JP2011519561A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011519561A5 JP2011519561A5 JP2011507667A JP2011507667A JP2011519561A5 JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5 JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- item
- naturally occurring
- microbial organism
- exogenous nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000039446 nucleic acids Human genes 0.000 claims description 219
- 108020004707 nucleic acids Proteins 0.000 claims description 219
- 150000007523 nucleic acids Chemical class 0.000 claims description 219
- 230000000813 microbial effect Effects 0.000 claims description 216
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 160
- 230000037361 pathway Effects 0.000 claims description 143
- 102000004190 Enzymes Human genes 0.000 claims description 121
- 108090000790 Enzymes Proteins 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 118
- 102000004867 Hydro-Lyases Human genes 0.000 claims description 68
- 108090001042 Hydro-Lyases Proteins 0.000 claims description 68
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 claims description 62
- DBXBTMSZEOQQDU-UHFFFAOYSA-N 3-hydroxyisobutyric acid Chemical compound OCC(C)C(O)=O DBXBTMSZEOQQDU-UHFFFAOYSA-N 0.000 claims description 50
- 229920001791 ((R)-3-Hydroxybutanoyl)(n-2) Polymers 0.000 claims description 40
- QHHKKMYHDBRONY-RMNRSTNRSA-N 3-hydroxybutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QHHKKMYHDBRONY-RMNRSTNRSA-N 0.000 claims description 40
- 102000003960 Ligases Human genes 0.000 claims description 34
- 108090000364 Ligases Proteins 0.000 claims description 34
- 102000004357 Transferases Human genes 0.000 claims description 34
- 108090000992 Transferases Proteins 0.000 claims description 34
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 25
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims description 25
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims description 25
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims description 25
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims description 25
- 244000005700 microbiome Species 0.000 claims description 25
- FFVUICCDNWZCRC-ZSJPKINUSA-N 2-hydroxyisobutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)(C)O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FFVUICCDNWZCRC-ZSJPKINUSA-N 0.000 claims description 24
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims description 24
- 102000004157 Hydrolases Human genes 0.000 claims description 22
- 108090000604 Hydrolases Proteins 0.000 claims description 22
- 102000019010 Methylmalonyl-CoA Mutase Human genes 0.000 claims description 21
- 108010051862 Methylmalonyl-CoA mutase Proteins 0.000 claims description 21
- 238000012258 culturing Methods 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 102000004316 Oxidoreductases Human genes 0.000 claims description 17
- 108090000854 Oxidoreductases Proteins 0.000 claims description 17
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims description 16
- 108010093991 Vinylacetyl-CoA Delta-isomerase Proteins 0.000 claims description 16
- 238000012239 gene modification Methods 0.000 claims description 16
- 230000005017 genetic modification Effects 0.000 claims description 16
- 235000013617 genetically modified food Nutrition 0.000 claims description 16
- 102000030503 Methylmalonyl-CoA epimerase Human genes 0.000 claims description 15
- MZFOKIKEPGUZEN-FBMOWMAESA-N methylmalonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MZFOKIKEPGUZEN-FBMOWMAESA-N 0.000 claims description 15
- 108091000124 methylmalonyl-CoA epimerase Proteins 0.000 claims description 15
- 108010077268 3-hydroxyisobutyryl-CoA hydrolase Proteins 0.000 claims description 12
- 102100034767 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Human genes 0.000 claims description 12
