DK2455452T4 - Pluripotent stamcelle, der kan isoleres fra kropsvæv - Google Patents

Pluripotent stamcelle, der kan isoleres fra kropsvæv Download PDF

Info

Publication number
DK2455452T4
DK2455452T4 DK10799956.7T DK10799956T DK2455452T4 DK 2455452 T4 DK2455452 T4 DK 2455452T4 DK 10799956 T DK10799956 T DK 10799956T DK 2455452 T4 DK2455452 T4 DK 2455452T4
Authority
DK
Denmark
Prior art keywords
isolated
stem cell
pluripotent stem
body tissue
tissue
Prior art date
Application number
DK10799956.7T
Other languages
English (en)
Other versions
DK2455452T3 (da
Inventor
Mari Dezawa
Yoshinori Fujiyoshi
Shohei Wakao
Youichi Nabeshima
Original Assignee
Yoshinori Fujiyoshi
Youichi Nabeshima
Shohei Wakao
Kitada Masaaki
Mari Dezawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43449509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2455452(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yoshinori Fujiyoshi, Youichi Nabeshima, Shohei Wakao, Kitada Masaaki, Mari Dezawa filed Critical Yoshinori Fujiyoshi
Application granted granted Critical
Publication of DK2455452T3 publication Critical patent/DK2455452T3/da
Publication of DK2455452T4 publication Critical patent/DK2455452T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
DK10799956.7T 2009-07-15 2010-07-15 Pluripotent stamcelle, der kan isoleres fra kropsvæv DK2455452T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21378809P 2009-07-15 2009-07-15
US29015909P 2009-12-24 2009-12-24
PCT/JP2010/062480 WO2011007900A1 (ja) 2009-07-15 2010-07-15 生体組織から単離できる多能性幹細胞

Publications (2)

Publication Number Publication Date
DK2455452T3 DK2455452T3 (da) 2017-10-23
DK2455452T4 true DK2455452T4 (da) 2020-11-02

Family

ID=43449509

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17163323.3T DK3214170T3 (da) 2009-07-15 2010-07-15 Pluripotent stamcelle, der kan isoleres fra kropsvæv
DK10799956.7T DK2455452T4 (da) 2009-07-15 2010-07-15 Pluripotent stamcelle, der kan isoleres fra kropsvæv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK17163323.3T DK3214170T3 (da) 2009-07-15 2010-07-15 Pluripotent stamcelle, der kan isoleres fra kropsvæv

Country Status (15)

