JP2014519811A5 - - Google Patents
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- JP2014519811A5 JP2014519811A5 JP2014508154A JP2014508154A JP2014519811A5 JP 2014519811 A5 JP2014519811 A5 JP 2014519811A5 JP 2014508154 A JP2014508154 A JP 2014508154A JP 2014508154 A JP2014508154 A JP 2014508154A JP 2014519811 A5 JP2014519811 A5 JP 2014519811A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- gene
- mvae
- derived
- mvas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 77
- 108090000623 proteins and genes Proteins 0.000 claims 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims 36
- 229920001184 polypeptide Polymers 0.000 claims 35
- 102000004196 processed proteins & peptides Human genes 0.000 claims 35
- 101150063369 mvaS gene Proteins 0.000 claims 34
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 28
- 150000003505 terpenes Chemical class 0.000 claims 26
- 108020004707 nucleic acids Proteins 0.000 claims 23
- 102000039446 nucleic acids Human genes 0.000 claims 23
- 150000007523 nucleic acids Chemical class 0.000 claims 23
- 241000194031 Enterococcus faecium Species 0.000 claims 21
- 241000194030 Enterococcus gallinarum Species 0.000 claims 21
- 238000004519 manufacturing process Methods 0.000 claims 20
- 241000588724 Escherichia coli Species 0.000 claims 16
- 241001522957 Enterococcus casseliflavus Species 0.000 claims 15
- 230000001965 increasing effect Effects 0.000 claims 13
- 241000186806 Listeria grayi Species 0.000 claims 12
- 239000002243 precursor Substances 0.000 claims 12
- 108700040132 Mevalonate kinases Proteins 0.000 claims 11
- 102000002678 mevalonate kinase Human genes 0.000 claims 11
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 10
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 10
- 101100507308 Enterococcus faecalis mvaS gene Proteins 0.000 claims 9
- 108010065958 Isopentenyl-diphosphate Delta-isomerase Proteins 0.000 claims 8
- 102100027665 Isopentenyl-diphosphate Delta-isomerase 1 Human genes 0.000 claims 8
- 108010075483 isoprene synthase Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims 6
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims 6
- 108010000775 Hydroxymethylglutaryl-CoA synthase Proteins 0.000 claims 6
- 102100028889 Hydroxymethylglutaryl-CoA synthase, mitochondrial Human genes 0.000 claims 6
- 108060008225 Thiolase Proteins 0.000 claims 6
- 102000002932 Thiolase Human genes 0.000 claims 6
- 230000003197 catalytic effect Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000037361 pathway Effects 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 210000005253 yeast cell Anatomy 0.000 claims 4
- OKZYCXHTTZZYSK-UHFFFAOYSA-N 3-hydroxy-3-methyl-5-phosphonooxypentanoic acid Chemical compound OC(=O)CC(O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-UHFFFAOYSA-N 0.000 claims 3
- 241000194032 Enterococcus faecalis Species 0.000 claims 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 3
- 241000187747 Streptomyces Species 0.000 claims 3
- JSNRRGGBADWTMC-UHFFFAOYSA-N alpha-farnesene Natural products CC(C)=CCCC(C)=CCCC(=C)C=C JSNRRGGBADWTMC-UHFFFAOYSA-N 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 229940032049 enterococcus faecalis Drugs 0.000 claims 3
- 230000002538 fungal effect Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- SIGQQUBJQXSAMW-ZCFIWIBFSA-N (R)-5-diphosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(=O)OP(O)(O)=O SIGQQUBJQXSAMW-ZCFIWIBFSA-N 0.000 claims 2
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims 2
- 241000193749 Bacillus coagulans Species 0.000 claims 2
- 241000193422 Bacillus lentus Species 0.000 claims 2
- 241000149420 Bothrometopus brevis Species 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims 2
- 241000205274 Methanosarcina mazei Species 0.000 claims 2
- 241000168036 Populus alba Species 0.000 claims 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 claims 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 2
- 235000011180 diphosphates Nutrition 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 2
- 229920001550 polyprenyl Polymers 0.000 claims 2
- 125000001185 polyprenyl group Polymers 0.000 claims 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 claims 2
- CXENHBSYCFFKJS-UHFFFAOYSA-N α-farnesene Chemical compound CC(C)=CCCC(C)=CCC=C(C)C=C CXENHBSYCFFKJS-UHFFFAOYSA-N 0.000 claims 2
- YKFLAYDHMOASIY-UHFFFAOYSA-N γ-terpinene Chemical compound CC(C)C1=CCC(C)=CC1 YKFLAYDHMOASIY-UHFFFAOYSA-N 0.000 claims 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 claims 1
