JP2014531904A5 - - Google Patents
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- JP2014531904A5 JP2014531904A5 JP2014534810A JP2014534810A JP2014531904A5 JP 2014531904 A5 JP2014531904 A5 JP 2014531904A5 JP 2014534810 A JP2014534810 A JP 2014534810A JP 2014534810 A JP2014534810 A JP 2014534810A JP 2014531904 A5 JP2014531904 A5 JP 2014531904A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- polypeptide
- cell according
- isoprenoid
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 48
- 229920001184 polypeptide Polymers 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 150000003505 terpenes Chemical class 0.000 claims 15
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 11
- 108010004621 phosphoketolase Proteins 0.000 claims 10
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 7
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 108010075483 isoprene synthase Proteins 0.000 claims 5
- 230000037361 pathway Effects 0.000 claims 5
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- 241000186012 Bifidobacterium breve Species 0.000 claims 3
- JSNRRGGBADWTMC-UHFFFAOYSA-N alpha-farnesene Natural products CC(C)=CCCC(C)=CCCC(=C)C=C JSNRRGGBADWTMC-UHFFFAOYSA-N 0.000 claims 3
- SIGQQUBJQXSAMW-ZCFIWIBFSA-N (R)-5-diphosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(=O)OP(O)(O)=O SIGQQUBJQXSAMW-ZCFIWIBFSA-N 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 2
- 108010092060 Acetate kinase Proteins 0.000 claims 2
- 241000228245 Aspergillus niger Species 0.000 claims 2
- 240000006439 Aspergillus oryzae Species 0.000 claims 2
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 2
- 241001608472 Bifidobacterium longum Species 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000194033 Enterococcus Species 0.000 claims 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims 2
- 240000006024 Lactobacillus plantarum Species 0.000 claims 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 2
- 241000186604 Lactobacillus reuteri Species 0.000 claims 2
- 241000520244 Tatumella citrea Species 0.000 claims 2
- 241000499912 Trichoderma reesei Species 0.000 claims 2
- 241000235015 Yarrowia lipolytica Species 0.000 claims 2
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 2
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 claims 2
- 229940009291 bifidobacterium longum Drugs 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 2
- 229940001882 lactobacillus reuteri Drugs 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 claims 2
- CXENHBSYCFFKJS-UHFFFAOYSA-N α-farnesene Chemical compound CC(C)=CCCC(C)=CCC=C(C)C=C CXENHBSYCFFKJS-UHFFFAOYSA-N 0.000 claims 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 claims 1
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 claims 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-CMKODMSKSA-N (-)-Abietadiene Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CCC(C(C)C)=C3)C3=CC[C@H]21 BBPXZLJCPUPNGH-CMKODMSKSA-N 0.000 claims 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 claims 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 1
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 1
- JSNRRGGBADWTMC-QINSGFPZSA-N (E)-beta-Farnesene Natural products CC(C)=CCC\C(C)=C/CCC(=C)C=C JSNRRGGBADWTMC-QINSGFPZSA-N 0.000 claims 1
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 claims 1
- LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 claims 1
- OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 claims 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 1
- JXBSHSBNOVLGHF-UHFFFAOYSA-N 10-cis-Dihydrofarnesen Natural products CC=C(C)CCC=C(C)CCC=C(C)C JXBSHSBNOVLGHF-UHFFFAOYSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-UHFFFAOYSA-N Abietadien Natural products CC1(C)CCCC2(C)C(CCC(C(C)C)=C3)C3=CCC21 BBPXZLJCPUPNGH-UHFFFAOYSA-N 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 101001074421 Bacillus subtilis (strain 168) Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG Proteins 0.000 claims 1
- 241001134770 Bifidobacterium animalis Species 0.000 claims 1
