JP2012511579A5 - - Google Patents
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- JP2012511579A5 JP2012511579A5 JP2011540854A JP2011540854A JP2012511579A5 JP 2012511579 A5 JP2012511579 A5 JP 2012511579A5 JP 2011540854 A JP2011540854 A JP 2011540854A JP 2011540854 A JP2011540854 A JP 2011540854A JP 2012511579 A5 JP2012511579 A5 JP 2012511579A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- rsv
- arginine
- vlp
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12112608P | 2008-12-09 | 2008-12-09 | |
| US61/121,126 | 2008-12-09 | ||
| US16907709P | 2009-04-14 | 2009-04-14 | |
| US61/169,077 | 2009-04-14 | ||
| US22478709P | 2009-07-10 | 2009-07-10 | |
| US61/224,787 | 2009-07-10 | ||
| PCT/US2009/067269 WO2010077717A1 (en) | 2008-12-09 | 2009-12-09 | Modified rsv f proteins and methods of their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124158A Division JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾ｒｓｖｆタンパク質及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511579A JP2012511579A (ja) | 2012-05-24 |
| JP2012511579A5 true JP2012511579A5 (enExample) | 2013-01-17 |
| JP5813513B2 JP5813513B2 (ja) | 2015-11-17 |
Family
ID=42310119
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540854A Active JP5813513B2 (ja) | 2008-12-09 | 2009-12-09 | 修飾ｒｓｖｆタンパク質及びその使用方法 |
| JP2015124158A Active JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾ｒｓｖｆタンパク質及びその使用方法 |
| JP2017118032A Active JP6462048B2 (ja) | 2008-12-09 | 2017-06-15 | 修飾ｒｓｖ ｆタンパク質及びその使用方法 |
| JP2018242108A Active JP6782289B2 (ja) | 2008-12-09 | 2018-12-26 | 修飾ｒｓｖ ｆタンパク質及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124158A Active JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾ｒｓｖｆタンパク質及びその使用方法 |
| JP2017118032A Active JP6462048B2 (ja) | 2008-12-09 | 2017-06-15 | 修飾ｒｓｖ ｆタンパク質及びその使用方法 |
| JP2018242108A Active JP6782289B2 (ja) | 2008-12-09 | 2018-12-26 | 修飾ｒｓｖ ｆタンパク質及びその使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US8715692B2 (enExample) |
| EP (3) | EP2370099B1 (enExample) |
| JP (4) | JP5813513B2 (enExample) |
| KR (2) | KR101691574B1 (enExample) |
| CN (2) | CN106146671B (enExample) |
| AU (1) | AU2009333484B2 (enExample) |
| BR (1) | BRPI0922867B8 (enExample) |
| CA (1) | CA2746228C (enExample) |
| CY (2) | CY1117757T1 (enExample) |
| DK (2) | DK2370099T3 (enExample) |
| ES (3) | ES2796725T3 (enExample) |
| HR (2) | HRP20160859T1 (enExample) |
| HU (2) | HUE051666T2 (enExample) |
| IL (2) | IL213450B (enExample) |
| LT (1) | LT3067064T (enExample) |
| MX (4) | MX2011006205A (enExample) |
| PL (2) | PL2370099T3 (enExample) |
| PT (2) | PT2370099T (enExample) |
| RU (1) | RU2531510C2 (enExample) |
| SG (2) | SG10201500161XA (enExample) |
| SI (2) | SI2370099T1 (enExample) |
| SM (1) | SMT202000411T1 (enExample) |
| WO (1) | WO2010077717A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160000902A1 (en) * | 2003-07-11 | 2016-01-07 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| EP2367844A4 (en) * | 2008-11-18 | 2012-08-01 | Ligocyte Pharmaceuticals Inc | RSV-F VLP AND MANUFACTURING METHOD AND METHOD OF USE THEREOF |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| WO2010077717A1 (en) * | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| PL3178490T3 (pl) * | 2009-07-15 | 2022-08-01 | Glaxosmithkline Biologicals S.A. | Kompozycje białka f rsv i sposoby ich wytwarzania |
| WO2011046925A1 (en) * | 2009-10-12 | 2011-04-21 | Technovax, Inc. | Respiratory syncytial virus (rsv) virus-like particles (vlps) |
