ES2647360T5 - Célula madre pluripotente que puede aislarse de tejido corporal - Google Patents

Célula madre pluripotente que puede aislarse de tejido corporal Download PDF

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Publication number
ES2647360T5
ES2647360T5 ES10799956T ES10799956T ES2647360T5 ES 2647360 T5 ES2647360 T5 ES 2647360T5 ES 10799956 T ES10799956 T ES 10799956T ES 10799956 T ES10799956 T ES 10799956T ES 2647360 T5 ES2647360 T5 ES 2647360T5
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cells
cell
pluripotent stem
muse
fractions
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ES2647360T3 (es
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Mari Dezawa
Yoshinori Fujiyoshi
Youichi Nabeshima
Shohei Wakao
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
ES10799956T 2009-07-15 2010-07-15 Célula madre pluripotente que puede aislarse de tejido corporal Active ES2647360T5 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21378809P 2009-07-15 2009-07-15
US213788P 2009-07-15
US29015909P 2009-12-24 2009-12-24
US290159P 2009-12-24
PCT/JP2010/062480 WO2011007900A1 (ja) 2009-07-15 2010-07-15 生体組織から単離できる多能性幹細胞

Publications (2)

Publication Number Publication Date
ES2647360T3 ES2647360T3 (es) 2017-12-21
ES2647360T5 true ES2647360T5 (es) 2021-06-14

Family

ID=43449509

Family Applications (3)

Application Number Title Priority Date Filing Date
ES10799956T Active ES2647360T5 (es) 2009-07-15 2010-07-15 Célula madre pluripotente que puede aislarse de tejido corporal
ES20160074T Active ES3015175T3 (en) 2009-07-15 2010-07-15 Pluripotent stem cell that can be isolated from body tissue
ES17163323T Active ES2831030T3 (es) 2009-07-15 2010-07-15 Célula madre pluripotente que puede aislarse de tejido corporal

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES20160074T Active ES3015175T3 (en) 2009-07-15 2010-07-15 Pluripotent stem cell that can be isolated from body tissue
ES17163323T Active ES2831030T3 (es) 2009-07-15 2010-07-15 Célula madre pluripotente que puede aislarse de tejido corporal

Country Status (16)

