JP2017525359A5 - - Google Patents
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- Publication number
- JP2017525359A5 JP2017525359A5 JP2017508541A JP2017508541A JP2017525359A5 JP 2017525359 A5 JP2017525359 A5 JP 2017525359A5 JP 2017508541 A JP2017508541 A JP 2017508541A JP 2017508541 A JP2017508541 A JP 2017508541A JP 2017525359 A5 JP2017525359 A5 JP 2017525359A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- copper
- enzyme
- copper metal
- oxidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 53
- 229910052802 copper Inorganic materials 0.000 claims description 53
- 239000010949 copper Substances 0.000 claims description 53
- 239000002184 metal Substances 0.000 claims description 28
- 229910052751 metal Inorganic materials 0.000 claims description 28
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 27
- 230000014509 gene expression Effects 0.000 claims description 11
- 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 claims description 7
- 102000005431 Molecular Chaperones Human genes 0.000 claims description 7
- 102000040945 Transcription factor Human genes 0.000 claims description 3
- 108091023040 Transcription factor Proteins 0.000 claims description 3
- 230000002018 overexpression Effects 0.000 claims description 3
- 239000013604 expression vector Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 28
- 102000004190 Enzymes Human genes 0.000 claims 20
- 108090000790 Enzymes Proteins 0.000 claims 20
- 241000499912 Trichoderma reesei Species 0.000 claims 9
- 102000020856 Copper Transport Proteins Human genes 0.000 claims 8
- 108091004554 Copper Transport Proteins Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 108091006566 Copper transporters Proteins 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 241000228245 Aspergillus niger Species 0.000 claims 4
- 240000006439 Aspergillus oryzae Species 0.000 claims 4
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 4
- 102000030523 Catechol oxidase Human genes 0.000 claims 4
- 108010031396 Catechol oxidase Proteins 0.000 claims 4
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 4
- 108010022637 Copper-Transporting ATPases Proteins 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 108091006112 ATPases Proteins 0.000 claims 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 2
- 108010024957 Ascorbate Oxidase Proteins 0.000 claims 2
- 108010015428 Bilirubin oxidase Proteins 0.000 claims 2
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 claims 2
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 claims 2
- 108010015133 Galactose oxidase Proteins 0.000 claims 2
- 108010029541 Laccase Proteins 0.000 claims 2
- 101710154526 Lytic chitin monooxygenase Proteins 0.000 claims 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 2
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 108010057985 Quercetin 2,3-dioxygenase Proteins 0.000 claims 2
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 2
- 108010012715 Superoxide dismutase Proteins 0.000 claims 2
- 102000003425 Tyrosinase Human genes 0.000 claims 2
- 108060008724 Tyrosinase Proteins 0.000 claims 2
- 101150052795 cbh-1 gene Proteins 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 108010018734 hexose oxidase Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010007262 peptidylglycine monooxygenase Proteins 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 claims 1
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 1
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 239000012190 activator Substances 0.000 description 3
- 102100025169 Max-binding protein MNT Human genes 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 108091006107 transcriptional repressors Proteins 0.000 description 2
- 206010010957 Copper deficiency Diseases 0.000 description 1
- 101710135406 Metal-binding activator 1 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038095P | 2014-08-15 | 2014-08-15 | |
| US62/038,095 | 2014-08-15 | ||
| PCT/US2015/045260 WO2016025825A1 (en) | 2014-08-15 | 2015-08-14 | Compositions and methods for improved protein production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525359A JP2017525359A (ja) | 2017-09-07 |
| JP2017525359A5 true JP2017525359A5 (enExample) | 2020-01-16 |
Family
ID=54065453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508541A Pending JP2017525359A (ja) | 2014-08-15 | 2015-08-14 | タンパク質の産生改善のための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170233746A1 (enExample) |
| EP (1) | EP3180354A1 (enExample) |
| JP (1) | JP2017525359A (enExample) |
| KR (1) | KR20170036102A (enExample) |
| CN (1) | CN106795503A (enExample) |
| WO (1) | WO2016025825A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105916981A (zh) | 2013-07-29 | 2016-08-31 | 丹尼斯科美国公司 | 变体酶 |
| CN115786142A (zh) * | 2022-11-22 | 2023-03-14 | 中国农业大学 | 一种高产酪氨酸酶2的里氏木霉工程菌株的构建方法和应用 |
| KR20250132725A (ko) | 2024-02-29 | 2025-09-05 | 청주대학교 산학협력단 | 무인수상정 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| DE10046932B4 (de) * | 2000-09-21 | 2006-03-09 | Consortium für elektrochemische Industrie GmbH | Expressionssystem zur Überexpression von Kupfer-abhängigen sekretierten Proteinen in eukaryontischen Zellen |
| US20090221030A1 (en) * | 2007-11-01 | 2009-09-03 | Kai Bao | Signal sequences and co-expressed chaperones for improving protein production in a host cell |
| CA2801799C (en) * | 2010-06-03 | 2018-11-20 | Danisco Us Inc. | Filamentous fungal host strains and dna constructs, and methods of use thereof |
-
2015
- 2015-08-14 CN CN201580055291.7A patent/CN106795503A/zh active Pending
- 2015-08-14 KR KR1020177006654A patent/KR20170036102A/ko not_active Withdrawn
- 2015-08-14 WO PCT/US2015/045260 patent/WO2016025825A1/en not_active Ceased
- 2015-08-14 US US15/503,859 patent/US20170233746A1/en not_active Abandoned
- 2015-08-14 JP JP2017508541A patent/JP2017525359A/ja active Pending
- 2015-08-14 EP EP15760323.4A patent/EP3180354A1/en not_active Withdrawn
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