LT2900675T - Tienopirimidino darinių gamybos būdas - Google Patents
Tienopirimidino darinių gamybos būdasInfo
- Publication number
- LT2900675T LT2900675T LTEP13779938.3T LT13779938T LT2900675T LT 2900675 T LT2900675 T LT 2900675T LT 13779938 T LT13779938 T LT 13779938T LT 2900675 T LT2900675 T LT 2900675T
- Authority
- LT
- Lithuania
- Prior art keywords
- production method
- thienopyrimidine derivative
- thienopyrimidine
- derivative
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012217679 | 2012-09-28 | ||
PCT/JP2013/077013 WO2014051164A2 (en) | 2012-09-28 | 2013-09-27 | Production method of thienopyrimidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2900675T true LT2900675T (lt) | 2019-05-27 |
Family
ID=49448235
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP13779938.3T LT2900675T (lt) | 2012-09-28 | 2013-09-27 | Tienopirimidino darinių gamybos būdas |
LTEP18185835.8T LT3415517T (lt) | 2012-09-28 | 2013-09-27 | Kristalinė 1-(4-(1-(2,6-difluorbenzil)-5-dimetilaminometil-3-(6-metoksipiridazin-3-il)-2,4-diokso-1,2,3,4- tetrahidrotieno(2,3-d)pirimidin-6-il)fenil)-3-metoksikarbamido forma |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP18185835.8T LT3415517T (lt) | 2012-09-28 | 2013-09-27 | Kristalinė 1-(4-(1-(2,6-difluorbenzil)-5-dimetilaminometil-3-(6-metoksipiridazin-3-il)-2,4-diokso-1,2,3,4- tetrahidrotieno(2,3-d)pirimidin-6-il)fenil)-3-metoksikarbamido forma |
Country Status (20)
Country | Link |
---|---|
US (8) | US9758528B2 (lt) |
EP (3) | EP2900675B1 (lt) |
JP (1) | JP6250564B2 (lt) |
CN (3) | CN109053766B (lt) |
AR (1) | AR092707A1 (lt) |
CA (1) | CA2881132C (lt) |
CY (1) | CY1121641T1 (lt) |
DK (2) | DK3415517T3 (lt) |
ES (2) | ES2724206T3 (lt) |
HR (2) | HRP20220622T1 (lt) |
HU (2) | HUE059077T2 (lt) |
LT (2) | LT2900675T (lt) |
PL (2) | PL2900675T3 (lt) |
PT (2) | PT3415517T (lt) |
RS (2) | RS58703B1 (lt) |
SI (2) | SI3415517T1 (lt) |
TR (1) | TR201906318T4 (lt) |
TW (3) | TWI663171B (lt) |
UY (1) | UY35058A (lt) |
WO (1) | WO2014051164A2 (lt) |
Families Citing this family (49)
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UY35058A (es) | 2012-09-28 | 2014-04-30 | Takeda Pharmaceutical | Método de producción de derivado de tienopirimidina |
FI3263110T3 (fi) | 2015-02-26 | 2023-07-25 | Takeda Pharmaceuticals Co | Tabletti, joka käsittää metoksiureajohdannaista ja mannitolipartikkeleita |
PL3518933T3 (pl) | 2016-09-30 | 2022-06-20 | Myovant Sciences Gmbh | Metody leczenia mięśniaków macicy i endometriozy |
IL300071A (en) | 2016-09-30 | 2023-03-01 | Takeda Pharmaceuticals Co | Prostate cancer treatment |
WO2018086608A1 (zh) * | 2016-11-14 | 2018-05-17 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
CN110996956A (zh) | 2017-06-05 | 2020-04-10 | 奥布赛瓦股份公司 | 用于治疗子宫内膜异位症的促性腺激素释放激素拮抗剂给药方案 |
CN107188855A (zh) * | 2017-07-14 | 2017-09-22 | 常州工程职业技术学院 | 一种3‑氨基‑6甲氧基哒嗪的制备方法 |
US11306104B2 (en) | 2018-03-14 | 2022-04-19 | Teva Pharmaceuticals International Gmbh | Solid state forms of Relugolix |
