JP2012139246A5 - - Google Patents
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- JP2012139246A5 JP2012139246A5 JP2012104994A JP2012104994A JP2012139246A5 JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5 JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5
- Authority
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- Prior art keywords
- negative
- pluripotent stem
- culture
- cells
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 20
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 19
- 108091005804 Peptidases Proteins 0.000 claims 12
- 239000004365 Protease Substances 0.000 claims 12
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- 230000006355 external stress Effects 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108010017842 Telomerase Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000001654 germ layer Anatomy 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 1
- 102000035101 Aspartic proteases Human genes 0.000 claims 1
- 108091005502 Aspartic proteases Proteins 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- 241000237858 Gastropoda Species 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 101100154912 Mus musculus Tyrp1 gene Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 102000035100 Threonine proteases Human genes 0.000 claims 1
- 108091005501 Threonine proteases Proteins 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010007093 dispase Proteins 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 101150077014 sox10 gene Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21378809P | 2009-07-15 | 2009-07-15 | |
| US61/213,788 | 2009-07-15 | ||
| US29015909P | 2009-12-24 | 2009-12-24 | |
| US61/290,159 | 2009-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Division JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Division JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012139246A JP2012139246A (ja) | 2012-07-26 |
| JP2012139246A5 true JP2012139246A5 (enExample) | 2013-08-29 |
| JP5852503B2 JP5852503B2 (ja) | 2016-02-03 |
Family
ID=43449509
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
| JP2012104994A Active JP5852503B2 (ja) | 2009-07-15 | 2012-05-01 | 生体組織から単離できる多能性幹細胞 |
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9550975B2 (enExample) |
| EP (3) | EP2455452B2 (enExample) |
| JP (7) | JP5185443B2 (enExample) |
| KR (4) | KR101651795B1 (enExample) |
| CN (2) | CN107012117B (enExample) |
| AU (1) | AU2010271722B8 (enExample) |
| CA (1) | CA2768238C (enExample) |
| DK (2) | DK2455452T4 (enExample) |
| ES (3) | ES2831030T3 (enExample) |
| HR (1) | HRP20250245T1 (enExample) |
| HU (3) | HUE037448T2 (enExample) |
| NO (1) | NO2455452T3 (enExample) |
| PL (3) | PL3680323T3 (enExample) |
| PT (2) | PT2455452T (enExample) |
| SG (1) | SG177705A1 (enExample) |
| WO (1) | WO2011007900A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014133703A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物 |
| US9399758B2 (en) | 2009-07-15 | 2016-07-26 | Mari Dezawa | SSEA3(+) pluripotent stem cell that can be isolated from body tissue |
| JP2014132830A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体の臍帯又は脂肪組織から単離できる多能性幹細胞 |
| US9550975B2 (en) | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| CA2771303A1 (en) | 2009-08-21 | 2011-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| WO2012168295A1 (en) * | 2011-06-06 | 2012-12-13 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
| JP6090937B2 (ja) | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
| KR101751355B1 (ko) | 2011-08-24 | 2017-07-04 | (주)아모레퍼시픽 | 인간 피부 진피 유래 성체 줄기세포 |
| WO2013058403A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
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| KR20150045935A (ko) | 2012-04-24 | 2015-04-29 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 다능성 세포를 다시 생성하는 방법 |
| AU2013295793A1 (en) * | 2012-07-27 | 2015-02-19 | Bioquark, Inc. | Extracts isolated from electroporated ambhibian oocytes and use thereof in treating diseases and disorders |
