JP2011518564A5 - - Google Patents
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- JP2011518564A5 JP2011518564A5 JP2011506460A JP2011506460A JP2011518564A5 JP 2011518564 A5 JP2011518564 A5 JP 2011518564A5 JP 2011506460 A JP2011506460 A JP 2011506460A JP 2011506460 A JP2011506460 A JP 2011506460A JP 2011518564 A5 JP2011518564 A5 JP 2011518564A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- polypeptide
- amino acid
- isoprene
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 10
- 230000037361 pathway Effects 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 8
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 5
- 108010075483 isoprene synthase Proteins 0.000 claims 5
- 102220606412 Contactin-5_L70R_mutation Human genes 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102200081495 rs1341175303 Human genes 0.000 claims 2
- 102200068287 rs281875291 Human genes 0.000 claims 2
- 102220028560 rs370169077 Human genes 0.000 claims 2
- 102200102378 rs387906638 Human genes 0.000 claims 2
- 102220147269 rs529420082 Human genes 0.000 claims 2
- 102200110711 rs587777733 Human genes 0.000 claims 2
- 102220046369 rs587782872 Human genes 0.000 claims 2
- 102220278125 rs746681057 Human genes 0.000 claims 2
- 102220169675 rs750125257 Human genes 0.000 claims 2
- 102220097243 rs876659111 Human genes 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 239000002028 Biomass Substances 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N Isopentenyl diphosphate Natural products CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 241000157935 Promicromonospora citrea Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241000223259 Trichoderma Species 0.000 claims 1
- 241000499912 Trichoderma reesei Species 0.000 claims 1
- 241000235013 Yarrowia Species 0.000 claims 1
- 241000235015 Yarrowia lipolytica Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 102220354962 c.208C>G Human genes 0.000 claims 1
- 229940041514 candida albicans extract Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940120503 dihydroxyacetone Drugs 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229960001031 glucose Drugs 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 102200056122 rs11570605 Human genes 0.000 claims 1
- 102220044222 rs587781255 Human genes 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 239000012138 yeast extract Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12533608P | 2008-04-23 | 2008-04-23 | |
| US61/125,336 | 2008-04-23 | ||
| PCT/US2009/041581 WO2009132220A2 (en) | 2008-04-23 | 2009-04-23 | Isoprene synthase variants for improved microbial production of isoprene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085377A Division JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011518564A JP2011518564A (ja) | 2011-06-30 |
| JP2011518564A5 true JP2011518564A5 (enExample) | 2013-09-12 |
Family
ID=40810540
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506460A Pending JP2011518564A (ja) | 2008-04-23 | 2009-04-23 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| JP2014085377A Pending JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085377A Pending JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8173410B2 (enExample) |
| EP (1) | EP2279251A2 (enExample) |
| JP (2) | JP2011518564A (enExample) |
| KR (1) | KR20110020234A (enExample) |
| CN (1) | CN102171335A (enExample) |
| AU (1) | AU2009240505B2 (enExample) |
| BR (1) | BRPI0911667A2 (enExample) |
| CA (1) | CA2722440A1 (enExample) |
| MX (1) | MX2010011706A (enExample) |
