JP2015503904A5 - - Google Patents
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- Publication number
- JP2015503904A5 JP2015503904A5 JP2014539095A JP2014539095A JP2015503904A5 JP 2015503904 A5 JP2015503904 A5 JP 2015503904A5 JP 2014539095 A JP2014539095 A JP 2014539095A JP 2014539095 A JP2014539095 A JP 2014539095A JP 2015503904 A5 JP2015503904 A5 JP 2015503904A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- host cell
- cell
- isolated
- bacillus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 37
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 12
- 230000001580 bacterial effect Effects 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 4
- 210000005253 yeast cell Anatomy 0.000 claims 4
- 241000195493 Cryptophyta Species 0.000 claims 3
- 230000002538 fungal effect Effects 0.000 claims 3
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims 2
- 241000193422 Bacillus lentus Species 0.000 claims 2
- 241000193764 Brevibacillus brevis Species 0.000 claims 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 2
- 241000219000 Populus Species 0.000 claims 2
- 241000218979 Populus sp. Species 0.000 claims 2
- 241000219492 Quercus Species 0.000 claims 2
- 240000009089 Quercus robur Species 0.000 claims 2
- 235000011471 Quercus robur Nutrition 0.000 claims 2
- 241000235070 Saccharomyces Species 0.000 claims 2
- 241000124033 Salix Species 0.000 claims 2
- 241001278097 Salix alba Species 0.000 claims 2
- 241000921305 Salix sp. Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000193752 Bacillus circulans Species 0.000 claims 1
- 241001328122 Bacillus clausii Species 0.000 claims 1
- 241000193749 Bacillus coagulans Species 0.000 claims 1
- 241000006382 Bacillus halodurans Species 0.000 claims 1
- 241000194108 Bacillus licheniformis Species 0.000 claims 1
- 241000194107 Bacillus megaterium Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000193388 Bacillus thuringiensis Species 0.000 claims 1
- 241000195628 Chlorophyta Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 1
- 241000192700 Cyanobacteria Species 0.000 claims 1
- 241000199914 Dinophyceae Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000195620 Euglena Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 241000194109 Paenibacillus lautus Species 0.000 claims 1
- 240000005827 Phyllostachys nigra Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000235061 Pichia sp. Species 0.000 claims 1
- 240000008334 Pisonia alba Species 0.000 claims 1
- 240000004923 Populus tremuloides Species 0.000 claims 1
- 241000157935 Promicromonospora citrea Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000168225 Pseudomonas alcaligenes Species 0.000 claims 1
- 241000589774 Pseudomonas sp. Species 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000206572 Rhodophyta Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 244000020191 Salix babylonica Species 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000720795 Schizosaccharomyces sp. Species 0.000 claims 1
- 241000063122 Streptacidiphilus griseus Species 0.000 claims 1
- 241000187759 Streptomyces albus Species 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000187398 Streptomyces lividans Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229940097012 bacillus thuringiensis Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 108010075483 isoprene synthase Proteins 0.000 claims 1
- 244000209700 shan ge teng Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552453P | 2011-10-27 | 2011-10-27 | |
| US61/552,453 | 2011-10-27 | ||
| PCT/US2012/062308 WO2013063528A2 (en) | 2011-10-27 | 2012-10-26 | Isoprene synthase variants with improved solubility for production of isoprene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503904A JP2015503904A (ja) | 2015-02-05 |
| JP2015503904A5 true JP2015503904A5 (enExample) | 2015-12-17 |
| JP6101275B2 JP6101275B2 (ja) | 2017-03-22 |
Family
