ES2582005T3 - Proteínas F del RSV modificadas y métodos de su uso - Google Patents
Proteínas F del RSV modificadas y métodos de su uso Download PDFInfo
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- ES2582005T3 ES2582005T3 ES09836751.9T ES09836751T ES2582005T3 ES 2582005 T3 ES2582005 T3 ES 2582005T3 ES 09836751 T ES09836751 T ES 09836751T ES 2582005 T3 ES2582005 T3 ES 2582005T3
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Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160000902A1 (en) * | 2003-07-11 | 2016-01-07 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| AU2009316680B2 (en) * | 2008-11-18 | 2016-03-24 | Takeda Vaccines, Inc. | RSV F VLPs and methods of manufacture and use thereof |
| PL3067064T3 (pl) | 2008-12-09 | 2020-11-02 | Novavax, Inc. | Zmodyfikowane białka f rsv i sposoby ich wykorzystania |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| SI3178490T1 (sl) * | 2009-07-15 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Sestavki proteina F RSV-ja in postopki za pripravo le-teh |
| US20110097358A1 (en) * | 2009-10-12 | 2011-04-28 | Techno Vax, Inc. | RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs) |
| PT2635257T (pt) | 2010-11-05 | 2017-08-16 | Novavax Inc | Partículas semelhantes a vírus de glicoproteína de raiva (vlps) |
| WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| HRP20190791T1 (hr) | 2011-01-26 | 2019-06-28 | Glaxosmithkline Biologicals Sa | Režim imuniziranja protiv rsv |
| SI3275892T1 (sl) | 2011-05-13 | 2020-06-30 | Glaxosmithkline Biologicals S.A. | Prefuzijski RSV F antigeni |
| EP2739307B1 (en) * | 2011-08-01 | 2017-09-06 | Emory University | Vlps containing ligands and methods related thereto |
| EP2752199A4 (en) | 2011-08-29 | 2015-04-29 | Univ Tokushima | RSV MUCOSA VACCINE |
| CA2849471A1 (en) * | 2011-09-30 | 2013-04-04 | Novavax, Inc. | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| CN103239734B (zh) * | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| WO2014019718A1 (en) | 2012-08-01 | 2014-02-06 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine |
| BR112015011389A2 (pt) | 2012-11-20 | 2017-08-22 | Glaxosmithkline Biologicals Sa | Complexo f do vírus sincicial respiratório, métodos para produzir um complexo f do vírus sincicial respiratório e para indução de uma resposta imunológica a um f de rsv em um indivíduo, e, composição imunogênica |
| BR112015019126A2 (pt) * | 2013-02-11 | 2017-08-22 | Novavax Inc | Vacina de combinação para vírus sincicial respiratório e influenza |
| AU2014239583B2 (en) * | 2013-03-14 | 2020-07-02 | Children's Healthcare Of Atlanta, Inc. | Recombinant RSV with silent mutations, vaccines, and methods related thereto |
| DE102013004595A1 (de) * | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| EP3046579A1 (en) | 2013-09-19 | 2016-07-27 | Novavax, Inc. | Immunogenic middle east respiratory syndrome coronavirus (mers-cov) compositions and methods |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| WO2015195961A1 (en) * | 2014-06-18 | 2015-12-23 | Georgia State University And Research Foundation, Inc. | Recombinant rsv reporter virus |
| JP6824154B2 (ja) * | 2014-08-08 | 2021-02-03 | ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC | 修飾エンベロープタンパク質e3を含むウイルス様粒子 |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| EA039065B1 (ru) | 2015-07-07 | 2021-11-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
| US10426829B2 (en) | 2015-09-03 | 2019-10-01 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| WO2017075125A1 (en) | 2015-10-29 | 2017-05-04 | Emory University | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
| PE20181354A1 (es) | 2015-12-23 | 2018-08-22 | Pfizer | Mutantes de proteina f de rsv |
| EP3808374A1 (en) | 2016-04-05 | 2021-04-21 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f proteins for use in the prophylaxis of rsv infection |
| CN109069612A (zh) * | 2016-04-05 | 2018-12-21 | 扬森疫苗与预防公司 | 针对rsv的疫苗 |
