HUE044048T2 - Eljárás tienopirimidin származék elõállítására - Google Patents
Eljárás tienopirimidin származék elõállításáraInfo
- Publication number
- HUE044048T2 HUE044048T2 HUE13779938A HUE13779938A HUE044048T2 HU E044048 T2 HUE044048 T2 HU E044048T2 HU E13779938 A HUE13779938 A HU E13779938A HU E13779938 A HUE13779938 A HU E13779938A HU E044048 T2 HUE044048 T2 HU E044048T2
- Authority
- HU
- Hungary
- Prior art keywords
- production method
- thienopyrimidine derivative
- thienopyrimidine
- derivative
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012217679 | 2012-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE044048T2 true HUE044048T2 (hu) | 2019-09-30 |
Family
ID=49448235
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE13779938A HUE044048T2 (hu) | 2012-09-28 | 2013-09-27 | Eljárás tienopirimidin származék elõállítására |
HUE18185835A HUE059077T2 (hu) | 2012-09-28 | 2013-09-27 | 1-(4-1-(2,6-difluorbenzil)-5-dimetilaminometil-3-(6-metoxipiridazin-3-il)-2,4 -dioxo-1,2,3,4-tetrahidrotieno(2,3-D)-pirimidin-6-il)fenil)-3-metoxikarbamid kristályos alakja |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE18185835A HUE059077T2 (hu) | 2012-09-28 | 2013-09-27 | 1-(4-1-(2,6-difluorbenzil)-5-dimetilaminometil-3-(6-metoxipiridazin-3-il)-2,4 -dioxo-1,2,3,4-tetrahidrotieno(2,3-D)-pirimidin-6-il)fenil)-3-metoxikarbamid kristályos alakja |
Country Status (20)
Country | Link |
---|---|
US (8) | US9758528B2 (hu) |
EP (3) | EP4119564A1 (hu) |
JP (1) | JP6250564B2 (hu) |
CN (3) | CN113372358A (hu) |
AR (1) | AR092707A1 (hu) |
CA (1) | CA2881132C (hu) |
CY (1) | CY1121641T1 (hu) |
DK (2) | DK2900675T3 (hu) |
ES (2) | ES2913753T3 (hu) |
HR (2) | HRP20220622T1 (hu) |
HU (2) | HUE044048T2 (hu) |
LT (2) | LT2900675T (hu) |
PL (2) | PL2900675T3 (hu) |
PT (2) | PT2900675T (hu) |
RS (2) | RS63199B1 (hu) |
SI (2) | SI3415517T1 (hu) |
TR (1) | TR201906318T4 (hu) |
TW (3) | TWI663171B (hu) |
UY (1) | UY35058A (hu) |
WO (1) | WO2014051164A2 (hu) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE044048T2 (hu) | 2012-09-28 | 2019-09-30 | Takeda Pharmaceuticals Co | Eljárás tienopirimidin származék elõállítására |
SI3263110T1 (sl) | 2015-02-26 | 2023-09-29 | Takeda Pharmaceutical Company Limited | Tableta, ki vsebuje derivat metoksisečnine in delce manitola |
JP7062673B2 (ja) | 2016-09-30 | 2022-05-06 | ミオバント サイエンシズ ゲーエムベーハー | 前立腺がんの治療 |
JP7043503B2 (ja) | 2016-09-30 | 2022-03-29 | ミオバント サイエンシズ ゲーエムベーハー | 子宮筋腫及び子宮内膜症を治療する方法 |
KR102516017B1 (ko) * | 2016-11-14 | 2023-03-30 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | GnRH 수용체 길항제의 결정질 형태 및 그의 제조 방법 |
KR20200027481A (ko) | 2017-06-05 | 2020-03-12 | 옵스에파 에스에이 | 자궁내막증의 치료를 위한 고나도트로핀 방출호르몬 길항제 투약요법 |
CN107188855A (zh) * | 2017-07-14 | 2017-09-22 | 常州工程职业技术学院 | 一种3‑氨基‑6甲氧基哒嗪的制备方法 |
WO2019178304A1 (en) | 2018-03-14 | 2019-09-19 | Teva Pharmaceuticals International Gmbh | Solid state forms of relugolix |
