JP2011522897A5 - - Google Patents
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- Publication number
- JP2011522897A5 JP2011522897A5 JP2011513647A JP2011513647A JP2011522897A5 JP 2011522897 A5 JP2011522897 A5 JP 2011522897A5 JP 2011513647 A JP2011513647 A JP 2011513647A JP 2011513647 A JP2011513647 A JP 2011513647A JP 2011522897 A5 JP2011522897 A5 JP 2011522897A5
- Authority
- JP
- Japan
- Prior art keywords
- phentermine
- cancer
- formulated
- kit
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 claims 12
- 239000002552 dosage form Substances 0.000 claims 9
- 229960001277 phentermine hydrochloride Drugs 0.000 claims 7
- NCAIGTHBQTXTLR-UHFFFAOYSA-N phentermine hydrochloride Chemical compound [Cl-].CC(C)([NH3+])CC1=CC=CC=C1 NCAIGTHBQTXTLR-UHFFFAOYSA-N 0.000 claims 7
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 6
- 229960003562 phentermine Drugs 0.000 claims 6
- 229960004394 topiramate Drugs 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 5
- 238000013270 controlled release Methods 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 206010020772 Hypertension Diseases 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- 150000003626 triacylglycerols Chemical class 0.000 claims 3
- 230000004580 weight loss Effects 0.000 claims 3
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010021024 Hypolipidaemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000037093 Menstruation Disturbances Diseases 0.000 claims 1
- 206010027339 Menstruation irregular Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000002787 Pregnancy Complications Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 208000020694 gallbladder disease Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000029498 hypoalphalipoproteinemia Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000004228 ovarian endometrial cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000000689 peptic esophagitis Diseases 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 208000012113 pregnancy disease Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/135,953 US20090304789A1 (en) | 2008-06-09 | 2008-06-09 | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| US12/135,953 | 2008-06-09 | ||
| PCT/US2009/046805 WO2009152190A1 (en) | 2008-06-09 | 2009-06-09 | Escalating dosing regimen for effecting weight loss and treating obesity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015102962A Division JP6077053B2 (ja) | 2008-06-09 | 2015-05-20 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇｄｏｓｉｎｇｒｅｇｉｍｅｎ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522897A JP2011522897A (ja) | 2011-08-04 |
| JP2011522897A5 true JP2011522897A5 (https=) | 2013-11-14 |
| JP5752595B2 JP5752595B2 (ja) | 2015-07-22 |
Family
ID=40863844
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513646A Pending JP2011522896A (ja) | 2008-06-09 | 2009-06-09 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
| JP2011513647A Active JP5752595B2 (ja) | 2008-06-09 | 2009-06-09 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇｄｏｓｉｎｇｒｅｇｉｍｅｎ） |
| JP2015102962A Active JP6077053B2 (ja) | 2008-06-09 | 2015-05-20 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇｄｏｓｉｎｇｒｅｇｉｍｅｎ） |
| JP2015151088A Pending JP2016006085A (ja) | 2008-06-09 | 2015-07-30 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
| JP2016246871A Active JP6214750B2 (ja) | 2008-06-09 | 2016-12-20 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
| JP2017002448A Pending JP2017105788A (ja) | 2008-06-09 | 2017-01-11 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇ ｄｏｓｉｎｇ ｒｅｇｉｍｅｎ） |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513646A Pending JP2011522896A (ja) | 2008-06-09 | 2009-06-09 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015102962A Active JP6077053B2 (ja) | 2008-06-09 | 2015-05-20 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇｄｏｓｉｎｇｒｅｇｉｍｅｎ） |