| PE20190110A1 (es) | 2016-05-30 | 2019-01-15 | Janssen Vaccines And Prevention B V | Proteinas f de prefusion del vrs estabilizadas |
| CN106011086A (zh) * | 2016-06-15 | 2016-10-12 | 湖北省农业科学院畜牧兽医研究所 | 表达信号肽替换的呼吸道合胞病毒f蛋白的重组新城疫耐热疫苗株及制备方法 |
| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Respiratory syncytial virus vaccine |
| BR112019019813A2 (pt) * | 2017-03-30 | 2020-04-22 | Univ Queensland | moléculas quiméricas e usos das mesmas |
| LT3606942T (lt) | 2017-04-04 | 2025-10-10 | Savaiminės sąrankos baltymų nanostruktūros, eksponuojančios paramiksoviruso ir (arba) pneumoviruso f baltymus ir jų naudojimas | |
| MX2019014719A (es) | 2017-06-14 | 2020-08-03 | Virometix Ag | Peptidos ciclicos para proteccion contra el virus sincitial respiratorio. |
| ES3028362T3 (en) | 2017-07-24 | 2025-06-19 | Novavax Inc | Methods and compositions for treating respiratory disease |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| AU2019228551B2 (en) | 2018-02-28 | 2025-07-24 | University Of Washington | Self-assembling nanostructure vaccines |
| CA3092984A1 (en) | 2018-03-19 | 2019-09-26 | Novavax, Inc. | Multivalent influenza nanoparticle vaccines |
| EP3775174A4 (en) * | 2018-03-30 | 2022-07-06 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (rsv) vaccines |
| CN112512567A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性呼吸道合胞病毒多肽 |
| WO2020092365A1 (en) | 2018-10-29 | 2020-05-07 | Binh Ha | Rsv virus-like particles and methods of use thereof |
| KR102725189B1 (ko) | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| PH12021550974A1 (en) | 2018-11-13 | 2022-05-02 | Janssen Vaccines & Prevention Bv | Stablized pre-fusion rsv f proteins |
| CN113260377B (zh) | 2018-12-20 | 2025-08-22 | 维罗米蒂克斯股份公司 | 脂肽构建块和合成病毒样颗粒 |
| US20220125909A1 (en) * | 2019-02-11 | 2022-04-28 | Emory University | Chimeric rsv and hmpv f proteins, immunogenic compositions, and methods of use |
| KR102679227B1 (ko) | 2019-02-28 | 2024-06-28 | 케이엠 바이올로직스 가부시키가이샤 | Rsv f/g 키메라 백신 |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| IL295142A (en) * | 2020-01-27 | 2022-09-01 | Novavax Inc | Coronavirus vaccine formulations |
| JP2023522249A (ja) | 2020-04-22 | 2023-05-29 | ビオンテック・ソシエタス・エウロパエア | コロナウイルスワクチン |
| CN113855796B (zh) * | 2021-07-30 | 2024-01-26 | 河北医科大学 | 卡介苗作为呼吸道合胞病毒灭活疫苗佐剂的应用 |
| WO2023062651A1 (en) * | 2021-10-13 | 2023-04-20 | Padmanabh Patil Harshad | Virus-like particles for respiratory syncytial virus and method of preparation thereof |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| CN115927751B (zh) * | 2022-09-17 | 2024-12-20 | 宁夏大学 | 牛呼吸道合胞体病毒实时荧光定量pcr检测的引物探针组及检测方法 |
| WO2024193380A1 (zh) * | 2023-03-17 | 2024-09-26 | 成都威斯克生物医药有限公司 | 抗呼吸道合胞病毒感染的疫苗 |
| WO2025026448A1 (zh) * | 2023-08-03 | 2025-02-06 | 广州穗和生物技术有限公司 | 修饰的呼吸道合胞病毒f蛋白及其用途 |
| CN119504955A (zh) * | 2023-08-25 | 2025-02-25 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸及疫苗 |
| CN119569835A (zh) * | 2023-09-07 | 2025-03-07 | 北京科兴中维生物技术有限公司 | 呼吸道合胞病毒f蛋白及其应用 |
| WO2025101668A1 (en) | 2023-11-06 | 2025-05-15 | Novavax, Inc. | Intranasal immunogenic compositions |
| CN117645655B (zh) * | 2024-01-26 | 2024-05-24 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌多糖-rsv重组蛋白结合疫苗及其制备方法 |
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| CN118480560B (zh) * | 2024-07-09 | 2024-11-26 | 北京悦康科创医药科技股份有限公司 | 呼吸道合胞病毒mRNA疫苗及其制备方法和应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| US5149650A (en) | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| ES2370937T3 (es) | 1993-09-13 | 2011-12-23 | Protein Sciences Corporation | Un método para producir vacunas antigripales polivalentes a base de hemaglutinina. |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| NZ512980A (en) | 1998-12-17 | 2003-07-25 | Aventis Pasteur | Multivalent immunogenic composition containing RSV subunit composition and influenza virus preparation |
