JP2012139246A5 - - Google Patents
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- JP2012139246A5 JP2012139246A5 JP2012104994A JP2012104994A JP2012139246A5 JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5 JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5
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- Prior art keywords
- negative
- pluripotent stem
- culture
- cells
- protease
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims 20
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 19
- 108091005804 Peptidases Proteins 0.000 claims 12
- 239000004365 Protease Substances 0.000 claims 12
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- 230000006355 external stress Effects 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108010017842 Telomerase Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000001654 germ layer Anatomy 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 1
- 102000035101 Aspartic proteases Human genes 0.000 claims 1
- 108091005502 Aspartic proteases Proteins 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- 241000237858 Gastropoda Species 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 101100154912 Mus musculus Tyrp1 gene Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 102000035100 Threonine proteases Human genes 0.000 claims 1
- 108091005501 Threonine proteases Proteins 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010007093 dispase Proteins 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 101150077014 sox10 gene Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21378809P | 2009-07-15 | 2009-07-15 | |
| US61/213,788 | 2009-07-15 | ||
| US29015909P | 2009-12-24 | 2009-12-24 | |
| US61/290,159 | 2009-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Division JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Division JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012139246A JP2012139246A (ja) | 2012-07-26 |
| JP2012139246A5 true JP2012139246A5 (enExample) | 2013-08-29 |
| JP5852503B2 JP5852503B2 (ja) | 2016-02-03 |
Family
ID=43449509
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
| JP2012104994A Active JP5852503B2 (ja) | 2009-07-15 | 2012-05-01 | 生体組織から単離できる多能性幹細胞 |
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9550975B2 (enExample) |
| EP (3) | EP2455452B2 (enExample) |
| JP (7) | JP5185443B2 (enExample) |
| KR (4) | KR101945343B1 (enExample) |
| CN (2) | CN107012117B (enExample) |
| AU (1) | AU2010271722B8 (enExample) |
| CA (1) | CA2768238C (enExample) |
| DK (2) | DK3214170T3 (enExample) |
| ES (3) | ES2647360T5 (enExample) |
| HR (1) | HRP20250245T1 (enExample) |
| HU (3) | HUE071170T2 (enExample) |
| NO (1) | NO2455452T3 (enExample) |
| PL (3) | PL3680323T3 (enExample) |
| PT (2) | PT2455452T (enExample) |
| SG (1) | SG177705A1 (enExample) |
| WO (1) | WO2011007900A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9399758B2 (en) | 2009-07-15 | 2016-07-26 | Mari Dezawa | SSEA3(+) pluripotent stem cell that can be isolated from body tissue |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| JP2014133703A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物 |
| JP2014132830A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体の臍帯又は脂肪組織から単離できる多能性幹細胞 |
| JP2013502220A (ja) | 2009-08-21 | 2013-01-24 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | ヒト体細胞からの誘導多能性幹細胞の生成効率を向上させる方法 |
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| CN108410797A (zh) * | 2011-06-06 | 2018-08-17 | 里珍西斯私人有限公司 | 在中空纤维生物反应器中扩增干细胞 |
| WO2013015457A1 (en) | 2011-07-27 | 2013-01-31 | Kyoto University | Novel markers for dopaminergic neuron progenitor cells |
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| US20150329827A1 (en) * | 2012-12-21 | 2015-11-19 | Rutgers , The State University Of New Jersey | Muse cells isolation and expansion |
| US9709554B2 (en) | 2013-01-31 | 2017-07-18 | Rutgers, The State University Of New Jersey | In vitro model of macrosteatotic (fatty) liver |
| WO2014123242A1 (ja) | 2013-02-08 | 2014-08-14 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
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| EP2999780B1 (en) | 2013-05-22 | 2019-10-09 | The Regents of the University of California | Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications |
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| CN121136933A (zh) | 2013-09-05 | 2025-12-16 | 国立大学法人京都大学 | 由多能干细胞制造产多巴胺神经前体细胞的方法、产多巴胺神经前体细胞、帕金森病治疗剂和试剂盒 |
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| JP2021073305A (ja) * | 2021-02-09 | 2021-05-13 | 株式会社生命科学インスティテュート | 慢性腎障害治療のための多能性幹細胞 |
| TWI832070B (zh) * | 2021-07-15 | 2024-02-11 | 國璽幹細胞應用技術股份有限公司 | 幹細胞製劑用於治療關節炎的用途及用於製備幹細胞製劑的方法 |
| JP2023041486A (ja) * | 2021-09-13 | 2023-03-24 | 国立大学法人東北大学 | 毛髪損傷の治療剤 |
| JPWO2023153464A1 (enExample) | 2022-02-09 | 2023-08-17 | ||
| WO2023228908A1 (ja) | 2022-05-23 | 2023-11-30 | 国立大学法人京都大学 | 腎集合管細胞および腎盂上皮細胞の製造方法 |
| CN121219404A (zh) | 2023-04-03 | 2025-12-26 | 大塚制药株式会社 | 巨核细胞的制造方法 |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
| CN117187174B (zh) * | 2023-11-08 | 2024-02-06 | 广州正源生物技术有限公司 | 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法 |
| JP2025123077A (ja) * | 2024-02-09 | 2025-08-22 | 国立大学法人東北大学 | 脊髄梗塞治療のための多能性幹細胞 |
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| JP5398941B2 (ja) | 1999-08-05 | 2014-01-29 | エイビーティー ホールディング カンパニー | 多能性成体幹細胞およびそれを単離する方法 |
| US7575921B2 (en) | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| US20020151050A1 (en) | 2000-10-30 | 2002-10-17 | Vacanti Charles A. | Isolation of spore-like cells from tissues exposed to extreme conditions |
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| US20050042595A1 (en) | 2003-08-14 | 2005-02-24 | Martin Haas | Banking of multipotent amniotic fetal stem cells |
| CN1845987A (zh) * | 2003-08-29 | 2006-10-11 | 明尼苏达大学董事会 | 肾来源的干细胞及其分离、分化和使用方法 |
| US20060216821A1 (en) | 2004-02-26 | 2006-09-28 | Reliance Life Sciences Pvt. Ltd. | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
| EP1893748A1 (en) * | 2005-05-17 | 2008-03-05 | Reliance Life Sciences Pvt., Ltd. | Establishment of a human embryonic stem cell line using mammalian cells |
| US9388382B2 (en) | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| JP2009514509A (ja) | 2005-10-17 | 2009-04-09 | アカデミア シニカ | 肺幹細胞および関連の方法およびキット |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
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| US20090172832A1 (en) * | 2007-12-28 | 2009-07-02 | Timothy Caspar | Expression of rubisco enzyme from a non-rubisco locus |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
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