Country Link
US (1) US9550975B2 (enExample)
EP (3) EP2455452B2 (enExample)
JP (7) JP5185443B2 (enExample)
KR (4) KR101764080B1 (enExample)
CN (2) CN107012117B (enExample)
AU (1) AU2010271722B8 (enExample)
CA (1) CA2768238C (enExample)
DK (2) DK3214170T3 (enExample)
ES (3) ES2647360T5 (enExample)
HR (1) HRP20250245T1 (enExample)
HU (3) HUE052559T2 (enExample)
NO (1) NO2455452T3 (enExample)
PL (3) PL3214170T3 (enExample)
PT (2) PT2455452T (enExample)
SG (1) SG177705A1 (enExample)
WO (1) WO2011007900A1 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399758B2 (en) 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
JP2014133703A (ja) * 2011-03-30 2014-07-24 Clio Inc 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
JP2014132830A (ja) * 2011-03-30 2014-07-24 Clio Inc 生体の臍帯又は脂肪組織から単離できる多能性幹細胞
WO2011022507A1 (en) 2009-08-21 2011-02-24 The Board Of Trustees Of The Leland Stanford Junior University Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
PL2718416T3 (pl) * 2011-06-06 2020-05-18 ReGenesys BVBA Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych
JP6090937B2 (ja) 2011-07-27 2017-03-08 国立大学法人京都大学 新規ドーパミン産生神経前駆細胞マーカー
KR101751355B1 (ko) * 2011-08-24 2017-07-04 (주)아모레퍼시픽 인간 피부 진피 유래 성체 줄기세포
WO2013058403A1 (ja) 2011-10-21 2013-04-25 国立大学法人京都大学 層流による多能性維持単一分散細胞培養法
WO2013131192A1 (en) * 2012-03-06 2013-09-12 Aris Aziz Placental stem cells, methods for isolating same and use thereof
CN104718283A (zh) * 2012-04-24 2015-06-17 布里格姆及妇女医院股份有限公司 从头生成多能细胞
WO2014018663A1 (en) * 2012-07-27 2014-01-30 Bioquark, Inc. Extracts isolated from electroporated ambhibian oocytes and use thereof in treating diseases and disorders
WO2014027474A1 (ja) * 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
US20150329827A1 (en) * 2012-12-21 2015-11-19 Rutgers , The State University Of New Jersey Muse cells isolation and expansion
US9709554B2 (en) 2013-01-31 2017-07-18 Rutgers, The State University Of New Jersey In vitro model of macrosteatotic (fatty) liver
WO2014123242A1 (ja) 2013-02-08 2014-08-14 国立大学法人京都大学 巨核球及び血小板の製造方法
WO2014133090A1 (ja) * 2013-02-28 2014-09-04 国立大学法人浜松医科大学 脳腫瘍治療のための多能性幹細胞
ES2877555T3 (es) 2013-03-01 2021-11-17 Univ Tohoku Composición farmacéutica que incluye factor migratorio para guiar a las células madre pluripotenciales hacia la lesión
JP6602745B2 (ja) * 2013-03-15 2019-11-06 ザ ジャクソン ラボラトリー 非胚性幹細胞の単離とその使用
WO2014148646A1 (ja) 2013-03-21 2014-09-25 国立大学法人京都大学 神経分化誘導用の多能性幹細胞
US10072242B2 (en) 2013-03-25 2018-09-11 Foundation For Biomedical Research And Innovation At Kobe Cell sorting method
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
EP2998391B1 (en) 2013-05-14 2020-02-19 Kyoto University Efficient myocardial cell induction method
US10131880B2 (en) 2013-05-22 2018-11-20 The Regents Of The University Of California Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
JP6378183B2 (ja) 2013-08-07 2018-08-22 国立大学法人京都大学 膵ホルモン産生細胞の製造法
CN105492598B (zh) * 2013-08-29 2019-12-03 三浦典正 与细胞的抗衰老相关的生物分子群
EP3569699A1 (en) 2013-09-04 2019-11-20 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
ES2721440T3 (es) 2013-09-05 2019-07-31 Univ Kyoto Nuevo método para inducir células precursoras neurales productoras de dopamina
EP3064577B1 (en) 2013-11-01 2020-09-09 Kyoto University Novel chondrocyte induction method
WO2015081094A1 (en) * 2013-11-27 2015-06-04 University Of Louisville Research Foundation, Inc. Cardiac progenitor cells and methods of use therefor
JP6519038B2 (ja) * 2014-02-26 2019-05-29 株式会社生命科学インスティテュート 脳梗塞治療のための多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
KR102327986B1 (ko) 2014-03-19 2021-11-18 브이셀 세라퓨틱스 인코포레이티드 다능성 세포에 관한 방법
EP3147353B1 (en) 2014-05-21 2022-03-30 Kyoto University Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells
KR101592401B1 (ko) * 2014-06-13 2016-02-05 주식회사 비비에이치씨 지방-유래 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포
JP6391364B2 (ja) * 2014-08-25 2018-09-19 国立大学法人 鹿児島大学 認知機能障害改善用細胞製剤
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
KR101700598B1 (ko) * 2014-11-11 2017-01-31 한국원자력의학원 Cd105를 포함하는 줄기세포능을 가진 섬유아세포 분리용 바이오마커 조성물 및 이를 이용한 줄기세포능을 가진 섬유아세포 분리 방법
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
KR101919817B1 (ko) * 2015-05-29 2018-11-19 니폰 조키 세야쿠 가부시키가이샤 다능성 간세포 유주 촉진제
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
JP6627027B2 (ja) * 2015-09-11 2020-01-08 福美人株式会社 皮膚細胞の活性化作用を呈するフラボノイド誘導体
KR102262248B1 (ko) * 2016-01-15 2021-06-08 국립대학법인 도야마 다이가쿠 허혈성 뇌경색에의 다능성 줄기 세포의 동원
