JP2013522230A5 - - Google Patents
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- Publication number
- JP2013522230A5 JP2013522230A5 JP2012557260A JP2012557260A JP2013522230A5 JP 2013522230 A5 JP2013522230 A5 JP 2013522230A5 JP 2012557260 A JP2012557260 A JP 2012557260A JP 2012557260 A JP2012557260 A JP 2012557260A JP 2013522230 A5 JP2013522230 A5 JP 2013522230A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- lower alkyl
- methoxy
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims description 2
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 229960005243 carmustine Drugs 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 208000031169 hemorrhagic disease Diseases 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 229960002247 lomustine Drugs 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000030266 primary brain neoplasm Diseases 0.000 claims description 2
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 claims description 2
- 229960000624 procarbazine Drugs 0.000 claims description 2
- 229960001052 streptozocin Drugs 0.000 claims description 2
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims description 2
- 230000004614 tumor growth Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 1
- 101710152983 Beta-2 adrenergic receptor Proteins 0.000 claims 1
- 229960002297 fenofibrate Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 0 C*(C)c1ccc(*)cc1 Chemical compound C*(C)c1ccc(*)cc1 0.000 description 18
- NMCQISYZJJUMBB-UHFFFAOYSA-N CC(C)c(cc(c1c2cccc1)OC)c2OC Chemical compound CC(C)c(cc(c1c2cccc1)OC)c2OC NMCQISYZJJUMBB-UHFFFAOYSA-N 0.000 description 2
- JFQYSUIAIZPZGB-UHFFFAOYSA-N CNc1c(ccc(OC)c2)c2ccc1 Chemical compound CNc1c(ccc(OC)c2)c2ccc1 JFQYSUIAIZPZGB-UHFFFAOYSA-N 0.000 description 2
- -1 aminocarbonyl (carbamoyl) Chemical group 0.000 description 1
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 description 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31264210P | 2010-03-10 | 2010-03-10 | |
| US61/312,642 | 2010-03-10 | ||
| PCT/US2011/027988 WO2011112867A1 (en) | 2010-03-10 | 2011-03-10 | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522230A JP2013522230A (ja) | 2013-06-13 |
| JP2013522230A5 true JP2013522230A5 (https=) | 2014-04-17 |
| JP5837890B2 JP5837890B2 (ja) | 2015-12-24 |
Family
ID=43858307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557260A Active JP5837890B2 (ja) | 2010-03-10 | 2011-03-10 | 神経膠芽腫および星状細胞腫の治療におけるフェノテロールおよびフェノテロール類似体の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9492405B2 (https=) |
| EP (1) | EP2544676B1 (https=) |
| JP (1) | JP5837890B2 (https=) |
| AU (2) | AU2011224241B2 (https=) |
| BR (1) | BR112012022552A8 (https=) |
| CA (1) | CA2791702C (https=) |
| WO (1) | WO2011112867A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013177418A1 (en) | 2012-05-25 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of regulating cannabinoid receptor activity-related disorders and diseases |
| US20170172944A1 (en) * | 2014-04-03 | 2017-06-22 | Mitchell Woods Pharmaceuticals, Inc. | Methods of treating melanoma |
| WO2015153719A2 (en) * | 2014-04-03 | 2015-10-08 | Mitchell Woods Pharmaceuticals, Inc. | Methods of treating breast cancer |
| KR101585619B1 (ko) * | 2014-11-20 | 2016-01-15 | 주식회사 아모텍 | 감전보호소자 및 이를 구비한 휴대용 전자장치 |
| WO2016144371A1 (en) * | 2015-03-06 | 2016-09-15 | Mitchell Woods Pharmaceuticals, Inc. | Methods of treating cancer |
| WO2017059268A1 (en) * | 2015-10-01 | 2017-04-06 | Mitchell Woods Pharmaceuticals, Inc. | Methods of reducing chemoresistance and treating cancer |
| WO2017070052A1 (en) * | 2015-10-18 | 2017-04-27 | Onco Therapies Llc | Compositions and methods of regulating cancer related disorders and diseases |
| EP3490542A4 (en) * | 2016-07-26 | 2020-07-08 | Flagship Pioneering Innovations V, Inc. | NEUROMODULATION COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF CANCER BY MODULATION OF AN ANTI-CANCER RESPONSE |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| CN109942462B (zh) * | 2019-03-06 | 2022-01-14 | 宏冠生物药业有限公司 | 一种盐酸班布特罗的合成工艺 |
| GB201903832D0 (en) | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
| CN114456078B (zh) * | 2022-01-19 | 2022-09-16 | 汉瑞药业(荆门)有限公司 | 一种(r)-n-苄基-1-(4-甲氧基苯基)丙-2-胺的制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL296701A (https=) | ||||
| SE354279B (https=) | 1969-06-13 | 1973-03-05 | Draco Ab | |
