JP2014528705A5 - - Google Patents
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- Publication number
- JP2014528705A5 JP2014528705A5 JP2014524145A JP2014524145A JP2014528705A5 JP 2014528705 A5 JP2014528705 A5 JP 2014528705A5 JP 2014524145 A JP2014524145 A JP 2014524145A JP 2014524145 A JP2014524145 A JP 2014524145A JP 2014528705 A5 JP2014528705 A5 JP 2014528705A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant microorganism
- cell
- nucleic acids
- coa
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 244000005700 microbiome Species 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 230000001580 bacterial effect Effects 0.000 claims 14
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 10
- 230000037361 pathway Effects 0.000 claims 8
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 7
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 7
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 6
- 210000005253 yeast cell Anatomy 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108010075483 isoprene synthase Proteins 0.000 claims 5
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 4
- 230000002538 fungal effect Effects 0.000 claims 4
- 241000195493 Cryptophyta Species 0.000 claims 3
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims 3
- 230000002194 synthesizing effect Effects 0.000 claims 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 2
- SIGQQUBJQXSAMW-ZCFIWIBFSA-N (R)-5-diphosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(=O)OP(O)(O)=O SIGQQUBJQXSAMW-ZCFIWIBFSA-N 0.000 claims 2
- OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 2
- 108030002854 Acetoacetyl-CoA synthases Proteins 0.000 claims 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims 2
- 241000193749 Bacillus coagulans Species 0.000 claims 2
- 241000193422 Bacillus lentus Species 0.000 claims 2
- 241000149420 Bothrometopus brevis Species 0.000 claims 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 2
- 241000186249 Corynebacterium sp. Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 108010065958 Isopentenyl-diphosphate Delta-isomerase Proteins 0.000 claims 2
- 102100027665 Isopentenyl-diphosphate Delta-isomerase 1 Human genes 0.000 claims 2
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 2
- 241000219000 Populus Species 0.000 claims 2
- 241000168036 Populus alba Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 241000193752 Bacillus circulans Species 0.000 claims 1
- 241001328122 Bacillus clausii Species 0.000 claims 1
- 241000006382 Bacillus halodurans Species 0.000 claims 1
- 241000194108 Bacillus licheniformis Species 0.000 claims 1
- 241000194107 Bacillus megaterium Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000193388 Bacillus thuringiensis Species 0.000 claims 1
- 241001147674 Chlorarachniophyceae Species 0.000 claims 1
- 241000195628 Chlorophyta Species 0.000 claims 1
- 241000199914 Dinophyceae Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000195620 Euglena Species 0.000 claims 1
- 241000195623 Euglenida Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 241000194109 Paenibacillus lautus Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000521555 Pichia nakasei Species 0.000 claims 1
- 241000235061 Pichia sp. Species 0.000 claims 1
- 241000218982 Populus nigra Species 0.000 claims 1
- 241000183024 Populus tremula Species 0.000 claims 1
- 240000004923 Populus tremuloides Species 0.000 claims 1
- 235000011263 Populus tremuloides Nutrition 0.000 claims 1
- 241000218976 Populus trichocarpa Species 0.000 claims 1
- 241000168225 Pseudomonas alcaligenes Species 0.000 claims 1
- 241000589774 Pseudomonas sp. Species 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000913776 Pueraria montana Species 0.000 claims 1
- 241000219781 Pueraria montana var. lobata Species 0.000 claims 1
- 241000206572 Rhodophyta Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000235088 Saccharomyces sp. Species 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000720795 Schizosaccharomyces sp. Species 0.000 claims 1
- 241001512747 Streptacidiphilus albus Species 0.000 claims 1
- 241000063122 Streptacidiphilus griseus Species 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000187398 Streptomyces lividans Species 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
- 229960004630 chlorambucil Drugs 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000004087 circulation Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515300P | 2011-08-04 | 2011-08-04 | |
| US61/515,300 | 2011-08-04 | ||
| PCT/US2012/049659 WO2013020118A1 (en) | 2011-08-04 | 2012-08-03 | Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528705A JP2014528705A (ja) | 2014-10-30 |
| JP2014528705A5 true JP2014528705A5 (enExample) | 2015-09-17 |
Family
ID=46724633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524145A Withdrawn JP2014528705A (ja) | 2011-08-04 | 2012-08-03 | アセトアセチルＣｏＡシンターゼを用いるイソプレン、イソプレノイド前駆体、及びイソプレノイドの生産 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130122562A1 (enExample) |
| EP (1) | EP2739658A1 (enExample) |
| JP (1) | JP2014528705A (enExample) |
| CN (1) | CN104039844A (enExample) |
| AU (1) | AU2012289886A1 (enExample) |
| BR (1) | BR112014002661A2 (enExample) |
| CA (1) | CA2844064A1 (enExample) |
| HK (1) | HK1199048A1 (enExample) |
