| WO2018067000A1 (en) | 2016-10-07 | 2018-04-12 | Sentinext Therapeutics Sdn Bhd | Expression cassettes and methods for obtaining enterovirus virus-like particles |
| US20190224304A1 (en) * | 2016-10-07 | 2019-07-25 | Sentinext Therapeutics Sdn Bhd | Chimeric enterovirus virus-like particles |
| KR102091372B1 (ko) | 2017-02-28 | 2020-05-27 | 대한민국 | 엔테로바이러스 71형 불활화 백신 및 이의 용도 |
| CN108624601B (zh) * | 2017-03-17 | 2023-08-11 | 中国科学院上海巴斯德研究所 | 酵母表达的柯萨奇病毒a10病毒样颗粒及其应用 |
| KR102673090B1 (ko) * | 2017-07-03 | 2024-06-05 | 브하라트 바이오테크 인터내셔날 리미티드 | 합성 폴리펩타이드 에피토프 기반의 백신 조성물 |
| CN108152511B (zh) * | 2017-12-20 | 2019-01-04 | 广州瑞辉生物科技股份有限公司 | 柯萨奇A16病毒抗原多肽及其IgM抗体检测试剂盒 |
| CN108424881B (zh) * | 2018-03-23 | 2021-07-27 | 中国食品药品检定研究院 | 一株肠道病毒68型及其在制备ev-d68型感染动物中的应用 |
| JPWO2020067027A1 (ja) * | 2018-09-28 | 2021-08-30 | 一般財団法人阪大微生物病研究会 | Ｖｌｐ発現ｃｈｏ細胞株の構築 |
| CN110045105B (zh) * | 2018-11-09 | 2022-04-26 | 广州市妇女儿童医疗中心 | 柯萨奇A16病毒IgA抗体量子点免疫荧光层析试纸条及试剂盒 |
| EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 CONTAINING VACCINES AND THEIR USES |
| CN110684781B (zh) * | 2019-06-24 | 2021-05-28 | 四川农业大学 | 一种3型鸭甲肝病毒突变基因isa-a117c-t1142a及构建方法 |
| CN112048004B (zh) * | 2020-07-14 | 2021-10-22 | 桂林医学院 | 一种柯萨奇病毒b5型病毒样颗粒、其制备方法及应用 |
| WO2022070210A1 (en) * | 2020-09-29 | 2022-04-07 | Bharat Biotech International Limited | Stable formulations of low abundance enteroviruses vaccines and process of manufacture thereof |
| CN114107392A (zh) * | 2021-11-22 | 2022-03-01 | 昆明理工大学 | 一种cvb5病毒类病毒样颗粒的制备方法 |
| CN115010813B (zh) * | 2022-05-19 | 2024-04-05 | 桂林医学院 | 一种肠道病毒71型病毒样颗粒、其制备方法及应用 |
| CN116200348A (zh) * | 2022-09-21 | 2023-06-02 | 武汉生物制品研究所有限责任公司 | 一种适应Vero细胞的柯萨奇病毒A10型毒株的构建方法及其应用 |
| US11826418B1 (en) | 2023-01-06 | 2023-11-28 | King Faisal University | Virus-like particle (VLP)-based vaccine against CVB4 |
| WO2025029700A1 (en) * | 2023-07-28 | 2025-02-06 | Modernatx, Inc. | Vlp enteroviral vaccines |
| CN117456519B (zh) * | 2023-12-22 | 2024-03-12 | 江西科益高新技术有限公司 | 一种用于工控安全的仿真光电靶标装置及其仿真方法 |
| CN120665160A (zh) * | 2025-08-21 | 2025-09-19 | 国药中生生物技术研究院有限公司 | 肠道病毒71型的突变体及其病毒样颗粒 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8102740A (nl) | 1981-06-05 | 1983-01-03 | Nederlanden Staat | Virusvaccins en werkwijze ter bereiding daarvan. |
| US7968086B2 (en) | 2001-11-26 | 2011-06-28 | Duke University | Genetically stable enterovirus expression vector with replaced stem loop VI |
| US20050112095A1 (en) * | 2002-07-09 | 2005-05-26 | Tsu-An Hsu | Internal ribosome entry sites for recombinant protein expression |
| EP1479761A1 (en) * | 2003-05-21 | 2004-11-24 | PrimaGen Holding B.V. | New enterovirus, vaccines, medicaments and diagnostic kits |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| EP2842572A1 (en) * | 2005-11-01 | 2015-03-04 | Novartis Vaccines and Diagnostics GmbH | Cell-derived viral vaccines with low levels of residual cell dna |