EP3666776A1 (en) | 2018-12-11 | 2020-06-17 | Sandoz AG | Hydrate of a gonadotropin-releasing hormone receptor antagonist |
WO2020230094A1 (en) * | 2019-05-15 | 2020-11-19 | Dr. Reddy’S Laboratories Limited | Amorphous and crystalline forms of relugolix |
CN110194776B (zh) * | 2019-06-27 | 2021-05-28 | 四川伊诺达博医药科技有限公司 | 一种瑞卢戈利的合成方法 |
WO2021018105A1 (en) * | 2019-07-29 | 2021-02-04 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrimidinedione compounds and uses thereof |
BR112022001002A2 (pt) * | 2019-08-02 | 2022-04-12 | Johnson Matthey Plc | Solvato de dmf, forma a, forma c, processos para a preparação do solvato de dmf, para a preparação da forma a de relugolix anidra, para a preparação da forma b de relugolix anidra e para a preparação da forma c de relugolix anidra, composição farmacêutica, e, método de tratamento de doença |
CN112321602A (zh) * | 2019-08-05 | 2021-02-05 | 苏州鹏旭医药科技有限公司 | 一种瑞卢戈利药物中间体的制备方法 |
CN112390812A (zh) * | 2019-08-14 | 2021-02-23 | 苏州鹏旭医药科技有限公司 | 瑞卢戈利化合物的晶型和无定型固体及其制备方法 |
CN112771052B (zh) * | 2019-08-21 | 2023-04-07 | 深圳仁泰医药科技有限公司 | 促性腺素释放激素拮抗剂的晶型及其制备方法和用途 |
CN115279769A (zh) * | 2019-10-10 | 2022-11-01 | 梦欧文科学有限责任公司 | N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n’-甲氧基脲的结晶形式 |
EP4041738A1 (en) * | 2019-10-10 | 2022-08-17 | Myovant Sciences GmbH | Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
CN112745304A (zh) * | 2019-10-29 | 2021-05-04 | 上海度德医药科技有限公司 | 一种Relugolix的制备方法及中间体化合物 |
CN111423452B (zh) * | 2020-03-26 | 2023-08-22 | 江西青峰药业有限公司 | 瑞卢戈利的中间体及其制备方法和应用 |
CN113444105A (zh) * | 2020-03-27 | 2021-09-28 | 南京海润医药有限公司 | 一种Relugolix的制备方法 |
CN111333633B (zh) * | 2020-04-01 | 2023-10-20 | 江西科睿药业有限公司 | 一种瑞卢戈利的中间体化合物及其制备方法和用途 |
CN111574534B (zh) * | 2020-05-25 | 2021-06-04 | 东莞市东阳光新药研发有限公司 | 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途 |
AR122175A1 (es) | 2020-05-29 | 2022-08-24 | Myovant Sciences Gmbh | Formas de dosificación oral sólidas de combinación de antagonistas de la hormona liberadora de gonadotropina |
US11655256B1 (en) | 2020-11-06 | 2023-05-23 | Macfarlan Smith Limited | Processes for making a solid-state form of relugolix |
WO2022101303A1 (en) | 2020-11-11 | 2022-05-19 | Myovant Sciences Gmbh | Methods of administering relugolix |
CN112552312B (zh) * | 2020-12-07 | 2022-08-05 | 杭州科巢生物科技有限公司 | 一种瑞卢戈利或其盐的合成方法 |
CN114685468A (zh) * | 2020-12-25 | 2022-07-01 | 成都硕德药业有限公司 | 用于治疗子宫肌瘤的药物的中间体化合物及其制备方法 |
CN113620972A (zh) * | 2021-02-02 | 2021-11-09 | 奥锐特药业(天津)有限公司 | 瑞卢戈利新晶型及其制备方法 |
CN114907370B (zh) | 2021-02-10 | 2023-11-03 | 奥锐特药业(天津)有限公司 | 高纯度的噻吩并嘧啶化合物及其制备方法 |
CN115073491A (zh) * | 2021-03-12 | 2022-09-20 | 上海医药工业研究院 | 一种瑞卢戈利中间体、其制备方法及其应用 |
WO2022214645A1 (en) | 2021-04-09 | 2022-10-13 | Farmhispania Group, S.L. | Processes and intermediates for the preparation of relugolix |
CN115594688B (zh) * | 2021-06-28 | 2023-11-17 | 成都倍特药业股份有限公司 | 瑞卢戈利中间体的制备方法 |
WO2023066941A1 (en) * | 2021-10-18 | 2023-04-27 | Myovant Sciences Gmbh | Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
