MX337932B - Proteinas f del vrs modificadas y metodos de uso de las mismas. - Google Patents

Proteinas f del vrs modificadas y metodos de uso de las mismas.

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Publication number
MX337932B
MX337932B MX2014011966A MX2014011966A MX337932B MX 337932 B MX337932 B MX 337932B MX 2014011966 A MX2014011966 A MX 2014011966A MX 2014011966 A MX2014011966 A MX 2014011966A MX 337932 B MX337932 B MX 337932B
Authority
MX
Mexico
Prior art keywords
proteins
methods
modified rsv
modified
rsv
Prior art date
Application number
MX2014011966A
Other languages
English (en)
Inventor
Gale Smith
Yingyun Wu
Michael Massare
Ye Liu
Peter Pushko
Bin Zhou
Original Assignee
Novavax Inc
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Publication date
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Application filed by Novavax Inc filed Critical Novavax Inc
Publication of MX337932B publication Critical patent/MX337932B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18523—Virus like particles [VLP]
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18571—Demonstrated in vivo effect

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Abstract

La presente invención se refiere a una proteína de fusión (F) del virus respiratorio sincicial (VRS), caracterizada porque la proteína F del VRS comprende: i. una deleción de uno o más aminoácidos correspondiente con los aminoácidos 137-146 de la proteína F del VRS nativa (SEQ ID NO: 2); y ii. un sitio de escisión de furina primario inactivado, en donde el sitio de escisión de furina primario corresponde a los aminoácidos 131-136 de la proteína F del VRS nativa (SEC ID NO: 2), en donde la activación se lleva a cabo por mutación.
MX2014011966A 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas. MX337932B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12112608P 2008-12-09 2008-12-09
US16907709P 2009-04-14 2009-04-14
US22478709P 2009-07-10 2009-07-10
PCT/US2009/067269 WO2010077717A1 (en) 2008-12-09 2009-12-09 Modified rsv f proteins and methods of their use

Publications (1)

Publication Number Publication Date
MX337932B true MX337932B (es) 2016-03-28

Family

ID=42310119

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2011006205A MX2011006205A (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.
MX2014011966A MX337932B (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.
MX2017001924A MX358836B (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.
MX2016003771A MX345700B (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011006205A MX2011006205A (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2017001924A MX358836B (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.
MX2016003771A MX345700B (es) 2008-12-09 2009-12-09 Proteinas f del vrs modificadas y metodos de uso de las mismas.

Country Status (23)

Country Link
US (7) US8715692B2 (es)
EP (3) EP2370099B1 (es)
JP (4) JP5813513B2 (es)
KR (2) KR101691574B1 (es)
CN (2) CN106146671B (es)
AU (1) AU2009333484B2 (es)
BR (1) BRPI0922867B8 (es)
CA (1) CA2746228C (es)
CY (2) CY1117757T1 (es)
DK (2) DK2370099T3 (es)
ES (3) ES2796725T3 (es)
HR (2) HRP20160859T1 (es)
HU (2) HUE051666T2 (es)
IL (2) IL213450B (es)
LT (1) LT3067064T (es)
MX (4) MX2011006205A (es)
PL (2) PL2370099T3 (es)
PT (2) PT2370099T (es)
RU (1) RU2531510C2 (es)
SG (2) SG10201500161XA (es)
SI (2) SI2370099T1 (es)
SM (1) SMT202000411T1 (es)
WO (1) WO2010077717A1 (es)

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