| JP2015151088A Pending JP2016006085A (ja) | 2008-06-09 | 2015-07-30 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
| JP2016246871A Active JP6214750B2 (ja) | 2008-06-09 | 2016-12-20 | 低用量トピラメート／フェンテルミン組成物およびその使用方法 |
| JP2017002448A Pending JP2017105788A (ja) | 2008-06-09 | 2017-01-11 | 体重減少の達成および肥満症の治療のための漸増用量投与計画（ｅｓｃａｌａｔｉｎｇ ｄｏｓｉｎｇ ｒｅｇｉｍｅｎ） |
Country Status (18)
| Country | Link |
|---|---|
| US (11) | US20090304789A1 (https=) |
| EP (2) | EP2300002A1 (https=) |
| JP (6) | JP2011522896A (https=) |
| KR (3) | KR20140121491A (https=) |
| CN (4) | CN104825477A (https=) |
| AU (2) | AU2009257572C1 (https=) |
| BR (2) | BRPI0914985B1 (https=) |
| CA (2) | CA2727319C (https=) |
| CL (2) | CL2010001365A1 (https=) |
| CY (1) | CY1118103T1 (https=) |
| DK (1) | DK2317997T3 (https=) |
| ES (1) | ES2606041T3 (https=) |
| HK (1) | HK1213489A1 (https=) |
| IL (2) | IL209874B (https=) |
| MX (2) | MX2010013503A (https=) |
| PT (1) | PT2317997T (https=) |
| WO (2) | WO2009152190A1 (https=) |
| ZA (2) | ZA201008840B (https=) |
Families Citing this family (36)
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| US20080255093A1 (en) * | 1999-06-14 | 2008-10-16 | Tam Peter Y | Compositions and methods for treating obesity and related disorders |
| US7674776B2 (en) | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US8580298B2 (en) * | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
| US20090304789A1 (en) * | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| MX2012007813A (es) * | 2010-01-07 | 2012-08-01 | Vivus Inc | Tratamiento del sindrome de apnea obstructiva del sueño con una combinacion de un hinibidor de anhidrasa carbonica y un agente activo adicional. |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| BR102012004888A2 (pt) * | 2012-03-05 | 2013-10-22 | Phartrials Pesquisas Farmaceuticas Ltda | Associação de um derivado de sulfamato monossubstituído do monossacarídeo natural d-frutose (topiramato) com um anti-depressivo da classe das fenilcetonas (bupropiona) para tratamento de obesidade e das síndromes plurimetabólicas |
| IN2012DE00826A (https=) * | 2012-03-21 | 2015-08-21 | Ranbaxy Lab Ltd | |
| CN102579367B (zh) * | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| WO2013139292A1 (zh) * | 2012-03-23 | 2013-09-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种含辛弗林和托吡酯的联合产品 |
| CN103316026B (zh) * | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| BR102012026555B1 (pt) * | 2012-10-17 | 2022-10-04 | Phartrials Pesquisas Farmacêuticas Ltda | Processo de obtenção e composição de fármaco proveniente do quenodeoxicolato ligado a um derivado de sulfamato monossacarídeo natural d-frutose (topiramato) e a uma fenilcetona (bupropriona) para tratamento da obesidade e das síndromes plurimetabólicas |
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| US11116914B2 (en) | 2014-11-09 | 2021-09-14 | Sipnose Ltd. | Device and method for aerosolized delivering of substance to a natural orifice of the body |
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| US12329902B2 (en) | 2013-08-22 | 2025-06-17 | Sipnose Ltd. | Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization |
| DE202013105715U1 (de) | 2013-08-22 | 2014-02-19 | Sipnose Ltd. | Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers |
| US11278682B2 (en) | 2014-11-09 | 2022-03-22 | Sipnose Ltd. | Device and method for aerosolized delivery of substance to a natural orifice of the body |
| US12491325B2 (en) | 2013-08-22 | 2025-12-09 | Aptargroup, Inc. | Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization for treatment of binge-eating disorders and/or obesity |
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| CN109999044B (zh) * | 2019-05-24 | 2020-06-09 | 北京大学 | 一种含有醉茄素a的组合物及其应用 |
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