|
US7276497B2
(en)
*
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
CN101098854B
(zh)
|
2004-07-23 |
2012-12-05 |
恩多塞特公司 |
二价连接体及其轭合物
|
|
US7811572B2
(en)
|
2005-08-24 |
2010-10-12 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
|
CN104127878A
(zh)
|
2007-03-14 |
2014-11-05 |
恩多塞特公司 |
结合配体连接的微管溶素递药缀合物
|
|
AU2008230795B2
(en)
|
2007-03-27 |
2014-05-29 |
Bioassets, Llc |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
BRPI0812970A2
(pt)
|
2007-06-25 |
2019-09-24 |
Endocyte Inc |
conjugados contendo espaçadores hidrofílicos
|
|
NZ588884A
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Cross-linkers and their uses
|
|
UA108598C2
(xx)
|
2008-04-30 |
2015-05-25 |
|
Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери)
|
|
US20120128671A1
(en)
|
2009-05-13 |
2012-05-24 |
Lawrence Horowitz |
Neutralizing molecules to influenza viruses
|
|
JP5784592B2
(ja)
|
2009-06-03 |
2015-09-24 |
イミュノジェン・インコーポレーテッド |
抱合方法
|
|
AU2015201534B2
(en)
*
|
2009-06-03 |
2016-11-24 |
Immunogen, Inc. |
Conjugation methods
|
|
FR2947269B1
(fr)
|
2009-06-29 |
2013-01-18 |
Sanofi Aventis |
Nouveaux composes anticancereux
|
|
FR2949469A1
(fr)
*
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
AU2010292172A1
(en)
*
|
2009-09-09 |
2012-05-03 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
UY32913A
(es)
*
|
2009-10-02 |
2011-04-29 |
Sanofi Aventis |
Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero
|
|
CN102596922A
(zh)
*
|
2009-10-06 |
2012-07-18 |
免疫基因公司 |
有效的缀合物和亲水性连接体
|
|
CN105777907B
(zh)
|
2010-02-24 |
2020-03-17 |
伊缪诺金公司 |
叶酸受体1抗体与免疫缀合物以及其用途
|
|
LT2544719T
(lt)
|
2010-03-12 |
2019-10-25 |
Debiopharm Int Sa |
Cd37 surišančios molekulės, ir jų imunokonjugatai
|
|
FR2963007B1
(fr)
|
2010-07-26 |
2013-04-05 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application therapeutique
|
|
WO2012019024A2
(en)
|
2010-08-04 |
2012-02-09 |
Immunogen, Inc. |
Her3-binding molecules and immunoconjugates thereof
|
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
|
JP5828902B2
(ja)
|
2010-10-29 |
2015-12-09 |
イミュノジェン， インコーポレイテッド |
非拮抗性ｅｇｆｒ結合分子およびその免疫複合体
|
|
CA2815277A1
(en)
|
2010-10-29 |
2012-05-03 |
Immunogen, Inc. |
Novel egfr-binding molecules and immunoconjugates thereof
|
|
US9090629B2
(en)
|
2010-11-03 |
2015-07-28 |
Immunogen, Inc. |
Cytotoxic agents comprising new ansamitocin derivatives
|
|
EP2640727B1
(en)
*
|
2010-11-17 |
2015-05-13 |
Genentech, Inc. |
Alaninyl maytansinol antibody conjugates
|
|
PL3153504T3
(pl)
|
2010-12-09 |
2019-04-30 |
Immunogen Inc |
Sposoby otrzymywania naładowanych środków sieciujących
|
|
SI2675480T1
(sl)
|
2011-02-15 |
2019-05-31 |
Immunogen, Inc. |
Metode priprave konjugatov
|
|
US20140079722A1
(en)
*
|
2011-03-09 |
2014-03-20 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
EA033468B1
(ru)
|
2011-03-29 |
2019-10-31 |
Immunogen Inc |
Способы получения конъюгата "антитело-майтансиноид"
|
|
WO2012135517A2
(en)
|
2011-03-29 |
2012-10-04 |
Immunogen, Inc. |
Preparation of maytansinoid antibody conjugates by a one-step process