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
CA3056209A1 (en) * 2016-03-17 2017-09-21 Synova Life Sciences, Inc. Separation, dissociation and/or disaggregation of cells using shockwaves or mechanical impacts
KR102312123B1 (ko) 2016-04-22 2021-10-13 고쿠리츠 다이가쿠 호진 교토 다이가쿠 도파민 생산 신경전구세포의 제조방법
KR20180130578A (ko) 2016-05-16 2018-12-07 고쿠리츠 다이가쿠 호우징 나고야 다이가쿠 다능성 간세포에 의한 주산기 뇌장애의 개선 및 치료
CN109689073A (zh) 2016-07-01 2019-04-26 国立大学法人东北大学 器官纤维化的预防或治疗剂
EP3492091B1 (en) * 2016-07-29 2021-07-14 Tohoku University "muse" cells as prophylactic or therapeutic agent for aneurysm
US12083149B2 (en) * 2016-08-03 2024-09-10 Tohoku University Amelioration and treatment of chronic lung disease using pluripotent stem cells
EP3495471A4 (en) * 2016-08-03 2020-02-19 Life Science Institute, Inc. METHOD FOR INDUCING THE DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN VITRO
US20190201456A1 (en) 2016-08-03 2019-07-04 Life Science Institute, Inc. Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
CN110475855A (zh) 2017-02-03 2019-11-19 国立大学法人九州大学 用于从牙髓组织衍生的细胞制备牙髓干细胞的方法
CN110494559B (zh) * 2017-03-28 2023-10-31 味之素株式会社 不分化地维持用培养基添加剂
US20200206272A1 (en) * 2017-06-19 2020-07-02 National University Corporation Hokkaido University Treatment agent for epidermolysis bullosa
JP7255805B2 (ja) 2017-06-20 2023-04-11 国立大学法人東海国立大学機構 多能性幹細胞による胎児発育不全に伴う脳障害の改善及び治療
AU2018352904A1 (en) * 2017-10-17 2020-05-21 Hiroshima University Pluripotent stem cells inducing osteochondral repair
EP3708662A4 (en) * 2017-11-10 2021-08-25 Regenesis Science Co., Ltd. METHOD FOR PRODUCING A CULTIVATED CELL, AND METHOD FOR PRODUCING A THERAPEUTIC AGENT FOR SPINAL CORD INJURY DISEASE
JP7336143B2 (ja) 2017-11-28 2023-08-31 セルツーイン、 インコーポレイテッド リアルタイムなグルタチオンの測定による治療用細胞の品質向上方法
JP6604492B2 (ja) * 2018-04-09 2019-11-13 株式会社生命科学インスティテュート 脳梗塞治療のための多能性幹細胞
US20210228638A1 (en) * 2018-05-09 2021-07-29 Life Science Institute, Inc. Therapeutic agent for spinal cord injury
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
EP3824912A4 (en) 2018-07-19 2022-04-20 Kyoto University PLATEFORM CARTILAGE DERIVED FROM PLURIPOTENTS STEM CELLS AND METHODS FOR PRODUCTION OF PLATEFORM CARTILAGE
WO2020100788A1 (ja) * 2018-11-14 2020-05-22 株式会社片岡製作所 インスリン産生細胞の製造方法、及び組成物
WO2020111249A1 (ja) 2018-11-30 2020-06-04 京都府公立大学法人 末梢血流障害の治療剤
WO2020130147A1 (ja) 2018-12-21 2020-06-25 国立大学法人京都大学 ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物
WO2020210429A1 (en) * 2019-04-09 2020-10-15 Rutgers, The State University Of New Jersey Methods for enriching populations of cells
WO2021029346A1 (ja) 2019-08-09 2021-02-18 国立大学法人東北大学 脳血管性認知症の治療または予防剤
EP4026551A1 (en) 2019-09-05 2022-07-13 Tohoku University Therapeutic agent for myocarditis
BR112022006286A2 (pt) 2019-10-01 2022-06-21 Univ Kyoto Métodos para isolar uma célula da ponta do broto uretérico, para produzir uma colônia celular da ponta do broto uretérico, para produzir um organoide, para produzir uma célula progenitora do duto de coleta, para produzir uma população celular de ponta do broto uretérico e para monitorar uma célula da ponta do broto uretérico, e, composição para isolar ou monitorar uma célula da ponta do broto uretérico
WO2021085639A1 (ja) 2019-10-31 2021-05-06 株式会社生命科学インスティテュート 多能性幹細胞による間質性膀胱炎の治療
WO2021117886A1 (ja) 2019-12-12 2021-06-17 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
WO2021187601A1 (ja) 2020-03-19 2021-09-23 国立大学法人京都大学 心筋細胞の精製方法
CN115427552A (zh) 2020-03-19 2022-12-02 千纸鹤治疗公司 心肌细胞的精制方法
JPWO2021201286A1 (enExample) 2020-04-02 2021-10-07
WO2022014604A1 (ja) 2020-07-13 2022-01-20 国立大学法人京都大学 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法
EP4183402A4 (en) * 2020-07-15 2024-09-04 National University Corporation Okayama University EFFECTIVE PLURIPOTENT STEM CELLS FOR THE TREATMENT OF MOTOR NEURON DISEASE (MND)
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
TWI832070B (zh) * 2021-07-15 2024-02-11 國璽幹細胞應用技術股份有限公司 幹細胞製劑用於治療關節炎的用途及用於製備幹細胞製劑的方法
JP2023041486A (ja) * 2021-09-13 2023-03-24 国立大学法人東北大学 毛髪損傷の治療剤
EP4477746A1 (en) 2022-02-09 2024-12-18 Sumitomo Pharma Co., Ltd. Method for assessing differentiation potential of cells in culture broth in differentiation of pluripotent stem cells into neural cells of midbrain floor plate region
JPWO2023228908A1 (enExample) 2022-05-23 2023-11-30
CN117187174B (zh) * 2023-11-08 2024-02-06 广州正源生物技术有限公司 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法
JP2025123077A (ja) * 2024-02-09 2025-08-22 国立大学法人東北大学 脊髄梗塞治療のための多能性幹細胞