EP3666776A1 (en) | 2018-12-11 | 2020-06-17 | Sandoz AG | Hydrate of a gonadotropin-releasing hormone receptor antagonist |
US20220220123A1 (en) * | 2019-05-15 | 2022-07-14 | Dr. Reddy's Laboratories Limited | Amorphous and crystalline forms of relugolix |
CN110194776B (zh) * | 2019-06-27 | 2021-05-28 | 四川伊诺达博医药科技有限公司 | 一种瑞卢戈利的合成方法 |
US20220267347A1 (en) * | 2019-07-29 | 2022-08-25 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrimidinedione compounds and uses thereof |
US20230374030A1 (en) * | 2019-08-02 | 2023-11-23 | Macfarlan Smith Limited | Solid-state forms of relugolix |
CN112321602A (zh) * | 2019-08-05 | 2021-02-05 | 苏州鹏旭医药科技有限公司 | 一种瑞卢戈利药物中间体的制备方法 |
CN112390812A (zh) * | 2019-08-14 | 2021-02-23 | 苏州鹏旭医药科技有限公司 | 瑞卢戈利化合物的晶型和无定型固体及其制备方法 |
CN112771052B (zh) * | 2019-08-21 | 2023-04-07 | 深圳仁泰医药科技有限公司 | 促性腺素释放激素拮抗剂的晶型及其制备方法和用途 |
EP4041739A1 (en) * | 2019-10-10 | 2022-08-17 | Myovant Sciences GmbH | Crystalline forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo- 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'- methoxyurea |
EP4041738A1 (en) * | 2019-10-10 | 2022-08-17 | Myovant Sciences GmbH | Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
CN112745304A (zh) * | 2019-10-29 | 2021-05-04 | 上海度德医药科技有限公司 | 一种Relugolix的制备方法及中间体化合物 |
CN111423452B (zh) * | 2020-03-26 | 2023-08-22 | 江西青峰药业有限公司 | 瑞卢戈利的中间体及其制备方法和应用 |
CN113444105A (zh) * | 2020-03-27 | 2021-09-28 | 南京海润医药有限公司 | 一种Relugolix的制备方法 |
CN111333633B (zh) * | 2020-04-01 | 2023-10-20 | 江西科睿药业有限公司 | 一种瑞卢戈利的中间体化合物及其制备方法和用途 |
CN111574534B (zh) * | 2020-05-25 | 2021-06-04 | 东莞市东阳光新药研发有限公司 | 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途 |
EP4157227A1 (en) | 2020-05-29 | 2023-04-05 | Myovant Sciences GmbH | Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists |
US11655256B1 (en) | 2020-11-06 | 2023-05-23 | Macfarlan Smith Limited | Processes for making a solid-state form of relugolix |
EP4243829A1 (en) | 2020-11-11 | 2023-09-20 | Myovant Sciences GmbH | Methods of administering relugolix |
CN112552312B (zh) * | 2020-12-07 | 2022-08-05 | 杭州科巢生物科技有限公司 | 一种瑞卢戈利或其盐的合成方法 |
CN114685468A (zh) * | 2020-12-25 | 2022-07-01 | 成都硕德药业有限公司 | 用于治疗子宫肌瘤的药物的中间体化合物及其制备方法 |
CN113620972A (zh) * | 2021-02-02 | 2021-11-09 | 奥锐特药业(天津)有限公司 | 瑞卢戈利新晶型及其制备方法 |
CN114907370B (zh) | 2021-02-10 | 2023-11-03 | 奥锐特药业(天津)有限公司 | 高纯度的噻吩并嘧啶化合物及其制备方法 |
CN115073491A (zh) * | 2021-03-12 | 2022-09-20 | 上海医药工业研究院 | 一种瑞卢戈利中间体、其制备方法及其应用 |
WO2022214645A1 (en) | 2021-04-09 | 2022-10-13 | Farmhispania Group, S.L. | Processes and intermediates for the preparation of relugolix |
CN115594688B (zh) * | 2021-06-28 | 2023-11-17 | 成都倍特药业股份有限公司 | 瑞卢戈利中间体的制备方法 |
WO2023066941A1 (en) | 2021-10-18 | 2023-04-27 | Myovant Sciences Gmbh | Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
CN114230576A (zh) * | 2021-12-21 | 2022-03-25 | 伊诺药物研究(南京)有限公司 | 一种瑞卢戈利的制备方法 |
WO2023119333A1 (en) * | 2021-12-25 | 2023-06-29 | Dr. Reddy’S Laboratories Limited | Process for preparation of relugolix and its intermediates |