|
|
ES2661466T3
(es)
|
2011-04-01 |
2018-04-02 |
Immunogen, Inc. |
Métodos para aumentar la eficacia de la terapia contra el cáncer con FOLR1
|
|
US20120282282A1
(en)
*
|
2011-04-04 |
2012-11-08 |
Immunogen, Inc. |
Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
|
|
NO2699601T3
(enExample)
*
|
2011-04-21 |
2018-06-16 |
|
|
|
EP2717916B1
(en)
|
2011-06-10 |
2017-03-08 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
CA2842860A1
(en)
|
2011-07-28 |
2013-01-31 |
Sea Lane Biotechnologies, Llc |
Sur-binding proteins
|
|
JP2014533954A
(ja)
|
2011-11-21 |
2014-12-18 |
イミュノジェン， インコーポレイテッド |
Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法
|
|
US9975956B2
(en)
|
2011-12-22 |
2018-05-22 |
I2 Pharmaceuticals, Inc. |
Surrogate binding proteins which bind DR4 and/or DR5
|
|
BR112014013135A2
(pt)
*
|
2012-01-27 |
2017-12-05 |
Hoffmann La Roche |
composto, composição farmacêutica, método para o tratamento da inflamação, uso de um composto e invenção
|
|
WO2013126797A1
(en)
|
2012-02-24 |
2013-08-29 |
Purdue Research Foundation |
Cholecystokinin b receptor targeting for imaging and therapy
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
SG11201500938XA
(en)
|
2012-08-31 |
2015-04-29 |
Immunogen Inc |
Diagnostic assays and kits for detection of folate receptor 1
|
|
EP2904089A4
(en)
|
2012-10-04 |
2016-05-25 |
Immunogen Inc |
USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES
|
|
WO2014055842A1
(en)
*
|
2012-10-04 |
2014-04-10 |
Immunogen, Inc. |
Process for preparing stable antibody maytansinoid conjugates
|
|
EA201590622A1
(ru)
|
2012-10-16 |
2015-10-30 |
Эндосайт, Инк. |
Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения
|
|
ES2623209T3
(es)
*
|
2012-10-24 |
2017-07-10 |
Polytherics Limited |
Conjugados fármaco-proteína
|
|
NO2789793T3
(enExample)
*
|
2012-10-24 |
2018-01-27 |
|
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
US9353150B2
(en)
|
2012-12-04 |
2016-05-31 |
Massachusetts Institute Of Technology |
Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
|
|
CN104688740A
(zh)
*
|
2012-12-21 |
2015-06-10 |
百奥泰生物科技(广州)有限公司 |
类美登素衍生物及其制备方法和用途
|
|
CN104530235A
(zh)
|
2012-12-21 |
2015-04-22 |
百奥泰生物科技(广州)有限公司 |
一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途
|
|
US9968673B2
(en)
*
|
2013-02-26 |
2018-05-15 |
Commissariat á l'ènergie atomique et aux ènergies alternatives |
Immunogenic composition in emulsion form comprising two dispersed phases, one comprising an antigen and the other comprising an immunostimulating agent
|
|
FR3002454B1
(fr)
*
|
2013-02-26 |
2015-04-10 |
Commissariat Energie Atomique |
Composition immunogene sous forme d'emulsion
|
|
HK1219422A1
(zh)
*
|
2013-02-28 |
2017-04-07 |
Immunogen, Inc. |
包含细胞结合剂及细胞毒素剂的轭合物
|
|
EP3964237B1
(en)
*
|
2013-03-15 |
2026-02-18 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecules, conjugates thereof, and therapeutic uses
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
ES2693370T3
(es)
*
|
2013-05-02 |
2018-12-11 |
F. Hoffmann-La Roche Ag |