Country Link
US (1) US9550975B2 (da)
EP (3) EP2455452B2 (da)
JP (7) JP5185443B2 (da)
KR (4) KR101651795B1 (da)
CN (2) CN107012117B (da)
AU (1) AU2010271722B8 (da)
CA (1) CA2768238C (da)
DK (2) DK3214170T3 (da)
ES (2) ES2831030T3 (da)
HU (2) HUE052559T2 (da)
NO (1) NO2455452T3 (da)
PL (2) PL2455452T5 (da)
PT (2) PT2455452T (da)
SG (1) SG177705A1 (da)
WO (1) WO2011007900A1 (da)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014132830A (ja) * 2011-03-30 2014-07-24 Clio Inc 生体の臍帯又は脂肪組織から単離できる多能性幹細胞
JP2014133703A (ja) * 2011-03-30 2014-07-24 Clio Inc 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物
US9399758B2 (en) 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
MX2012002117A (es) 2009-08-21 2012-06-01 Univ Leland Stanford Junior Eficiencia mejorada para la generacion de celulas madre pluripotentes inducidas a partir de las celulas somaticas humanas.
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
KR102073530B1 (ko) * 2011-06-06 2020-02-04 리제네시스 비브이비에이 중공 섬유 생물 반응기에서의 줄기 세포의 확장
WO2013015457A1 (en) 2011-07-27 2013-01-31 Kyoto University Novel markers for dopaminergic neuron progenitor cells
KR101751355B1 (ko) 2011-08-24 2017-07-04 (주)아모레퍼시픽 인간 피부 진피 유래 성체 줄기세포
JP6162604B2 (ja) 2011-10-21 2017-07-12 国立大学法人京都大学 層流による多能性維持単一分散細胞培養法
WO2013131192A1 (en) * 2012-03-06 2013-09-12 Aris Aziz Placental stem cells, methods for isolating same and use thereof
CN112048466A (zh) * 2012-04-24 2020-12-08 细胞疗法有限责任公司 从头生成多能细胞
EP2877577A4 (en) * 2012-07-27 2016-02-10 Bioquark Inc ELECTROPORATED AMPHIBIENOO CYTS ISOLATED EXTRACTS AND THEIR USE FOR THE TREATMENT OF ILLNESSES AND DISORDERS
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
US20150329827A1 (en) * 2012-12-21 2015-11-19 Rutgers , The State University Of New Jersey Muse cells isolation and expansion
US9709554B2 (en) 2013-01-31 2017-07-18 Rutgers, The State University Of New Jersey In vitro model of macrosteatotic (fatty) liver
JP6495658B2 (ja) 2013-02-08 2019-04-03 国立大学法人京都大学 巨核球及び血小板の製造方法
WO2014133090A1 (ja) * 2013-02-28 2014-09-04 国立大学法人浜松医科大学 脳腫瘍治療のための多能性幹細胞
CN105188754B (zh) 2013-03-01 2019-11-26 株式会社Ｃｌｉｏ 含有将多能干细胞诱导至损伤部位的迁移因子的药物组合物
SG11201507510PA (en) * 2013-03-15 2015-10-29 Jackson Lab Isolation of non-embryonic stem cells and uses thereof
EP2977449B1 (en) 2013-03-21 2020-02-26 Kyoto University Pluripotent stem cell for neuronal differentiation induction
US10072242B2 (en) 2013-03-25 2018-09-11 Foundation For Biomedical Research And Innovation At Kobe Cell sorting method
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
JP6429280B2 (ja) 2013-05-14 2018-11-28 国立大学法人京都大学 効率的な心筋細胞の誘導方法
US10131880B2 (en) 2013-05-22 2018-11-20 The Regents Of The University Of California Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
EP3031905A4 (en) 2013-08-07 2017-04-26 Kyoto University Method for producing pancreatic hormone-producing cell
US10265347B2 (en) 2013-08-29 2019-04-23 Norimasa Miura Biomolecular group related to cell anti-aging
EP3048169B1 (en) 2013-09-04 2019-07-10 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
DK3042951T3 (da) 2013-09-05 2019-04-15 Univ Kyoto Hidtil ukendt fremgangsmåde til at inducere dopamin-producerende neurale precursorceller
KR102219743B1 (ko) 2013-11-01 2021-02-23 고쿠리츠 다이가쿠 호진 교토 다이가쿠 신규 연골 세포 유도 방법
WO2015081094A1 (en) * 2013-11-27 2015-06-04 University Of Louisville Research Foundation, Inc. Cardiac progenitor cells and methods of use therefor
JP6519038B2 (ja) * 2014-02-26 2019-05-29 株式会社生命科学インスティテュート 脳梗塞治療のための多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