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 claims 1
- NGHMDNPXVRFFGS-IUYQGCFVSA-N D-erythrose 4-phosphate Chemical compound O=C[C@H](O)[C@H](O)COP(O)(O)=O NGHMDNPXVRFFGS-IUYQGCFVSA-N 0.000 claims 1
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 claims 1
- FNZLKVNUWIIPSJ-RFZPGFLSSA-N D-xylulose 5-phosphate Chemical compound OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O FNZLKVNUWIIPSJ-RFZPGFLSSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000207201 Gardnerella vaginalis Species 0.000 claims 1
- 239000005792 Geraniol Substances 0.000 claims 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims 1
- 241001340632 Mucilaginibacter paludis Species 0.000 claims 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 claims 1
- 241000424623 Nostoc punctiforme Species 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 1
- 241000219000 Populus Species 0.000 claims 1
- 241000168036 Populus alba Species 0.000 claims 1
- 241000218982 Populus nigra Species 0.000 claims 1
- 241001600128 Populus tremula x Populus alba Species 0.000 claims 1
- 240000004923 Populus tremuloides Species 0.000 claims 1
- 235000011263 Populus tremuloides Nutrition 0.000 claims 1
- 241000218976 Populus trichocarpa Species 0.000 claims 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000913776 Pueraria montana Species 0.000 claims 1
- 241000219781 Pueraria montana var. lobata Species 0.000 claims 1
- 241001478271 Rahnella aquatilis Species 0.000 claims 1
- 241000190950 Rhodopseudomonas palustris Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- 241000899950 Salix glauca Species 0.000 claims 1
- 241000187747 Streptomyces Species 0.000 claims 1
- 241001468227 Streptomyces avermitilis Species 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000187392 Streptomyces griseus Species 0.000 claims 1
- 241000187398 Streptomyces lividans Species 0.000 claims 1
- 241000203780 Thermobifida fusca Species 0.000 claims 1
- 229930014549 abietadiene Natural products 0.000 claims 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 claims 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 claims 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-CBBWQLFWSA-N amorpha-4,11-diene Chemical compound C1=C(C)CC[C@H]2[C@H](C)CC[C@@H](C(C)=C)[C@H]21 HMTAHNDPLDKYJT-CBBWQLFWSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-UHFFFAOYSA-N amorphadiene Natural products C1=C(C)CCC2C(C)CCC(C(C)=C)C21 HMTAHNDPLDKYJT-UHFFFAOYSA-N 0.000 claims 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 claims 1
- YSNRTFFURISHOU-UHFFFAOYSA-N beta-farnesene Natural products C=CC(C)CCC=C(C)CCC=C(C)C YSNRTFFURISHOU-UHFFFAOYSA-N 0.000 claims 1
- 229930006722 beta-pinene Natural products 0.000 claims 1
- 229940118852 bifidobacterium animalis Drugs 0.000 claims 1
- 229930006737 car-3-ene Natural products 0.000 claims 1
- 229930007796 carene Natural products 0.000 claims 1
- BQOFWKZOCNGFEC-UHFFFAOYSA-N carene Chemical compound C1C(C)=CCC2C(C)(C)C12 BQOFWKZOCNGFEC-UHFFFAOYSA-N 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229930004069 diterpene Natural products 0.000 claims 1
- 125000000567 diterpene group Chemical group 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 claims 1
- 229940113087 geraniol Drugs 0.000 claims 1
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 claims 1
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 229930007744 linalool Natural products 0.000 claims 1
- 229930003658 monoterpene Natural products 0.000 claims 1
- 150000002773 monoterpene derivatives Chemical class 0.000 claims 1
- 235000002577 monoterpenes Nutrition 0.000 claims 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001550 polyprenyl Polymers 0.000 claims 1
- 125000001185 polyprenyl group Polymers 0.000 claims 1
- 150000003097 polyterpenes Chemical class 0.000 claims 1
- 229930006696 sabinene Natural products 0.000 claims 1
- RXHIKAIVEMAPRU-JRIGQVHBSA-N sequiterpene Natural products C1=C(C)[C@@H](OC(C)=O)[C@H](O)[C@@]2(O)[C@H](C)CC[C@@H](C(C)=C)[C@H]21 RXHIKAIVEMAPRU-JRIGQVHBSA-N 0.000 claims 1