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ517002A (en) 1999-08-05 2004-06-25 Mcl Llc Multipotent adult stem cells and methods for isolation
US7575921B2 (en) * 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
US20020151050A1 (en) * 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
JP4182742B2 (ja) 2002-12-12 2008-11-19 日産自動車株式会社 自動車の前部車体構造
US7569385B2 (en) 2003-08-14 2009-08-04 The Regents Of The University Of California Multipotent amniotic fetal stem cells
AU2004269409A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use
US20060216821A1 (en) * 2004-02-26 2006-09-28 Reliance Life Sciences Pvt. Ltd. Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
CN101180389A (zh) * 2005-05-17 2008-05-14 利莱恩斯生命科学有限公司 采用哺乳动物细胞确立人胚胎干细胞系
US9388382B2 (en) * 2005-10-05 2016-07-12 The Board Of Trustees Of The University Of Illinois Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells
AU2006304390A1 (en) 2005-10-17 2007-04-26 Academia Sinica Pulmonary stem cells, related methods and kits
WO2009059032A2 (en) * 2007-10-30 2009-05-07 University Of Louisville Research Foundation, Inc. Uses and isolation of very small embryonic-like (vsel) stem cells
WO2007069666A1 (ja) * 2005-12-13 2007-06-21 Kyoto University 核初期化因子
WO2008080200A1 (en) 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20090172832A1 (en) * 2007-12-28 2009-07-02 Timothy Caspar Expression of rubisco enzyme from a non-rubisco locus
ITRM20080342A1 (it) * 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue

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