DK2900675T3 - Fremgangsmåde til fremstilling af et thienopyrimidinderivat - Google Patents
Fremgangsmåde til fremstilling af et thienopyrimidinderivat Download PDFInfo
- Publication number
- DK2900675T3 DK2900675T3 DK13779938.3T DK13779938T DK2900675T3 DK 2900675 T3 DK2900675 T3 DK 2900675T3 DK 13779938 T DK13779938 T DK 13779938T DK 2900675 T3 DK2900675 T3 DK 2900675T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- manufacture
- thienopyrimidine derivative
- thienopyrimidine
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012217679 | 2012-09-28 | ||
| PCT/JP2013/077013 WO2014051164A2 (en) | 2012-09-28 | 2013-09-27 | Production method of thienopyrimidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2900675T3 true DK2900675T3 (da) | 2019-06-03 |
Family
ID=49448235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13779938.3T DK2900675T3 (da) | 2012-09-28 | 2013-09-27 | Fremgangsmåde til fremstilling af et thienopyrimidinderivat |
| DK18185835.8T DK3415517T3 (da) | 2012-09-28 | 2013-09-27 | Krystallinsk form af 1-(4-1-(2,6-difluorbenzyl)-5-dimethylaminomethyl-3-(6- methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)-pyrimidin- 6yl)phenyl)-3-methoxyurea |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18185835.8T DK3415517T3 (da) | 2012-09-28 | 2013-09-27 | Krystallinsk form af 1-(4-1-(2,6-difluorbenzyl)-5-dimethylaminomethyl-3-(6- methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)-pyrimidin- 6yl)phenyl)-3-methoxyurea |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US9758528B2 (da) |
| EP (3) | EP2900675B1 (da) |
| JP (1) | JP6250564B2 (da) |
| CN (3) | CN104703992B (da) |
| AR (1) | AR092707A1 (da) |
| CA (1) | CA2881132C (da) |
| CY (1) | CY1121641T1 (da) |
| DK (2) | DK2900675T3 (da) |
| ES (2) | ES2913753T3 (da) |
| HR (2) | HRP20220622T1 (da) |
| HU (2) | HUE044048T2 (da) |
| LT (2) | LT2900675T (da) |
| PL (2) | PL2900675T3 (da) |
| PT (2) | PT2900675T (da) |
| RS (2) | RS63199B1 (da) |
| SI (2) | SI3415517T1 (da) |
| TR (1) | TR201906318T4 (da) |
| TW (3) | TWI602819B (da) |
| UY (1) | UY35058A (da) |
| WO (1) | WO2014051164A2 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2900675B1 (en) | 2012-09-28 | 2019-03-06 | Takeda Pharmaceutical Company Limited | Production method of thienopyrimidine derivative |
| MX2017010945A (es) | 2015-02-26 | 2018-07-06 | Takeda Pharmaceuticals Co | Preparacion solida. |
| HUE059101T2 (hu) | 2016-09-30 | 2022-10-28 | Myovant Sciences Gmbh | Eljárások uterinális fibroidok és endometriózis kezelésére |
| AU2017334035B2 (en) | 2016-09-30 | 2022-11-24 | Myovant Sciences Gmbh | Treatment of prostate cancer |
| CA3040026A1 (en) * | 2016-11-14 | 2018-05-17 | Jiangsu Hengrui Medicine Co., Ltd. | Crystalline form of gnrh receptor antagonist and preparation method therefor |
| EP3634418A1 (en) | 2017-06-05 | 2020-04-15 | ObsEva S.A. | Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis |
| CN107188855A (zh) * | 2017-07-14 | 2017-09-22 | 常州工程职业技术学院 | 一种3‑氨基‑6甲氧基哒嗪的制备方法 |
| EP3765464A1 (en) | 2018-03-14 | 2021-01-20 | Teva Pharmaceuticals USA, Inc. | Solid state forms of relugolix |
| EP3666776A1 (en) | 2018-12-11 | 2020-06-17 | Sandoz AG | Hydrate of a gonadotropin-releasing hormone receptor antagonist |
| EP3969455A4 (en) * | 2019-05-15 | 2023-07-05 | Dr. Reddy's Laboratories Limited | AMORPHOUS AND CRYSTALLINE FORMS OF RELUGOLIX |
