JP2014519812A5 - - Google Patents

Download PDF

Info

Publication number
JP2014519812A5
JP2014519812A5 JP2014508164A JP2014508164A JP2014519812A5 JP 2014519812 A5 JP2014519812 A5 JP 2014519812A5 JP 2014508164 A JP2014508164 A JP 2014508164A JP 2014508164 A JP2014508164 A JP 2014508164A JP 2014519812 A5 JP2014519812 A5 JP 2014519812A5
Authority
JP
Japan
Prior art keywords
cell
gene
activity
endogenous
cell according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014508164A
Other languages
English (en)
Japanese (ja)
Other versions
JP6301827B2 (ja
JP2014519812A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/035687 external-priority patent/WO2012149491A2/en
Publication of JP2014519812A publication Critical patent/JP2014519812A/ja
Publication of JP2014519812A5 publication Critical patent/JP2014519812A5/ja
Application granted granted Critical
Publication of JP6301827B2 publication Critical patent/JP6301827B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014508164A 2011-04-29 2012-04-27 メバロン酸、イソプレン及びイソプレノイドの生産量を増加させるための組み換え微生物 Active JP6301827B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161481121P 2011-04-29 2011-04-29
US61/481,121 2011-04-29
PCT/US2012/035687 WO2012149491A2 (en) 2011-04-29 2012-04-27 Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017083583A Division JP2017148063A (ja) 2011-04-29 2017-04-20 メバロン酸、イソプレン及びイソプレノイドの生産量を増加させるための組み換え微生物

Publications (3)

Publication Number Publication Date
JP2014519812A JP2014519812A (ja) 2014-08-21
JP2014519812A5 true JP2014519812A5 (enExample) 2015-06-18
JP6301827B2 JP6301827B2 (ja) 2018-03-28

Family

ID=46052905

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014508164A Active JP6301827B2 (ja) 2011-04-29 2012-04-27 メバロン酸、イソプレン及びイソプレノイドの生産量を増加させるための組み換え微生物
JP2017083583A Pending JP2017148063A (ja) 2011-04-29 2017-04-20 メバロン酸、イソプレン及びイソプレノイドの生産量を増加させるための組み換え微生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017083583A Pending JP2017148063A (ja) 2011-04-29 2017-04-20 メバロン酸、イソプレン及びイソプレノイドの生産量を増加させるための組み換え微生物

Country Status (10)

