JP2012511579A5 - - Google Patents
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- JP2012511579A5 JP2012511579A5 JP2011540854A JP2011540854A JP2012511579A5 JP 2012511579 A5 JP2012511579 A5 JP 2012511579A5 JP 2011540854 A JP2011540854 A JP 2011540854A JP 2011540854 A JP2011540854 A JP 2011540854A JP 2012511579 A5 JP2012511579 A5 JP 2012511579A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- rsv
- arginine
- vlp
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12112608P | 2008-12-09 | 2008-12-09 | |
| US61/121,126 | 2008-12-09 | ||
| US16907709P | 2009-04-14 | 2009-04-14 | |
| US61/169,077 | 2009-04-14 | ||
| US22478709P | 2009-07-10 | 2009-07-10 | |
| US61/224,787 | 2009-07-10 | ||
| PCT/US2009/067269 WO2010077717A1 (en) | 2008-12-09 | 2009-12-09 | Modified rsv f proteins and methods of their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124158A Division JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾rsvfタンパク質及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511579A JP2012511579A (ja) | 2012-05-24 |
| JP2012511579A5 true JP2012511579A5 (enExample) | 2013-01-17 |
| JP5813513B2 JP5813513B2 (ja) | 2015-11-17 |
Family
ID=42310119
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540854A Active JP5813513B2 (ja) | 2008-12-09 | 2009-12-09 | 修飾rsvfタンパク質及びその使用方法 |
| JP2015124158A Active JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾rsvfタンパク質及びその使用方法 |
| JP2017118032A Active JP6462048B2 (ja) | 2008-12-09 | 2017-06-15 | 修飾rsv fタンパク質及びその使用方法 |
| JP2018242108A Active JP6782289B2 (ja) | 2008-12-09 | 2018-12-26 | 修飾rsv fタンパク質及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124158A Active JP6162751B2 (ja) | 2008-12-09 | 2015-06-19 | 修飾rsvfタンパク質及びその使用方法 |
| JP2017118032A Active JP6462048B2 (ja) | 2008-12-09 | 2017-06-15 | 修飾rsv fタンパク質及びその使用方法 |
| JP2018242108A Active JP6782289B2 (ja) | 2008-12-09 | 2018-12-26 | 修飾rsv fタンパク質及びその使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US8715692B2 (enExample) |
| EP (3) | EP3067064B1 (enExample) |
| JP (4) | JP5813513B2 (enExample) |
| KR (2) | KR101801213B1 (enExample) |
| CN (2) | CN102307591B (enExample) |
| AU (1) | AU2009333484B2 (enExample) |
| BR (1) | BRPI0922867B8 (enExample) |
| CA (1) | CA2746228C (enExample) |
| CY (2) | CY1117757T1 (enExample) |
| DK (2) | DK2370099T3 (enExample) |
| ES (3) | ES2987238T3 (enExample) |
| HR (2) | HRP20160859T1 (enExample) |
| HU (2) | HUE029037T2 (enExample) |
| IL (2) | IL213450B (enExample) |
| LT (1) | LT3067064T (enExample) |
| MX (4) | MX358836B (enExample) |
| PL (2) | PL2370099T3 (enExample) |
| PT (2) | PT2370099T (enExample) |
| RU (1) | RU2531510C2 (enExample) |
| SG (2) | SG172022A1 (enExample) |
| SI (2) | SI3067064T1 (enExample) |
| SM (1) | SMT202000411T1 (enExample) |
| WO (1) | WO2010077717A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160000902A1 (en) * | 2003-07-11 | 2016-01-07 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| AU2009316680B2 (en) * | 2008-11-18 | 2016-03-24 | Takeda Vaccines, Inc. | RSV F VLPs and methods of manufacture and use thereof |
| ES2987238T3 (es) * | 2008-12-09 | 2024-11-14 | Novavax Inc | Proteínas F del RSV modificadas y métodos de su uso |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| EP4183412B1 (en) * | 2009-07-15 | 2024-08-14 | GlaxoSmithKline Biologicals SA | Rsv f protein compositions and methods for making same |
| WO2011046925A1 (en) * | 2009-10-12 | 2011-04-21 | Technovax, Inc. | Respiratory syncytial virus (rsv) virus-like particles (vlps) |
| WO2012061815A2 (en) * | 2010-11-05 | 2012-05-10 | Novavax Inc. | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
| WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| ES3018416T3 (es) | 2011-01-26 | 2025-05-16 | Glaxosmithkline Biologicals Sa | Régimen de inmunización del VRS |
| RS56748B1 (sr) | 2011-05-13 | 2018-03-30 | Glaxosmithkline Biologicals Sa | Pre-fuzioni rsv f antigeni |
| EP3275464A1 (en) * | 2011-08-01 | 2018-01-31 | Emory University | Vlps containing ligands and methods related thereto |
| US9463236B2 (en) | 2011-08-29 | 2016-10-11 | Tokushima University | RSV mucosal vaccine |
| SG10201602434UA (en) * | 2011-09-30 | 2016-05-30 | Novavax Inc | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| CN103239734B (zh) * | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| SI2879702T1 (sl) | 2012-08-01 | 2020-02-28 | Bavarian Nordic A/S | Cepivo na osnovi rekombinantnega modificiranega virusa vakcinacije Ankara (MVA) proti respiratornemu sincitialnemu virusu (RSV) |
| KR20150085843A (ko) | 2012-11-20 | 2015-07-24 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Rsv f 융합전 삼합체 |
| JP2016509015A (ja) * | 2013-02-11 | 2016-03-24 | ノババックス,インコーポレイテッド | 呼吸器合胞体ウイルス及びインフルエンザ用の混合ワクチン |
| CN105189756B (zh) * | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| DE102013004595A1 (de) * | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| EP3046579A1 (en) | 2013-09-19 | 2016-07-27 | Novavax, Inc. | Immunogenic middle east respiratory syndrome coronavirus (mers-cov) compositions and methods |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| US10100372B2 (en) | 2014-06-18 | 2018-10-16 | Georgia State University Research Foundation, Inc. | Recombinant RSV reporter virus |
| TWI720946B (zh) * | 2014-08-08 | 2021-03-11 | 美商Vlp醫療股份有限公司 | 包含改質套膜蛋白質e3之類病毒粒子 |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| CN107847580B (zh) | 2015-07-07 | 2022-08-12 | 扬森疫苗与预防公司 | 针对rsv的疫苗 |
| CN114617959A (zh) | 2015-09-03 | 2022-06-14 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
| SG11201803581VA (en) | 2015-10-29 | 2018-05-30 | Univ Emory | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
| RU2723039C2 (ru) | 2015-12-23 | 2020-06-08 | Пфайзер Инк. | Мутанты белка f rsv |
| MX2018012094A (es) * | 2016-04-05 | 2019-01-10 | Janssen Vaccines & Prevention Bv | Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas. |
| AU2017248018A1 (en) * | 2016-04-05 | 2018-09-27 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
| SG11201810078PA (en) | 2016-05-30 | 2018-12-28 | Janssen Vaccines & Prevention Bv | Stabilized pre-fusion rsv f proteins |
| CN106011086A (zh) * | 2016-06-15 | 2016-10-12 | 湖北省农业科学院畜牧兽医研究所 | 表达信号肽替换的呼吸道合胞病毒f蛋白的重组新城疫耐热疫苗株及制备方法 |
| WO2018170260A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| CN110506060B (zh) * | 2017-03-30 | 2024-05-07 | 昆士兰大学 | 嵌合分子及其用途 |
| EP3606942B1 (en) | 2017-04-04 | 2025-06-11 | University of Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
| JP7356911B2 (ja) | 2017-06-14 | 2023-10-05 | ヴァイロメティックス アーゲー | 呼吸器合胞体ウイルスに対する予防のための環状ペプチド |
| CN111148509A (zh) | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| CN112088014B (zh) | 2018-02-28 | 2026-03-24 | 华盛顿大学 | 自组装纳米结构疫苗 |
| CN120227451A (zh) | 2018-03-19 | 2025-07-01 | 诺瓦瓦克斯股份有限公司 | 多价流感纳米颗粒疫苗 |
| EP3775174A4 (en) * | 2018-03-30 | 2022-07-06 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (rsv) vaccines |
| JP7614841B2 (ja) | 2018-04-03 | 2025-01-16 | サノフイ | 抗原性呼吸器合胞体ウイルスポリペプチド |
| WO2020092365A1 (en) | 2018-10-29 | 2020-05-07 | Binh Ha | Rsv virus-like particles and methods of use thereof |