| RS56157B1 (sr) | 2010-11-05 | 2017-11-30 | Novavax Inc | Glikoproteinske čestice nalik virusu (vlp) besnila |
| WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| PL2667892T3 (pl) | 2011-01-26 | 2019-09-30 | Glaxosmithkline Biologicals Sa | Schemat szczepień przeciwko rsv |
| ES2651143T3 (es) | 2011-05-13 | 2018-01-24 | Glaxosmithkline Biologicals Sa | Antígenos de F de prefusión del VRS |
| EP3275464A1 (en) * | 2011-08-01 | 2018-01-31 | Emory University | Vlps containing ligands and methods related thereto |
| WO2013031827A1 (ja) | 2011-08-29 | 2013-03-07 | 国立大学法人徳島大学 | Rsv粘膜ワクチン |
| JP2014530010A (ja) * | 2011-09-30 | 2014-11-17 | ノババックス，インコーポレイテッド | 呼吸器合胞体ウイルス用の組み換えナノ粒子ｒｓｖｆワクチン |
| CN103239734B (zh) * | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| BR112015002131B1 (pt) | 2012-08-01 | 2022-11-01 | Bavarian Nordic A/S | Vírus vaccinia ankara modificado (mva) recombinante, composição farmacêutica e uso do referido mva recombinante |
| EP2922570A1 (en) | 2012-11-20 | 2015-09-30 | GlaxoSmithKline Biologicals SA | Rsv f prefusion trimers |
| US20140227309A1 (en) * | 2013-02-11 | 2014-08-14 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| CN113322264B (zh) * | 2013-03-14 | 2024-05-31 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| DE102013004595A1 (de) * | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| HK1225631A1 (zh) | 2013-09-19 | 2017-09-15 | Novavax, Inc. | 免疫原性中东呼吸综合征冠状病毒(mers-cov)组合物和方法 |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| US10100372B2 (en) | 2014-06-18 | 2018-10-16 | Georgia State University Research Foundation, Inc. | Recombinant RSV reporter virus |
| CN106795513B (zh) * | 2014-08-08 | 2021-06-11 | Vlp治疗公司 | 包含修饰的包膜蛋白e3的病毒样颗粒 |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| JP7189014B2 (ja) | 2015-07-07 | 2022-12-13 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｒｓｖに対するワクチン |
| MX2018002728A (es) * | 2015-09-03 | 2018-09-05 | Novavax Inc | Composiciones de vacuna que tienen estabilidad e inmunogenicidad mejoradas. |
| MX2018005462A (es) | 2015-10-29 | 2018-08-01 | Univ Emory | Composiciones inmunogénicas de rsv quimérico y métodos de uso. |
| MY205060A (en) | 2015-12-23 | 2024-09-30 | Pfizer | Rsv f protein mutants |
| KR20220041966A (ko) | 2016-04-05 | 2022-04-01 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 용해성 융합-전 rsv f 단백질 |
| BR112018070323A2 (pt) * | 2016-04-05 | 2019-01-29 | Janssen Vaccines & Prevention Bv | vacina contra rsv |
| IL264119B2 (en) | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
| CN106011086A (zh) * | 2016-06-15 | 2016-10-12 | 湖北省农业科学院畜牧兽医研究所 | 表达信号肽替换的呼吸道合胞病毒f蛋白的重组新城疫耐热疫苗株及制备方法 |
| WO2018170260A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| CN110506060B (zh) * | 2017-03-30 | 2024-05-07 | 昆士兰大学 | 嵌合分子及其用途 |
| CN110603262A (zh) | 2017-04-04 | 2019-12-20 | 华盛顿大学 | 显示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
| KR20200018483A (ko) | 2017-06-14 | 2020-02-19 | 비로메틱스 아게 | 호흡기 합포체 바이러스에 대한 방어를 위한 고리형 펩티드 |
| CN111148509A (zh) | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| WO2019148101A1 (en) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Rsv rna vaccines |
| AU2019228551B2 (en) | 2018-02-28 | 2025-07-24 | University Of Washington | Self-assembling nanostructure vaccines |
| IL277274B2 (en) | 2018-03-19 | 2024-02-01 | Novavax Inc | Multifunctional nanoparticle vaccines for influenza |