ID=47178953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539095A Expired - Fee Related JP6101275B2 (ja) | 2011-10-27 | 2012-10-26 | イソプレン産生時の溶解度が向上されたイソプレン合成酵素変異体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8735134B2 (enExample) |
| EP (1) | EP2771460B1 (enExample) |
| JP (1) | JP6101275B2 (enExample) |
| BR (1) | BR112014010053A8 (enExample) |
| CA (1) | CA2853125A1 (enExample) |
| DK (1) | DK2771460T3 (enExample) |
| HK (1) | HK1201554A1 (enExample) |
| WO (1) | WO2013063528A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| WO2013063528A2 (en) | 2011-10-27 | 2013-05-02 | Danisco Us Inc. | Isoprene synthase variants with improved solubility for production of isoprene |
| EP2794851A2 (en) * | 2011-12-23 | 2014-10-29 | Danisco US Inc. | Enhanced production of isoprene using marine bacterial cells |
| CN111621453A (zh) * | 2012-10-23 | 2020-09-04 | 积水化学工业株式会社 | 重组细胞以及异戊二烯的生产方法 |
| MY172689A (en) | 2013-11-22 | 2019-12-10 | Ajinomoto Kk | Modified isoprene synthase |
| CN105985971B (zh) * | 2015-02-10 | 2021-01-22 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8407828D0 (en) | 1984-03-27 | 1984-05-02 | Ontario Research Foundation | In situ preparation |
| US4570029A (en) | 1985-03-04 | 1986-02-11 | Uop Inc. | Process for separating isoprene |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US6176176B1 (en) | 1998-04-30 | 2001-01-23 | Board Of Trustees Operating Michigan State University | Apparatus for treating cellulosic materials |
| US20030033626A1 (en) | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| US7947478B2 (en) | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| US20090076743A1 (en) | 2007-08-01 | 2009-03-19 | Drexel University | Novel method for zero point detection |
| BRPI0823506A8 (pt) | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| JP2011518564A (ja) * | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| SG167485A1 (en) | 2008-06-30 | 2011-01-28 | Danisco Us Inc | Polymers of isoprene from renewable resources |
| EP2310490B1 (en) | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| CA2737082A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MY156562A (en) | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
| BRPI0918936A2 (pt) | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
| WO2010031079A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| CN102333866B (zh) | 2008-12-30 | 2015-04-29 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
| EP2421966A2 (en) | 2009-04-23 | 2012-02-29 | Danisco US Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TW201120213A (en) | 2009-06-17 | 2011-06-16 | Danisco Us Inc | Polymerization of isoprene from renewable resources |
| CN102884028B (zh) | 2009-12-18 | 2015-08-19 | 丹尼斯科美国公司 | 从可再生资源中纯化异戊二烯 |
| CA2785530A1 (en) | 2009-12-22 | 2011-06-23 | Danisco Us Inc. | Membrane bioreactor for increased production of isoprene gas |
| AU2010336342B2 (en) | 2009-12-23 | 2015-02-26 | Danisco Us Inc. | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (PGL) |
| JP2014502148A (ja) * | 2010-10-27 | 2014-01-30 | ダニスコ・ユーエス・インク | イソプレン生産の向上を目的としたイソプレン合成酵素変異体 |
| WO2013063528A2 (en) | 2011-10-27 | 2013-05-02 | Danisco Us Inc. | Isoprene synthase variants with improved solubility for production of isoprene |
-
2012
- 2012-10-26 WO PCT/US2012/062308 patent/WO2013063528A2/en not_active Ceased
- 2012-10-26 HK HK15101956.3A patent/HK1201554A1/xx unknown
- 2012-10-26 US US13/662,328 patent/US8735134B2/en not_active Expired - Fee Related
- 2012-10-26 BR BR112014010053A patent/BR112014010053A8/pt not_active Application Discontinuation
- 2012-10-26 JP JP2014539095A patent/JP6101275B2/ja not_active Expired - Fee Related
- 2012-10-26 EP EP12787268.7A patent/EP2771460B1/en not_active Not-in-force
- 2012-10-26 DK DK12787268.7T patent/DK2771460T3/en active
- 2012-10-26 CA CA2853125A patent/CA2853125A1/en not_active Abandoned
-
2014
- 2014-04-11 US US14/251,311 patent/US9273299B2/en not_active Expired - Fee Related
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