| MY (1) | MY153871A (enExample) |
| RU (2) | RU2516343C2 (enExample) |
| SG (2) | SG192545A1 (enExample) |
| WO (1) | WO2009132220A2 (enExample) |
| ZA (2) | ZA201007564B (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153903A2 (en) * | 2007-06-08 | 2008-12-18 | Danisco Us, Inc., Genencor Division | Heterologous and homologous cellulase expression system |
| EP3354740A1 (en) | 2007-12-13 | 2018-08-01 | Danisco US Inc. | Compositions and methods for producing isoprene |
| WO2009132220A2 (en) | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| US8420759B2 (en) * | 2008-06-30 | 2013-04-16 | The Goodyear Tire & Rubber Company | Polymers of isoprene from renewable resources |
| SG169640A1 (en) * | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Increased isoprene production using mevalonate kinase and isoprene synthase |
| EP2334788A1 (en) | 2008-09-15 | 2011-06-22 | Danisco US Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| SG169652A1 (en) * | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MX312376B (es) * | 2009-04-02 | 2013-08-15 | Amyris Inc | Metodos de estabilización e hidrogenacion de olefinas de origen microbiano. |
| US8518686B2 (en) | 2009-04-23 | 2013-08-27 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TW201120213A (en) | 2009-06-17 | 2011-06-16 | Danisco Us Inc | Polymerization of isoprene from renewable resources |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| US20110039323A1 (en) * | 2009-08-14 | 2011-02-17 | Eric Lawrence Singsaas | Isoprene Production |
| JP5855576B2 (ja) * | 2009-12-22 | 2016-02-09 | ダニスコ・ユーエス・インク | イソプレンガスの生成量を増大させるための膜バイオリアクター |
| CN102906268A (zh) | 2009-12-23 | 2013-01-30 | 丹尼斯科美国公司 | 用6-磷酸葡萄糖酸内酯酶(pgl)来增加异戊二烯及其他产物的产量的组合物和方法 |
| JP5911847B2 (ja) * | 2010-05-05 | 2016-04-27 | ジェノマティカ， インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| US20130158106A1 (en) * | 2010-06-02 | 2013-06-20 | The United States Of America As Represented By The Department Of Veteran Affairs | Tocopherol derivatives and methods of use |
| WO2011160081A1 (en) | 2010-06-17 | 2011-12-22 | Danisco Us Inc. | Fuel compositions comprising isoprene derivatives |
| CA2807558A1 (en) | 2010-08-06 | 2012-02-09 | Danisco Us Inc. | Production of isoprene under neutral ph conditions |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| SG191235A1 (en) | 2010-12-22 | 2013-07-31 | Danisco Us Inc | Compositions and methods for improved isoprene production using two types of ispg enzymes |
| WO2012088450A1 (en) | 2010-12-22 | 2012-06-28 | Danisco Us Inc. | Biological production of pentose sugars using recombinant cells |
| CA2826554C (en) | 2011-02-02 | 2015-03-31 | Amyris, Inc. | Methods of developing terpene synthase variants |
| WO2012106516A1 (en) | 2011-02-02 | 2012-08-09 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| CA2834379A1 (en) | 2011-04-29 | 2012-11-01 | The Goodyear Tire & Rubber Company | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
| ES2699747T3 (es) | 2011-04-29 | 2019-02-12 | Danisco Us Inc | Microorganismos recombinantes para la producción potenciada de mevalonato, isopreno e isoprenoides |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| WO2013016591A1 (en) * | 2011-07-26 | 2013-01-31 | Zuvachem, Inc. | High efficiency isoprene synthases produced by protein engineering |
| EP2739658A1 (en) | 2011-08-04 | 2014-06-11 | Danisco US Inc. | Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase |
| HK1198837A1 (en) | 2011-08-05 | 2015-06-12 | Danisco Us Inc. | Production of isoprenoids under neutral ph conditions |