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 claims 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-CMKODMSKSA-N (-)-Abietadiene Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CCC(C(C)C)=C3)C3=CC[C@H]21 BBPXZLJCPUPNGH-CMKODMSKSA-N 0.000 claims 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 claims 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 1
- JSNRRGGBADWTMC-QINSGFPZSA-N (E)-beta-Farnesene Natural products CC(C)=CCC\C(C)=C/CCC(=C)C=C JSNRRGGBADWTMC-QINSGFPZSA-N 0.000 claims 1
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 claims 1
- OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 claims 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 1
- JXBSHSBNOVLGHF-UHFFFAOYSA-N 10-cis-Dihydrofarnesen Natural products CC=C(C)CCC=C(C)CCC=C(C)C JXBSHSBNOVLGHF-UHFFFAOYSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-UHFFFAOYSA-N Abietadien Natural products CC1(C)CCCC2(C)C(CCC(C(C)C)=C3)C3=CCC21 BBPXZLJCPUPNGH-UHFFFAOYSA-N 0.000 claims 1
- 241000228212 Aspergillus Species 0.000 claims 1
- 241000193752 Bacillus circulans Species 0.000 claims 1
- 241001328122 Bacillus clausii Species 0.000 claims 1
- 241000006382 Bacillus halodurans Species 0.000 claims 1
- 241000194108 Bacillus licheniformis Species 0.000 claims 1
- 241000194107 Bacillus megaterium Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000193388 Bacillus thuringiensis Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims 1
- 239000005792 Geraniol Substances 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241000186612 Lactobacillus sakei Species 0.000 claims 1
- 241001148031 Methanococcoides burtonii Species 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 claims 1
- 241000194109 Paenibacillus lautus Species 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 241000521555 Pichia nakasei Species 0.000 claims 1
- 241000235061 Pichia sp. Species 0.000 claims 1
- 241000218982 Populus nigra Species 0.000 claims 1
- 241001600128 Populus tremula x Populus alba Species 0.000 claims 1
- 240000004923 Populus tremuloides Species 0.000 claims 1
- 235000011263 Populus tremuloides Nutrition 0.000 claims 1
- 241000218976 Populus trichocarpa Species 0.000 claims 1
- 241000982698 Prorodonopsis coli Species 0.000 claims 1
- 241000168225 Pseudomonas alcaligenes Species 0.000 claims 1
- 241000589774 Pseudomonas sp. Species 0.000 claims 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000913776 Pueraria montana Species 0.000 claims 1
- 241000235088 Saccharomyces sp. Species 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- 241000720795 Schizosaccharomyces sp. Species 0.000 claims 1
- 241000063122 Streptacidiphilus griseus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000187759 Streptomyces albus Species 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000187398 Streptomyces lividans Species 0.000 claims 1
- 241000223259 Trichoderma Species 0.000 claims 1
- 229930014549 abietadiene Natural products 0.000 claims 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 claims 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 claims 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-CBBWQLFWSA-N amorpha-4,11-diene Chemical compound C1=C(C)CC[C@H]2[C@H](C)CC[C@@H](C(C)=C)[C@H]21 HMTAHNDPLDKYJT-CBBWQLFWSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-UHFFFAOYSA-N amorphadiene Natural products C1=C(C)CCC2C(C)CCC(C(C)=C)C21 HMTAHNDPLDKYJT-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- YSNRTFFURISHOU-UHFFFAOYSA-N beta-farnesene Natural products C=CC(C)CCC=C(C)CCC=C(C)C YSNRTFFURISHOU-UHFFFAOYSA-N 0.000 claims 1
- 229930006722 beta-pinene Natural products 0.000 claims 1
- 229930006737 car-3-ene Natural products 0.000 claims 1
- 229930007796 carene Natural products 0.000 claims 1
- BQOFWKZOCNGFEC-UHFFFAOYSA-N carene Chemical compound C1C(C)=CCC2C(C)(C)C12 BQOFWKZOCNGFEC-UHFFFAOYSA-N 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000004087 circulation Effects 0.000 claims 1
- 229930004069 diterpene Natural products 0.000 claims 1
- 125000000567 diterpene group Chemical group 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 claims 1
- 229940113087 geraniol Drugs 0.000 claims 1
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 claims 1
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 229930007744 linalool Natural products 0.000 claims 1
- 229930003658 monoterpene Natural products 0.000 claims 1
- 150000002773 monoterpene derivatives Chemical class 0.000 claims 1
