MX2018013782A - Antigenos y vacunas dirigidos contra enterovirus humanos. - Google Patents

Antigenos y vacunas dirigidos contra enterovirus humanos.

Info

Publication number
MX2018013782A
MX2018013782A MX2018013782A MX2018013782A MX2018013782A MX 2018013782 A MX2018013782 A MX 2018013782A MX 2018013782 A MX2018013782 A MX 2018013782A MX 2018013782 A MX2018013782 A MX 2018013782A MX 2018013782 A MX2018013782 A MX 2018013782A
Authority
MX
Mexico
Prior art keywords
enterovirus
antigens
prevention
infection
human
Prior art date
Application number
MX2018013782A
Other languages
English (en)
Inventor
Mary Jane Cardosa
Mohamad Fakruddin Jamiluddin
Sharifah Binti Hamid
Original Assignee
Sentinext Therapeutics Sdn Bhd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sentinext Therapeutics Sdn Bhd filed Critical Sentinext Therapeutics Sdn Bhd
Publication of MX2018013782A publication Critical patent/MX2018013782A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32323—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32351—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32371—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a un cassette de expresión caracterizado porque comprende un promotor unido operativamente a un ácido nucleico que codifica un polipéptido P1 de enterovirus humano, un Sitio de Entrada de Ribosoma Interno (IRES) y una proteasa 3CD de enterovirus humano bajo el control translacional de IRES.
MX2018013782A 2011-11-03 2014-05-02 Antigenos y vacunas dirigidos contra enterovirus humanos. MX2018013782A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2011005318 2011-11-03

Publications (1)

Publication Number Publication Date
MX2018013782A true MX2018013782A (es) 2021-12-08

Family

ID=47215776

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014005315A MX363409B (es) 2011-11-03 2012-11-01 Antigenos y vacunas dirigidos contra enterovirus hunanos.
MX2018013782A MX2018013782A (es) 2011-11-03 2014-05-02 Antigenos y vacunas dirigidos contra enterovirus humanos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014005315A MX363409B (es) 2011-11-03 2012-11-01 Antigenos y vacunas dirigidos contra enterovirus hunanos.

Country Status (16)

Country Link
US (3) US9987350B2 (es)
EP (2) EP3290050B1 (es)
JP (2) JP6190378B2 (es)
KR (3) KR102002103B1 (es)
CN (2) CN104093420B (es)
AU (1) AU2012360168C1 (es)
BR (1) BR112014010658A2 (es)
CA (1) CA2854594C (es)
CL (1) CL2014001160A1 (es)
HK (3) HK1202803A1 (es)
MX (2) MX363409B (es)
MY (1) MY172501A (es)
PH (2) PH12014501041B1 (es)
SG (1) SG11201401998VA (es)
TW (2) TWI571512B (es)
WO (1) WO2013098655A2 (es)