| SG (1) | SG2014007991A (enExample) |
| WO (1) | WO2013020118A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9663801B2 (en) | 2011-06-17 | 2017-05-30 | Invista North America S.A.R.L. | Methods of producing four carbon molecules |
| DK2776571T3 (en) | 2011-11-09 | 2017-06-26 | Amyris Inc | PREPARATION OF ACETYL-COENZYM A-DERIVED ISOPRENOIDS |
| EP2794851A2 (en) * | 2011-12-23 | 2014-10-29 | Danisco US Inc. | Enhanced production of isoprene using marine bacterial cells |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| BR112015002940A2 (pt) | 2012-08-10 | 2018-04-24 | Opx Biotechnologies Inc | microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos. |
| CN104903455A (zh) | 2012-11-28 | 2015-09-09 | 英威达技术有限责任公司 | 用于异丁烯生物合成的方法 |
| WO2014106122A1 (en) * | 2012-12-31 | 2014-07-03 | Genomatica, Inc. | Compositions and methods for bio-butadiene production screening |
| US9447438B2 (en) | 2013-03-15 | 2016-09-20 | Cargill, Incorporated | Acetyl-coA carboxylases |
| WO2015010103A2 (en) * | 2013-07-19 | 2015-01-22 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN105683385A (zh) * | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异戊二烯的方法 |
| AU2014306074B2 (en) * | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| EP3030668A1 (en) | 2013-08-05 | 2016-06-15 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
| US10648004B2 (en) | 2014-02-20 | 2020-05-12 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products |
| CN106795519A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生成戊二酸和戊二酸甲酯的方法 |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| WO2017131488A1 (ko) * | 2016-01-26 | 2017-08-03 | 경상대학교산학협력단 | 이소프렌의 생산 방법 |
| KR101936825B1 (ko) * | 2016-01-26 | 2019-01-11 | 경상대학교산학협력단 | 이소프렌의 생산 방법 |
| JP2018014960A (ja) * | 2016-07-29 | 2018-02-01 | 横浜ゴム株式会社 | 発現ベクター、形質転換された藻類、形質転換された珪藻、及び、ポリヌクレオチド |
| CN107815424B (zh) * | 2016-09-12 | 2021-03-05 | 华东理工大学 | 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用 |
| KR20190100386A (ko) | 2017-01-06 | 2019-08-28 | 그린라이트 바이오사이언시스, 아이엔씨. | 당의 무세포 생산 |
| CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
| CN107118988B (zh) * | 2017-05-17 | 2020-11-24 | 重庆理工大学 | 高效复合沼气发酵催化剂 |
| WO2019006257A1 (en) | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| CN109797173B (zh) * | 2019-03-27 | 2022-09-20 | 山东泓达生物科技有限公司 | 一种β-法尼烯的生产方法 |
| US20230090600A1 (en) * | 2021-08-24 | 2023-03-23 | Lanzatech, Inc. | Microbial fermentation for the production of isoprenoid alcohols and derivatives |
| CN115820527B (zh) * | 2022-12-09 | 2024-03-19 | 天津大学 | 一种生产甲羟戊酸的重组盐单胞菌及构建方法与应用 |
| WO2024215256A2 (en) * | 2023-04-11 | 2024-10-17 | Allozymes Pte Ltd | Methods and compositions |
| CN116925991B (zh) * | 2023-07-28 | 2024-08-09 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
| CN117965414B (zh) * | 2024-04-01 | 2024-06-14 | 北京微构工场生物技术有限公司 | 一种重组盐单胞菌及其在生产异戊二烯中的应用 |
| CN118773228A (zh) * | 2024-06-25 | 2024-10-15 | 广州新鑫生物科技有限公司 | 一种改造大肠杆菌代谢通路以提高乙酰辅酶a合成效率的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| CA2651747C (en) | 2006-05-26 | 2017-10-24 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| BRPI0823506A8 (pt) | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| WO2009100231A2 (en) | 2008-02-06 | 2009-08-13 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| JP2011518564A (ja) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| EP2310490B1 (en) | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| BRPI0918936A2 (pt) | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MY156562A (en) | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
| WO2010031079A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| CN102333866B (zh) | 2008-12-30 | 2015-04-29 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| EP2421966A2 (en) | 2009-04-23 | 2012-02-29 | Danisco US Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| CA2773675A1 (en) | 2009-09-15 | 2011-03-24 | Sapphire Energy, Inc. | A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| CA2785530A1 (en) * | 2009-12-22 | 2011-06-23 | Danisco Us Inc. | Membrane bioreactor for increased production of isoprene gas |
| AU2010336342B2 (en) * | 2009-12-23 | 2015-02-26 | Danisco Us Inc. | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (PGL) |
| US9309543B2 (en) * | 2010-03-18 | 2016-04-12 | William Marsh Rice University | Bacteria and method for synthesizing fatty acids |
| JP2014502148A (ja) | 2010-10-27 | 2014-01-30 | ダニスコ・ユーエス・インク | イソプレン生産の向上を目的としたイソプレン合成酵素変異体 |
-
2012
- 2012-08-03 AU AU2012289886A patent/AU2012289886A1/en not_active Abandoned
- 2012-08-03 CN CN201280048738.4A patent/CN104039844A/zh active Pending
- 2012-08-03 EP EP12750655.8A patent/EP2739658A1/en not_active Withdrawn
- 2012-08-03 CA CA2844064A patent/CA2844064A1/en active Pending
- 2012-08-03 HK HK14112310.2A patent/HK1199048A1/xx unknown
- 2012-08-03 US US13/566,916 patent/US20130122562A1/en not_active Abandoned
- 2012-08-03 BR BR112014002661A patent/BR112014002661A2/pt not_active IP Right Cessation
- 2012-08-03 SG SG2014007991A patent/SG2014007991A/en unknown
- 2012-08-03 JP JP2014524145A patent/JP2014528705A/ja not_active Withdrawn
- 2012-08-03 WO PCT/US2012/049659 patent/WO2013020118A1/en not_active Ceased
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