Politerapia de un anticuerpo CD20 afucosilado con un conjugado de anticuerpo CD22-fármaco
|
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
|
TWI641620B
(zh)
*
|
2013-08-21 |
2018-11-21 |
再生元醫藥公司 |
抗－ｐｒｌｒ抗體及其用途
|
|
AU2014311361B2
(en)
|
2013-08-26 |
2018-11-29 |
Regeneron Pharmaceuticals, Inc. |
Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses
|
|
NZ717140A
(en)
|
2013-08-30 |
2022-05-27 |
Immunogen Inc |
Antibodies and assays for detection of folate receptor 1
|
|
EP3296408A1
(en)
|
2013-09-05 |
2018-03-21 |
The Jackson Laboratory |
Compositions for rna-chromatin interaction analysis and uses thereof
|
|
JP6463744B2
(ja)
|
2013-10-08 |
2019-02-06 |
イミュノジェン， インコーポレイテッド |
抗ｆｏｌｒ１免疫抱合体投薬レジメン
|
|
WO2015054659A1
(en)
|
2013-10-11 |
2015-04-16 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
CA2927022C
(en)
|
2013-10-11 |
2018-08-21 |
Asana Biosciences, Llc |
Protein-polymer-drug conjugates
|
|
CN103483357B
(zh)
*
|
2013-10-12 |
2015-11-18 |
齐鲁制药有限公司 |
一种抗体-美登素偶联物的中间体新晶型及其制备方法
|
|
CN105793268B
(zh)
*
|
2013-12-02 |
2019-03-15 |
香港浸会大学 |
具有两个稠合大环的抗癌性美登木素类化合物
|
|
KR102384740B1
(ko)
|
2013-12-27 |
2022-04-07 |
자임워크스 인코포레이티드 |
약물 접합체를 위한 설폰아마이드-함유 연결 시스템
|
|
CA2937561A1
(en)
*
|
2014-01-29 |
2015-08-06 |
Shanghai Hengrui Pharmaceutical Co., Ltd. |
Ligand-cytotoxic drug conjugate, preparation method thereof, and uses thereof
|
|
AU2015229591B2
(en)
|
2014-03-11 |
2020-10-22 |
Regeneron Pharmaceuticals, Inc. |
Anti-EGFRvlll antibodies and uses thereof
|
|
US10240195B2
(en)
*
|
2014-03-24 |
2019-03-26 |
The Trustees Of Columbia University In The City Of New York |
Chemical methods for producing tagged nucleotides
|
|
EP3517114A1
(en)
*
|
2014-04-29 |
2019-07-31 |
Genequantum Healthcare (Suzhou) Co., Ltd. |
New stable antibody-drug conjugate, preparation method and use thereof
|
|
CN110478495A
(zh)
|
2014-06-30 |
2019-11-22 |
塔弗达治疗有限公司 |
靶向缀合物及其颗粒和制剂
|
|
US10973920B2
(en)
|
2014-06-30 |
2021-04-13 |
Glykos Finland Oy |
Saccharide derivative of a toxic payload and antibody conjugates thereof
|
|
MA40539A
(fr)
|
2014-09-02 |
2016-03-10 |
Immunogen Inc |
Procédés de formulation de compositions de conjugués anticorps-médicaments
|
|
SG11201701565PA
(en)
*
|
2014-09-03 |
2017-03-30 |
Immunogen Inc |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
CR20170111A
(es)
|
2014-09-03 |
2017-05-23 |
Immunogen Inc |
Derivados de benzodiazepina citotóxicos
|
|
EP3189057A1
(en)
|
2014-09-03 |
2017-07-12 |
ImmunoGen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
ES2905569T3
(es)
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
CA2978340C
(en)
|
2015-03-27 |
2024-05-28 |
Regeneron Pharmaceuticals, Inc. |
Maytansinoid derivatives, conjugates thereof, and methods of use
|
|
BR112017023872A2
(pt)
|
2015-05-04 |
2018-07-24 |
Cytomx Therapeutics Inc |
anticorpos anti-cd166, anticorpos anti-cd166 ativáveis e métodos de uso dos mesmos
|
|
EP3308801A4
(en)
*
|
2015-06-09 |
2019-02-27 |
XDCExplorer (Shanghai) Co., Ltd. |