| CN110194776B (zh) * | 2019-06-27 | 2021-05-28 | 四川伊诺达博医药科技有限公司 | 一种瑞卢戈利的合成方法 |
| CN111943960B (zh) * | 2019-07-29 | 2022-02-15 | 广东东阳光药业有限公司 | 取代的嘧啶二酮类化合物及其用途 |
| CA3145993A1 (en) * | 2019-08-02 | 2021-02-11 | Johnson Matthey Public Limited Company | Solid-state forms of relugolix |
| CN112321602A (zh) * | 2019-08-05 | 2021-02-05 | 苏州鹏旭医药科技有限公司 | 一种瑞卢戈利药物中间体的制备方法 |
| CN112390812A (zh) * | 2019-08-14 | 2021-02-23 | 苏州鹏旭医药科技有限公司 | 瑞卢戈利化合物的晶型和无定型固体及其制备方法 |
| CN112771052B (zh) * | 2019-08-21 | 2023-04-07 | 深圳仁泰医药科技有限公司 | 促性腺素释放激素拮抗剂的晶型及其制备方法和用途 |
| WO2021069700A1 (en) * | 2019-10-10 | 2021-04-15 | Myovant Sciences Gmbh | Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
| CN115279769A (zh) * | 2019-10-10 | 2022-11-01 | 梦欧文科学有限责任公司 | N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n’-甲氧基脲的结晶形式 |
| CN112745304A (zh) * | 2019-10-29 | 2021-05-04 | 上海度德医药科技有限公司 | 一种Relugolix的制备方法及中间体化合物 |
| CN111423452B (zh) * | 2020-03-26 | 2023-08-22 | 江西青峰药业有限公司 | 瑞卢戈利的中间体及其制备方法和应用 |
| CN113444105A (zh) * | 2020-03-27 | 2021-09-28 | 南京海润医药有限公司 | 一种Relugolix的制备方法 |
| CN111333633B (zh) * | 2020-04-01 | 2023-10-20 | 江西科睿药业有限公司 | 一种瑞卢戈利的中间体化合物及其制备方法和用途 |
| CN111574534B (zh) * | 2020-05-25 | 2021-06-04 | 东莞市东阳光新药研发有限公司 | 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途 |
| JP2023528014A (ja) | 2020-05-29 | 2023-07-03 | ミオバント サイエンシズ ゲーエムベーハー | ゴナドトロピン放出ホルモンアンタゴニストの組合せ固体経口製剤 |
| US11655256B1 (en) | 2020-11-06 | 2023-05-23 | Macfarlan Smith Limited | Processes for making a solid-state form of relugolix |
| WO2022101303A1 (en) | 2020-11-11 | 2022-05-19 | Myovant Sciences Gmbh | Methods of administering relugolix |
| CN112552312B (zh) * | 2020-12-07 | 2022-08-05 | 杭州科巢生物科技有限公司 | 一种瑞卢戈利或其盐的合成方法 |
| CN114685468A (zh) * | 2020-12-25 | 2022-07-01 | 成都硕德药业有限公司 | 用于治疗子宫肌瘤的药物的中间体化合物及其制备方法 |
| CN113620972A (zh) * | 2021-02-02 | 2021-11-09 | 奥锐特药业(天津)有限公司 | 瑞卢戈利新晶型及其制备方法 |
| CN114907370B (zh) | 2021-02-10 | 2023-11-03 | 奥锐特药业(天津)有限公司 | 高纯度的噻吩并嘧啶化合物及其制备方法 |
| CN115073491A (zh) * | 2021-03-12 | 2022-09-20 | 上海医药工业研究院 | 一种瑞卢戈利中间体、其制备方法及其应用 |
| WO2022214645A1 (en) | 2021-04-09 | 2022-10-13 | Farmhispania Group, S.L. | Processes and intermediates for the preparation of relugolix |
| CN115594688B (zh) * | 2021-06-28 | 2023-11-17 | 成都倍特药业股份有限公司 | 瑞卢戈利中间体的制备方法 |
| WO2023066941A1 (en) * | 2021-10-18 | 2023-04-27 | Myovant Sciences Gmbh | Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
| CN114230576A (zh) * | 2021-12-21 | 2022-03-25 | 伊诺药物研究(南京)有限公司 | 一种瑞卢戈利的制备方法 |
| WO2023119333A1 (en) * | 2021-12-25 | 2023-06-29 | Dr. Reddy’S Laboratories Limited | Process for preparation of relugolix and its intermediates |
| CN114409629B (zh) * | 2022-02-22 | 2023-12-29 | 浙江科聚生物医药有限公司 | 一种高纯度Relugolix关键中间体的制备方法及应用 |
| CN114790189B (zh) * | 2022-02-24 | 2023-06-09 | 海化生命(厦门)科技有限公司 | 瑞卢戈利中间体的制备方法 |
| CN114755320A (zh) * | 2022-03-17 | 2022-07-15 | 南京方生和医药科技有限公司 | 一种3-氨基-6-甲氧基哒嗪有关物质的检测方法 |
| WO2023194924A1 (en) * | 2022-04-08 | 2023-10-12 | Glenmark Life Sciences Limited | Process for preparation of relugolix |
| CN114621249B (zh) * | 2022-04-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 瑞卢戈利关键中间体的制备 |
| WO2023214935A1 (en) * | 2022-05-05 | 2023-11-09 | Scinopharm Taiwan, Ltd. | Process for preparing relugolix and intermediates thereof |
| CN114989134B (zh) * | 2022-07-14 | 2023-11-14 | 江西同和药业股份有限公司 | 一种噻吩类化合物及其制备方法与应用 |
| CN115594689B (zh) * | 2022-07-14 | 2024-03-19 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体、一种瑞卢戈利的合成方法 |
| CN115417883A (zh) * | 2022-09-16 | 2022-12-02 | 浙江科聚生物医药有限公司 | 一种瑞卢戈利的晶型及其制备方法 |
| WO2024069492A1 (en) | 2022-09-29 | 2024-04-04 | Macfarlan Smith Limited | Processes for the preparation and manufacture of relugolix |
| CN115650950A (zh) * | 2022-11-03 | 2023-01-31 | 江西同和药业股份有限公司 | 一种瑞卢戈利中间体及其制备方法以及一种酰胺缩合方法 |
| CN115650965B (zh) * | 2022-12-26 | 2023-03-31 | 南京威凯尔生物医药科技有限公司 | 一种瑞卢戈利关键中间体的制备方法 |
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| JPS5116436B1 (da) * | 1971-05-31 | 1976-05-24 | ||
| EP0237289A3 (en) * | 1986-03-14 | 1988-07-27 | Takeda Chemical Industries, Ltd. | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use |
| US5312958A (en) | 1992-01-31 | 1994-05-17 | Takeda Chemical Industries, Ltd. | Process for producing 4-bromomethylbiphenyl compounds |
| JP2859791B2 (ja) | 1992-01-31 | 1999-02-24 | 吉富製薬株式会社 | ４−ブロモメチルビフェニル化合物の製造法 |
| JPH10298156A (ja) | 1997-04-28 | 1998-11-10 | Nippon Nohyaku Co Ltd | 置換ハロメチルフェニルカルバミド酸エステル類の製造方法 |
| US6297379B1 (en) | 1999-03-24 | 2001-10-02 | Takeda Chemical Industries, Ltd. | Thienopyrimidine compounds, their production and use |
| TWI225863B (en) | 1999-03-24 | 2005-01-01 | Takeda Chemical Industries Ltd | Thienopyrimidine compounds, their production and use |
| JP2001316391A (ja) * | 2000-02-29 | 2001-11-13 | Takeda Chem Ind Ltd | チエノピリミジン誘導体の製造法 |
| CA2401379A1 (en) * | 2000-02-29 | 2001-09-07 | Junichi Kawakami | Processes for the production of thienopyrimidine derivatives |
| GB2361917A (en) * | 2000-05-04 | 2001-11-07 | Astrazeneca Ab | Novel thieno[2,3-d]pyrimidinediones |
| JP2002068044A (ja) | 2000-09-04 | 2002-03-08 | Yamaha Motor Co Ltd | 自動二輪車用ハンドルシート |
| JP2002088044A (ja) | 2000-09-14 | 2002-03-27 | Sumitomo Seika Chem Co Ltd | ４’−ブロモメチル−２−シアノビフェニルの製造方法 |
| WO2003020727A1 (en) | 2001-09-04 | 2003-03-13 | Akzo Nobel N.V. | GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY |
| WO2003064429A1 (fr) * | 2002-01-30 | 2003-08-07 | Takeda Chemical Industries, Ltd. | Thienopyrimidines, procedes de fabrication et d'utilisation correspondants |
| JP2006511160A (ja) | 2002-12-20 | 2006-03-30 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 先行する画像強化に依存したビデオ画像強化 |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| KR101074462B1 (ko) * | 2003-01-29 | 2011-10-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 티에노피리미딘 화합물 및 그 용도 |
| US7947691B2 (en) * | 2004-07-21 | 2011-05-24 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| RU2007115517A (ru) * | 2004-10-25 | 2008-10-27 | Нихон Нохияку Ко. | Гербицидная композиция для пастбищно-выпасного хозяйства на холмах и способ борьбы с сорняками |
| US20090048273A1 (en) * | 2005-07-22 | 2009-02-19 | Takeda Pharmaceutical Company Limited | Premature ovulation preventive agent |
| US20110172249A1 (en) | 2008-09-03 | 2011-07-14 | Takeda Pharmaceutical Company Limted | Method for improving absorbability of preparation, and preparation having improved absorbability |
| PL2678327T3 (pl) * | 2011-02-23 | 2017-02-28 | Lupin Limited | Pochodne heteroarylowe jako modulatory Alfa 7 NACHR |
| JP2012217679A (ja) | 2011-04-11 | 2012-11-12 | Okumura Yu-Ki Co Ltd | パチンコ遊技機 |
