JP2012006970A5 - - Google Patents
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- JP2012006970A5 JP2012006970A5 JP2011201117A JP2011201117A JP2012006970A5 JP 2012006970 A5 JP2012006970 A5 JP 2012006970A5 JP 2011201117 A JP2011201117 A JP 2011201117A JP 2011201117 A JP2011201117 A JP 2011201117A JP 2012006970 A5 JP2012006970 A5 JP 2012006970A5
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- XTTZERNUQAFMOF-UHFFFAOYSA-N 7-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC=C(Cl)C=C12 XTTZERNUQAFMOF-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 44
- 241000124008 Mammalia Species 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 21
- 208000024172 Cardiovascular disease Diseases 0.000 claims 12
- 206010020772 Hypertension Diseases 0.000 claims 12
- 206010012601 diabetes mellitus Diseases 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 230000037396 body weight Effects 0.000 claims 8
- XTTZERNUQAFMOF-QMMMGPOBSA-N lorcaserin Chemical compound C[C@H]1CNCCC2=CC=C(Cl)C=C12 XTTZERNUQAFMOF-QMMMGPOBSA-N 0.000 claims 8
- 238000012423 maintenance Methods 0.000 claims 8
- 201000002859 sleep apnea Diseases 0.000 claims 8
- 230000004580 weight loss Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- 210000000577 adipose tissue Anatomy 0.000 claims 4
- 230000037213 diet Effects 0.000 claims 4
- 235000005911 diet Nutrition 0.000 claims 4
- 230000037081 physical activity Effects 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000036186 satiety Effects 0.000 claims 2
- 235000019627 satiety Nutrition 0.000 claims 2
- 230000004584 weight gain Effects 0.000 claims 2
- 235000019786 weight gain Nutrition 0.000 claims 2
- XTTZERNUQAFMOF-MRVPVSSYSA-N (5s)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound C[C@@H]1CNCCC2=CC=C(Cl)C=C12 XTTZERNUQAFMOF-MRVPVSSYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37205802P | 2002-04-12 | 2002-04-12 | |
| US60/372,058 | 2002-04-12 | ||
| US40549502P | 2002-08-23 | 2002-08-23 | |
| US60/405,495 | 2002-08-23 | ||
| US43460702P | 2002-12-18 | 2002-12-18 | |
| US60/434,607 | 2002-12-18 | ||
| US10/410,991 US6953787B2 (en) | 2002-04-12 | 2003-04-10 | 5HT2C receptor modulators |
| US10/410,991 | 2003-04-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008202412A Division JP4966929B2 (ja) | 2002-04-12 | 2008-08-05 | ５ｈｔ２ｃレセプター修飾因子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012211059A Division JP2013018780A (ja) | 2002-04-12 | 2012-09-25 | ５ｈｔ２ｃレセプター修飾因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012006970A JP2012006970A (ja) | 2012-01-12 |
| JP2012006970A5 true JP2012006970A5 (https=) | 2012-11-15 |
| JP5602116B2 JP5602116B2 (ja) | 2014-10-08 |
Family
ID=29255581
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583332A Expired - Lifetime JP4155926B2 (ja) | 2002-04-12 | 2003-04-11 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2006058747A Expired - Lifetime JP4191741B2 (ja) | 2002-04-12 | 2006-03-03 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2008202412A Expired - Lifetime JP4966929B2 (ja) | 2002-04-12 | 2008-08-05 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2011201117A Expired - Lifetime JP5602116B2 (ja) | 2002-04-12 | 2011-09-14 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2012211059A Withdrawn JP2013018780A (ja) | 2002-04-12 | 2012-09-25 | ５ｈｔ２ｃレセプター修飾因子 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583332A Expired - Lifetime JP4155926B2 (ja) | 2002-04-12 | 2003-04-11 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2006058747A Expired - Lifetime JP4191741B2 (ja) | 2002-04-12 | 2006-03-03 | ５ｈｔ２ｃレセプター修飾因子 |
| JP2008202412A Expired - Lifetime JP4966929B2 (ja) | 2002-04-12 | 2008-08-05 | ５ｈｔ２ｃレセプター修飾因子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012211059A Withdrawn JP2013018780A (ja) | 2002-04-12 | 2012-09-25 | ５ｈｔ２ｃレセプター修飾因子 |
Country Status (28)
| Country | Link |
|---|---|
| US (11) | US6953787B2 (https=) |
| EP (4) | EP2363394A1 (https=) |
| JP (5) | JP4155926B2 (https=) |
| KR (3) | KR100908166B1 (https=) |
| CN (5) | CN100486967C (https=) |
| AT (1) | ATE294781T1 (https=) |
| AU (1) | AU2003221866B2 (https=) |
| BR (2) | BRPI0309303B8 (https=) |
| CA (1) | CA2481723C (https=) |
| CR (2) | CR7503A (https=) |
| DE (1) | DE60300610T2 (https=) |
| DK (1) | DK1411881T3 (https=) |
| ES (2) | ES2670568T3 (https=) |
| GE (1) | GEP20074197B (https=) |
| IL (1) | IL164162A0 (https=) |
| IS (1) | IS2134B (https=) |
| MX (1) | MXPA04009965A (https=) |
| MY (1) | MY141476A (https=) |
| NO (1) | NO323528B1 (https=) |
| NZ (1) | NZ535381A (https=) |
| PL (4) | PL231405B1 (https=) |
| PT (1) | PT1411881E (https=) |
| RU (1) | RU2317982C2 (https=) |
| SI (1) | SI1411881T1 (https=) |
| TW (1) | TWI252105B (https=) |
| UA (1) | UA77788C2 (https=) |
| WO (1) | WO2003086306A2 (https=) |
| ZA (1) | ZA200408506B (https=) |
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| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
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-
2003
- 2003-04-10 US US10/410,991 patent/US6953787B2/en not_active Expired - Lifetime
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- 2003-04-11 CN CNA2009100001925A patent/CN101486679A/zh active Pending
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- 2003-04-11 EP EP10010297.9A patent/EP2374796B1/en not_active Expired - Lifetime
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2004
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2006
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