ANTIBODY-ACTIVE CONJUGATE, INTERMEDIATE PRODUCT, METHOD OF MANUFACTURE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
|
|
SI3313845T1
(sl)
|
2015-06-29 |
2021-01-29 |
Immunogen, Inc. |
Konjugati spremenjenih protiteles cisteina
|
|
CN113698335A
(zh)
*
|
2015-07-04 |
2021-11-26 |
杭州多禧生物科技有限公司 |
细胞结合分子的特异性偶联
|
|
JP6993958B2
(ja)
|
2015-07-06 |
2022-02-04 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
多重特異性抗原結合分子およびその使用
|
|
EP3778602B1
(en)
|
2015-07-21 |
2023-07-12 |
ImmunoGen, Inc. |
Methods of preparing cytotoxic benzodiazepine derivatives
|
|
WO2017025458A1
(en)
|
2015-08-07 |
2017-02-16 |
Gamamabs Pharma |
Antibodies, antibody drug conjugates and methods of use
|
|
CN122075735A
(zh)
|
2015-09-17 |
2026-05-26 |
伊缪诺金公司 |
包含抗folr1免疫缀合物的治疗组合
|
|
CN108473538B
(zh)
|
2015-10-28 |
2022-01-28 |
塔弗达治疗有限公司 |
Sstr靶向缀合物及其颗粒和制剂
|
|
SG11201803915UA
(en)
|
2015-11-10 |
2018-06-28 |
Childrens Research Institute Childrens National Medical Center |
Echinomycin formulation, method of making and method of use thereof
|
|
RS65120B1
(sr)
|
2015-11-25 |
2024-02-29 |
Immunogen Inc |
Farmaceutske formulacije i postupci za njihovu upotrebu
|
|
MA43416A
(fr)
|
2015-12-11 |
2018-10-17 |
Regeneron Pharma |
Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3
|
|
MX390630B
(es)
|
2016-01-25 |
2025-03-21 |
Regeneron Pharma |
Derivados de maitansinoide, conjugados de los mismos y metodos de uso.
|
|
MY199595A
(en)
*
|
2016-03-02 |
2023-11-08 |
Eisai R&D Man Co Ltd |
Eribulin-based antibody-drug conjugates and methods of use
|
|
CN109071419A
(zh)
*
|
2016-03-07 |
2018-12-21 |
韩美药品株式会社 |
聚乙二醇衍生物及其用途
|
|
WO2017190079A1
(en)
|
2016-04-28 |
2017-11-02 |
Regeneron Pharmaceuticals, Inc. |
Methods of making multispecific antigen-binding molecules
|
|
US10918627B2
(en)
|
2016-05-11 |
2021-02-16 |
Massachusetts Institute Of Technology |
Convergent and enantioselective total synthesis of Communesin analogs
|
|
RS61828B1
(sr)
|
2016-06-08 |
2021-06-30 |
Abbvie Inc |
Anti-b7-h3 antitela i antitelske konjugacije lekova
|
|
WO2018002902A1
(en)
|
2016-07-01 |
2018-01-04 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Antibody-drug conjugates and therapeutic methods using the same
|
|
RU2653443C2
(ru)
*
|
2016-07-15 |
2018-05-08 |
Закрытое Акционерное Общество "Биокад" |
Биспецифичные анти-her2/анти-her3 антитела
|
|
KR102531251B1
(ko)
|
2016-09-23 |
2023-05-15 |
리제너론 파아마슈티컬스, 인크. |
이특이적 항-muc16-cd3 항체 및 항-muc16 약물 접합체
|
|
KR102520731B1
(ko)
|
2016-09-23 |
2023-04-14 |
리제너론 파아마슈티컬스, 인크. |
항-steap2 항체, 항체-약물 컨쥬게이트, 및 steap2 및 cd3에 결합하는 이중특이적 항원-결합 분자, 및 이의 용도
|
|
CA3042428A1
(en)
|
2016-11-08 |
2018-05-17 |
Regeneron Pharmaceuticals, Inc. |
Steroids and protein-conjugates thereof
|
|
TWI782930B
(zh)
|
2016-11-16 |
2022-11-11 |
美商再生元醫藥公司 |
抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
|
|
EP3544983A2
(en)
|
2016-11-23 |
2019-10-02 |
Immunogen, Inc. |
Selective sulfonation of benzodiazepine derivatives
|
|
MX2019006131A
(es)
|
2016-11-29 |
2019-08-21 |
Regeneron Pharma |
Metodos para tratar cancer de mama positivo para prlr.