| EP3775174A4 (en) * | 2018-03-30 | 2022-07-06 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (rsv) vaccines |
| KR20210018206A (ko) | 2018-04-03 | 2021-02-17 | 사노피 | 항원성 호흡기 세포융합 바이러스 폴리펩타이드 |
| EP3873517A4 (en) | 2018-10-29 | 2022-09-28 | Emory University | RSV VIRUS-LIKE PARTICLES AND METHODS OF PRODUCTION THEREOF |
| KR102725189B1 (ko) | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| JOP20210106A1 (ar) | 2018-11-13 | 2023-01-30 | Janssen Vaccines And Prevention B V | بروتينات rsv f سابقة الاندماج مستقرة |
| JP7550762B2 (ja) | 2018-12-20 | 2024-09-13 | ヴァイロメティックス アーゲー | リポペプチドビルディングブロックおよび合成ウイルス様粒子 |
| WO2020167813A1 (en) * | 2019-02-11 | 2020-08-20 | Emory University | Chimeric rsv and hmpv f proteins, immunogenic compositions, and methods of use |
| WO2020175660A1 (ja) | 2019-02-28 | 2020-09-03 | Ｋｍバイオロジクス株式会社 | Ｒｓｖ ｆ／ｇキメラワクチン |
| TW202142555A (zh) * | 2020-01-27 | 2021-11-16 | 美商諾瓦瓦克斯股份有限公司 | 冠狀病毒疫苗配製品 |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| US11547673B1 (en) | 2020-04-22 | 2023-01-10 | BioNTech SE | Coronavirus vaccine |
| CN113855796B (zh) * | 2021-07-30 | 2024-01-26 | 河北医科大学 | 卡介苗作为呼吸道合胞病毒灭活疫苗佐剂的应用 |
| WO2023062651A1 (en) * | 2021-10-13 | 2023-04-20 | Padmanabh Patil Harshad | Virus-like particles for respiratory syncytial virus and method of preparation thereof |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| US20240076320A1 (en) * | 2022-09-01 | 2024-03-07 | Novavax, Inc. | Downstream process for purification of viral proteins with hydrophobic membrane domain for use in vaccine compositions |
| CN115927751B (zh) * | 2022-09-17 | 2024-12-20 | 宁夏大学 | 牛呼吸道合胞体病毒实时荧光定量pcr检测的引物探针组及检测方法 |
| WO2024193380A1 (zh) * | 2023-03-17 | 2024-09-26 | 成都威斯克生物医药有限公司 | 抗呼吸道合胞病毒感染的疫苗 |
| WO2025026448A1 (zh) * | 2023-08-03 | 2025-02-06 | 广州穗和生物技术有限公司 | 修饰的呼吸道合胞病毒f蛋白及其用途 |
| CN119504955A (zh) * | 2023-08-25 | 2025-02-25 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸及疫苗 |
| WO2025051250A1 (zh) * | 2023-09-07 | 2025-03-13 | 北京科兴中维生物技术有限公司 | 呼吸道合胞病毒f蛋白及其应用 |
| US20250144200A1 (en) | 2023-11-06 | 2025-05-08 | Novavax, Inc. | Intranasal immunogenic compositions |
| CN117645655B (zh) * | 2024-01-26 | 2024-05-24 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌多糖-rsv重组蛋白结合疫苗及其制备方法 |
| WO2025201243A1 (zh) * | 2024-03-25 | 2025-10-02 | 中国医学科学院医学生物学研究所 | 重组呼吸道合胞病毒融合前f蛋白突变体和其用途 |
| CN118146321B (zh) * | 2024-03-27 | 2024-08-27 | 普大生物科技(泰州)有限公司 | 一种rsv重组蛋白疫苗及其制备方法 |
| CN118480560B (zh) * | 2024-07-09 | 2024-11-26 | 北京悦康科创医药科技股份有限公司 | 呼吸道合胞病毒mRNA疫苗及其制备方法和应用 |
| CN119161422A (zh) * | 2024-08-26 | 2024-12-20 | 扬州大学 | 一种呼吸道合胞病毒融合前f蛋白及其应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| US5149650A (en) | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| ES2370937T3 (es) | 1993-09-13 | 2011-12-23 | Protein Sciences Corporation | Un método para producir vacunas antigripales polivalentes a base de hemaglutinina. |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| NZ512980A (en) | 1998-12-17 | 2003-07-25 | Aventis Pasteur | Multivalent immunogenic composition containing RSV subunit composition and influenza virus preparation |
| CA2799545A1 (en) | 2000-03-07 | 2001-09-13 | Merck Sharp & Dohme Corp. | Adenovirus formulations |
| NZ525076A (en) | 2000-10-02 | 2004-09-24 | Glaxosmithkline Biolog S | A split enveloped RSV virus vaccine fomulation |
| WO2003068933A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| CN1813061B (zh) | 2003-04-25 | 2013-05-29 | 免疫医疗有限责任公司 | 重组副流感病毒表达系统以及包含源自间质肺病毒的异种抗原的疫苗 |