- QCHPKSFMDHPSNR-UHFFFAOYSA-N 3-aminoisobutyric acid Chemical compound NCC(C)C(O)=O QCHPKSFMDHPSNR-UHFFFAOYSA-N 0.000 claims description 11
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 11
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims description 11
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 101710088194 Dehydrogenase Proteins 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims description 8
- WWEOGFZEFHPUAM-MIZDRFBCSA-N 3-hydroxy-2-methylpropanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(CO)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WWEOGFZEFHPUAM-MIZDRFBCSA-N 0.000 claims description 8
- 108020003281 3-hydroxyisobutyrate dehydrogenase Proteins 0.000 claims description 8
- 102000006027 3-hydroxyisobutyrate dehydrogenase Human genes 0.000 claims description 8
- 102000009836 Aconitate hydratase Human genes 0.000 claims description 8
- 108010009924 Aconitate hydratase Proteins 0.000 claims description 8
- 102100034229 Citramalyl-CoA lyase, mitochondrial Human genes 0.000 claims description 8
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims description 8
- 102000006732 Citrate synthase Human genes 0.000 claims description 8
- 108020003285 Isocitrate lyase Proteins 0.000 claims description 8
- 108020004687 Malate Synthase Proteins 0.000 claims description 8
- 108010031852 Pyruvate Synthase Proteins 0.000 claims description 8
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 claims description 8
- VNAIXPVBNZGXNO-UHFFFAOYSA-N 3-amino-2-methylpropanoic acid azane Chemical compound N.NCC(C(=O)O)C VNAIXPVBNZGXNO-UHFFFAOYSA-N 0.000 claims description 7
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 7
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims description 7
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims description 7
- 108090000673 Ammonia-Lyases Proteins 0.000 claims description 7
- 102000004118 Ammonia-Lyases Human genes 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 102000003929 Transaminases Human genes 0.000 claims description 7
- 108090000340 Transaminases Proteins 0.000 claims description 7
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 6
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims description 6
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims description 6
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims description 6
- GXSDWXSYZHGBBO-RXMQYKEDSA-N (2r)-2-amino-2-hydroxypentanedioic acid Chemical compound OC(=O)[C@@](O)(N)CCC(O)=O GXSDWXSYZHGBBO-RXMQYKEDSA-N 0.000 claims description 4
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 4
- NPYQJIHHTGFBLN-UHFFFAOYSA-N 3-methylmalic acid Chemical compound OC(=O)C(C)C(O)C(O)=O NPYQJIHHTGFBLN-UHFFFAOYSA-N 0.000 claims description 4
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 4
- 108010065059 methylaspartate ammonia-lyase Proteins 0.000 claims description 4
- 108010009674 methylaspartate mutase Proteins 0.000 claims description 4
- 108010092060 Acetate kinase Proteins 0.000 claims description 3
- 108700016171 Aspartate ammonia-lyases Proteins 0.000 claims description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims description 3
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 3
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 3
- 102000006746 NADH Dehydrogenase Human genes 0.000 claims description 3
- 108010086428 NADH Dehydrogenase Proteins 0.000 claims description 3
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims description 3
- 108091000080 Phosphotransferase Proteins 0.000 claims description 3
- 102000001253 Protein Kinase Human genes 0.000 claims description 3
- 108010065064 acetaldehyde dehydrogenase (acylating) Proteins 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims description 3
- 102000020233 phosphotransferase Human genes 0.000 claims description 3
- -1 2-hydroxyisobutyryl Chemical group 0.000 claims description 2