|
|
EP3554544A4
(en)
|
2016-12-16 |
2020-07-29 |
Bluefin Biomedicine, Inc. |
ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
|
|
MD3558391T2
(ro)
|
2016-12-23 |
2022-05-31 |
Immunogen Inc |
Imunoconjugate care țintesc ADAM9 și procedee de utilizare a acestora
|
|
TW201825515A
(zh)
|
2017-01-04 |
2018-07-16 |
美商伊繆諾金公司 |
Ｍｅｔ抗體以及其免疫結合物及用途
|
|
IL298414B2
(en)
|
2017-02-28 |
2024-12-01 |
Immunogen Inc |
Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
|
|
US12667557B2
(en)
|
2017-02-28 |
2026-06-30 |
Daiichi Sankyo Company, Limited |
Method for treating EGFR-TKI-resistant non-small cell lung cancer by administration of anti-HER3 antibody-drug conjugate
|
|
EP3381474A1
(en)
*
|
2017-03-27 |
2018-10-03 |
Alfasigma S.p.A. |
Histone deacetylase inhibitors-based antibody drug conjugates (adcs) and use in therapy
|
|
JP6990355B2
(ja)
*
|
2017-03-30 |
2022-01-12 |
日油株式会社 |
ヘテロ二官能性単分散ポリエチレングリコール及びそれを用いた複合体
|
|
WO2018195243A1
(en)
|
2017-04-20 |
2018-10-25 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives and conjugates thereof
|
|
US11932650B2
(en)
|
2017-05-11 |
2024-03-19 |
Massachusetts Institute Of Technology |
Potent agelastatin derivatives as modulators for cancer invasion and metastasis
|
|
EP3625209A1
(en)
|
2017-05-18 |
2020-03-25 |
Regeneron Pharmaceuticals, Inc. |
Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
|
|
KR20250008984A
(ko)
|
2017-05-18 |
2025-01-16 |
리제너론 파마슈티칼스 인코포레이티드 |
사이클로덱스트린 단백질 약물 접합체
|
|
AU2018281280B2
(en)
|
2017-06-07 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for internalizing enzymes
|
|
JP7359700B2
(ja)
*
|
2017-06-20 |
2023-10-11 |
ソレント・セラピューティクス・インコーポレイテッド |
Ｃｄ３８抗体薬物コンジュゲート
|
|
US10640508B2
(en)
|
2017-10-13 |
2020-05-05 |
Massachusetts Institute Of Technology |
Diazene directed modular synthesis of compounds with quaternary carbon centers
|
|
CA3247730A1
(en)
|
2017-11-07 |
2025-10-30 |
Regeneron Pharmaceuticals, Inc. |
Hydrophilic linkers for antibody drug conjugates
|
|
CN109771658B
(zh)
*
|
2017-11-14 |
2021-12-10 |
博瑞生物医药（苏州）股份有限公司 |
靶向多臂偶联物
|
|
WO2019133652A1
(en)
|
2017-12-28 |
2019-07-04 |
Immunogen, Inc. |
Benzodiazepine derivatives
|
|
MA50259A1
(fr)
|
2018-01-08 |
2021-07-29 |
Regeneron Pharma |
Stéroïdes et leurs conjugués-anticorps
|
|
AU2019206587A1
(en)
*
|
2018-01-12 |
2020-08-06 |
Immunogen, Inc. |
Methods for antibody drug conjugation, purification, and formulation