KR102443578B1 (ko) 2014-03-19 2022-09-16 브이셀 세라퓨틱스 인코포레이티드 다능성 세포에 관한 방법
EP3147353B1 (en) 2014-05-21 2022-03-30 Kyoto University Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells
KR101592401B1 (ko) * 2014-06-13 2016-02-05 주식회사 비비에이치씨 지방-유래 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 및 그 방법에 의해 제조된 유도만능 줄기세포
JP6391364B2 (ja) * 2014-08-25 2018-09-19 国立大学法人 鹿児島大学 認知機能障害改善用細胞製剤
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
KR101700598B1 (ko) * 2014-11-11 2017-01-31 한국원자력의학원 Cd105를 포함하는 줄기세포능을 가진 섬유아세포 분리용 바이오마커 조성물 및 이를 이용한 줄기세포능을 가진 섬유아세포 분리 방법
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
CA2987712A1 (en) * 2015-05-29 2016-12-08 Nippon Zoki Pharmaceutical Co., Ltd. Agent for promoting migration of pluripotent stem cells
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
JP6627027B2 (ja) * 2015-09-11 2020-01-08 福美人株式会社 皮膚細胞の活性化作用を呈するフラボノイド誘導体
US10641762B2 (en) * 2016-01-15 2020-05-05 University Of Toyama Mobilization of pluripotent stem cells for ischemic cerebral infarction
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
DK3430122T3 (da) 2016-03-17 2021-08-23 Synova Life Sciences Inc Separering, adskillelse og/eller opdeling af celler ved hjælp af mekaniske stød
SG11201809279YA (en) 2016-04-22 2018-11-29 Univ Kyoto Method for producing dopamine-producing neural precursor cells
CA3024518C (en) * 2016-05-16 2022-02-15 National University Corporation Nagoya University Amelioration and treatment of perinatal brain damage with pluripotent stem cells
SG11201811806TA (en) 2016-07-01 2019-02-27 Univ Tohoku Prophylactic or therapeutic agent for organ fibrosis
CN109843308A (zh) 2016-07-29 2019-06-04 国立大学法人东北大学 血管障碍的预防或治疗剂
AU2017305067B2 (en) 2016-08-03 2022-11-03 Hiroshi Yabuki Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
JP7148402B2 (ja) * 2016-08-03 2022-10-05 株式会社生命科学インスティテュート インビトロで多能性幹細胞を分化誘導する方法
EP3494978A4 (en) 2016-08-03 2020-03-11 National University Corporation Nagoya University IMPROVEMENT AND TREATMENT OF CHRONIC PULMONARY DISEASES USING PLURIPOTENT STEM CELLS
CN110475855A (zh) 2017-02-03 2019-11-19 国立大学法人九州大学 用于从牙髓组织衍生的细胞制备牙髓干细胞的方法
WO2018181342A1 (ja) * 2017-03-28 2018-10-04 味の素株式会社 未分化維持培地添加剤
AU2018289935A1 (en) * 2017-06-19 2020-01-23 Life Science Institute, Inc. Treatment agent for epidermolysis bullosa
SG11201912831TA (en) 2017-06-20 2020-01-30 Univ Nagoya Nat Univ Corp Amelioration and treatment of brain disorder resulting from fetal growth retardation using pluripotent stem cells
US20200237828A1 (en) 2017-10-17 2020-07-30 Hiroshima University Pluripotent stem cells inducing osteochondral repair
AU2018364852B2 (en) * 2017-11-10 2022-06-30 Regenesis Science Co., Ltd. Method for producing cultured cell, and method for producing therapeutic agent for spinal cord injury disease
WO2019107913A1 (ko) 2017-11-28 2019-06-06 주식회사 셀투인 실시간 글루타치온 측정을 통한 치료용 세포의 품질 향상 방법
JP6604492B2 (ja) * 2018-04-09 2019-11-13 株式会社生命科学インスティテュート 脳梗塞治療のための多能性幹細胞
US20210228638A1 (en) 2018-05-09 2021-07-29 Life Science Institute, Inc. Therapeutic agent for spinal cord injury
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
WO2020017575A1 (ja) 2018-07-19 2020-01-23 国立大学法人京都大学 多能性幹細胞由来の板状軟骨およびその製造方法
KR20210099014A (ko) 2018-11-30 2021-08-11 교토후고리츠다이가쿠호진 말초 혈류 장애의 치료제
EP3900787A4 (en) 2018-12-21 2022-02-23 Kyoto University CARTILAGE-LIKE TISSUE WITH LOCALIZED LUBRICINE, METHOD FOR THE PRODUCTION THEREOF, AND COMPOSITION COMPRISING IT FOR THE TREATMENT OF ARTICULAR CARTILAGE LESIONS