- 108010014720 2-methylacyl-CoA dehydrogenase Proteins 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 2
- 102100021646 Isobutyryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 2
- 108010008386 malonyl-Coa reductase Proteins 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000010079 Coenzyme A-Transferases Human genes 0.000 claims 1
- 108010077385 Coenzyme A-Transferases Proteins 0.000 claims 1
- 108030005217 Isobutyryl-CoA mutases Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 108010085747 Methylmalonyl-CoA Decarboxylase Proteins 0.000 claims 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 108010067653 lactate dehydratase Proteins 0.000 claims 1
- 108010033041 valine aminotransferase Proteins 0.000 claims 1
- 239000001963 growth medium Substances 0.000 description 22
- 239000002609 medium Substances 0.000 description 6
- BWLBGMIXKSTLSX-UHFFFAOYSA-M 2-hydroxyisobutyrate Chemical compound CC(C)(O)C([O-])=O BWLBGMIXKSTLSX-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4973008P | 2008-05-01 | 2008-05-01 | |
| US61/049,730 | 2008-05-01 | ||
| PCT/US2009/042426 WO2009135074A2 (en) | 2008-05-01 | 2009-04-30 | Microorganisms for the production of methacrylic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Division JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011519561A JP2011519561A (ja) | 2011-07-14 |
| JP2011519561A5 true JP2011519561A5 (https=) | 2012-06-07 |
Family
ID=41255834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507667A Pending JP2011519561A (ja) | 2008-05-01 | 2009-04-30 | メタクリル酸の産生のための微生物 |
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US8241877B2 (https=) |
| EP (1) | EP2285973A4 (https=) |
| JP (2) | JP2011519561A (https=) |
| AU (1) | AU2009242615A1 (https=) |
| BR (1) | BRPI0911759A2 (https=) |
| CA (1) | CA2722680A1 (https=) |
| WO (1) | WO2009135074A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| WO2009135074A2 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| BRPI0913901A2 (pt) | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
| EP3514242A3 (en) | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Microrganisms for the production of 1,4-butanediol |
| WO2010057022A1 (en) * | 2008-11-14 | 2010-05-20 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| US9637746B2 (en) | 2008-12-15 | 2017-05-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| EP2373781A4 (en) | 2008-12-16 | 2012-10-10 | Genomatica Inc | MICRO-ORGANISMS AND METHODS OF CONVERTING SYNGAS AND OTHER CARBON RESOURCES IN USEFUL PRODUCTS |
| CN105132387A (zh) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | 用于制造化合物的组合物和方法 |
| WO2010098865A1 (en) * | 2009-02-26 | 2010-09-02 | Gt Life Sciences, Inc. | Mammalian cell line models and related methods |
| LT2438036T (lt) | 2009-06-04 | 2017-06-26 | Genomatica, Inc. | Fermentacijos sultinio komponentų išskyrimo būdas |
| WO2010141920A2 (en) | 2009-06-04 | 2010-12-09 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol and related methods |
| EP2440669A4 (en) | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
| KR20120083908A (ko) | 2009-10-13 | 2012-07-26 | 게노마티카 인코포레이티드 | 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-ｃｏａ, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법 |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| KR20120120493A (ko) | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| CA2797409C (en) | 2010-05-05 | 2019-12-24 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| EP2566953B1 (en) | 2010-05-07 | 2019-01-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
| EP2611922A1 (en) | 2010-08-31 | 2013-07-10 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
| BR112013025226A2 (pt) | 2011-04-01 | 2018-09-11 | Genomatica Inc | micro-organismos para produzir ácido metacrílico e ésteres de metacrilato e métodos relacionados a eles |