| EP2756082A4 (en) | 2011-09-16 | 2015-10-28 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PREPARATION OF ALKENES |
| EP3339426B1 (en) | 2011-10-07 | 2022-08-24 | Danisco US Inc. | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| HK1201554A1 (en) * | 2011-10-27 | 2015-09-04 | Danisco Us Inc. | Isoprene synthase variants with improved solubility for production of isoprene |
| WO2013096683A2 (en) * | 2011-12-23 | 2013-06-27 | Danisco Us Inc. | Enhanced production of isoprene using marine bacterial cells |
| SG11201403163QA (en) | 2011-12-23 | 2014-09-26 | Danisco Us Inc | Enhanced production of isoprene using host cells having decreased ispa activity |
| US8865442B2 (en) | 2011-12-23 | 2014-10-21 | Danisco Us Inc. | Production of isoprene under reduced oxygen inlet levels |
| WO2013130481A1 (en) * | 2012-03-02 | 2013-09-06 | Codexis, Inc. | Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate |
| US9315831B2 (en) | 2012-03-30 | 2016-04-19 | Danisco Us Inc. | Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids |
| US8895277B2 (en) | 2012-05-02 | 2014-11-25 | Danisco Us Inc. | Legume isoprene synthase for production of isoprene |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
| US8962296B2 (en) | 2012-05-30 | 2015-02-24 | Bridgestone Corporation | Isoprene synthase and gene encoding the same, and method for producing isoprene monomer |
| WO2013179722A1 (ja) | 2012-05-30 | 2013-12-05 | 株式会社ブリヂストン | イソプレンシンターゼおよびそれをコードするポリヌクレオチド、ならびにイソプレンモノマーの製造方法 |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| US9382554B2 (en) | 2012-07-27 | 2016-07-05 | Wisys Technology Foundation, Inc. | Methods for isoprene and pinene production in cyanobacteria |
| CN111621453A (zh) | 2012-10-23 | 2020-09-04 | 积水化学工业株式会社 | 重组细胞以及异戊二烯的生产方法 |
| WO2014066892A1 (en) * | 2012-10-26 | 2014-05-01 | Coelho Pedro S | De novo metabolic pathways for isoprene biosynthesis |
| EP2935364A2 (en) | 2012-12-21 | 2015-10-28 | Danisco US Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
| US9695447B2 (en) | 2012-12-27 | 2017-07-04 | Sekisui Chemical Co., Ltd. | Recombinant cell and method for producing isoprene |
| US9175330B2 (en) * | 2013-02-20 | 2015-11-03 | Korea Research Institute Of Bioscience And Biotechnology | Method for screening and quantifying isoprene biosynthesis enzyme activity |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
| US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
| US10246694B2 (en) | 2013-04-10 | 2019-04-02 | Danisco Us Inc. | Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
| CN103215315B (zh) * | 2013-04-15 | 2015-05-20 | 上海工业生物技术研发中心 | 利用蓝藻生产异戊二烯 |
| EP3011018B1 (en) | 2013-06-21 | 2019-03-27 | Danisco US Inc. | Compositions and methods for clostridial transformation |
| US10920230B2 (en) | 2013-08-08 | 2021-02-16 | Knipbio, Inc. | Methylotrophs for aquaculture and animal feed |
| JP2016530333A (ja) | 2013-09-13 | 2016-09-29 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 放射線の影響から防護するため及び放射線の影響を緩和するための組成物の調製及び使用 |
| BR112016011006A2 (pt) | 2013-11-22 | 2017-12-05 | Ajinomoto Kk | isopreno sintase modificada, polinucleotídeo, vetor de expressão, célula hospedeira, métodos para produzir uma isopreno sintase modificada, um monômero de isopreno modificado e um polímero de isopreno, polímero derivado de um monômero de isopreno, composição de borracha, e, pneu |
| BR112016011677A2 (pt) * | 2013-11-28 | 2017-09-26 | Ajinomoto Kk | micro-organismo que expressa isopreno sintase, métodos para produzir um monômero de isopreno e um polímero de isopreno, polímero derivado de um monômero de isopreno, composição de borracha, e, pneu |