| WO2014027474A1 (ja) * | 2012-08-17 | 2014-02-20 | 株式会社Ｃｌｉｏ | 心筋梗塞の修復再生を誘導する多能性幹細胞 |
| TW201441369A (zh) * | 2012-12-21 | 2014-11-01 | Univ Rutgers | 多向分化壓力耐受（ｍｕｓｅ）細胞分離及擴增 |
| US9709554B2 (en) | 2013-01-31 | 2017-07-18 | Rutgers, The State University Of New Jersey | In vitro model of macrosteatotic (fatty) liver |
| US20160002599A1 (en) | 2013-02-08 | 2016-01-07 | Kyoto University | Production methods for megakaryocytes and platelets |
| WO2014133090A1 (ja) * | 2013-02-28 | 2014-09-04 | 国立大学法人浜松医科大学 | 脳腫瘍治療のための多能性幹細胞 |
| JP6511606B2 (ja) | 2013-03-01 | 2019-05-15 | 株式会社生命科学インスティテュート | 多能性幹細胞を損傷部位に誘導する遊走因子を含む医薬組成物 |
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| US10519421B2 (en) | 2013-03-21 | 2019-12-31 | Kyoto University | Induction of motor neurons from pluripotent stem cells |
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| US10131880B2 (en) | 2013-05-22 | 2018-11-20 | The Regents Of The University Of California | Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications |
| EP3027235A1 (en) | 2013-07-30 | 2016-06-08 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
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| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
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| TWI832070B (zh) * | 2021-07-15 | 2024-02-11 | 國璽幹細胞應用技術股份有限公司 | 幹細胞製劑用於治療關節炎的用途及用於製備幹細胞製劑的方法 |
| JP2023041486A (ja) * | 2021-09-13 | 2023-03-24 | 国立大学法人東北大学 | 毛髪損傷の治療剤 |
| EP4477746A4 (en) | 2022-02-09 | 2026-02-18 | Racthera Co Ltd | METHOD FOR EVALUATING THE DIFFERENTIATION POTENTIAL OF CELLS IN A CULTURE BROTH IN THE DIFFERENCE OF MULTIPOTENTED STEM CELLS INTO NEURAL CELLS OF THE MENSCEPHAL FLOOR PLAQUE REGION |
| JPWO2023228908A1 (enExample) | 2022-05-23 | 2023-11-30 | ||
| CN121219404A (zh) | 2023-04-03 | 2025-12-26 | 大塚制药株式会社 | 巨核细胞的制造方法 |
| EP4722345A1 (en) | 2023-05-29 | 2026-04-08 | Riken | Method for maturing cardiomyocytes, and method for producing matured cardiomyocytes |
| CN117187174B (zh) * | 2023-11-08 | 2024-02-06 | 广州正源生物技术有限公司 | 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法 |
| JP2025123077A (ja) * | 2024-02-09 | 2025-08-22 | 国立大学法人東北大学 | 脊髄梗塞治療のための多能性幹細胞 |
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| CA2381292C (en) | 1999-08-05 | 2016-05-24 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| US7575921B2 (en) * | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| WO2002057428A1 (en) * | 2000-10-30 | 2002-07-25 | University Of Massachusetts | Isolation of spore-like cells from tissues exposed to extreme conditions |
| JP4182742B2 (ja) | 2002-12-12 | 2008-11-19 | 日産自動車株式会社 | 自動車の前部車体構造 |
| US7569385B2 (en) | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| EP1660644A1 (en) * | 2003-08-29 | 2006-05-31 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US20060216821A1 (en) * | 2004-02-26 | 2006-09-28 | Reliance Life Sciences Pvt. Ltd. | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
| WO2007020655A1 (en) * | 2005-05-17 | 2007-02-22 | Reliance Life Sciences Pvt Ltd | Establishment of a human embryonic stem cell line using mammalian cells |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| TW200732475A (en) | 2005-10-17 | 2007-09-01 | Academia Sinica | Pulmonary stem cells, related methods and kits |
| WO2009059032A2 (en) * | 2007-10-30 | 2009-05-07 | University Of Louisville Research Foundation, Inc. | Uses and isolation of very small embryonic-like (vsel) stem cells |
| CN101864392B (zh) * | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| WO2008080200A1 (en) | 2006-12-29 | 2008-07-10 | Irina Kerkis | Process for obtaining stem cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US20090172832A1 (en) * | 2007-12-28 | 2009-07-02 | Timothy Caspar | Expression of rubisco enzyme from a non-rubisco locus |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
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