| US20120330560A1 (en) * | 2011-06-23 | 2012-12-27 | Ramot At Tel-Aviv University Ltd. | Method and system for predicting pertubations altering metabolic states |
| RS54444B1 (sr) | 2011-07-12 | 2016-06-30 | Scientist Of Fortune S.A. | Rekombinantni mikroorganizmi za proizvodnju korisnih metabolita |
| ES2599482T3 (es) | 2011-07-29 | 2017-02-01 | Mitsui Chemicals, Inc. | Microorganismo que tiene un ciclo de fijación de dióxido de carbono introducido en el mismo |
| CN104093848A (zh) | 2011-09-09 | 2014-10-08 | 绿光生物科学公司 | 碳青霉烯(carbapenem)的无细胞制备 |
| MY171760A (en) | 2011-11-02 | 2019-10-28 | Genomatica Inc | Microorganisms and methods for the production of caprolactone |
| DE102012207921A1 (de) | 2012-05-11 | 2013-11-14 | Evonik Industries Ag | Mehrstufiges Syntheseverfahren mit Synthesegas |
| WO2013173711A1 (en) | 2012-05-18 | 2013-11-21 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| SI2855687T1 (sl) | 2012-06-04 | 2020-09-30 | Genomatica, Inc. | Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine |
| EP2674489A1 (en) * | 2012-06-15 | 2013-12-18 | Evonik Industries AG | Biotechnological 2-hydroxyisobutyric acid production |
| ES2689477T3 (es) | 2012-09-10 | 2018-11-14 | Mitsubishi Chemical Corporation | Método para producir éster del ácido metacrílico |
| BR112015004355A8 (pt) | 2012-09-10 | 2018-01-02 | Mitsubishi Rayon Co | Método para produção de ácido metacrílico e/ou éster do mesmo |
| CN104619721A (zh) | 2012-09-27 | 2015-05-13 | 诺维信股份有限公司 | 具有改进的转化效率的细菌突变体 |
| HK1216547A1 (zh) | 2012-12-21 | 2016-11-18 | Greenlight Biosciences Inc. | 用於將甲烷轉化成燃料、丙酮酸或異丁醇的無細胞系統 |
| BE1021047B1 (fr) * | 2013-01-18 | 2015-02-25 | Man To Tree S.A. | Actinobacillus succinogenes genetiquement modifiee et son utilisation pour la production d'acide succinique |
| US9828618B2 (en) | 2013-01-24 | 2017-11-28 | Mitsui Chemicals, Inc. | Microorganism having carbon dioxide fixation cycle introduced thereinto |
| WO2014152665A1 (en) | 2013-03-15 | 2014-09-25 | Genomatica, Inc. | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
| JP2016165225A (ja) | 2013-07-09 | 2016-09-15 | 味の素株式会社 | 有用物質の製造方法 |
| KR101812426B1 (ko) | 2013-08-01 | 2017-12-26 | 미쯔비시 케미컬 주식회사 | 메타크릴릴-CoA의 제조법 |
| AU2014306074B2 (en) | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| JP6202772B2 (ja) | 2013-08-26 | 2017-09-27 | スティヒティング ディーンスト ランドバウクンディフ オンデルズーク | メタクリル酸の生成のためのプロセス |
| WO2015084633A1 (en) | 2013-12-03 | 2015-06-11 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| WO2015100338A2 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| BR112016017426A2 (pt) * | 2014-01-28 | 2017-10-17 | Lanzatech New Zealand Ltd | bactéria, e, método para produzir um produto |
| JP6296512B2 (ja) | 2014-03-07 | 2018-03-20 | 公立大学法人 富山県立大学 | メタクリル酸エステルの製造方法および新規メタクリル酸エステル合成酵素 |
| WO2016044713A1 (en) | 2014-09-18 | 2016-03-24 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| WO2016130597A1 (en) * | 2015-02-10 | 2016-08-18 | GeneSys Consulting, LLC | Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same |
| BR112017020690A2 (pt) | 2015-03-30 | 2018-06-26 | Greenlight Biosciences Inc | produção livre de células de ácido ribonucleico |
| DE102016212497B4 (de) | 2015-07-13 | 2024-04-25 | Sk Innovation Co., Ltd. | Mutanter Mikroorganismus, der ein Gen umfasst, das Methylmalonyl-CoA-Reductase codiert, und seine Verwendung |
| AU2016340470B2 (en) * | 2015-10-23 | 2019-10-03 | Mitsubishi Chemical Corporation | Biological production of methyl methacrylate |
| US11441128B2 (en) | 2015-10-30 | 2022-09-13 | Genomatica, Inc. | Methanol dehydrogenase fusion proteins |
| CA3020312A1 (en) | 2016-04-06 | 2017-10-12 | Greenlight Biosciences, Inc. | Cell-free production of ribonucleic acid |
| EP3565892A4 (en) | 2017-01-06 | 2020-10-07 | Greenlight Biosciences, Inc. | Cell-free production of sugars |