|
|
JP7328990B2
(ja)
|
2018-04-30 |
2023-08-17 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｈｅｒ２及び／またはａｐｌｐ２に結合する抗体及び二重特異性抗原結合分子、ならびにそれらのコンジュゲート及び使用
|
|
WO2019217591A1
(en)
|
2018-05-09 |
2019-11-14 |
Regeneron Pharmaceuticals, Inc. |
Anti-msr1 antibodies and methods of use thereof
|
|
EP3793591A1
(en)
|
2018-05-17 |
2021-03-24 |
Regeneron Pharmaceuticals, Inc. |
Anti-cd63 antibodies, conjugates, and uses thereof
|
|
MX2020013466A
(es)
|
2018-06-26 |
2021-04-19 |
Immunogen Inc |
Inmunoconjugados dirigidos a adam9 y métodos para usarlos.
|
|
WO2020014306A1
(en)
|
2018-07-10 |
2020-01-16 |
Immunogen, Inc. |
Met antibodies and immunoconjugates and uses thereof
|
|
WO2020059772A1
(ja)
|
2018-09-20 |
2020-03-26 |
第一三共株式会社 |
抗ｈｅｒ３抗体－薬物コンジュゲート投与によるｈｅｒ３変異がんの治療
|
|
CN109350748B
(zh)
*
|
2018-10-24 |
2021-06-11 |
沈阳药科大学 |
氧化还原双敏感键桥连小分子前药及其自组装纳米粒
|
|
TWI897855B
(zh)
|
2018-10-26 |
2025-09-21 |
美商免疫遺傳股份有限公司 |
Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
|
|
CA3120528A1
(en)
|
2018-11-20 |
2020-05-28 |
Regeneron Pharmaceuticals, Inc. |
Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists
|
|
WO2020132658A2
(en)
|
2018-12-21 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Tubulysins and protein-tubulysin conjugates
|
|
WO2020132483A1
(en)
|
2018-12-21 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Rifamycin analogs and antibody-drug conjugates thereof
|
|
JP2022517767A
(ja)
|
2019-01-08 |
2022-03-10 |
レゲネロン ファーマシューティカルス，インコーポレーテッド |
無痕跡型リンカー及びそのタンパク質－コンジュゲート
|
|
KR20210130755A
(ko)
|
2019-02-21 |
2021-11-01 |
리제너론 파마슈티칼스 인코포레이티드 |
항-met 항체 및 met에 결합하는 이중특이적 항원 결합 분자를 사용하여 안구암을 치료하는 방법
|
|
WO2020191344A1
(en)
|
2019-03-20 |
2020-09-24 |
The Regents Of The University Of California |
Claudin-6 bispecific antibodies
|
|
DK3941946T3
(da)
|
2019-03-20 |
2025-03-24 |
Univ California |
Claudin-6-antistoffer og lægemiddelkonjugater
|
|
US20230094471A1
(en)
|
2019-03-29 |
2023-03-30 |
Immunogen, Inc. |
Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases
|
|
RS64961B1
(sr)
|
2019-04-26 |
2024-01-31 |
Immunogen Inc |
Derivati kamptotecina
|
|
WO2020247054A1
(en)
|
2019-06-05 |
2020-12-10 |
Massachusetts Institute Of Technology |
Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
|
|
MX2022000449A
(es)
|
2019-07-10 |
2022-04-25 |
Cybrexa 2 Inc |
Conjugados peptídicos de citotoxinas como terapéuticos.