- 229930004725 sesquiterpene Natural products 0.000 claims 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 1
- 229930006978 terpinene Natural products 0.000 claims 1
- 150000003507 terpinene derivatives Chemical class 0.000 claims 1
- 150000003535 tetraterpenes Chemical class 0.000 claims 1
- 235000009657 tetraterpenes Nutrition 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545083P | 2011-10-07 | 2011-10-07 | |
| US61/545,083 | 2011-10-07 | ||
| PCT/US2012/059136 WO2013066568A1 (en) | 2011-10-07 | 2012-10-05 | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192631A Division JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531904A JP2014531904A (ja) | 2014-12-04 |
| JP2014531904A5 true JP2014531904A5 (enExample) | 2015-11-26 |
| JP6420147B2 JP6420147B2 (ja) | 2018-11-07 |
Family
ID=47046886
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534810A Active JP6420147B2 (ja) | 2011-10-07 | 2012-10-05 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
| JP2018192631A Active JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192631A Active JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8993305B2 (enExample) |
| EP (2) | EP2764084B2 (enExample) |
| JP (2) | JP6420147B2 (enExample) |
| CN (1) | CN104053765A (enExample) |
| AU (1) | AU2012332996A1 (enExample) |
| BR (1) | BR112014008278A2 (enExample) |
| CA (1) | CA2851265A1 (enExample) |
| DK (2) | DK3339426T3 (enExample) |
| HK (1) | HK1201071A1 (enExample) |
| MX (1) | MX2014004209A (enExample) |
| SG (1) | SG11201401249PA (enExample) |
| WO (1) | WO2013066568A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| CN103328631B (zh) * | 2011-01-20 | 2017-04-26 | 丰田自动车株式会社 | 重组酵母和使用该重组酵母的物质生产方法 |
| SG2014012520A (en) | 2011-07-12 | 2014-06-27 | Scientist Of Fortune Sa | Recombinant microorganism for the production of useful metabolites |
| SG11201401249PA (en) | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| EP2794851A2 (en) * | 2011-12-23 | 2014-10-29 | Danisco US Inc. | Enhanced production of isoprene using marine bacterial cells |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| BR112015014843A2 (pt) | 2012-12-21 | 2017-10-10 | Danisco Us Inc | produção de isopreno, isoprenoide, e precursores de isoprenoide usando uma via de mevalonato inferior alternativa |
| US9518278B2 (en) | 2013-03-14 | 2016-12-13 | The Regents Of The University Of California | Recombinant microorganisms having a methanol elongation cycle (MEC) |
| ES2735331T3 (es) | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
| WO2015002977A1 (en) * | 2013-07-01 | 2015-01-08 | Braskem S/A Ap 09 | Modified microorganisms and methods of using same for anaerobic coproduction of isoprene and acetic acid |
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2012
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- 2012-10-05 CN CN201280059852.7A patent/CN104053765A/zh active Pending
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- 2012-10-05 CA CA2851265A patent/CA2851265A1/en not_active Abandoned
- 2012-10-05 WO PCT/US2012/059136 patent/WO2013066568A1/en not_active Ceased
- 2012-10-05 US US13/646,562 patent/US8993305B2/en active Active
- 2012-10-05 EP EP17206148.3A patent/EP3339426B1/en active Active
- 2012-10-05 MX MX2014004209A patent/MX2014004209A/es unknown
- 2012-10-05 JP JP2014534810A patent/JP6420147B2/ja active Active
- 2012-10-05 BR BR112014008278A patent/BR112014008278A2/pt not_active Application Discontinuation
- 2012-10-05 HK HK15101539.9A patent/HK1201071A1/xx unknown
- 2012-10-05 DK DK17206148.3T patent/DK3339426T3/da active
- 2012-10-05 AU AU2012332996A patent/AU2012332996A1/en not_active Abandoned
- 2012-10-05 DK DK12775413.3T patent/DK2764084T4/da active
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- 2015-02-18 US US14/625,487 patent/US9493791B2/en active Active
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- 2016-09-28 US US15/279,184 patent/US10113185B2/en active Active
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- 2018-10-11 JP JP2018192631A patent/JP6639606B2/ja active Active
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