| KR102894284B1 (ko) | 2017-10-11 | 2025-12-03 | 그린라이트 바이오사이언시스, 아이엔씨. | 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물 |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| EP3746559A4 (en) | 2018-02-01 | 2021-12-22 | INVISTA Textiles (U.K.) Limited | METHODS AND MATERIALS FOR THE BIOSYNTHESIS OF BETA HYDROXY FATTY ACID ANIONS AND / OR DERIVATIVES THEREOF AND / OR COMPOUNDS ASSOCIATED WITH THEM |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| JP2023548979A (ja) * | 2020-11-10 | 2023-11-21 | インダストリアル マイクロブス， インコーポレイテッド | 供給原料からポリ（ｈｉｂａ）を産生可能な微生物 |
| US20250197895A1 (en) * | 2022-03-29 | 2025-06-19 | Riken | Method for producing methacrylic acid |
| CN115851799B (zh) * | 2022-12-15 | 2025-01-28 | 南京纽邦生物科技有限公司 | L-3-氨基异丁酸生产菌株、其构建方法及其用途 |
| CN121065059B (zh) * | 2025-11-08 | 2026-04-21 | 中国农业科学院北京畜牧兽医研究所 | 一种通过辅酶a转移酶途径提高丁酸合成的丁酸梭菌工程菌株及其构建方法和应用 |
Family Cites Families (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| GB1230276A (https=) | 1968-12-09 | 1971-04-28 | ||
| US3965182A (en) | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (https=) | 1970-09-04 | 1973-09-26 | ||
| GB1344557A (en) | 1972-06-23 | 1974-01-23 | Mitsubishi Petrochemical Co | Process for preparing 1,4-butanediol |
| JPS5543759B2 (https=) | 1972-06-28 | 1980-11-07 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| DE2501499A1 (de) | 1975-01-16 | 1976-07-22 | Hoechst Ag | Verfahren zur herstellung von butandiol-(1.4) |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| IT1190783B (it) | 1981-04-29 | 1988-02-24 | Davy Mckee Oil & Chem | Processo per l'idrogenolisi di esteri di acidi carbossilici |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| DE3783081T2 (de) | 1986-06-11 | 1993-04-15 | Michigan Biotech Inst | Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation. |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5182199A (en) | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| EP0633319B1 (en) | 1988-04-27 | 1999-03-17 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| EP0470172B1 (en) | 1989-04-27 | 1995-06-28 | BioControl Systems, Incorporated | Precipitate test for microorganisms |
| US5192673A (en) | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| EP0769557B1 (en) | 1990-10-15 | 2000-11-15 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| JP2000506012A (ja) | 1996-02-27 | 2000-05-23 | ミシガン ステイト ユニヴァーシティー | サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け |
| US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| KR100387301B1 (ko) | 1996-07-01 | 2003-06-12 | 바이오 엔지니어링 리소스 인코포레이티드 | 폐가스로부터의 생성물의 생물학적 제조방법 |
| KR100459818B1 (ko) | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| WO1998036078A1 (en) | 1997-02-13 | 1998-08-20 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| US20010045575A1 (en) * | 1998-05-01 | 2001-11-29 | Mark Ashby | Device and method for facilitating hemostasis of a biopsy tract |
| DE19820652A1 (de) | 1998-05-08 | 1999-11-11 | Basf Ag | Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| US6187569B1 (en) | 1998-07-02 | 2001-02-13 | E. I. Du Pont De Nemours And Company | Microbial production of terephthalic acid and isophthalic acid |
| EP1097222A1 (en) | 1998-07-15 | 2001-05-09 | E.I. Du Pont De Nemours And Company | Tetrahydrofolate metabolism enzymes |
| DE19856136C2 (de) | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| AU3482200A (en) | 1999-02-02 | 2000-08-25 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| AU3516100A (en) | 1999-03-05 | 2000-09-21 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| WO2000071738A1 (en) | 1999-05-21 | 2000-11-30 | Cargill Dow Llc | Methods and materials for the synthesis of organic products |
| BR0008355A (pt) | 1999-08-30 | 2002-07-16 | Wisconsin Alumni Res Found | Produção de ácido 3-hidroxipropionico em organismos recombinantes |