CN114409629B (zh) * | 2022-02-22 | 2023-12-29 | 浙江科聚生物医药有限公司 | 一种高纯度Relugolix关键中间体的制备方法及应用 |
CN114790189B (zh) * | 2022-02-24 | 2023-06-09 | 海化生命(厦门)科技有限公司 | 瑞卢戈利中间体的制备方法 |
CN114755320A (zh) * | 2022-03-17 | 2022-07-15 | 南京方生和医药科技有限公司 | 一种3-氨基-6-甲氧基哒嗪有关物质的检测方法 |
WO2023194924A1 (en) * | 2022-04-08 | 2023-10-12 | Glenmark Life Sciences Limited | Process for preparation of relugolix |
CN114621249B (zh) * | 2022-04-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 瑞卢戈利关键中间体的制备 |
WO2023214935A1 (en) * | 2022-05-05 | 2023-11-09 | Scinopharm Taiwan, Ltd. | Process for preparing relugolix and intermediates thereof |
CN117285506A (zh) * | 2022-07-14 | 2023-12-26 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体及其制备方法 |
CN115594689B (zh) * | 2022-07-14 | 2024-03-19 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体、一种瑞卢戈利的合成方法 |
CN115417883A (zh) * | 2022-09-16 | 2022-12-02 | 浙江科聚生物医药有限公司 | 一种瑞卢戈利的晶型及其制备方法 |
WO2024069492A1 (en) | 2022-09-29 | 2024-04-04 | Macfarlan Smith Limited | Processes for the preparation and manufacture of relugolix |
CN115650950A (zh) * | 2022-11-03 | 2023-01-31 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体及其制备方法以及一种酰胺缩合方法 |
WO2024126674A1 (en) | 2022-12-15 | 2024-06-20 | Medichem, S.A. | Process for the preparation of relugolix |
CN115650965B (zh) * | 2022-12-26 | 2023-03-31 | 南京威凯尔生物医药科技有限公司 | 一种瑞卢戈利关键中间体的制备方法 |
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TWI225863B (en) | 1999-03-24 | 2005-01-01 | Takeda Chemical Industries Ltd | Thienopyrimidine compounds, their production and use |
US6297379B1 (en) | 1999-03-24 | 2001-10-02 | Takeda Chemical Industries, Ltd. | Thienopyrimidine compounds, their production and use |
JP2001316391A (ja) * | 2000-02-29 | 2001-11-13 | Takeda Chem Ind Ltd | チエノピリミジン誘導体の製造法 |
KR20030005205A (ko) | 2000-02-29 | 2003-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 티에노피리미딘 유도체의 제조 방법 |
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WO2003020727A1 (en) * | 2001-09-04 | 2003-03-13 | Akzo Nobel N.V. | GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY |
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ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
SI1591446T1 (sl) | 2003-01-29 | 2013-07-31 | Takeda Pharmaceutical Company Limited | Tienopiridinske spojine in njihova uporaba |
WO2006014647A2 (en) * | 2004-07-21 | 2006-02-09 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
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JPWO2010026993A1 (ja) | 2008-09-03 | 2012-02-02 | 武田薬品工業株式会社 | 製剤における吸収性改善方法および吸収性が改善された製剤 |
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JP2012217679A (ja) | 2011-04-11 | 2012-11-12 | Okumura Yu-Ki Co Ltd | パチンコ遊技機 |
UY35058A (es) | 2012-09-28 | 2014-04-30 | Takeda Pharmaceutical | Método de producción de derivado de tienopirimidina |
FI3263110T3 (fi) | 2015-02-26 | 2023-07-25 | Takeda Pharmaceuticals Co | Tabletti, joka käsittää metoksiureajohdannaista ja mannitolipartikkeleita |
-
2013
- 2013-09-27 UY UY0001035058A patent/UY35058A/es not_active Application Discontinuation