CN114230576A (zh) * | 2021-12-21 | 2022-03-25 | 伊诺药物研究(南京)有限公司 | 一种瑞卢戈利的制备方法 |
WO2023119333A1 (en) * | 2021-12-25 | 2023-06-29 | Dr. Reddy’S Laboratories Limited | Process for preparation of relugolix and its intermediates |
CN114409629B (zh) * | 2022-02-22 | 2023-12-29 | 浙江科聚生物医药有限公司 | 一种高纯度Relugolix关键中间体的制备方法及应用 |
CN114790189B (zh) * | 2022-02-24 | 2023-06-09 | 海化生命(厦门)科技有限公司 | 瑞卢戈利中间体的制备方法 |
CN114755320A (zh) * | 2022-03-17 | 2022-07-15 | 南京方生和医药科技有限公司 | 一种3-氨基-6-甲氧基哒嗪有关物质的检测方法 |
WO2023194924A1 (en) * | 2022-04-08 | 2023-10-12 | Glenmark Life Sciences Limited | Process for preparation of relugolix |
CN114621249B (zh) * | 2022-04-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 瑞卢戈利关键中间体的制备 |
WO2023214935A1 (en) * | 2022-05-05 | 2023-11-09 | Scinopharm Taiwan, Ltd. | Process for preparing relugolix and intermediates thereof |
CN115594689B (zh) * | 2022-07-14 | 2024-03-19 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体、一种瑞卢戈利的合成方法 |
CN117285506A (zh) * | 2022-07-14 | 2023-12-26 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体及其制备方法 |
CN115417883A (zh) * | 2022-09-16 | 2022-12-02 | 浙江科聚生物医药有限公司 | 一种瑞卢戈利的晶型及其制备方法 |
WO2024069492A1 (en) | 2022-09-29 | 2024-04-04 | Macfarlan Smith Limited | Processes for the preparation and manufacture of relugolix |
CN115650950A (zh) * | 2022-11-03 | 2023-01-31 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体及其制备方法以及一种酰胺缩合方法 |
CN115650965B (zh) * | 2022-12-26 | 2023-03-31 | 南京威凯尔生物医药科技有限公司 | 一种瑞卢戈利关键中间体的制备方法 |
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TWI225863B (en) | 1999-03-24 | 2005-01-01 | Takeda Chemical Industries Ltd | Thienopyrimidine compounds, their production and use |
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AU2003303269A1 (en) | 2002-12-20 | 2004-07-14 | Koninklijke Philips Electronics N.V. | Enhancing video images depending on prior image enhancements |
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CN101153042A (zh) | 2003-01-29 | 2008-04-02 | 武田药品工业株式会社 | 噻吩并嘧啶化合物及其用途 |
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CN101272806A (zh) * | 2005-07-22 | 2008-09-24 | 武田药品工业株式会社 | 过早排卵抑制剂 |
EP2329823A4 (en) | 2008-09-03 | 2013-04-03 | Takeda Pharmaceutical | METHOD FOR IMPROVING CAPACITY OF PREPARATION TO BE ABSORBED AND PREPARATION WHICH CAPACITY TO BE ABSORBED IS IMPROVED |
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JP2012217679A (ja) | 2011-04-11 | 2012-11-12 | Okumura Yu-Ki Co Ltd | パチンコ遊技機 |
HUE044048T2 (hu) | 2012-09-28 | 2019-09-30 | Takeda Pharmaceuticals Co | Eljárás tienopirimidin származék elõállítására |
SI3263110T1 (sl) | 2015-02-26 | 2023-09-29 | Takeda Pharmaceutical Company Limited | Tableta, ki vsebuje derivat metoksisečnine in delce manitola |
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2013
- 2013-09-27 HU HUE13779938A patent/HUE044048T2/hu unknown
- 2013-09-27 PL PL13779938T patent/PL2900675T3/pl unknown
