JP2018523471A5 - - Google Patents

Download PDF

Info

Publication number
JP2018523471A5
JP2018523471A5 JP2018502006A JP2018502006A JP2018523471A5 JP 2018523471 A5 JP2018523471 A5 JP 2018523471A5 JP 2018502006 A JP2018502006 A JP 2018502006A JP 2018502006 A JP2018502006 A JP 2018502006A JP 2018523471 A5 JP2018523471 A5 JP 2018523471A5
Authority
JP
Japan
Prior art keywords
cysteine
antibody
substituted
cdr
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2018502006A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018523471A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/042645 external-priority patent/WO2017011803A1/en
Publication of JP2018523471A publication Critical patent/JP2018523471A/ja
Publication of JP2018523471A5 publication Critical patent/JP2018523471A5/ja
Withdrawn legal-status Critical Current

Links

JP2018502006A 2015-07-16 2016-07-15 システイン置換免疫グロブリン Withdrawn JP2018523471A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562193531P 2015-07-16 2015-07-16
US62/193,531 2015-07-16
PCT/US2016/042645 WO2017011803A1 (en) 2015-07-16 2016-07-15 Cysteine-substituted immunoglobulins

Publications (2)

Publication Number Publication Date
JP2018523471A JP2018523471A (ja) 2018-08-23
JP2018523471A5 true JP2018523471A5 (enExample) 2019-08-29

Family

ID=56550419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018502006A Withdrawn JP2018523471A (ja) 2015-07-16 2016-07-15 システイン置換免疫グロブリン

Country Status (8)

Country Link
US (1) US20180312592A1 (enExample)
EP (1) EP3322449A1 (enExample)
JP (1) JP2018523471A (enExample)
CN (1) CN108025092A (enExample)
AU (1) AU2016293606A1 (enExample)
CA (1) CA2992539A1 (enExample)
HK (1) HK1255234A1 (enExample)
WO (1) WO2017011803A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3004743A1 (en) * 2015-11-24 2017-06-01 Cellerant Therapeutics, Inc. Humanized anti-cll-1 antibodies
TWI852735B (zh) 2015-12-04 2024-08-11 美商思進公司 四級胺化妥布賴森(tubulysin)化合物之結合物
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
MX2018015755A (es) 2016-06-15 2019-08-29 Icahn School Med Mount Sinai Proteinas de hemaglutinina de virus de influenza y usos de las mismas.
MX2018015684A (es) 2016-06-17 2019-08-29 Magenta Therapeutics Inc Composiciones y metodos para el agotamiento de celulas cd117.
IL268058B2 (en) 2017-01-20 2023-09-01 Magenta Therapeutics Inc Compositions and methods for depleting cd137 plus cells
DK3579848T3 (da) 2017-02-08 2025-01-20 Dragonfly Therapeutics Inc Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft
KR20240060739A (ko) 2017-02-20 2024-05-08 드래곤플라이 쎄라퓨틱스, 인크. Her2, nkg2d 및 cd16에 결합하는 단백질
CA3058652A1 (en) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
EP3638699A1 (en) * 2017-06-16 2020-04-22 Eli Lilly and Company Engineered antibody compounds and conjugates thereof
CN108743968B (zh) * 2017-06-20 2022-04-19 成都百利多特生物药业有限责任公司 半胱氨酸改造的抗体-毒素偶联物(tdc)定点偶联位点筛选
SG11202007579TA (en) 2018-02-08 2020-09-29 Dragonfly Therapeutics Inc Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells
SG11202007482WA (en) 2018-02-08 2020-09-29 Dragonfly Therapeutics Inc Antibody variable domains targeting the nkg2d receptor
US12172986B2 (en) * 2018-06-01 2024-12-24 Eisai R&D Management Co., Ltd Splicing modulator antibody-drug conjugates and methods of use
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
EP3833385A4 (en) 2018-08-08 2021-12-22 Dragonfly Therapeutics, Inc. PROTEINS THAT BINDING NKG2D, CD16 AND A TUMOR-ASSOCIATED ANTIGEN
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
TW202021618A (zh) 2018-08-17 2020-06-16 美商23與我有限公司 抗il1rap抗體及其使用方法
CA3137160A1 (en) 2019-04-24 2020-10-29 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
AU2020368163A1 (en) * 2019-10-15 2022-04-28 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and FLT3
AR120222A1 (es) * 2019-10-15 2022-02-02 Dragonfly Therapeutics Inc Anticuerpos dirigidos a flt3 y uso de los mismos
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
WO2022187539A1 (en) 2021-03-03 2022-09-09 Dragonfly Therapeutics, Inc. Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen
AU2023298568A1 (en) 2022-06-30 2025-01-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
WO2025103355A1 (zh) * 2023-11-14 2025-05-22 信达生物制药(苏州)有限公司 抗egfr和her3双特异性抗体-药物偶联物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2099823T4 (da) * 2006-12-01 2022-05-09 Seagen Inc Målbindingsmiddelvarianter og anvendelser deraf
PT2437785E (pt) * 2009-06-04 2015-04-20 Novartis Ag Método de identificação de sítios para conjugação de igg
EP2533811A4 (en) * 2010-02-12 2013-12-25 Res Corp Technologies Inc MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS
US9163090B2 (en) * 2012-05-07 2015-10-20 Cellerant Therapeutics, Inc. Antibodies specific for CLL-1

Similar Documents

Publication Publication Date Title
US20230293536A1 (en) Anti-erbb2 antibody-drug conjugate and composition thereof, preparation method therefor, and application thereof
AU2019272250B2 (en) Anti-mesothelin antibody and antibody-drug conjugate thereof
US8568727B2 (en) Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
US20180312592A1 (en) Cysteine-substituted immunoglobulins
JP2024075771A (ja) 固形腫瘍を治療するためのチューブリン破壊剤を含む抗体薬物コンジュゲートの使用
JP2024517776A (ja) ネクチン-4を標的とする抗体薬物コンジュゲート並びにその調製方法及びその使用
RU2010148740A (ru) Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры)
CN107735093A (zh) Cd123抗体和其结合物
KR20220054700A (ko) 항-folr1 면역접합체 투약 섭생
JP7455188B2 (ja) コンジュゲーションのためのポリペプチド複合体及びその応用
US20250034273A1 (en) Composition of multispecific antibodies targeting cadherin-17-expressing tumors and method of making and using thereof
KR20200106987A (ko) 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도
CN113456829A (zh) 新型亲水连接体和其在配体-药物共轭偶联物上的应用
TWI897953B (zh) 包含抗ceacam5抗體接合物、三氟胸苷和替吡嘧啶的抗腫瘤組合
JP2023522392A (ja) 抗ceacam5抗体コンジュゲートおよびフォルフィリを含有する抗腫瘍組み合わせ
JP2023522393A (ja) 抗ceacam5抗体コンジュゲートおよびセツキシマブを含有する抗腫瘍組み合わせ
JP2023522395A (ja) 抗ceacam5抗体コンジュゲートおよびフォルフォックスを含有する抗腫瘍組み合わせ
WO2026060187A1 (en) Multispecific antibody-drug conjugates (adc) targeting cdh17-expressing tumors and method of making and using thereof
RU2835019C1 (ru) Противоопухолевые комбинации, включающие конъюгаты на основе антитела к ceacam5, трифлуридин и типирацил
WO2025194123A1 (en) Muc16/napi-2b antibodies and methods of use
CN121240889A (zh) 抗体药物缀合物
HK40044344A (en) Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor