HK1201554A1 - Isoprene synthase variants with improved solubility for production of isoprene - Google Patents

Isoprene synthase variants with improved solubility for production of isoprene

Info

Publication number
HK1201554A1
HK1201554A1 HK15101956.3A HK15101956A HK1201554A1 HK 1201554 A1 HK1201554 A1 HK 1201554A1 HK 15101956 A HK15101956 A HK 15101956A HK 1201554 A1 HK1201554 A1 HK 1201554A1
Authority
HK
Hong Kong
Prior art keywords
isoprene
production
improved solubility
synthase variants
isoprene synthase
Prior art date
Application number
HK15101956.3A
Other languages
English (en)
Chinese (zh)
Inventor
Christopher L Rife
Derek H Wells
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Publication of HK1201554A1 publication Critical patent/HK1201554A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03007—Pentalenene synthase (4.2.3.7)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L7/00—Compositions of natural rubber

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
HK15101956.3A 2011-10-27 2015-02-27 Isoprene synthase variants with improved solubility for production of isoprene HK1201554A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552453P 2011-10-27 2011-10-27
PCT/US2012/062308 WO2013063528A2 (en) 2011-10-27 2012-10-26 Isoprene synthase variants with improved solubility for production of isoprene

Publications (1)

Publication Number Publication Date
HK1201554A1 true HK1201554A1 (en) 2015-09-04

Family

ID=47178953

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101956.3A HK1201554A1 (en) 2011-10-27 2015-02-27 Isoprene synthase variants with improved solubility for production of isoprene

Country Status (8)

Country Link
US (2) US8735134B2 (xx)
EP (1) EP2771460B1 (xx)
JP (1) JP6101275B2 (xx)
BR (1) BR112014010053A8 (xx)
CA (1) CA2853125A1 (xx)
DK (1) DK2771460T3 (xx)
HK (1) HK1201554A1 (xx)
WO (1) WO2013063528A2 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG169640A1 (en) * 2008-09-15 2011-04-29 Danisco Us Inc Increased isoprene production using mevalonate kinase and isoprene synthase
JP6101275B2 (ja) 2011-10-27 2017-03-22 ダニスコ・ユーエス・インク イソプレン産生時の溶解度が向上されたイソプレン合成酵素変異体
EP2794851A2 (en) * 2011-12-23 2014-10-29 Danisco US Inc. Enhanced production of isoprene using marine bacterial cells
CN111621453A (zh) * 2012-10-23 2020-09-04 积水化学工业株式会社 重组细胞以及异戊二烯的生产方法
BR112016011006A2 (pt) 2013-11-22 2017-12-05 Ajinomoto Kk isopreno sintase modificada, polinucleotídeo, vetor de expressão, célula hospedeira, métodos para produzir uma isopreno sintase modificada, um monômero de isopreno modificado e um polímero de isopreno, polímero derivado de um monômero de isopreno, composição de borracha, e, pneu
CN105985971B (zh) * 2015-02-10 2021-01-22 中国科学院微生物研究所 异戊二烯合成酶基因及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8407828D0 (en) 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US6176176B1 (en) 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
DE60335574D1 (de) 2002-10-04 2011-02-10 Du Pont Verfahren zur biologischen herstellung von 1,3-propandiol mit hoher ausbeute
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
JP4986547B2 (ja) 2006-09-04 2012-07-25 株式会社Ａｄｅｋａ 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法
US20090076743A1 (en) 2007-08-01 2009-03-19 Drexel University Novel method for zero point detection
RU2545699C2 (ru) 2007-12-13 2015-04-10 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена
SG165884A1 (en) 2008-04-23 2010-11-29 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
CN102131935B (zh) 2008-06-30 2013-11-13 固特异轮胎和橡胶公司 来自可再生资源的异戊二烯的聚合物
CA2729801A1 (en) 2008-07-02 2010-01-07 Danisco Us Inc. Compositions and methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
WO2010031076A2 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
EP2334788A1 (en) 2008-09-15 2011-06-22 Danisco US Inc. Increased isoprene production using the archaeal lower mevalonate pathway
EP3323881A1 (en) 2008-09-15 2018-05-23 Danisco US Inc. Systems using cell culture for production of isoprene
SG169640A1 (en) 2008-09-15 2011-04-29 Danisco Us Inc Increased isoprene production using mevalonate kinase and isoprene synthase
US8470581B2 (en) 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
CN102333866B (zh) 2008-12-30 2015-04-29 丹尼斯科美国公司 生产异戊二烯和共同产物的方法
CN102656265A (zh) 2009-04-23 2012-09-05 丹尼斯科美国公司 异戊二烯合酶的三维结构及其用于产生变体的用途
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
TW201120213A (en) 2009-06-17 2011-06-16 Danisco Us Inc Polymerization of isoprene from renewable resources
AU2010331946A1 (en) 2009-12-18 2012-06-28 Danisco Us Inc. Purification of isoprene from renewable resources
JP5855576B2 (ja) 2009-12-22 2016-02-09 ダニスコ・ユーエス・インク イソプレンガスの生成量を増大させるための膜バイオリアクター
CA2785480A1 (en) 2009-12-23 2011-06-30 Danisco Us Inc. Compositions and methods of pgl for the increased production of isoprene
SG190043A1 (en) 2010-10-27 2013-06-28 Danisco Us Inc Isoprene synthase variants for improved production of isoprene
JP6101275B2 (ja) 2011-10-27 2017-03-22 ダニスコ・ユーエス・インク イソプレン産生時の溶解度が向上されたイソプレン合成酵素変異体

Also Published As

Publication number Publication date
US20130295632A1 (en) 2013-11-07
US8735134B2 (en) 2014-05-27
EP2771460B1 (en) 2017-04-26
US20140315275A1 (en) 2014-10-23
DK2771460T3 (en) 2017-06-06
WO2013063528A3 (en) 2013-06-20
EP2771460A2 (en) 2014-09-03
JP2015503904A (ja) 2015-02-05
JP6101275B2 (ja) 2017-03-22
WO2013063528A2 (en) 2013-05-02
CA2853125A1 (en) 2013-05-02
BR112014010053A2 (pt) 2017-06-13
US9273299B2 (en) 2016-03-01
BR112014010053A8 (pt) 2017-06-20

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