| US20200129446A1 (en) | 2018-10-29 | 2020-04-30 | University Of Iowa Research Foundation | Respiratory syncytial virus (rsv) polyanhydride nanoparticle vaccine |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| PE20211469A1 (es) | 2018-11-13 | 2021-08-05 | Janssen Vaccines And Prevention B V | Proteinas f de prefusion del vrs estabilizadas |
| CA3121724A1 (en) | 2018-12-20 | 2020-06-25 | Virometix Ag | Lipopeptide building blocks and synthetic virus-like particles |
| EP3923983A4 (en) * | 2019-02-11 | 2023-02-22 | Emory University | CHIMERIC RSV AND HMPV F PROTEINS, IMMUNOGENIC COMPOSITIONS AND METHODS OF USE |
| WO2020176524A1 (en) * | 2019-02-28 | 2020-09-03 | Novavax, Inc. | Methods for preventing disease or disorder caused by rsv infection |
| WO2020175660A1 (ja) | 2019-02-28 | 2020-09-03 | Kmバイオロジクス株式会社 | Rsv f/gキメラワクチン |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| AU2021214064A1 (en) * | 2020-01-27 | 2022-08-18 | Novavax, Inc. | Coronavirus vaccine formulations |
| CN118490818A (zh) | 2020-04-22 | 2024-08-16 | 生物技术欧洲股份公司 | 冠状病毒疫苗 |
| CN113855796B (zh) * | 2021-07-30 | 2024-01-26 | 河北医科大学 | 卡介苗作为呼吸道合胞病毒灭活疫苗佐剂的应用 |
| WO2023062651A1 (en) * | 2021-10-13 | 2023-04-20 | Padmanabh Patil Harshad | Virus-like particles for respiratory syncytial virus and method of preparation thereof |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| KR102785012B1 (ko) * | 2021-12-14 | 2025-03-20 | 경희대학교 산학협력단 | Rsv 항원 단백질을 포함하는 바이러스 유사입자 및 이를 이용한 백신 |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| US20240076320A1 (en) * | 2022-09-01 | 2024-03-07 | Novavax, Inc. | Downstream process for purification of viral proteins with hydrophobic membrane domain for use in vaccine compositions |
| CN115927751B (zh) * | 2022-09-17 | 2024-12-20 | 宁夏大学 | 牛呼吸道合胞体病毒实时荧光定量pcr检测的引物探针组及检测方法 |
| US20260232787A1 (en) * | 2023-03-17 | 2026-08-13 | Westvac Biopharma Co., Ltd. | Vaccine against respiratory syncytial virus infection |
| CN122180699A (zh) * | 2023-08-03 | 2026-06-09 | 广州宾和企业管理合伙企业(有限合伙) | 修饰的呼吸道合胞病毒f蛋白及其用途 |
| CN119504955A (zh) * | 2023-08-25 | 2025-02-25 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸及疫苗 |
| WO2025051250A1 (zh) * | 2023-09-07 | 2025-03-13 | 北京科兴中维生物技术有限公司 | 呼吸道合胞病毒f蛋白及其应用 |
| US20250144200A1 (en) | 2023-11-06 | 2025-05-08 | Novavax, Inc. | Intranasal immunogenic compositions |
| CN117645655B (zh) * | 2024-01-26 | 2024-05-24 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌多糖-rsv重组蛋白结合疫苗及其制备方法 |
| WO2025201243A1 (zh) * | 2024-03-25 | 2025-10-02 | 中国医学科学院医学生物学研究所 | 重组呼吸道合胞病毒融合前f蛋白突变体和其用途 |
| CN118146321B (zh) * | 2024-03-27 | 2024-08-27 | 普大生物科技(泰州)有限公司 | 一种rsv重组蛋白疫苗及其制备方法 |
| CN118480560B (zh) * | 2024-07-09 | 2024-11-26 | 北京悦康科创医药科技股份有限公司 | 呼吸道合胞病毒mRNA疫苗及其制备方法和应用 |
| CN119161422B (zh) * | 2024-08-26 | 2026-04-03 | 扬州大学 | 一种呼吸道合胞病毒融合前f蛋白及其应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| US5149650A (en) | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| ES2370937T3 (es) | 1993-09-13 | 2011-12-23 | Protein Sciences Corporation | Un método para producir vacunas antigripales polivalentes a base de hemaglutinina. |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| MXPA01006214A (es) | 1998-12-17 | 2004-09-06 | Aventis Pasteur | Composicion inmunogenica multivalente que contiene una preparacion de virus de influenza y una composicion de subunidad del virus sincicial respiratorio. |
| EP2420247A1 (en) | 2000-03-07 | 2012-02-22 | Merck Sharp & Dohme Corp. | Adenovirus formulations |
| US20040028698A1 (en) | 2000-10-02 | 2004-02-12 | Colau Brigitte Desiree Alberte | Vaccine |