| US6852517B1 (en) | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| WO2002008438A2 (en) | 2000-07-25 | 2002-01-31 | Bioengineering Resources, Inc. | Methods for increasing the production of ethanol from microbial fermentation |
| BR0115877A (pt) | 2000-11-20 | 2003-10-07 | Cargill Inc | ácido 3-hidroxipropiÈnico e outros compostos orgánicos |
| BR0115558A (pt) | 2000-11-22 | 2004-08-17 | Cargill Dow Polymers Llc | ácido nucleico isolado, construção de expressão recombinante, célula de levedura transformada com a construção de expressão recombinante, e, método para produzir ácido lático |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| EP1354955A4 (en) | 2000-12-28 | 2005-01-05 | Toyota Motor Co Ltd | PROCESS FOR PREPARING PRENYL ALCOHOL |
| JP4776146B2 (ja) | 2001-01-10 | 2011-09-21 | ザ・ペン・ステート・リサーチ・ファンデーション | 細胞代謝をモデル化する方法及びシステム |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| JP2004533037A (ja) | 2001-03-01 | 2004-10-28 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 調節された反応ネットワークの全体的特性を決定するためのモデルおよび方法 |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ATE393137T1 (de) | 2001-05-07 | 2008-05-15 | Cargill Inc | Verfahren zur herstellung von carbonsäuren und deren derivaten |
| JP4630486B2 (ja) | 2001-05-28 | 2011-02-09 | ダイセル化学工業株式会社 | 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| CA2356540A1 (en) | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| CA2466133A1 (en) | 2001-11-02 | 2003-05-15 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| DE60327804D1 (de) | 2002-01-18 | 2009-07-09 | Novozymes As | Alanin-2,3-aminomutase |
| US6582943B1 (en) * | 2002-02-05 | 2003-06-24 | E. I. Du Pont De Nemours And Company | Method for producing 2-hydroxyisobutyric acid and methacrylic acid from acetone cyanohydrin |
| EP1473368A4 (en) | 2002-02-06 | 2006-01-25 | Showa Denko Kk | REDUCTASE GENE OF ALPHA SUBSTITUTED ALPHA, BETA-UNSATURATED CARBONYL COMPOUND |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| AU2003222128A1 (en) | 2002-03-29 | 2003-10-13 | Genomatica, Inc. | Human metabolic models and methods |
| EP1510583A1 (en) | 2002-05-10 | 2005-03-02 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| JP4418793B2 (ja) | 2002-07-10 | 2010-02-24 | ザ ペン ステート リサーチ ファウンデーション | 遺伝子ノックアウト戦略を決定する方法 |
| US7413878B2 (en) | 2002-07-15 | 2008-08-19 | Kosan Biosciences, Inc. | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit |
| WO2004033646A2 (en) | 2002-10-04 | 2004-04-22 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| WO2004035009A2 (en) | 2002-10-15 | 2004-04-29 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| WO2004044210A2 (en) | 2002-11-06 | 2004-05-27 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| CA2512815A1 (en) | 2003-01-13 | 2004-07-29 | Cargill, Incorporated | Method for making industrial chemicals |
| JP4275666B2 (ja) | 2003-02-24 | 2009-06-10 | 財団法人地球環境産業技術研究機構 | 微生物による高効率水素製造方法 |
| RU2268300C2 (ru) | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| DE602004026192D1 (de) | 2003-07-29 | 2010-05-06 | Res Inst Innovative Tech Earth | Transformanten eines coryneformen bakteriums und deren verwendung in verfahren zur produktion von dicarbonsäure |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| CN1852978A (zh) | 2003-09-17 | 2006-10-25 | 三菱化学株式会社 | 制备无－氨基有机酸的方法 |
| EP1664286A1 (en) | 2003-09-18 | 2006-06-07 | Ciba SC Holding AG | Alcohol dehydrogenases with increased solvent and temperature stability |
| FR2862068B1 (fr) | 2003-11-06 | 2007-10-12 | Metabolic Explorer Sa | Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph |
| US7244610B2 (en) | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| EP2194139A1 (en) | 2004-01-19 | 2010-06-09 | DSM IP Assets B.V. | Biochemical synthesis of 6 amino caproic acid |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| WO2006020663A2 (en) | 2004-08-09 | 2006-02-23 | Rice University | Aerobic succinate production in bacteria |