| CH564509A5 (https=) | 1969-12-12 | 1975-07-31 | Boehringer Sohn Ingelheim | |
| DE1962497C3 (de) | 1969-12-12 | 1979-09-20 | C.H. Boehringer Sohn, 6507 Ingelheim | Naphthylalkyl- a -hydroxyphenäthyl-amine, ihre Herstellung und diese enthaltende Arzneimittel |
| DE2010883A1 (de) | 1970-03-07 | 1971-09-23 | Troponwerke Dinklage & Co, 5000 Köln-Mülheim | Pharmakologisch wirksame Aminoalkohole und Verfahren zu ihrer Darstellung |
| AT308139B (de) | 1970-07-27 | 1973-06-25 | Degussa | Verfahren zur Herstellung von neuen basisch substituierten Alkyltheophyllinen, ihren Isomeren und Säureadditionssalzen |
| IT1044214B (it) | 1971-04-22 | 1980-03-20 | Zambeletti Spa L | 2 idrossi 2 feniletilamine so stituite dotate di proprieta vasoattive e processo per la loro preparazione |
| JPS532194B2 (https=) | 1973-08-10 | 1978-01-26 | ||
| US6866839B2 (en) | 1991-04-05 | 2005-03-15 | Sepracor Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| GB9107196D0 (en) | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
| US5795564A (en) | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| US6299863B1 (en) | 1992-04-03 | 2001-10-09 | Sepracor Inc. | Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy |
| CA2130578A1 (en) | 1992-04-17 | 1993-10-28 | Geewananda P. Gunawardana | Taxol derivatives |
| WO1998001099A2 (en) | 1996-07-05 | 1998-01-15 | E.C. Pesterfield Assoc., Inc. | Method of treating retinal ischemia and glaucoma |
| US6015837A (en) | 1996-08-29 | 2000-01-18 | New York Medical College | Method for treating scoliosis with β2-adrenoceptor agonists |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| AU9672598A (en) | 1997-09-30 | 1999-04-23 | E.C. Pesterfield Associates, Inc. | Galenic forms of r-or rr-isomers of adrenergic beta-2 agonists |
| ZA994264B (en) | 1998-07-01 | 2000-01-25 | Warner Lambert Co | Stereoisomers with high affinity for adrenergic receptors. |
| AU6167599A (en) | 1998-09-30 | 2000-04-17 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of a beta2 adrenergic receptor agonist in the treatment of cardiovascular disease |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| ES2296923T3 (es) | 2001-03-22 | 2008-05-01 | Glaxo Group Limited | Derivados formanilidas como agonistas del adrenorreceptor beta2. |
| WO2003099764A1 (en) | 2002-05-28 | 2003-12-04 | Theravance, Inc. | ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS |
| EP2186811A1 (en) | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20050107417A1 (en) | 2003-07-28 | 2005-05-19 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising a novel anticholinergic and a betamimetic |
| ATE407925T1 (de) | 2003-11-03 | 2008-09-15 | Myogen Inc | 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen |
| JP2007530566A (ja) | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用 |
| EP1781331A1 (en) | 2004-08-09 | 2007-05-09 | Université Catholique de Louvain | Use of agonists and antagonists of beta-adrenoceptors for treating arterial diseases |
| NZ556335A (en) | 2005-01-11 | 2009-07-31 | Glaxo Group Ltd | Cinnamate salts of a beta-2 adrenergic agonist |
| WO2008022038A1 (en) * | 2006-08-10 | 2008-02-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
| GB0625270D0 (en) * | 2006-12-19 | 2007-01-31 | Univ Leicester | Angiogenesis |
| JP5546455B2 (ja) | 2007-10-02 | 2014-07-09 | リグスホスピタル | 交感神経系α‐および／またはβ‐アドレナリン受容体に対してアゴニスト作用を有する交感神経作動薬の血餅強度改善に関連した全身的止血促進効果 |
| EP2515946B1 (en) * | 2009-12-23 | 2019-05-22 | The Board of Trustees of the University of Illionis | Nanoconjugates and nanoconjugate formulations |
-
2011
- 2011-03-10 AU AU2011224241A patent/AU2011224241B2/en active Active
- 2011-03-10 JP JP2012557260A patent/JP5837890B2/ja active Active
- 2011-03-10 EP EP11708381.6A patent/EP2544676B1/en active Active
- 2011-03-10 CA CA2791702A patent/CA2791702C/en active Active
- 2011-03-10 BR BR112012022552A patent/BR112012022552A8/pt not_active IP Right Cessation
- 2011-03-10 US US13/583,206 patent/US9492405B2/en active Active
- 2011-03-10 WO PCT/US2011/027988 patent/WO2011112867A1/en not_active Ceased
-
2014
- 2014-08-08 AU AU2014210656A patent/AU2014210656B2/en active Active
-
2016
- 2016-09-22 US US15/273,147 patent/US10130594B2/en active Active
-
2018
- 2018-09-12 US US16/129,470 patent/US10617654B2/en active Active
-
2020
- 2020-03-02 US US16/806,659 patent/US10925840B2/en active Active
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