| EP2035565A4 (en) * | 2006-06-30 | 2010-07-21 | Novavax Inc | METHODS OF ENHANCING THE INCORPORATION OF PROTEINS IN VIRUS-LIKE PARTICLES (VLPs) |
| US9758779B2 (en) * | 2008-08-28 | 2017-09-12 | Novartis Ag | Cell surface display of polypeptide isoforms by stop codon readthrough |
| US8663951B2 (en) * | 2009-01-09 | 2014-03-04 | Academia Sinica | Method of producing virus-like particles of picornavirus using a small-ubiquitin-related fusion protein expression system |
| CN101831410B (zh) | 2009-03-09 | 2013-04-17 | 北京工业大学 | 重组肠病毒71型病毒样颗粒的制备方法 |
| GB0918375D0 (en) | 2009-10-20 | 2009-12-02 | Animal Health Inst | Construct |
| TWI670373B (zh) * | 2011-02-08 | 2019-09-01 | 淡馬錫生命科學實驗室有限公司 | 用於有效率地表面呈示抗原蛋白質之新穎表現匣 |
-
2012
- 2012-11-01 EP EP17195266.6A patent/EP3290050B1/en not_active Not-in-force
- 2012-11-01 KR KR1020177026513A patent/KR101900460B1/ko not_active Expired - Fee Related
- 2012-11-01 BR BR112014010658A patent/BR112014010658A2/pt not_active Application Discontinuation
- 2012-11-01 SG SG11201401998VA patent/SG11201401998VA/en unknown
- 2012-11-01 CA CA2854594A patent/CA2854594C/en not_active Expired - Fee Related
- 2012-11-01 KR KR1020147015175A patent/KR101782451B1/ko not_active Expired - Fee Related
- 2012-11-01 JP JP2014539428A patent/JP6190378B2/ja not_active Expired - Fee Related
- 2012-11-01 CN CN201710660575.XA patent/CN107441484A/zh active Pending
- 2012-11-01 MX MX2014005315A patent/MX363409B/es unknown
- 2012-11-01 MY MYPI2014700792A patent/MY172501A/en unknown
- 2012-11-01 US US14/402,495 patent/US9987350B2/en not_active Expired - Fee Related
- 2012-11-01 AU AU2012360168A patent/AU2012360168C1/en not_active Ceased
- 2012-11-01 TW TW105141067A patent/TWI626308B/zh not_active IP Right Cessation
- 2012-11-01 EP EP12846826.1A patent/EP2773372B1/en not_active Not-in-force
- 2012-11-01 KR KR1020187026574A patent/KR102002103B1/ko not_active Expired - Fee Related
- 2012-11-01 WO PCT/IB2012/003114 patent/WO2013098655A2/en not_active Ceased
- 2012-11-01 TW TW101140538A patent/TWI571512B/zh not_active IP Right Cessation
- 2012-11-01 CN CN201280066026.5A patent/CN104093420B/zh not_active Expired - Fee Related
-
2014
- 2014-05-02 CL CL2014001160A patent/CL2014001160A1/es unknown
- 2014-05-02 PH PH12014501041A patent/PH12014501041B1/en unknown
- 2014-05-02 MX MX2018013782A patent/MX2018013782A/es unknown
-
2017
- 2017-08-01 JP JP2017149338A patent/JP6419271B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-12 HK HK18104787.9A patent/HK1245128A1/zh unknown
- 2018-04-27 US US15/964,211 patent/US10548964B2/en not_active Expired - Fee Related
- 2018-04-27 US US15/964,198 patent/US10555997B2/en not_active Expired - Fee Related
- 2018-08-30 HK HK18111177.2A patent/HK1251492B/en not_active IP Right Cessation
-
2019
- 2019-02-11 PH PH12019500289A patent/PH12019500289A1/en unknown
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