|
|
BR112022000297A2
(pt)
|
2019-07-10 |
2022-03-15 |
Cybrexa 3 Inc |
Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos
|
|
CN114340684B
(zh)
|
2019-09-16 |
2025-09-12 |
瑞泽恩制药公司 |
用于免疫pet成像的放射性标记的met结合蛋白
|
|
US11814428B2
(en)
|
2019-09-19 |
2023-11-14 |
Regeneron Pharmaceuticals, Inc. |
Anti-PTCRA antibody-drug conjugates and uses thereof
|
|
MX2022008901A
(es)
|
2020-01-24 |
2022-08-16 |
Regeneron Pharma |
Conjugados de proteinas-compuestos antivirales.
|
|
US12029736B2
(en)
|
2020-02-25 |
2024-07-09 |
Mediboston Limited |
Camptothecin derivatives and conjugates thereof
|
|
CA3166619A1
(en)
|
2020-02-28 |
2021-09-02 |
Julian Andreev |
Bispecific antigen binding molecules that bind her2, and methods of use thereof
|
|
MX2022012821A
(es)
|
2020-04-16 |
2022-11-07 |
Regeneron Pharma |
Metodos de conjugacion de diels-alder.
|
|
MX2022015769A
(es)
|
2020-06-24 |
2023-01-19 |
Regeneron Pharma |
Tubulisinas y conjugados de proteina-tubulisina.
|
|
WO2022010797A2
(en)
|
2020-07-07 |
2022-01-13 |
Bionecure Therapeutics, Inc. |
Novel maytansinoids as adc payloads and their use for the treatment of cancer
|
|
US12605459B2
(en)
|
2020-07-13 |
2026-04-21 |
Regeneron Pharmaceuticals, Inc. |
Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
|
|
BR112023000711A2
(pt)
|
2020-07-17 |
2023-01-31 |
Daiichi Sankyo Co Ltd |
Método para produzir uma composição de conjugado de anticorpo-fármaco, e, composição de conjugado de anticorpo-fármaco
|
|
JP2023542295A
(ja)
|
2020-09-14 |
2023-10-06 |
リジェネロン ファーマシューティカルズ，インク． |
Ｇｌｐ１ペプチド模倣薬を含む抗体薬物複合体及びその使用
|
|
US11866502B2
(en)
|
2020-10-22 |
2024-01-09 |
Regeneron Pharmaceuticals, Inc. |
Anti-FGFR2 antibodies and methods of use thereof
|
|
AR124681A1
(es)
|
2021-01-20 |
2023-04-26 |
Abbvie Inc |
Conjugados anticuerpo-fármaco anti-egfr
|
|
WO2022182415A1
(en)
|
2021-02-24 |
2022-09-01 |
Massachusetts Institute Of Technology |
Himastatin derivatives, and processes of preparation thereof, and uses thereof
|
|
US12521444B2
(en)
|
2021-02-25 |
2026-01-13 |
Fortvita Biologics Limited |
Anti-HER2 antibody-drug conjugates and uses thereof
|
|
JP7844499B2
(ja)
|
2021-03-08 |
2026-04-13 |
ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． |
抗体－免疫アゴニストコンジュゲート及びその使用
|
|
CN115197297B
(zh)
|
2021-04-14 |
2023-08-01 |
启德医药科技（苏州）有限公司 |
连接子、缀合物及其应用
|
|
KR20240038928A
(ko)
|
2021-07-28 |
2024-03-26 |
리제너론 파마슈티칼스 인코포레이티드 |
단백질-항바이러스 화합물 접합체
|
|
JP7878763B2
(ja)
*
|
2021-08-20 |
2026-06-23 |
プサン ナショナル ユニバーシティ インダストリー － ユニバーシティ コーポレイション ファンデーション |
オブジェクトが固定された膨潤性高分子の製造方法
|
|
US12377157B2
(en)
|
2021-12-15 |
2025-08-05 |
The Administrators Of The Tulane Educational Fund |
Conjugates, their compositions, and their related methods
|
|
WO2023129518A1
(en)
|
2021-12-29 |
2023-07-06 |
Regeneron Pharmaceuticals, Inc. |
Tubulysins and protein-tubulysin conjugates
|
|
MX2024008640A
(es)
|
2022-01-12 |
2024-07-24 |
Regeneron Pharma |
Analogos de camptotecina conjugados a un residuo de glutamina en una proteina y su uso.