| KR101245428B1 (ko) | 2004-08-27 | 2013-03-19 | 라이스 유니버시티 | 숙신산 생산이 증가된 돌연변이 대장균 균주 |
| EP2434015B1 (en) | 2004-09-09 | 2013-11-20 | Research Institute Of Innovative Technology For The Earth | DNA fragment having promoter function |
| CN101023178A (zh) | 2004-09-17 | 2007-08-22 | 莱斯大学 | 高琥珀酸产出细菌 |
| WO2006069174A2 (en) | 2004-12-22 | 2006-06-29 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| EP1874334A4 (en) | 2005-04-15 | 2011-03-30 | Vascular Biogenics Ltd | COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES |
| WO2007001982A1 (en) | 2005-06-20 | 2007-01-04 | Archer-Daniels-Midland Company | Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals |
| KR100679638B1 (ko) | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100676160B1 (ko) | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| CN101300356A (zh) | 2005-09-09 | 2008-11-05 | 基因组股份公司 | 用于琥珀酸盐之生长关联性生产的方法和生物 |
| DE602006015208D1 (de) | 2005-09-19 | 2010-08-12 | Basf Se | Biokatalytische herstellung von (meth-)acrylsäureestern |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| MX359740B (es) | 2005-10-26 | 2018-10-09 | Du Pont | Produccion fermentativa de alcoholes de cuatro atomos de carbono. |
| US20080274526A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of isobutanol |
| DE102006017760A1 (de) | 2006-03-24 | 2007-09-27 | Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh | Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren |
| NZ600540A (en) | 2006-05-01 | 2013-12-20 | Univ Florida | Ethanol production in non-recombinant hosts |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| DE102006025821A1 (de) * | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| RU2311231C1 (ru) | 2006-08-15 | 2007-11-27 | ООО "Объединенный центр исследований и разработок" | Катализатор для получения эфиров акриловой кислоты по реакции метатезиса диалкилмалеатов (варианты) и каталитическая композиция на его основе |
| US8030045B2 (en) | 2006-08-30 | 2011-10-04 | Cargill, Incorporated | Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| BRPI0720566A2 (pt) | 2006-12-21 | 2014-02-04 | Gevo Inc | Produção de butanol através de levedura metabolicamente projetada |
| CA2675026A1 (en) | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| BRPI0823327A2 (pt) | 2007-03-16 | 2013-10-22 | Genomatica Inc | Biocatalisadores microbianos que não ocorrem naturalmente e métodos para a biosíntese de ácido 4-hidroxibutanóico e 1,4-butanodiol |
| DE102007015583A1 (de) | 2007-03-29 | 2008-10-02 | Albert-Ludwigs-Universität Freiburg | Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung |
| US20080293125A1 (en) | 2007-04-18 | 2008-11-27 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| EP2134849B1 (en) | 2007-04-18 | 2013-07-10 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US8426174B2 (en) | 2007-05-02 | 2013-04-23 | Butamax(Tm) Advanced Biofuels Llc | Method for the production of 2-butanol |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| CN101679187B (zh) * | 2007-06-01 | 2013-06-05 | 赢创罗姆有限责任公司 | 用于制备甲基丙烯酸或甲基丙烯酸酯的方法 |
| CN101849017A (zh) | 2007-06-15 | 2010-09-29 | 赢创德固赛有限责任公司 | 具有下调的维生素b12系统的微生物 |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| EP2171075A2 (en) | 2007-07-23 | 2010-04-07 | DSM IP Assets B.V. | Butanol production in a eukaryotic cell |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| BRPI0817545A2 (pt) | 2007-10-12 | 2014-11-25 | Univ California | Microorganismo recombinante, métodos para produzir um microorganismo recombinante e para produzir isopropanol, vetor recombinante, e, célula hospedeira recombinante. |
| WO2009085278A1 (en) | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| WO2009103026A1 (en) | 2008-02-15 | 2009-08-20 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| US20090246842A1 (en) | 2008-02-15 | 2009-10-01 | Gevo, Inc. | Engineered microorganisms for producing propanol |
