JP2015521036A5 - - Google Patents
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- Publication number
- JP2015521036A5 JP2015521036A5 JP2015510461A JP2015510461A JP2015521036A5 JP 2015521036 A5 JP2015521036 A5 JP 2015521036A5 JP 2015510461 A JP2015510461 A JP 2015510461A JP 2015510461 A JP2015510461 A JP 2015510461A JP 2015521036 A5 JP2015521036 A5 JP 2015521036A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- polypeptide
- cell according
- isoprene
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004027 cell Anatomy 0.000 claims 31
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 7
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 7
- 230000037361 pathway Effects 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 241000520244 Tatumella citrea Species 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- 108010075483 isoprene synthase Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 239000002028 Biomass Substances 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000488157 Escherichia sp. Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N Isopentenyl diphosphate Natural products CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 241000983368 Pantoea sp. Species 0.000 claims 1
- 244000062331 Pavetta montana Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241000223259 Trichoderma Species 0.000 claims 1
- 241000499912 Trichoderma reesei Species 0.000 claims 1
- 241000235015 Yarrowia lipolytica Species 0.000 claims 1
- 241000490645 Yarrowia sp. Species 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229940041514 candida albicans extract Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010060155 deoxyxylulose-5-phosphate synthase Proteins 0.000 claims 1
- 229940120503 dihydroxyacetone Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229960001031 glucose Drugs 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 239000012138 yeast extract Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261641861P | 2012-05-02 | 2012-05-02 | |
| US61/641,861 | 2012-05-02 | ||
| US13/802,360 US8895277B2 (en) | 2012-05-02 | 2013-03-13 | Legume isoprene synthase for production of isoprene |
| US13/802,360 | 2013-03-13 | ||
| PCT/US2013/039315 WO2013166320A1 (en) | 2012-05-02 | 2013-05-02 | Legume isoprene synthase for production of isoprene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015521036A JP2015521036A (ja) | 2015-07-27 |
| JP2015521036A5 true JP2015521036A5 (enExample) | 2016-06-30 |
Family
ID=48444622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510461A Withdrawn JP2015521036A (ja) | 2012-05-02 | 2013-05-02 | イソプレン生産用のマメ科植物イソプレン合成酵素 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8895277B2 (enExample) |
| EP (1) | EP2844664A1 (enExample) |
| JP (1) | JP2015521036A (enExample) |
| BR (1) | BR112014027488A2 (enExample) |
| WO (1) | WO2013166320A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US8962296B2 (en) * | 2012-05-30 | 2015-02-24 | Bridgestone Corporation | Isoprene synthase and gene encoding the same, and method for producing isoprene monomer |
| JP6169073B2 (ja) * | 2012-05-30 | 2017-07-26 | 株式会社ブリヂストン | イソプレンシンターゼおよびそれをコードするポリヌクレオチド、ならびにイソプレンモノマーの製造方法 |
| MY172689A (en) | 2013-11-22 | 2019-12-10 | Ajinomoto Kk | Modified isoprene synthase |
| US10648004B2 (en) | 2014-02-20 | 2020-05-12 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products |
| KR102330593B1 (ko) | 2014-07-28 | 2021-11-26 | 에스케이이노베이션 주식회사 | 신규 이소프렌 신타아제 및 이를 이용한 이소프렌의 제조방법 |
| SG11201703132UA (en) | 2014-10-22 | 2017-05-30 | Temasek Life Sciences Lab Ltd | Terpene synthases from ylang ylang (cananga odorata var. fruticosa) |
| WO2016129637A1 (ja) * | 2015-02-13 | 2016-08-18 | 積水化学工業株式会社 | 核酸、融合タンパク質、組換え細胞、並びに、イソプレン又は環式テルペンの生産方法 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP2018148797A (ja) * | 2015-08-05 | 2018-09-27 | 味の素株式会社 | イソプレンモノマーの製造方法 |
| KR102546640B1 (ko) * | 2016-01-26 | 2023-06-22 | 에스케이이노베이션 주식회사 | 재조합 호염성 메탄균주를 이용한 이소프렌의 제조방법 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019006257A1 (en) * | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| JP7565569B2 (ja) * | 2020-03-04 | 2024-10-11 | 国立大学法人千葉大学 | 変異型イソプレン合成酵素及びそのスクリーニング方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8407828D0 (en) | 1984-03-27 | 1984-05-02 | Ontario Research Foundation | In situ preparation |
| US4570029A (en) | 1985-03-04 | 1986-02-11 | Uop Inc. | Process for separating isoprene |
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| JP3666484B2 (ja) * | 2001-06-21 | 2005-06-29 | 東洋ゴム工業株式会社 | 液封入式防振装置 |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| CA2651747C (en) | 2006-05-26 | 2017-10-24 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| US7947478B2 (en) * | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| BRPI0823506A8 (pt) | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| WO2009100231A2 (en) | 2008-02-06 | 2009-08-13 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| JP2011518564A (ja) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| EP2310490B1 (en) | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| CA2737082A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MY156562A (en) | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
| BRPI0918936A2 (pt) | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
| WO2010031079A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| CN102333866B (zh) | 2008-12-30 | 2015-04-29 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| EP2421966A2 (en) * | 2009-04-23 | 2012-02-29 | Danisco US Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| CA2773675A1 (en) | 2009-09-15 | 2011-03-24 | Sapphire Energy, Inc. | A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| CN102884028B (zh) | 2009-12-18 | 2015-08-19 | 丹尼斯科美国公司 | 从可再生资源中纯化异戊二烯 |
| AU2010336342B2 (en) | 2009-12-23 | 2015-02-26 | Danisco Us Inc. | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (PGL) |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| JP2014502148A (ja) * | 2010-10-27 | 2014-01-30 | ダニスコ・ユーエス・インク | イソプレン生産の向上を目的としたイソプレン合成酵素変異体 |
-
2013
- 2013-03-13 US US13/802,360 patent/US8895277B2/en not_active Expired - Fee Related
- 2013-05-02 WO PCT/US2013/039315 patent/WO2013166320A1/en not_active Ceased
- 2013-05-02 EP EP13722943.1A patent/EP2844664A1/en not_active Withdrawn
- 2013-05-02 BR BR112014027488A patent/BR112014027488A2/pt not_active IP Right Cessation
- 2013-05-02 JP JP2015510461A patent/JP2015521036A/ja not_active Withdrawn
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