| WO2015084633A1 (en) | 2013-12-03 | 2015-06-11 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| WO2015127305A2 (en) | 2014-02-20 | 2015-08-27 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
| US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
| RU2014112066A (ru) | 2014-03-28 | 2015-10-10 | Адзиномото Ко., Инк. | Способ получения мономерного изопрена |
| WO2016004334A1 (en) | 2014-07-03 | 2016-01-07 | Genomatica, Inc. | Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto |
| KR101582259B1 (ko) | 2014-07-04 | 2016-01-04 | 명지대학교 산학협력단 | 이소프렌을 생산하는 대장균 균주 fmis2 및 이의 용도 |
| WO2016015021A1 (en) | 2014-07-24 | 2016-01-28 | The Regents Of The University Of California | Oxidative starch degradation by a new family of pmos |
| KR102330593B1 (ko) | 2014-07-28 | 2021-11-26 | 에스케이이노베이션 주식회사 | 신규 이소프렌 신타아제 및 이를 이용한 이소프렌의 제조방법 |
| RO130063A8 (ro) | 2014-08-28 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea ovotransferinei moderne () |
| BR112017005665A2 (pt) | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
| CN105985972A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
| CN105985976A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
| CN105985975A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
| CN105985977B (zh) * | 2015-02-10 | 2020-12-25 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
| CN105985973A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
| CA2974343A1 (en) * | 2015-02-13 | 2016-08-18 | Sekisui Chemical Co., Ltd. | Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method |
| US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
| KR102546640B1 (ko) * | 2016-01-26 | 2023-06-22 | 에스케이이노베이션 주식회사 | 재조합 호염성 메탄균주를 이용한 이소프렌의 제조방법 |
| CN107991399B (zh) * | 2016-10-27 | 2022-03-08 | 天士力医药集团股份有限公司 | 一种同时测定复方丹参提取物或相关药材中31种成分的方法 |
| CA3052635A1 (en) | 2017-02-06 | 2018-11-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of tyramine by fermentation |
| CN110268058B (zh) | 2017-02-27 | 2023-11-21 | 积水化学工业株式会社 | 重组细胞、重组细胞的制备方法以及异戊二烯或萜烯的生产方法 |
| CN110914416B (zh) | 2017-04-27 | 2023-07-21 | 加州大学董事会 | 产生大麻素和大麻素衍生物的微生物和方法 |
| US11560583B2 (en) | 2017-06-01 | 2023-01-24 | Knipbio, Inc. | Heterologous carotenoid production in microorganisms |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11452967B2 (en) | 2017-07-17 | 2022-09-27 | Zymergen Inc. | Metal-organic framework materials |
| KR101965210B1 (ko) * | 2017-09-26 | 2019-04-04 | 한국생명공학연구원 | 신규 이소프렌 합성 효소 및 이를 이용한 이소프렌 생산 방법 |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| CA3078323A1 (en) | 2017-10-05 | 2019-08-15 | Zymergen Inc. | Optically transparent polyimides |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
| WO2020069142A1 (en) | 2018-09-26 | 2020-04-02 | Demetrix, Inc. | Optimized expression systems for expressing berberine bridge enzyme and berberine bridge enzyme-like polypeptides |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| AU2020278665A1 (en) | 2019-05-22 | 2021-12-02 | Demetrix, Inc. | Optimized cannabinoid synthase polypeptides |
| CN110241103B (zh) * | 2019-07-04 | 2021-01-19 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种生物酶法生产异戊二烯的方法 |
| EP4031657A1 (en) | 2019-09-18 | 2022-07-27 | Demetrix, Inc. | Optimized tetrahydrocannabinolic acid (thca) synthase polypeptides |
| WO2021183448A1 (en) | 2020-03-09 | 2021-09-16 | Demetrix, Inc. | Optimized olivetolic acid cyclase polypeptides |