| EP2285948B1 (en) | 2008-03-03 | 2014-01-08 | Joule Unlimited Technologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| ES2656790T3 (es) | 2008-03-27 | 2018-02-28 | Genomatica, Inc. | Microorganismos para la producción de ácido adípico y otros compuestos |
| JP5395063B2 (ja) | 2008-04-25 | 2014-01-22 | 公益財団法人地球環境産業技術研究機構 | イソプロパノール生産能を有するコリネ型細菌の形質転換体 |
| WO2009135074A2 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| BRPI0913901A2 (pt) | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
| WO2010022763A1 (en) | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| US8344188B2 (en) | 2008-10-16 | 2013-01-01 | Maverick Biofuels, Inc. | Methods and apparatus for synthesis of alcohols from syngas |
| EP3260532A1 (en) | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| US20100191224A1 (en) | 2008-12-15 | 2010-07-29 | C.R. Bard, Inc. | Magnetic detent mechanism for medical instruments |
| EP2373781A4 (en) | 2008-12-16 | 2012-10-10 | Genomatica Inc | MICRO-ORGANISMS AND METHODS OF CONVERTING SYNGAS AND OTHER CARBON RESOURCES IN USEFUL PRODUCTS |
| WO2010141920A2 (en) | 2009-06-04 | 2010-12-09 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol and related methods |
| KR20120120493A (ko) | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
-
2009
- 2009-04-30 WO PCT/US2009/042426 patent/WO2009135074A2/en not_active Ceased
- 2009-04-30 EP EP09739876A patent/EP2285973A4/en not_active Ceased
- 2009-04-30 CA CA2722680A patent/CA2722680A1/en not_active Abandoned
- 2009-04-30 AU AU2009242615A patent/AU2009242615A1/en not_active Abandoned
- 2009-04-30 BR BRPI0911759A patent/BRPI0911759A2/pt not_active IP Right Cessation
- 2009-04-30 US US12/433,829 patent/US8241877B2/en not_active Expired - Fee Related
- 2009-04-30 JP JP2011507667A patent/JP2011519561A/ja active Pending
-
2012
- 2012-06-22 US US13/531,377 patent/US8900837B2/en active Active
- 2012-07-10 US US13/545,880 patent/US8865439B2/en active Active
-
2014
- 2014-05-27 JP JP2014108853A patent/JP2014147400A/ja active Pending
- 2014-12-01 US US14/557,188 patent/US9951355B2/en active Active
-
2018
- 2018-04-23 US US15/960,252 patent/US20190376096A1/en not_active Abandoned
-
2020
- 2020-08-19 US US16/997,704 patent/US20210040511A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011519561A5 (https=) | ||
| KR101631719B1 (ko) | 유효한 숙시네이트 및 말레이트 제조를 위한 물질 및 방법 | |
| RU2013148813A (ru) | Микроорганизмы для получения метакриловой кислоты и сложные эфиры метакриловой кислоты и относящиеся к ним способы | |
| TWI573869B (zh) | 導入有二氧化碳固定循環之微生物 | |
| JP6359037B2 (ja) | Ｌ−バリン産生能が向上した菌株及びこれを用いたｌ−バリンの産生方法 | |
| JP2012501678A5 (https=) | ||
| JP2013504326A5 (https=) | ||
| JP2013507145A5 (https=) | ||
| JP2014526262A5 (https=) | ||
| US10246726B2 (en) | Photosynthetic production of 3-hydroxybutyrate from carbon dioxide | |
| US10385328B2 (en) | Carbon dioxide fixation via bypassing feedback regulation | |
| Chang et al. | Engineering efficient production of itaconic acid from diverse substrates in Escherichia coli | |
| CN104718292B (zh) | 导入了二氧化碳固定循环的微生物 | |
| JP2016165225A (ja) | 有用物質の製造方法 | |
| CN105431520A (zh) | 利用表达昆虫天冬氨酸1-脱羧酶的重组酵母的3-羟基丙酸生产 | |
| WO2021081185A1 (en) | Microorganisms and methods for increasing co-factors | |
| JP2023541809A (ja) | 一炭素基質での合成的増殖 | |
| WO2012147903A1 (ja) | 乳酸生産酵母変異株および乳酸の製造方法 | |
| WO2014016328A1 (en) | Genetically engineered micro-organisms for production of fatty acids | |
| KR101985021B1 (ko) | 헥산올 생산을 위한 재조합 미생물 및 이를 이용한 헥산올 제조방법 | |
| JP6816970B2 (ja) | 多価不飽和脂肪酸ポリケチドシンターゼ及びその利用 | |
| KR101974221B1 (ko) | 유기산 생산을 위한 재조합 미생물 및 이를 이용한 유기산 제조방법 | |
| JP2005102625A (ja) | Ｄ−乳酸製造法 | |
| Fei et al. | Advanced fermentation strategies to enhance lipid production from lignocellulosic biomass | |
| Wang et al. | Engineering thioesterase as a driving force for novel itaconate production via its degradation scheme |