Country Link
US (3) US9121038B2 (enExample)
EP (1) EP2702140B1 (enExample)
JP (2) JP6301827B2 (enExample)
CN (1) CN103930541A (enExample)
AU (1) AU2012249320A1 (enExample)
BR (1) BR112013027555A2 (enExample)
CA (1) CA2834633A1 (enExample)
ES (1) ES2699747T3 (enExample)
SG (1) SG194690A1 (enExample)
WO (1) WO2012149491A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US9121038B2 (en) 2011-04-29 2015-09-01 The Goodyear Tire & Rubber Company Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
EP2794851A2 (en) * 2011-12-23 2014-10-29 Danisco US Inc. Enhanced production of isoprene using marine bacterial cells
WO2013181647A2 (en) * 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
RU2723620C2 (ru) * 2012-07-13 2020-06-16 Калиста, Инк. Система, способы и композиции для биопереработки
CN104540949B (zh) * 2012-08-07 2018-05-29 阿迈瑞斯公司 用于稳定乙酰-辅酶a衍生化合物生成的方法
MY171958A (en) * 2013-03-15 2019-11-08 Amyris Inc Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
ES2735331T3 (es) 2013-04-10 2019-12-18 Goodyear Tire & Rubber Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides
JP6139244B2 (ja) * 2013-04-23 2017-05-31 住友ゴム工業株式会社 ポリイソプレノイド増産方法、およびそのための増産剤、かかる方法で製造されたポリイソプレノイド
RU2013146377A (ru) 2013-10-17 2015-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ ИЗОПРЕНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Bacillus
US20160237442A1 (en) * 2013-10-18 2016-08-18 University Of Washington Through Its Center For Commercialization Modified group i methanotrophic bacteria and uses thereof
US20160237398A1 (en) * 2013-10-18 2016-08-18 University Of Washington Through Its Center For Commercialization Methods of microbial production of excreted products from methane and related bacterial strains
US20160376600A1 (en) 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
PL3077501T3 (pl) 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa
CN104164457B (zh) * 2014-07-15 2016-05-04 青岛农业大学 一种利用新mva途径合成异戊二烯的方法及其相应重组细胞和应用
JP6470532B2 (ja) * 2014-09-17 2019-02-13 積水化学工業株式会社 組換え細胞、並びに、有機化合物の生産方法
CN104593405A (zh) * 2014-11-24 2015-05-06 安徽大学 一种高产丙氨酸的枯草杆菌工程菌的构建方法
KR101776375B1 (ko) * 2015-03-18 2017-09-08 씨제이제일제당 (주) 피루브산 디하이드로게나아제 변이체, 이를 포함하는 미생물 및 이를 이용한 l-아미노산 생산 방법
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN105624180B (zh) * 2016-02-06 2018-12-28 中国热带农业科学院橡胶研究所 HbCS3基因在提高原核表达菌生长速率、研究橡胶树抗逆境胁迫和产胶能力中的应用
CN105647953A (zh) * 2016-03-18 2016-06-08 黑龙江大学 高产2,3-丁二醇的产酸克雷伯氏基因工程菌株的构建方法及其发酵方法
CN105647954A (zh) * 2016-03-18 2016-06-08 黑龙江大学 高产2,3-丁二醇的产酸克雷伯氏基因工程菌株的构建方法及其发酵方法
CN106148262B (zh) * 2016-07-01 2019-09-03 江南大学 提高乙酰氨基葡萄糖产量的重组枯草芽孢杆菌及其构建方法
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN109234216B (zh) * 2017-07-10 2022-05-20 上海医药工业研究院 一种生产鲨烯的基因工程菌及其方法
CN107937431A (zh) * 2017-10-28 2018-04-20 国际竹藤中心 一种提高酿酒酵母合成芳樟醇能力的方法
CN109722403B (zh) * 2017-10-30 2020-12-04 中国石油化工股份有限公司 一种利用纤维素制备金合欢烯的工程菌株及方法
CN108179114B (zh) * 2017-11-27 2021-08-20 南京晓庄学院 产抗厌氧菌化合物的菌株和发酵方法、抗厌氧菌化合物提取及制备方法和使用方法
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
CN111868047A (zh) 2017-12-21 2020-10-30 齐默尔根公司 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物
HUE065696T2 (hu) 2018-03-06 2024-06-28 Danisco Us Inc Acetát-termelés csökkentése PAB1-et túltermelõ élesztõvel
CN110964679B (zh) * 2018-09-29 2022-06-28 中国石油化工股份有限公司 一种利用纤维素制备金合欢烯的工程菌株及方法
CN110964680B (zh) * 2018-09-29 2022-06-28 中国石油化工股份有限公司 利用纤维素制备金合欢烯的工程菌株及方法
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
US11845940B2 (en) * 2020-02-27 2023-12-19 The Regents Of The University Of California Genetically modified fungal cells and methods useful for producing prespatane
AU2021305200A1 (en) * 2020-07-08 2023-02-16 The Regents Of The University Of California Modified yeast host cells useful for producing isoprenol
WO2022032084A1 (en) * 2020-08-06 2022-02-10 Synlogic Operating Company, Inc. Recombinant bacteria for production of d-lactate and/or l-lactate and uses thereof
CN115704038B (zh) * 2021-08-10 2025-08-15 西北农林科技大学 一种基因、重组载体、工程菌及其应用
JP2023105728A (ja) * 2022-01-19 2023-07-31 旭化成株式会社 改変微生物及び化合物の製造方法
CN115948444A (zh) * 2022-10-21 2023-04-11 江南大学 一种利用硝酸盐和全局厌氧调节因子Fnr提高地衣芽孢杆菌厌氧活性的方法
CN116925991B (zh) * 2023-07-28 2024-08-09 天津大学 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用
CN119286752B (zh) * 2024-12-10 2025-07-11 杭州合碳创物科技有限公司 一种生产甲瓦龙酸的重组大肠杆菌及其应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
WO2000078935A1 (en) 1999-06-22 2000-12-28 Smithkline Beecham Corporation Mevalonate pathway genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US20050287655A1 (en) 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
JP4168870B2 (ja) * 2003-08-14 2008-10-22 トヨタ自動車株式会社 プレニルアルコールの製造方法
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
CA2651747C (en) * 2006-05-26 2017-10-24 Amyris Biotechnologies, Inc. Production of isoprenoids
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
JP4986547B2 (ja) 2006-09-04 2012-07-25 株式会社Ａｄｅｋａ 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法
MX2009004221A (es) * 2006-10-20 2009-09-10 Univ Arizona State Cianobacterias modificadas.
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
BRPI0823506A8 (pt) 2007-12-13 2018-05-15 Danisco Us Inc Genencor Div composições e métodos para a produção de isoprene
WO2009100231A2 (en) 2008-02-06 2009-08-13 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
CN102015995B (zh) * 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
US7632995B2 (en) 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
US10100334B2 (en) * 2008-05-23 2018-10-16 Nucelis Inc. Production of squalene using yeast
EP2310490B1 (en) 2008-07-02 2019-01-02 Danisco US Inc. Methods for producing isoprene
HU3516U (en) 2008-07-31 2008-11-28 Zoltan Kuthi Anti-theft protection of draining for fuel tanks
CA2737082A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
MY156562A (en) 2008-09-15 2016-02-26 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
WO2010031079A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Systems using cell culture for production of isoprene
CA2737223A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
BRPI0918936A2 (pt) 2008-09-15 2019-09-24 Danisco Us Inc conversão de derivados de prenila em isopreno
CN102333866B (zh) 2008-12-30 2015-04-29 丹尼斯科美国公司 生产异戊二烯和共同产物的方法
US20100297749A1 (en) 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
EP2421966A2 (en) 2009-04-23 2012-02-29 Danisco US Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
CA2773675A1 (en) 2009-09-15 2011-03-24 Sapphire Energy, Inc. A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
JP5978132B2 (ja) * 2009-11-23 2016-08-24 ニューセリス インコーポレイテッド 酵母を用いるスクアレン生成のための方法および組成物
CN102884028B (zh) 2009-12-18 2015-08-19 丹尼斯科美国公司 从可再生资源中纯化异戊二烯
AU2010336342B2 (en) 2009-12-23 2015-02-26 Danisco Us Inc. Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (PGL)
WO2012019169A1 (en) * 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
EP2655606A1 (en) * 2010-12-22 2013-10-30 Danisco US Inc. Compositions and methods for improved isoprene production using two types of ispg enzymes
US9121038B2 (en) 2011-04-29 2015-09-01 The Goodyear Tire & Rubber Company Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
JP2014519811A (ja) * 2011-04-29 2014-08-21 ダニスコ・ユーエス・インク チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産