| CN118475621A (zh) | 2023-06-19 | 2024-08-09 | 杭州恩和生物科技有限公司 | 生产7-脱氢胆固醇的融合多肽及其使用方法 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1344713A (en) * | 1915-12-02 | 1920-06-29 | Westinghouse Electric & Mfg Co | Reactance-coil |
| DE1793254A1 (de) * | 1968-08-23 | 1971-12-16 | Bayer Ag | Verfahren zur Gewinnung von Cyclopenten,Isopren und einem Diolefinstrom aus C?-Crackbenzinschnitten |
| US5380831A (en) * | 1986-04-04 | 1995-01-10 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene |
| DE3338269A1 (de) * | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung von isopren aus einem c(pfeil abwaerts)5(pfeil abwaerts)-kohlenwasserstoffgemisch |
| GB8407828D0 (en) * | 1984-03-27 | 1984-05-02 | Ontario Research Foundation | In situ preparation |
| US4570029A (en) * | 1985-03-04 | 1986-02-11 | Uop Inc. | Process for separating isoprene |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| NZ217373A (en) | 1985-08-29 | 1990-10-26 | Genencor Inc | Production of heterologous peptide in filamentous fungi, vectors and dna |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US4846872A (en) * | 1986-08-11 | 1989-07-11 | Fujisawa Pharmaceutical Co., Ltd. | Herbicide |
| US5322770A (en) * | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5545816A (en) * | 1990-03-02 | 1996-08-13 | Amoco Corporation | Phytoene biosynthesis in genetically engineered hosts |
| US5306862A (en) * | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| DK0562003T4 (en) * | 1990-12-10 | 2015-07-13 | Danisco Us Inc | Improved saccharification of cellulose by cloning and amplification of.-Glucosidase gene from Tricodermareesei |
| TW261517B (enExample) * | 1991-11-29 | 1995-11-01 | Mitsubishi Shozi Kk | |
| WO1995004134A1 (en) | 1993-08-02 | 1995-02-09 | Genencor International, Inc. | Method of reducing complex carbohydrates in fermentation products |
| CA2118071C (en) | 1993-10-28 | 2004-09-14 | Rodney B. Croteau | Dna encoding limonene synthase from mentha spicata |
| US5861271A (en) * | 1993-12-17 | 1999-01-19 | Fowler; Timothy | Cellulase enzymes and systems for their expressions |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| US5849970A (en) * | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| US8106260B2 (en) * | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| USRE39350E1 (en) * | 1997-01-17 | 2006-10-17 | The Scripps Research Institute | RNA binding protein and binding site useful for expression of recombinant molecules |
| CA2630341C (en) * | 1998-04-14 | 2011-07-26 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing isoprenoid compounds by microorganisms |
| US6176176B1 (en) * | 1998-04-30 | 2001-01-23 | Board Of Trustees Operating Michigan State University | Apparatus for treating cellulosic materials |
| AR022383A1 (es) | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
| US6268328B1 (en) * | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
| US6442536B1 (en) | 2000-01-18 | 2002-08-27 | Praxair Technology, Inc. | Method for predicting flammability limits of complex mixtures |
| WO2001058839A1 (en) | 2000-02-07 | 2001-08-16 | Eastman Chemical Company | Process to recover condensable gases from oxygen containing mixtures |
| KR20010084864A (ko) | 2000-02-29 | 2001-09-06 | 김수언 | 개똥쑥의 아모파-4,11-디엔 합성효소, 이를 코딩하는유전자, 이 유전자를 포함하는 발현벡터 및, 이발현벡터로 형질전환된 대장균 및 식물체 |
| US6270739B1 (en) * | 2000-06-16 | 2001-08-07 | Eastman Chemical Company | Process for the removal of carbon dioxide from 3,4-epoxy-1-butene process recycle streams |