|
|
MX2024008361A
(es)
|
2022-01-14 |
2024-09-10 |
Regeneron Pharma |
Derivados de verrucarina a y conjugados anticuerpo-fármaco de los mismos.
|
|
CA3243669A1
(en)
|
2022-03-11 |
2023-09-14 |
Regeneron Pharmaceuticals, Inc. |
ANTI-GLP1R ANTIBODY-DRUG CONJUGATES INCLUDING GLP1 PEPTIDOMIMETS AND THEIR USES
|
|
WO2024020164A2
(en)
|
2022-07-21 |
2024-01-25 |
Firefly Bio, Inc. |
Glucocorticoid receptor agonists and conjugates thereof
|
|
AU2023313117A1
(en)
|
2022-07-27 |
2025-02-13 |
Mediboston Limited |
Auristatin derivatives and conjugates thereof
|
|
EP4626553A2
(en)
|
2022-11-30 |
2025-10-08 |
Regeneron Pharmaceuticals, Inc. |
Tlr7 agonists and antibody-drug-conjugates thereof
|
|
WO2024138000A1
(en)
|
2022-12-21 |
2024-06-27 |
Regeneron Pharmaceuticals, Inc. |
Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
|
|
WO2024168199A1
(en)
|
2023-02-09 |
2024-08-15 |
Regeneron Pharmaceuticals, Inc. |
Antibody-drug conjugates via inverse electron demand diels-alder reactions
|
|
WO2024220628A1
(en)
*
|
2023-04-18 |
2024-10-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Target for combatting the foreign body response to implantable biomaterials
|
|
CN121039163A
(zh)
|
2023-05-02 |
2025-11-28 |
瑞泽恩制药公司 |
抗人m-钙粘蛋白（cdh15）抗体、缀合物及其用于将遗传有效负载递送至肌肉细胞的用途
|
|
JPWO2024248123A1
(enExample)
|
2023-06-02 |
2024-12-05 |
|
|
|
IL325400A
(en)
|
2023-07-10 |
2026-02-01 |
Regeneron Pharma |
Anti-human CACNG1 antibody-drug conjugates and their uses
|
|
WO2025094146A1
(en)
|
2023-11-02 |
2025-05-08 |
Immunogen Switzerland Gmbh |
Vasconstrictors for reducing ocular toxicity of antibody-maytansinoid conjugates
|
|
CN122295135A
(zh)
|
2023-11-03 |
2026-06-26 |
瑞泽恩制药公司 |
作为glp1r激动剂的肽酸及其抗体-药物缀合物
|
|
WO2025117727A1
(en)
|
2023-11-29 |
2025-06-05 |
Regeneron Pharmaceuticals, Inc. |
Analogs of quinoxaline/quinoline cytotoxins, linker- payloads, protein-drug conjugates, and uses thereof
|
|
CN118580194A
(zh)
*
|
2024-05-21 |
2024-09-03 |
南方科技大学 |
一种双功能分子探针的制备方法
|
|
US20260078179A1
(en)
|
2024-07-18 |
2026-03-19 |
Novarock Biotherapeutics, Ltd. |
Cdh17 antibodies and uses thereof
|
|
WO2026021443A1
(en)
|
2024-07-23 |
2026-01-29 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Antibody-drug conjugates targeting cdh3 and preparation methods and uses thereof
|
|
WO2026163182A1
(en)
*
|
2025-02-03 |
2026-08-06 |
Adienne Pharma & Biotech S.a. |
Cd26 antibody drug conjugates and methods of their use
|