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KR20170068410A (ko) * 2014-04-29 2017-06-19 내셔날 헬스 리서치 인스티튜트 엔테로바이러스 감염증에 대항하는 아데노바이러스 벡터-기반 백신
CN105624124B (zh) * 2014-11-07 2020-09-29 普莱柯生物工程股份有限公司 一种抗o型口蹄疫的疫苗组合物及其制备方法和应用
CN106554965B (zh) * 2015-09-28 2019-08-27 斯澳生物科技（苏州）有限公司 用于制备ev71病毒样颗粒的核酸构建体和方法
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CN105802923B (zh) * 2016-04-14 2019-07-16 中国科学院生物物理研究所 一种重组脊髓灰质炎病毒样颗粒及其制备方法与应用
EP3445396A4 (en) 2016-04-22 2020-03-11 Integrated Research Associates, LLC IMPROVED PROCESS FOR PRODUCING VIRUS-LIKE PARTICLES
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CN108152511B (zh) * 2017-12-20 2019-01-04 广州瑞辉生物科技股份有限公司 柯萨奇A16病毒抗原多肽及其IgM抗体检测试剂盒
CN108424881B (zh) * 2018-03-23 2021-07-27 中国食品药品检定研究院 一株肠道病毒68型及其在制备ev-d68型感染动物中的应用
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JP7022335B2 (ja) 2018-05-16 2022-02-18 住友電装株式会社 コネクタ
WO2020067027A1 (ja) * 2018-09-28 2020-04-02 一般財団法人阪大微生物病研究会 Ｖｌｐ発現ｃｈｏ細胞株の構築
CN110045105B (zh) * 2018-11-09 2022-04-26 广州市妇女儿童医疗中心 柯萨奇A16病毒IgA抗体量子点免疫荧光层析试纸条及试剂盒
WO2020132595A1 (en) * 2018-12-21 2020-06-25 The Regents Of The University Of California Il-10-containing vaccines and uses thereof
CN110684781B (zh) * 2019-06-24 2021-05-28 四川农业大学 一种3型鸭甲肝病毒突变基因isa-a117c-t1142a及构建方法
CN112048004B (zh) * 2020-07-14 2021-10-22 桂林医学院 一种柯萨奇病毒b5型病毒样颗粒、其制备方法及应用
WO2022070210A1 (en) * 2020-09-29 2022-04-07 Bharat Biotech International Limited Stable formulations of low abundance enteroviruses vaccines and process of manufacture thereof
CN114107392A (zh) * 2021-11-22 2022-03-01 昆明理工大学 一种cvb5病毒类病毒样颗粒的制备方法
CN115010813B (zh) * 2022-05-19 2024-04-05 桂林医学院 一种肠道病毒71型病毒样颗粒、其制备方法及应用
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Also Published As

Publication number Publication date
CA2854594C (en) 2018-08-21
HK1251492B (zh) 2019-10-25
US20180271971A1 (en) 2018-09-27
US20150140027A1 (en) 2015-05-21
AU2012360168A1 (en) 2014-05-22
EP3290050B1 (en) 2019-01-02
WO2013098655A2 (en) 2013-07-04
KR102002103B1 (ko) 2019-07-19
US10555997B2 (en) 2020-02-11
EP2773372B1 (en) 2018-12-26
HK1202803A1 (en) 2015-10-09
KR101782451B1 (ko) 2017-09-29
TW201716576A (zh) 2017-05-16
AU2012360168C1 (en) 2017-09-28
BR112014010658A2 (pt) 2017-06-13
CN104093420A (zh) 2014-10-08
CL2014001160A1 (es) 2014-11-03
KR101900460B1 (ko) 2018-11-08
AU2012360168A2 (en) 2015-04-30
TWI571512B (zh) 2017-02-21
JP6190378B2 (ja) 2017-08-30
EP2773372A2 (en) 2014-09-10
KR20170109700A (ko) 2017-09-29
MX363409B (es) 2019-03-20
US9987350B2 (en) 2018-06-05
MY172501A (en) 2019-11-27
TWI626308B (zh) 2018-06-11
US20180243400A1 (en) 2018-08-30
KR20140096343A (ko) 2014-08-05
US10548964B2 (en) 2020-02-04
WO2013098655A9 (en) 2013-12-19
MX2014005315A (es) 2015-03-09
HK1245128A1 (zh) 2018-08-24
JP6419271B2 (ja) 2018-11-07
PH12014501041A1 (en) 2014-08-04
TW201333195A (zh) 2013-08-16
CA2854594A1 (en) 2013-07-04
JP2014532691A (ja) 2014-12-08
KR20180104201A (ko) 2018-09-19
CN104093420B (zh) 2017-07-28
PH12014501041B1 (en) 2014-08-04
JP2017226677A (ja) 2017-12-28
SG11201401998VA (en) 2014-05-29
WO2013098655A3 (en) 2013-09-12
EP3290050A1 (en) 2018-03-07
PH12019500289A1 (en) 2020-02-17
AU2012360168B2 (en) 2017-06-22
CN107441484A (zh) 2017-12-08

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