| US20030033626A1 (en) * | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU2001286528A1 (en) * | 2000-08-18 | 2002-03-04 | Integrigen, Inc. | Methods and compositions for directed molecular evolution using DNA-end modification |
| US6553689B2 (en) * | 2000-09-24 | 2003-04-29 | 3M Innovative Properties Company | Vapor collection method and apparatus |
| US6582914B1 (en) * | 2000-10-26 | 2003-06-24 | Genencor International, Inc. | Method for generating a library of oligonucleotides comprising a controlled distribution of mutations |
| EP1377156A4 (en) | 2001-03-22 | 2007-08-29 | Scentgene Pollination Ltd | METHOD FOR INCREASING ENTOMOPHILIA |
| ATE513036T1 (de) * | 2001-04-04 | 2011-07-15 | Danisco Us Inc | Entkoppelte anabole und katabole stoffwechselwege in wirtszellen |
| RU2197461C2 (ru) * | 2001-04-05 | 2003-01-27 | Общество с ограниченной ответственностью "Еврохим-СПб-Трейдинг" | Способ получения изопрена |
| KR100704072B1 (ko) | 2001-06-06 | 2007-04-05 | 디에스엠 아이피 어셋츠 비.브이. | 개선된 이소프레노이드 제조 방법 |
| US6998471B2 (en) | 2001-07-25 | 2006-02-14 | E.I. Du Pont De Nemours And Company | Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) * | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| EP1499709B1 (en) | 2002-04-22 | 2012-01-04 | E.I. Du Pont De Nemours And Company | Promoter and plasmid system for genetic engineering |
| US20050287655A1 (en) * | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| US20040219629A1 (en) * | 2002-12-19 | 2004-11-04 | Qiong Cheng | Increasing carotenoid production in bacteria via chromosomal integration |
| FR2850101B1 (fr) * | 2003-01-22 | 2007-03-02 | Michelin Soc Tech | Procede d'obtention d'une coupe c5 "fcc" enrichie en isoprene et polymerisation selective de l'isoprene a partir de cette coupe |
| CA2915553A1 (en) | 2003-05-29 | 2005-01-06 | Genencor International, Inc. | Trichoderma genes |
| ES2323175T3 (es) | 2003-06-12 | 2009-07-08 | Dsm Ip Assets B.V. | Mevalonato-quinasas resistentes a la retroalimentacion. |
| PL202927B1 (pl) | 2003-07-20 | 2009-08-31 | Carr Daniel R | Peptyd i kompozycja farmaceutyczna oraz ich zastosowania medyczne |
| AU2004293789B2 (en) * | 2003-11-21 | 2009-07-23 | Genencor International, Inc. | Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates |
| EP2325318A1 (en) | 2004-02-13 | 2011-05-25 | Novozymes A/S | Protease variants |
| EP1765418B1 (en) | 2004-05-21 | 2011-12-14 | The Regents of the University of California | Method for enhancing production of isoprenoid compounds |
| BRPI0512169A (pt) * | 2004-06-18 | 2008-02-12 | Shell Int Research | processo para a produção de óxido de olefina, 1,2- diol, 1,2-diol éter,ou alcanolamina |
| CN101080490B (zh) | 2004-12-14 | 2012-08-15 | 帝斯曼知识产权资产管理有限公司 | 改进的甲羟戊酸激酶 |
| JP4117350B2 (ja) * | 2005-03-03 | 2008-07-16 | 富山県 | 機能改変フェニルアラニン脱水素酵素、およびこの酵素を用いた生体試料中のアミノ酸の分析方法 |
| JP4446482B2 (ja) | 2005-08-10 | 2010-04-07 | 独立行政法人産業技術総合研究所 | ユーカリ・モノテルペン合成酵素遺伝子 |
| ATE475711T1 (de) * | 2006-02-14 | 2010-08-15 | Firmenich & Cie | Verfahren zur herstellung von terpenen und mep- transformierte mikroorganismen dafür |
| WO2007136847A2 (en) | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| EP3031924A1 (en) * | 2006-05-26 | 2016-06-15 | Amyris, Inc. | Production of isoprenoids |
| CN101473036B (zh) | 2006-06-23 | 2012-12-12 | 丹尼斯科美国公司 | 利用用于工程改造多种性质的位点评价文库对序列和活性关系进行系统评价 |
| US7947478B2 (en) * | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| JP2008035831A (ja) | 2006-08-09 | 2008-02-21 | Nitta Ind Corp | 有用部分の生産性が高められた植物及びその作製方法 |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| JP2008182950A (ja) | 2007-01-30 | 2008-08-14 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 柑橘類酵素遺伝子調製方法 |