| CA2529710A1 (en) * | 2003-06-20 | 2005-03-10 | Protein Sciences Corporation | Vectors expressing sars immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using |
| US7588770B2 (en) | 2003-12-10 | 2009-09-15 | The Uab Research Foundation | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins |
| BRPI0517374A (pt) | 2004-10-29 | 2008-10-07 | Harvard College | formulação para tratamento ou prevenção de infecção respiratória, método para tratamento |
| KR20070110924A (ko) | 2005-03-10 | 2007-11-20 | 메드이뮨 백신즈 인코포레이티드 | 메타뉴모바이러스주 및 항원성 서열의 발현용 벡터 및 백신제제로서의 이의 용도 및 바이러스의 증식 방법 |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| WO2007149490A1 (en) | 2006-06-19 | 2007-12-27 | Progenics Pharmaceuticals, Inc. | Processes for recovering stabilized formulations of trimers of retroviral envelope (env) proteins |
| EP2089515A4 (en) * | 2006-11-16 | 2011-02-23 | Novavax Inc | VIRUSUAL PARTICLES OF RESPIRATORY SYNZYTIAL VIRUS |
| US8772256B2 (en) * | 2006-11-30 | 2014-07-08 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Codon modified immunogenic compositions and methods of use |
| EP1972348A1 (en) * | 2007-03-14 | 2008-09-24 | Pierre Fabre Medicament | Novel vaccine composition for the treatment of respiratory infectious diseases |
| WO2008114149A2 (en) | 2007-03-21 | 2008-09-25 | Id Biomedical Corporation Of Quebec | Chimeric antigens |
| DK2540312T3 (en) | 2007-07-19 | 2015-07-20 | Novavax Inc | Chimeric avian influenza VLPs |
| US20100239671A1 (en) | 2007-11-06 | 2010-09-23 | Edelman Elazer R | Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair |
| JP5711972B2 (ja) | 2007-12-24 | 2015-05-07 | アイディー バイオメディカル コーポレイション オブ ケベック | 組換えｒｓｖ抗原 |
| JP2011514337A (ja) | 2008-02-25 | 2011-05-06 | ノババックス，インコーポレイテッド | 糖ガラス化ウィルス様粒子（ｖｌｐ） |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| WO2010077717A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| CN107252482A (zh) | 2009-05-27 | 2017-10-17 | 西莱克塔生物科技公司 | 具有不同释放速率的纳米载体加工组分 |
| PT2445526T (pt) * | 2009-06-24 | 2016-08-16 | Glaxosmithkline Biologicals Sa | Antigénios de rsv recombinantes |
| PL3178490T3 (pl) * | 2009-07-15 | 2022-08-01 | Glaxosmithkline Biologicals S.A. | Kompozycje białka f rsv i sposoby ich wytwarzania |
| RS56157B1 (sr) | 2010-11-05 | 2017-11-30 | Novavax Inc | Glikoproteinske čestice nalik virusu (vlp) besnila |
| CN102107003A (zh) | 2011-01-05 | 2011-06-29 | 重庆大学 | 一种猪繁殖与呼吸综合症病毒体疫苗及其制备方法 |
| EP3508219A1 (en) | 2011-07-06 | 2019-07-10 | GlaxoSmithKline Biologicals S.A. | Self-replicating rna prime - protein boost vaccines |
| JP2014530010A (ja) | 2011-09-30 | 2014-11-17 | ノババックス，インコーポレイテッド | 呼吸器合胞体ウイルス用の組み換えナノ粒子ｒｓｖｆワクチン |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| US20140227309A1 (en) | 2013-02-11 | 2014-08-14 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| RU2531235C2 (ru) | 2013-02-15 | 2014-10-20 | Общество с ограниченной ответственностью "Универсальные БиоСистемы" (ООО "УБС") | Поливалентная вакцина против гриппа на основе гибридного белка |
| CN110590916A (zh) | 2013-04-25 | 2019-12-20 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| AU2014100888A4 (en) | 2014-08-07 | 2014-09-11 | Novartis Ag | Virus clearance and protein purification methods |
| WO2017000105A1 (zh) * | 2015-06-29 | 2017-01-05 | 尚平 | 便携式加湿器 |
| MX2018002728A (es) | 2015-09-03 | 2018-09-05 | Novavax Inc | Composiciones de vacuna que tienen estabilidad e inmunogenicidad mejoradas. |
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