| EP2900675B1 (en) | 2012-09-28 | 2019-03-06 | Takeda Pharmaceutical Company Limited | Production method of thienopyrimidine derivative |
| MX2017010945A (es) | 2015-02-26 | 2018-07-06 | Takeda Pharmaceuticals Co | Preparacion solida. |
-
2013
- 2013-09-27 EP EP13779938.3A patent/EP2900675B1/en active Active
- 2013-09-27 US US14/432,188 patent/US9758528B2/en active Active
- 2013-09-27 TW TW102134983A patent/TWI602819B/zh active
- 2013-09-27 RS RS20220449A patent/RS63199B1/sr unknown
- 2013-09-27 JP JP2014557263A patent/JP6250564B2/ja active Active
- 2013-09-27 CN CN201380051107.2A patent/CN104703992B/zh active Active
- 2013-09-27 TR TR2019/06318T patent/TR201906318T4/tr unknown
- 2013-09-27 SI SI201331988T patent/SI3415517T1/sl unknown
- 2013-09-27 HU HUE13779938A patent/HUE044048T2/hu unknown
- 2013-09-27 DK DK13779938.3T patent/DK2900675T3/da active
- 2013-09-27 TW TW106130632A patent/TWI641611B/zh active
- 2013-09-27 TW TW107136006A patent/TWI663171B/zh active
- 2013-09-27 CA CA2881132A patent/CA2881132C/en active Active
- 2013-09-27 CN CN201811130716.8A patent/CN109053766B/zh active Active
- 2013-09-27 UY UY0001035058A patent/UY35058A/es not_active Application Discontinuation
- 2013-09-27 EP EP22168256.0A patent/EP4119564A1/en active Pending
- 2013-09-27 PT PT13779938T patent/PT2900675T/pt unknown
- 2013-09-27 SI SI201331414T patent/SI2900675T1/sl unknown
- 2013-09-27 WO PCT/JP2013/077013 patent/WO2014051164A2/en active Application Filing
- 2013-09-27 PL PL13779938T patent/PL2900675T3/pl unknown
- 2013-09-27 ES ES18185835T patent/ES2913753T3/es active Active
- 2013-09-27 ES ES13779938T patent/ES2724206T3/es active Active
- 2013-09-27 LT LTEP13779938.3T patent/LT2900675T/lt unknown
- 2013-09-27 AR ARP130103480A patent/AR092707A1/es unknown
- 2013-09-27 PT PT181858358T patent/PT3415517T/pt unknown
- 2013-09-27 LT LTEP18185835.8T patent/LT3415517T/lt unknown
- 2013-09-27 RS RS20190473A patent/RS58703B1/sr unknown
- 2013-09-27 HU HUE18185835A patent/HUE059077T2/hu unknown
- 2013-09-27 DK DK18185835.8T patent/DK3415517T3/da active
- 2013-09-27 CN CN202110609164.4A patent/CN113372358A/zh active Pending
- 2013-09-27 PL PL18185835T patent/PL3415517T3/pl unknown
- 2013-09-27 HR HRP20220622TT patent/HRP20220622T1/hr unknown
- 2013-09-27 EP EP18185835.8A patent/EP3415517B1/en active Active
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2017
- 2017-04-07 US US15/481,505 patent/US10150778B2/en active Active
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2018
- 2018-07-12 US US16/034,002 patent/US10464945B2/en active Active
- 2018-08-29 US US16/116,804 patent/US10544160B2/en active Active
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2019
- 2019-04-17 HR HRP20190729TT patent/HRP20190729T1/hr unknown
- 2019-05-21 CY CY20191100544T patent/CY1121641T1/el unknown
- 2019-12-11 US US16/710,390 patent/US11053257B2/en active Active
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2021
- 2021-06-16 US US17/349,584 patent/US11731983B2/en active Active
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2022
- 2022-03-14 US US17/694,635 patent/US11795178B2/en active Active
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2023
- 2023-03-15 US US18/121,886 patent/US20230212184A1/en active Pending
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