| US8609385B2 (en) * | 2007-05-01 | 2013-12-17 | Zuvachem, Inc. | Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism |
| WO2008153925A2 (en) | 2007-06-06 | 2008-12-18 | Danisco Us, Inc., Genencor Division | Methods for improving multiple protein properties |
| AU2008299020A1 (en) | 2007-09-11 | 2009-03-19 | Sapphire Energy, Inc. | Molecule production by photosynthetic organisms |
| EP3354740A1 (en) | 2007-12-13 | 2018-08-01 | Danisco US Inc. | Compositions and methods for producing isoprene |
| US20110045563A1 (en) * | 2008-02-06 | 2011-02-24 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| JP2009207402A (ja) | 2008-03-04 | 2009-09-17 | Shizuokaken Koritsu Daigaku Hojin | 組換えサビネン合成酵素及びその利用 |
| WO2009132220A2 (en) * | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| US8420759B2 (en) | 2008-06-30 | 2013-04-16 | The Goodyear Tire & Rubber Company | Polymers of isoprene from renewable resources |
| EP2310490B1 (en) * | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| SG169614A1 (en) | 2008-09-15 | 2011-04-29 | Goodyear Tire & Rubber | Conversion of prenyl derivatives to isoprene |
| BRPI0918453A2 (pt) | 2008-09-15 | 2019-12-17 | Danisco Us Inc | sistemas usando cultura de células para a produção de isopreno |
| EP2334788A1 (en) | 2008-09-15 | 2011-06-22 | Danisco US Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| SG169640A1 (en) | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Increased isoprene production using mevalonate kinase and isoprene synthase |
| SG169652A1 (en) | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MY161071A (en) | 2008-12-30 | 2017-04-14 | Danisco Us Inc | Methods of producing isoprene and a co-product |
| US8518686B2 (en) | 2009-04-23 | 2013-08-27 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| EP2449107B1 (en) | 2009-06-29 | 2015-04-08 | The University Of Western Australia | Terpene synthases from santalum |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
-
2009
- 2009-04-23 WO PCT/US2009/041581 patent/WO2009132220A2/en not_active Ceased
- 2009-04-23 BR BRPI0911667A patent/BRPI0911667A2/pt not_active IP Right Cessation
- 2009-04-23 CA CA2722440A patent/CA2722440A1/en not_active Abandoned
- 2009-04-23 MY MYPI2010004990A patent/MY153871A/en unknown
- 2009-04-23 US US12/429,143 patent/US8173410B2/en not_active Expired - Fee Related
- 2009-04-23 SG SG2013055827A patent/SG192545A1/en unknown
- 2009-04-23 EP EP09735440A patent/EP2279251A2/en not_active Withdrawn
- 2009-04-23 KR KR1020107026164A patent/KR20110020234A/ko not_active Ceased
- 2009-04-23 RU RU2010147659/10A patent/RU2516343C2/ru not_active IP Right Cessation
- 2009-04-23 MX MX2010011706A patent/MX2010011706A/es unknown
- 2009-04-23 SG SG201007802A patent/SG165884A1/en unknown
- 2009-04-23 AU AU2009240505A patent/AU2009240505B2/en not_active Ceased
- 2009-04-23 JP JP2011506460A patent/JP2011518564A/ja active Pending
- 2009-04-23 ZA ZA201007564A patent/ZA201007564B/xx unknown
- 2009-04-23 CN CN2009801234600A patent/CN102171335A/zh active Pending
-
2011
- 2011-10-22 ZA ZA2011/08569A patent/ZA201108569B/en unknown
-
2012
- 2012-03-30 US US13/436,612 patent/US8916370B2/en not_active Expired - Fee Related
-
2014
- 2014-03-06 RU RU2014108776/10A patent/RU2014108776A/ru not_active Application Discontinuation
- 2014-04-17 JP JP2014085377A patent/JP2014158489A/ja active Pending
- 2014-11-17 US US14/543,628 patent/US20150191712A1/en not_active Abandoned
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