SG11201809279YA - Method for producing dopamine-producing neural precursor cells - Google Patents
Method for producing dopamine-producing neural precursor cellsInfo
- Publication number
- SG11201809279YA SG11201809279YA SG11201809279YA SG11201809279YA SG11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- producing
- lrtm1
- corin
- positive
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000001537 neural effect Effects 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 7
- 102100037293 Atrial natriuretic peptide-converting enzyme Human genes 0.000 abstract 3
- 101710133555 Atrial natriuretic peptide-converting enzyme Proteins 0.000 abstract 3
- 102000003693 Hedgehog Proteins Human genes 0.000 abstract 2
- 108090000031 Hedgehog Proteins Proteins 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000005064 dopaminergic neuron Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000003170 nutritional factors Nutrition 0.000 abstract 1
- 210000001778 pluripotent stem cell Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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Abstract
A cell population comprising Corin- and/or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and/or Lrtm1 positive cells are collected using a substance that binds to Corin and/or a substance that binds to Lrtm1, and dopaminergic neuron progenitor cells are produced by performing suspension culture of the Corin positive and/or Lrtm1 positive cells in a culture solution containing one or more nutritional factors: (1) a step of performing adhesion culture of pluripotent stem cells in a medium for maintaining undifferentiated state containing a Sonic hedgehog (SHH) signal stimulant, and an undifferentiated state-maintaining factor in the absence of feeder cells but in the presence of an extracellular matrix, and (2) a step of culturing the cell population obtained in the step (1) in a culture solution containing one or more differentiation-inducing factors. METHOD FOR PRODUCING DOPAMINE-PRODUCING NEURAL PRECURSOR CELLS [No Suitable Figure]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016086499 | 2016-04-22 | ||
PCT/JP2017/016246 WO2017183736A1 (en) | 2016-04-22 | 2017-04-24 | Method for producing dopamine-producing neural precursor cells |
Publications (1)
Publication Number | Publication Date |
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SG11201809279YA true SG11201809279YA (en) | 2018-11-29 |
Family
ID=60116215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SG11201809279YA SG11201809279YA (en) | 2016-04-22 | 2017-04-24 | Method for producing dopamine-producing neural precursor cells |
Country Status (10)
Country | Link |
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US (2) | US11898163B2 (en) |
EP (1) | EP3447130A4 (en) |
JP (2) | JP7011260B2 (en) |
KR (1) | KR102312123B1 (en) |
CN (1) | CN109072198B (en) |
AU (1) | AU2017254268B2 (en) |
CA (1) | CA3021628A1 (en) |
IL (1) | IL262475B2 (en) |
SG (1) | SG11201809279YA (en) |
WO (1) | WO2017183736A1 (en) |
Families Citing this family (14)
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JPWO2018193949A1 (en) * | 2017-04-19 | 2020-02-27 | 国立大学法人名古屋大学 | Method for preparing dopamine neurons |
WO2019160148A1 (en) | 2018-02-19 | 2019-08-22 | 大日本住友製薬株式会社 | Cell aggregate, mixture of cell aggregates, and method for preparing same |
CN112011510B (en) * | 2019-05-30 | 2023-01-03 | 中国科学院上海有机化学研究所 | Method for preparing dopamine neuron by human pluripotent stem cell |
US20230000923A1 (en) * | 2019-09-20 | 2023-01-05 | Korea Research Institute Of Bioscience And Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
AU2020202273B2 (en) * | 2019-09-25 | 2022-06-30 | S-Biomedics | Method for inducing differentiation of stem cell into dopaminergic neural precursor cell |
KR102392133B1 (en) * | 2019-09-25 | 2022-04-29 | (주) 에스바이오메딕스 | A method for Differentiation of Dopaminergic Neural Precursor Cells from Stem Cells |
EP4090734A1 (en) * | 2020-01-13 | 2022-11-23 | Aspen Neuroscience, Inc. | Method of differentiating neural cells and related compositions and methods of use |
WO2021216622A1 (en) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
WO2021216623A1 (en) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
WO2022020798A1 (en) * | 2020-07-24 | 2022-01-27 | The Scripps Research Institute | Methods of differentiating neurons and identification of disease phenotypes thereof |
CN112626023B (en) * | 2021-01-12 | 2023-08-04 | 中国人民解放军海军军医大学 | Spinal cord olig2+ nerve progenitor cell induction and self-renewal culture system, induction method and application |
CN113403262A (en) * | 2021-06-23 | 2021-09-17 | 昆明理工大学 | Layer-free culture method for stem cells of cynomolgus monkeys |
CN113481160B (en) * | 2021-08-20 | 2022-04-29 | 北京太东生物科技有限公司 | Retinal pigment epithelial cell induction culture medium and application thereof |
WO2023153464A1 (en) * | 2022-02-09 | 2023-08-17 | 住友ファーマ株式会社 | Method for assessing differentiation potential of cells in culture broth in differentiation of pluripotent stem cells into neural cells of midbrain floor plate region |
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US20240117304A1 (en) | 2024-04-11 |
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CA3021628A1 (en) | 2017-10-26 |
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IL262475B1 (en) | 2023-07-01 |
IL262475B2 (en) | 2023-11-01 |
JP7011260B2 (en) | 2022-02-10 |
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CN109072198B (en) | 2022-08-26 |
CN109072198A (en) | 2018-12-21 |
US20190112575A1 (en) | 2019-04-18 |
KR102312123B1 (en) | 2021-10-13 |
WO2017183736A1 (en) | 2017-10-26 |
JP2022037232A (en) | 2022-03-08 |
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