EP4011382A1 (en) 2019-08-09 2022-06-15 Tohoku University Agent for treating or preventing cerebrovascular dementia
JPWO2021045190A1 (da) 2019-09-05 2021-03-11
BR112022006286A2 (pt) 2019-10-01 2022-06-21 Univ Kyoto Métodos para isolar uma célula da ponta do broto uretérico, para produzir uma colônia celular da ponta do broto uretérico, para produzir um organoide, para produzir uma célula progenitora do duto de coleta, para produzir uma população celular de ponta do broto uretérico e para monitorar uma célula da ponta do broto uretérico, e, composição para isolar ou monitorar uma célula da ponta do broto uretérico
WO2021085639A1 (ja) 2019-10-31 2021-05-06 株式会社生命科学インスティテュート 多能性幹細胞による間質性膀胱炎の治療
WO2021117886A1 (ja) 2019-12-12 2021-06-17 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
US20230212519A1 (en) 2020-03-19 2023-07-06 Orizuru Therapeutics, Inc. Method for purifying cardiomyocytes
BR112022018640A2 (pt) 2020-03-19 2022-11-08 Orizuru Therapeutics Inc Métodos para produzir uma população de células compreendendo cardiomiócitos e para purificar cardiomiócitos, população de células contendo cardiomiócitos, e, agente para terapia de transplante de células
US20230203436A1 (en) 2020-04-02 2023-06-29 Tohoku University High-potential pluripotent stem cells
EP4180516A4 (en) 2020-07-13 2024-01-17 Univ Kyoto SKELETON MUSCLE PRECURSOR CELLS AND METHOD FOR PURIFICATION THEREOF, COMPOSITION FOR THE TREATMENT OF MYOGENIC DISEASES AND METHOD FOR PRODUCING SKELETON MUSCLE PRECURSOR CELLS CONTAINING CELL GROUPS
CA3186061A1 (en) 2020-07-15 2022-01-20 Koji Abe Pluripotent stem cells effective for treatment of motor neuron disease (mnd)
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
TWI832070B (zh) * 2021-07-15 2024-02-11 國璽幹細胞應用技術股份有限公司 幹細胞製劑用於治療關節炎的用途及用於製備幹細胞製劑的方法
CN117187174B (zh) * 2023-11-08 2024-02-06 广州正源生物技术有限公司 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2852534A1 (en) 1999-08-05 2001-02-15 Abt Holding Company Multipotent adult stem cells and methods for isolation
US7575921B2 (en) 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
WO2002057428A1 (en) 2000-10-30 2002-07-25 University Of Massachusetts Isolation of spore-like cells from tissues exposed to extreme conditions
JP4182742B2 (ja) 2002-12-12 2008-11-19 日産自動車株式会社 自動車の前部車体構造
US7569385B2 (en) 2003-08-14 2009-08-04 The Regents Of The University Of California Multipotent amniotic fetal stem cells
CA2536909A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use
US20060216821A1 (en) 2004-02-26 2006-09-28 Reliance Life Sciences Pvt. Ltd. Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
EP1893748A1 (en) * 2005-05-17 2008-03-05 Reliance Life Sciences Pvt., Ltd. Establishment of a human embryonic stem cell line using mammalian cells
US9388382B2 (en) 2005-10-05 2016-07-12 The Board Of Trustees Of The University Of Illinois Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells
EP1960553A2 (en) 2005-10-17 2008-08-27 Academia Sinica Pulmonary stem cells, related methods and kits
WO2009059032A2 (en) 2007-10-30 2009-05-07 University Of Louisville Research Foundation, Inc. Uses and isolation of very small embryonic-like (vsel) stem cells
CN101864392B (zh) 2005-12-13 2016-03-23 国立大学法人京都大学 核重新编程因子
WO2008080200A1 (en) 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20090172832A1 (en) * 2007-12-28 2009-07-02 Timothy Caspar Expression of rubisco enzyme from a non-rubisco locus
ITRM20080342A1 (it) * 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue

Also Published As

Publication number Publication date
JP2016028614A (ja) 2016-03-03
WO2011007900A1 (ja) 2011-01-20
SG177705A1 (en) 2012-02-28
ES2647360T3 (es) 2017-12-21
PL3214170T3 (pl) 2021-04-06
AU2010271722B8 (en) 2014-07-03
EP3214170B1 (en) 2020-09-02
AU2010271722A1 (en) 2012-03-01
EP2455452B2 (en) 2020-10-07
PL2455452T5 (pl) 2021-01-25
JP2021184754A (ja) 2021-12-09
US9550975B2 (en) 2017-01-24
JP2012139246A (ja) 2012-07-26
EP2455452B1 (en) 2017-09-06
AU2010271722B2 (en) 2014-05-29
CA2768238C (en) 2017-11-28
EP3680323A1 (en) 2020-07-15
JP6641441B2 (ja) 2020-02-05
ES2647360T5 (es) 2021-06-14
KR20160040728A (ko) 2016-04-14
KR101764080B1 (ko) 2017-08-01
CN102858951B (zh) 2016-12-07
DK3214170T3 (da) 2020-10-12
KR101945343B1 (ko) 2019-02-07
JP6937821B2 (ja) 2021-09-22
JP5852503B2 (ja) 2016-02-03
EP2455452A4 (en) 2013-11-27
JP5185443B2 (ja) 2013-04-17
JP7134317B2 (ja) 2022-09-09
US20110070647A1 (en) 2011-03-24
EP3214170A1 (en) 2017-09-06
JP2020058385A (ja) 2020-04-16
NO2455452T3 (da) 2018-02-03
CN102858951A (zh) 2013-01-02
ES2831030T3 (es) 2021-06-07
JP2017122095A (ja) 2017-07-13
PT2455452T (pt) 2017-11-20
PL2455452T3 (pl) 2018-02-28
JP2018203780A (ja) 2018-12-27
KR20150063168A (ko) 2015-06-08
EP2455452A1 (en) 2012-05-23
JPWO2011007900A1 (ja) 2012-12-27
KR101651795B1 (ko) 2016-08-26
PT3214170T (pt) 2020-11-16
KR20170089959A (ko) 2017-08-04
HUE037448T2 (hu) 2018-09-28
KR20120069663A (ko) 2012-06-28
JP6416298B2 (ja) 2018-10-31
HUE052559T2 (hu) 2021-05-28
CN107012117B (zh) 2020-10-23
JP6092357B2 (ja) 2017-03-08
DK2455452T3 (da) 2017-10-23
CN107012117A (zh) 2017-08-04
CA2768238A1 (en) 2011-01-20

Similar Documents

Publication Publication Date Title
DK2455452T4 (da) Pluripotent stamcelle, der kan isoleres fra kropsvæv
IL250234B (en) Creating blood vessels using placental stem cells
SG10201500674YA (en) Pluripotent stem cells
EP2414510A4 (en) INDUCED PLURIPOTENT STEM CELLS
GB201202848D0 (en) Differemtiaiotn of human embryonic stem cells
BR112012001557A2 (pt) diferenciação de células-tronco embrionárias humanas.
EP2315829A4 (en) INDUCED PLURIPOTENT STEM CELLS
IL223527B (en) Generation of induced stem cells with the ability to develop in different directions from small volumes of peripheral blood
EP2419511A4 (en) TARGETED INTEGRATION IN STEM CELLS
EP2504426A4 (en) METHOD FOR PRODUCING MESENCHYMAL STEM CELLS AND COMPOSITIONS AND KIT THEREWITH
GB0814249D0 (en) Uses of mesenchymal stem cells
SI2504469T1 (sl) Postopki elektropoliranja
IL217063A0 (en) Generation of induced pluripotent stem cells from cord blood
EP2531853A4 (en) USE OF NEW MARKERS OF PLURIPOTENT STEM CELLS
PL2456863T3 (pl) Pluripotencjalne komórki macierzyste otrzymywane z miazgi zęba
ZA201200949B (en) Cardiac tissue-derived cells
GB0919773D0 (en) Induced pluripotent stem cell
GB0918471D0 (en) Stem cells
TWI370178B (en) Cell markers for human embryonic stem cells
GB0908421D0 (en) Process for the ex vivo enhancement of autologous stem cells
GB0916476D0 (en) Stem cell culture methods
GB0901069D0 (en) Stem cell culture methods