| JP5118798B2 (ja) | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| BR0114392A (pt) | 2000-10-02 | 2003-09-02 | Glaxosmithkline Biolog Sa | Formulação de vacina, método para produzir uma formulação de vacina, uso de uma preparação de vacina contra rsv dividido, kit para liberação de uma formulação de vacina intranasal, dispositivo de liberação intranasal, e, método para proteger ou tratar um mamìfero susceptìvel a, ou sofrendo de doença causada por rsv |
| WO2003068163A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| CA2523657A1 (en) | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| AU2004269320B2 (en) * | 2003-06-20 | 2009-12-24 | Protein Sciences Corporation | Vectors expressing SARS immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using |
| EP1713824A2 (en) | 2003-12-10 | 2006-10-25 | The Uab Research Foundation | Recombinant viruses with heterologous envelope proteins |
| US8846607B2 (en) | 2004-10-29 | 2014-09-30 | President And Fellows Of Harvard College | Particles for treatment of pulmonary infection |
| US20060216700A1 (en) | 2005-03-10 | 2006-09-28 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EP2040746A4 (en) | 2006-06-19 | 2009-12-16 | Progenics Pharm Inc | METHODS OF RECOVERING STABILIZED FORMULATIONS OF RETROVIRAL ENVELOPE (ENV) PROTEIN TRIMERS |
| US20080233150A1 (en) * | 2006-11-16 | 2008-09-25 | Gale Smith | Respiratory syncytial virus-virus like particle (vlps) |
| WO2008133663A2 (en) * | 2006-11-30 | 2008-11-06 | Government Of The United States Of America, As Represented By The Secretary, | Codon modified immunogenic compositions and methods of use |
| EP1972348A1 (en) * | 2007-03-14 | 2008-09-24 | Pierre Fabre Medicament | Novel vaccine composition for the treatment of respiratory infectious diseases |
| US20100203071A1 (en) * | 2007-03-21 | 2010-08-12 | Norman Blais | Chimeric antigens |
| WO2009012487A2 (en) | 2007-07-19 | 2009-01-22 | Novavax, Inc. | Chimeric varicella zoster virus-virus like particles |
| US20100239671A1 (en) | 2007-11-06 | 2010-09-23 | Edelman Elazer R | Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair |
| WO2009079796A1 (en) | 2007-12-24 | 2009-07-02 | Id Biomedical Corporation Of Quebec | Recombinant rsv antigens |
| CA2716546A1 (en) | 2008-02-25 | 2009-09-03 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| PL3067064T3 (pl) | 2008-12-09 | 2020-11-02 | Novavax, Inc. | Zmodyfikowane białka f rsv i sposoby ich wykorzystania |
| WO2010138193A2 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| AU2010264688A1 (en) * | 2009-06-24 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Recombinant RSV antigens |
| SI3178490T1 (sl) | 2009-07-15 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Sestavki proteina F RSV-ja in postopki za pripravo le-teh |
| PT2635257T (pt) | 2010-11-05 | 2017-08-16 | Novavax Inc | Partículas semelhantes a vírus de glicoproteína de raiva (vlps) |
| CN102107003A (zh) | 2011-01-05 | 2011-06-29 | 重庆大学 | 一种猪繁殖与呼吸综合症病毒体疫苗及其制备方法 |
| EP2729168A2 (en) | 2011-07-06 | 2014-05-14 | Novartis AG | Immunogenic compositions and uses thereof |
| CA2849471A1 (en) | 2011-09-30 | 2013-04-04 | Novavax, Inc. | Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| BR112015019126A2 (pt) | 2013-02-11 | 2017-08-22 | Novavax Inc | Vacina de combinação para vírus sincicial respiratório e influenza |
| RU2531235C2 (ru) | 2013-02-15 | 2014-10-20 | Общество с ограниченной ответственностью "Универсальные БиоСистемы" (ООО "УБС") | Поливалентная вакцина против гриппа на основе гибридного белка |
| SG11201508567XA (en) | 2013-04-25 | 2015-11-27 | Crucell Holland Bv | Stabilized soluble prefusion rsv f polypeptides |
| AU2014100888A4 (en) | 2014-08-07 | 2014-09-11 | Novartis Ag | Virus clearance and protein purification methods |
| WO2017000105A1 (zh) * | 2015-06-29 | 2017-01-05 | 尚平 | 便携式加湿器 |
| US10426829B2 (en) | 2015-09-03 | 2019-10-01 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
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