- 2013-09-27 TW TW107136006A patent/TWI663171B/zh active
- 2013-09-27 EP EP22168256.0A patent/EP4119564A1/en active Pending
- 2013-09-27 DK DK13779938.3T patent/DK2900675T3/da active
- 2013-09-27 RS RS20220449A patent/RS63199B1/sr unknown
- 2013-09-27 DK DK18185835.8T patent/DK3415517T3/da active
- 2013-09-27 TW TW102134983A patent/TWI602819B/zh active
- 2013-09-27 ES ES18185835T patent/ES2913753T3/es active Active
- 2013-09-27 CN CN202110609164.4A patent/CN113372358A/zh active Pending
- 2013-09-27 PT PT13779938T patent/PT2900675T/pt unknown
- 2013-09-27 PL PL18185835T patent/PL3415517T3/pl unknown
- 2013-09-27 EP EP18185835.8A patent/EP3415517B1/en active Active
- 2013-09-27 TW TW106130632A patent/TWI641611B/zh active
- 2013-09-27 UY UY0001035058A patent/UY35058A/es not_active Application Discontinuation
- 2013-09-27 CN CN201811130716.8A patent/CN109053766B/zh active Active
- 2013-09-27 TR TR2019/06318T patent/TR201906318T4/tr unknown
- 2013-09-27 LT LTEP13779938.3T patent/LT2900675T/lt unknown
- 2013-09-27 CA CA2881132A patent/CA2881132C/en active Active
- 2013-09-27 PT PT181858358T patent/PT3415517T/pt unknown
- 2013-09-27 LT LTEP18185835.8T patent/LT3415517T/lt unknown
- 2013-09-27 HR HRP20220622TT patent/HRP20220622T1/hr unknown
- 2013-09-27 US US14/432,188 patent/US9758528B2/en active Active
- 2013-09-27 HU HUE18185835A patent/HUE059077T2/hu unknown
- 2013-09-27 WO PCT/JP2013/077013 patent/WO2014051164A2/en active Application Filing
- 2013-09-27 SI SI201331988T patent/SI3415517T1/sl unknown
- 2013-09-27 AR ARP130103480A patent/AR092707A1/es unknown
- 2013-09-27 EP EP13779938.3A patent/EP2900675B1/en active Active
- 2013-09-27 CN CN201380051107.2A patent/CN104703992B/zh active Active
- 2013-09-27 ES ES13779938T patent/ES2724206T3/es active Active
- 2013-09-27 JP JP2014557263A patent/JP6250564B2/ja active Active
- 2013-09-27 RS RS20190473A patent/RS58703B1/sr unknown
- 2013-09-27 SI SI201331414T patent/SI2900675T1/sl unknown
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2017
- 2017-04-07 US US15/481,505 patent/US10150778B2/en active Active
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2018
- 2018-07-12 US US16/034,002 patent/US10464945B2/en active Active
- 2018-08-29 US US16/116,804 patent/US10544160B2/en active Active
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2019
- 2019-04-17 HR HRP20190729TT patent/HRP20190729T1/hr unknown
- 2019-05-21 CY CY20191100544T patent/CY1121641T1/el unknown
- 2019-12-11 US US16/710,390 patent/US11053257B2/en active Active
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2021
- 2021-06-16 US US17/349,584 patent/US11731983B2/en active Active
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2022
- 2022-03-14 US US17/694,635 patent/US11795178B2/en active Active
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2023
- 2023-03-15 US US18/121,886 patent/US20230212184A1/en active Pending
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