| WO2003068804A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Novel insect cell line |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| CA2523657A1 (en) | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| EP1668112A4 (en) * | 2003-06-20 | 2009-04-29 | Protein Sciences Corp | SARS IMMUNOGENOUS EXPRESSING VECTORS, SUCH VECTORS OR EXPRESSION PRODUCTS COMPRISING THOSE COMPOSITIONS, PROCESSES AND TESTS FOR THE PREPARATION AND USE THEREOF |
| US7588770B2 (en) | 2003-12-10 | 2009-09-15 | The Uab Research Foundation | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins |
| WO2007011396A2 (en) | 2004-10-29 | 2007-01-25 | President And Fellows Of Harvard College | Particles for treatment of pulmonary infection |
| CN101548009A (zh) | 2005-03-10 | 2009-09-30 | 米迪缪尼有限公司 | 偏肺病毒株及其在疫苗制备和作为抗原序列表达载体的应用以及增殖该病毒的方法 |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| WO2007149490A1 (en) | 2006-06-19 | 2007-12-27 | Progenics Pharmaceuticals, Inc. | Processes for recovering stabilized formulations of trimers of retroviral envelope (env) proteins |
| WO2008061243A2 (en) * | 2006-11-16 | 2008-05-22 | Novavax, Inc. | Respiratory syncytial virus-virus like particle (vlps) |
| WO2008133663A2 (en) | 2006-11-30 | 2008-11-06 | Government Of The United States Of America, As Represented By The Secretary, | Codon modified immunogenic compositions and methods of use |
| EP1972348A1 (en) * | 2007-03-14 | 2008-09-24 | Pierre Fabre Medicament | Novel vaccine composition for the treatment of respiratory infectious diseases |
| EP2181121A4 (en) * | 2007-03-21 | 2012-07-11 | Id Biomedical Corp Quebec | CHIMÄRE ANTIGENE |
| PT2540312E (pt) | 2007-07-19 | 2015-08-31 | Novavax Inc | Vlps quiméricas de gripe aviária |
| US20100239671A1 (en) | 2007-11-06 | 2010-09-23 | Edelman Elazer R | Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair |
| US8563002B2 (en) | 2007-12-24 | 2013-10-22 | Glaxosmithkline Biologicals, S.A. | Recombinant RSV antigens |
| EP2254554A1 (en) | 2008-02-25 | 2010-12-01 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| ES2987238T3 (es) | 2008-12-09 | 2024-11-14 | Novavax Inc | Proteínas F del RSV modificadas y métodos de su uso |
| WO2010138193A2 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| PL2445526T3 (pl) * | 2009-06-24 | 2017-08-31 | Glaxosmithkline Biologicals S.A. | Rekombinowane antygeny rsv |
| EP4183412B1 (en) | 2009-07-15 | 2024-08-14 | GlaxoSmithKline Biologicals SA | Rsv f protein compositions and methods for making same |
| WO2012061815A2 (en) | 2010-11-05 | 2012-05-10 | Novavax Inc. | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
| CN102107003A (zh) | 2011-01-05 | 2011-06-29 | 重庆大学 | 一种猪繁殖与呼吸综合症病毒体疫苗及其制备方法 |
| US11058762B2 (en) * | 2011-07-06 | 2021-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic compositions and uses thereof |
| SG10201602434UA (en) | 2011-09-30 | 2016-05-30 | Novavax Inc | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| JP2016509015A (ja) | 2013-02-11 | 2016-03-24 | ノババックス,インコーポレイテッド | 呼吸器合胞体ウイルス及びインフルエンザ用の混合ワクチン |
| RU2531235C2 (ru) | 2013-02-15 | 2014-10-20 | Общество с ограниченной ответственностью "Универсальные БиоСистемы" (ООО "УБС") | Поливалентная вакцина против гриппа на основе гибридного белка |
| PT2988780T (pt) | 2013-04-25 | 2019-03-25 | Janssen Vaccines & Prevention Bv | Polipeptídeos f de pré-fusão do rsv solúveis estabilizados |
| AU2014100888A4 (en) | 2014-08-07 | 2014-09-11 | Novartis Ag | Virus clearance and protein purification methods |
| WO2017000105A1 (zh) * | 2015-06-29 | 2017-01-05 | 尚平 | 便携式加湿器 |
| CN114617959A (zh) | 2015-09-03 | 2022-06-14 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
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