Similar Documents

Publication Publication Date Title
JP2014519812A5 (enExample)
JP2014531904A5 (enExample)
JP2014519811A5 (enExample)
US10113185B2 (en) Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
US20140234926A1 (en) Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas
US20130122562A1 (en) Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
US11685937B2 (en) Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products
CN103764814B (zh) 利用编码具有硫解酶、hmg-coa合酶和hmg-coa还原酶酶活性的多肽的基因产生甲羟戊酸、异戊二烯和类异戊二烯
US10988750B2 (en) Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
US20140147902A1 (en) Compositions and methods for improved isoprene production using two types of ispg enzymes
WO2012149491A3 (en) Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
JP2016519577A5 (enExample)
US9315831B2 (en) Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US20140335576A1 (en) Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism
JP2017506078A5 (enExample)
WO2014193473A1 (en) Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas
US20210403954A1 (en) Method of producing isoprenoid compound
CN106350476A (zh) 联产异戊二烯和1,3‑丙二醇的基因工程菌及构建方法和应用
JP6520954B2 (ja) イソプレンモノマーの製造方法
US20150225743A1 (en) Biocatalyst for conversion of methane and methanol to isoprene
US20180334657A1 (en) Recombinant cell, method for producing recombinant cell, and method for producing organic compound
JP6470532B2 (ja) 組換え細胞、並びに、有機化合物の生産方法