- 2013-09-27 CA CA2881132A patent/CA2881132C/en not_active Expired - Fee Related
- 2013-09-27 RS RS20190473A patent/RS58703B1/sr unknown
- 2013-09-27 EP EP13779938.3A patent/EP2900675B1/en active Active
- 2013-09-27 TW TW107136006A patent/TWI663171B/zh active
- 2013-09-27 ES ES13779938T patent/ES2724206T3/es active Active
- 2013-09-27 CN CN201811130716.8A patent/CN109053766B/zh active Active
- 2013-09-27 RS RS20220449A patent/RS63199B1/sr unknown
- 2013-09-27 DK DK18185835.8T patent/DK3415517T3/da active
- 2013-09-27 HR HRP20220622TT patent/HRP20220622T1/hr unknown
- 2013-09-27 LT LTEP13779938.3T patent/LT2900675T/lt unknown
- 2013-09-27 US US14/432,188 patent/US9758528B2/en active Active
- 2013-09-27 TR TR2019/06318T patent/TR201906318T4/tr unknown
- 2013-09-27 AR ARP130103480A patent/AR092707A1/es unknown
- 2013-09-27 PL PL13779938T patent/PL2900675T3/pl unknown
- 2013-09-27 WO PCT/JP2013/077013 patent/WO2014051164A2/en active Application Filing
- 2013-09-27 SI SI201331988T patent/SI3415517T1/sl unknown
- 2013-09-27 TW TW106130632A patent/TWI641611B/zh active
- 2013-09-27 EP EP18185835.8A patent/EP3415517B1/en active Active
- 2013-09-27 PL PL18185835T patent/PL3415517T3/pl unknown
- 2013-09-27 CN CN201380051107.2A patent/CN104703992B/zh active Active
- 2013-09-27 TW TW102134983A patent/TWI602819B/zh active
- 2013-09-27 DK DK13779938.3T patent/DK2900675T3/da active
- 2013-09-27 SI SI201331414T patent/SI2900675T1/sl unknown
- 2013-09-27 EP EP22168256.0A patent/EP4119564A1/en active Pending
- 2013-09-27 LT LTEP18185835.8T patent/LT3415517T/lt unknown
- 2013-09-27 HU HUE18185835A patent/HUE059077T2/hu unknown
- 2013-09-27 JP JP2014557263A patent/JP6250564B2/ja active Active
- 2013-09-27 PT PT181858358T patent/PT3415517T/pt unknown
- 2013-09-27 PT PT13779938T patent/PT2900675T/pt unknown
- 2013-09-27 HU HUE13779938A patent/HUE044048T2/hu unknown
- 2013-09-27 CN CN202110609164.4A patent/CN113372358B/zh active Active
- 2013-09-27 ES ES18185835T patent/ES2913753T3/es active Active
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2017
- 2017-04-07 US US15/481,505 patent/US10150778B2/en active Active
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2018
- 2018-07-12 US US16/034,002 patent/US10464945B2/en active Active
- 2018-08-29 US US16/116,804 patent/US10544160B2/en active Active
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2019
- 2019-04-17 HR HRP20190729TT patent/HRP20190729T1/hr unknown
- 2019-05-21 CY CY20191100544T patent/CY1121641T1/el unknown
- 2019-12-11 US US16/710,390 patent/US11053257B2/en active Active
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2021
- 2021-06-16 US US17/349,584 patent/US11731983B2/en active Active
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2022
- 2022-03-14 US US17/694,635 patent/US11795178B2/en active Active
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2023
- 2023-03-15 US US18/121,886 patent/US20230212184A1/en active Pending
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