- 235000002577 monoterpenes Nutrition 0.000 claims 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 150000003097 polyterpenes Chemical class 0.000 claims 1
- 229930006696 sabinene Natural products 0.000 claims 1
- -1 sequiterpenes Chemical class 0.000 claims 1
- 229930004725 sesquiterpene Natural products 0.000 claims 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 150000003535 tetraterpenes Chemical class 0.000 claims 1
- 235000009657 tetraterpenes Nutrition 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161481098P | 2011-04-29 | 2011-04-29 | |
| US61/481,098 | 2011-04-29 | ||
| PCT/US2012/035655 WO2012149469A1 (en) | 2011-04-29 | 2012-04-27 | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014519811A JP2014519811A (ja) | 2014-08-21 |
| JP2014519811A5 true JP2014519811A5 (enExample) | 2015-06-18 |
Family
ID=46027009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508154A Pending JP2014519811A (ja) | 2011-04-29 | 2012-04-27 | チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8889383B2 (enExample) |
| EP (1) | EP2702139A1 (enExample) |
| JP (1) | JP2014519811A (enExample) |
| CN (1) | CN103764814B (enExample) |
| AU (1) | AU2012249389A1 (enExample) |
| BR (1) | BR112013027553A2 (enExample) |
| CA (1) | CA2834379A1 (enExample) |
| HK (1) | HK1197266A1 (enExample) |
| SG (1) | SG194691A1 (enExample) |
| WO (1) | WO2012149469A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2737223A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US9121038B2 (en) * | 2011-04-29 | 2015-09-01 | The Goodyear Tire & Rubber Company | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
| JP2014519811A (ja) | 2011-04-29 | 2014-08-21 | ダニスコ・ユーエス・インク | チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産 |
| SG11201401249PA (en) | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| WO2013181647A2 (en) * | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| ES2735331T3 (es) | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
| CN104178443B (zh) * | 2013-05-24 | 2017-04-12 | 中国科学院天津工业生物技术研究所 | 生产丁二酸的重组大肠杆菌及其应用 |
| MY203868A (en) | 2014-06-11 | 2024-07-22 | Univ Duke | Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves |
| CN104164457B (zh) * | 2014-07-15 | 2016-05-04 | 青岛农业大学 | 一种利用新mva途径合成异戊二烯的方法及其相应重组细胞和应用 |
| DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR101782891B1 (ko) * | 2015-07-08 | 2017-09-29 | 한국과학기술연구원 | 미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법 |
| CN106544348B (zh) * | 2015-09-23 | 2020-03-31 | 中国科学院微生物研究所 | 异戊烯基焦磷酸异构酶基因及其应用 |
| KR101936825B1 (ko) | 2016-01-26 | 2019-01-11 | 경상대학교산학협력단 | 이소프렌의 생산 방법 |
| WO2017131488A1 (ko) * | 2016-01-26 | 2017-08-03 | 경상대학교산학협력단 | 이소프렌의 생산 방법 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CA3047268A1 (en) * | 2016-12-16 | 2018-06-21 | Danisco Us Inc. | Bifunctional phosphoketolase-phosphotransacetylase fusion polypeptides |
| US10509601B2 (en) * | 2016-12-28 | 2019-12-17 | Amazon Technologies, Inc. | Data storage system with multi-tier control plane |
| CN107418978B (zh) * | 2017-06-24 | 2020-10-23 | 天津大学 | 一种利用生物柴油副产物制备金合欢烯的方法 |
| CN109234216B (zh) * | 2017-07-10 | 2022-05-20 | 上海医药工业研究院 | 一种生产鲨烯的基因工程菌及其方法 |
| CN107841523A (zh) * | 2017-10-19 | 2018-03-27 | 浙江大学 | 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法 |
| CN114634888B (zh) * | 2022-03-04 | 2023-05-26 | 中南大学 | 一种铊氧化菌、微生物菌剂及其应用 |
| AU2023289395A1 (en) | 2022-06-21 | 2025-01-09 | Lanzatech, Inc. | Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates |
| WO2024263850A1 (en) * | 2023-06-21 | 2024-12-26 | Lanzatech, Inc. | Engineered autotrophic microorganisms for isoprenoid production and methods |
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2012
- 2012-04-27 JP JP2014508154A patent/JP2014519811A/ja active Pending
- 2012-04-27 WO PCT/US2012/035655 patent/WO2012149469A1/en not_active Ceased
- 2012-04-27 US US13/459,033 patent/US8889383B2/en active Active
- 2012-04-27 CA CA2834379A patent/CA2834379A1/en not_active Abandoned
- 2012-04-27 CN CN201280031905.4A patent/CN103764814B/zh not_active Expired - Fee Related
- 2012-04-27 SG SG2013080312A patent/SG194691A1/en unknown
- 2012-04-27 AU AU2012249389A patent/AU2012249389A1/en not_active Abandoned
- 2012-04-27 HK HK14110798.7A patent/HK1197266A1/xx unknown
- 2012-04-27 BR BR112013027553A patent/BR112013027553A2/pt not_active IP Right Cessation
- 2012-04-27 EP EP12718881.1A patent/EP2702139A1/en not_active Withdrawn
-
2014
- 2014-10-15 US US14/514,962 patent/US9752162B2/en active Active
-
2017
- 2017-09-01 US US15/694,193 patent/US10364443B2/en active Active
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