HK1245128A1 - 针对人肠道病毒的抗原及疫苗 - Google Patents

针对人肠道病毒的抗原及疫苗 Download PDF

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Publication number
HK1245128A1
HK1245128A1 HK18104787.9A HK18104787A HK1245128A1 HK 1245128 A1 HK1245128 A1 HK 1245128A1 HK 18104787 A HK18104787 A HK 18104787A HK 1245128 A1 HK1245128 A1 HK 1245128A1
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Hong Kong
Prior art keywords
enterovirus
human enterovirus
human
polypeptide
vaccine
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HK18104787.9A
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English (en)
Chinese (zh)
Inventor
M‧J‧卡多萨
M‧J‧卡多薩
M‧F‧加米卢丁
S‧B‧哈米德
M‧F‧加米盧丁
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森提耐斯特治疗公司
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Publication of HK1245128A1 publication Critical patent/HK1245128A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32323—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32351—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32371—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK18104787.9A 2011-11-03 2018-04-12 针对人肠道病毒的抗原及疫苗 HK1245128A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2011005318 2011-11-03
MYPI2011005318 2011-11-03

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HK1245128A1 true HK1245128A1 (zh) 2018-08-24

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HK18104787.9A HK1245128A1 (zh) 2011-11-03 2018-04-12 针对人肠道病毒的抗原及疫苗
HK18111177.2A HK1251492B (en) 2011-11-03 2018-08-30 Vaccines directed against human enteroviruses

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Application Number Title Priority Date Filing Date
HK18111177.2A HK1251492B (en) 2011-11-03 2018-08-30 Vaccines directed against human enteroviruses

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US (3) US9987350B2 (enExample)
EP (2) EP2773372B1 (enExample)
JP (2) JP6190378B2 (enExample)
KR (3) KR102002103B1 (enExample)
CN (2) CN104093420B (enExample)
AU (1) AU2012360168C1 (enExample)
BR (1) BR112014010658A2 (enExample)
CA (1) CA2854594C (enExample)
CL (1) CL2014001160A1 (enExample)
HK (2) HK1245128A1 (enExample)
MX (2) MX363409B (enExample)
MY (1) MY172501A (enExample)
PH (2) PH12014501041B1 (enExample)
SG (1) SG11201401998VA (enExample)
TW (2) TWI571512B (enExample)
WO (1) WO2013098655A2 (enExample)

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DK4023249T3 (da) 2014-04-23 2025-01-13 Modernatx Inc Nukleinsyrevacciner
TWI686475B (zh) * 2014-04-29 2020-03-01 財團法人國家衛生研究院 對抗腸病毒感染之基於腺病毒載體之疫苗
CN111925423B (zh) * 2014-11-07 2022-08-19 普莱柯生物工程股份有限公司 一种抗o型口蹄疫的疫苗组合物及其制备方法和应用
CN106554965B (zh) * 2015-09-28 2019-08-27 斯澳生物科技（苏州）有限公司 用于制备ev71病毒样颗粒的核酸构建体和方法
CN105348391B (zh) * 2015-11-03 2019-06-28 李越希 埃可病毒6型vp1蛋白特异性抗原表位及其融合蛋白的制备、应用
CN105802923B (zh) * 2016-04-14 2019-07-16 中国科学院生物物理研究所 一种重组脊髓灰质炎病毒样颗粒及其制备方法与应用
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CN108424881B (zh) * 2018-03-23 2021-07-27 中国食品药品检定研究院 一株肠道病毒68型及其在制备ev-d68型感染动物中的应用
WO2020067027A1 (ja) * 2018-09-28 2020-04-02 一般財団法人阪大微生物病研究会 Ｖｌｐ発現ｃｈｏ細胞株の構築
CN110045105B (zh) * 2018-11-09 2022-04-26 广州市妇女儿童医疗中心 柯萨奇A16病毒IgA抗体量子点免疫荧光层析试纸条及试剂盒
EP4582440A3 (en) * 2018-12-21 2025-10-08 The Regents of the University of California Il-10-containing vaccines and uses thereof
CN110684781B (zh) * 2019-06-24 2021-05-28 四川农业大学 一种3型鸭甲肝病毒突变基因isa-a117c-t1142a及构建方法
CN112048004B (zh) * 2020-07-14 2021-10-22 桂林医学院 一种柯萨奇病毒b5型病毒样颗粒、其制备方法及应用
WO2022070210A1 (en) * 2020-09-29 2022-04-07 Bharat Biotech International Limited Stable formulations of low abundance enteroviruses vaccines and process of manufacture thereof
CN114107392A (zh) * 2021-11-22 2022-03-01 昆明理工大学 一种cvb5病毒类病毒样颗粒的制备方法
CN115010813B (zh) * 2022-05-19 2024-04-05 桂林医学院 一种肠道病毒71型病毒样颗粒、其制备方法及应用
CN116200348A (zh) * 2022-09-21 2023-06-02 武汉生物制品研究所有限责任公司 一种适应Vero细胞的柯萨奇病毒A10型毒株的构建方法及其应用
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PH12019500289A1 (en) 2020-02-17
KR101900460B1 (ko) 2018-11-08
EP3290050A1 (en) 2018-03-07
EP2773372A2 (en) 2014-09-10
TW201333195A (zh) 2013-08-16
CA2854594A1 (en) 2013-07-04
CN107441484A (zh) 2017-12-08
HK1251492B (en) 2019-10-25
MY172501A (en) 2019-11-27
BR112014010658A2 (pt) 2017-06-13
JP6419271B2 (ja) 2018-11-07
MX363409B (es) 2019-03-20
CN104093420B (zh) 2017-07-28
PH12014501041A1 (en) 2014-08-04
US9987350B2 (en) 2018-06-05
US20180271971A1 (en) 2018-09-27
TW201716576A (zh) 2017-05-16
AU2012360168A2 (en) 2015-04-30
JP6190378B2 (ja) 2017-08-30
WO2013098655A9 (en) 2013-12-19
TWI626308B (zh) 2018-06-11
US10555997B2 (en) 2020-02-11
JP2014532691A (ja) 2014-12-08
US20150140027A1 (en) 2015-05-21
AU2012360168A1 (en) 2014-05-22
HK1202803A1 (en) 2015-10-09
EP3290050B1 (en) 2019-01-02
KR20180104201A (ko) 2018-09-19
CA2854594C (en) 2018-08-21
PH12014501041B1 (en) 2014-08-04
KR102002103B1 (ko) 2019-07-19
TWI571512B (zh) 2017-02-21
US10548964B2 (en) 2020-02-04
KR20170109700A (ko) 2017-09-29
AU2012360168B2 (en) 2017-06-22
WO2013098655A3 (en) 2013-09-12
KR20140096343A (ko) 2014-08-05
MX2014005315A (es) 2015-03-09
EP2773372B1 (en) 2018-12-26
AU2012360168C1 (en) 2017-09-28
JP2017226677A (ja) 2017-12-28
MX2018013782A (es) 2021-12-08
KR101782451B1 (ko) 2017-09-29
CN104093420A (zh) 2014-10-08
WO2013098655A2 (en) 2013-07-04
US20180243400A1 (en) 2018-08-30
SG11201401998VA (en) 2014-05-29
CL2014001160A1 (es) 2014-11-03

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