BRPI0918936A2 - conversão de derivados de prenila em isopreno - Google Patents

conversão de derivados de prenila em isopreno

Info

Publication number
BRPI0918936A2
BRPI0918936A2 BRPI0918936A BRPI0918936A BRPI0918936A2 BR PI0918936 A2 BRPI0918936 A2 BR PI0918936A2 BR PI0918936 A BRPI0918936 A BR PI0918936A BR PI0918936 A BRPI0918936 A BR PI0918936A BR PI0918936 A2 BRPI0918936 A2 BR PI0918936A2
Authority
BR
Brazil
Prior art keywords
isoprene
conversion
prenyl derivatives
prenyl
derivatives
Prior art date
Application number
BRPI0918936A
Other languages
English (en)
Inventor
C Mcauliffe Joseph
J Sanford Karl
Rathnayake Samira
Original Assignee
Danisco Us Inc
Goodyear Tire & Rubber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Goodyear Tire & Rubber filed Critical Danisco Us Inc
Publication of BRPI0918936A2 publication Critical patent/BRPI0918936A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/20Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms
    • C07C1/207Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms from carbonyl compounds
    • C07C1/2078Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms from carbonyl compounds by a transformation in which at least one -C(=O)-O- moiety is eliminated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/20Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms
    • C07C1/24Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms by elimination of water
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/03Phosphoric monoester hydrolases (3.1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/07Diphosphoric monoester hydrolases (3.1.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y306/00Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y503/00Intramolecular oxidoreductases (5.3)
    • C12Y503/03Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
BRPI0918936A 2008-09-15 2009-09-15 conversão de derivados de prenila em isopreno BRPI0918936A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9720408P 2008-09-15 2008-09-15
PCT/US2009/057036 WO2010031076A2 (en) 2008-09-15 2009-09-15 Conversion of prenyl derivatives to isoprene

Publications (1)

Publication Number Publication Date
BRPI0918936A2 true BRPI0918936A2 (pt) 2019-09-24

Family

ID=42005829

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918936A BRPI0918936A2 (pt) 2008-09-15 2009-09-15 conversão de derivados de prenila em isopreno

Country Status (7)

Country Link
US (3) US8476049B2 (pt)
EP (1) EP2340312A2 (pt)
BR (1) BRPI0918936A2 (pt)
CA (1) CA2737195A1 (pt)
SG (1) SG169614A1 (pt)
WO (1) WO2010031076A2 (pt)
ZA (1) ZA201102109B (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100118973A (ko) 2007-12-13 2010-11-08 다니스코 유에스 인크. 이소프렌을 생성하기 위한 조성물 및 방법
US8173410B2 (en) * 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
KR20110038087A (ko) 2008-06-30 2011-04-13 더 굿이어 타이어 앤드 러버 캄파니 재생가능 자원으로부터의 이소프렌 중합체
SG169614A1 (en) 2008-09-15 2011-04-29 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene
SG169652A1 (en) * 2008-09-15 2011-04-29 Danisco Us Inc Reduction of carbon dioxide emission during isoprene production by fermentation
CN102333866B (zh) * 2008-12-30 2015-04-29 丹尼斯科美国公司 生产异戊二烯和共同产物的方法
US8324442B2 (en) 2009-03-03 2012-12-04 Amyris, Inc. Microbial derived isoprene and methods for making the same
CA2759700A1 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TW201120213A (en) 2009-06-17 2011-06-16 Danisco Us Inc Polymerization of isoprene from renewable resources
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
US20110039323A1 (en) * 2009-08-14 2011-02-17 Eric Lawrence Singsaas Isoprene Production
IN2012DN05187A (pt) 2009-12-18 2015-10-23 Danisco Us Inc
SG196782A1 (en) 2009-12-23 2014-02-13 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
BR112012032276A2 (pt) 2010-06-17 2016-11-16 Danisco Us Inc composições de combustível compreendendo derivados de isopreno
EP2601300A1 (en) 2010-08-06 2013-06-12 Danisco US Inc. Production of isoprene under neutral ph conditions
WO2012058494A2 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
JP2014502844A (ja) 2010-12-22 2014-02-06 ダニスコ・ユーエス・インク 組み換え細胞による五炭糖の生物学的生産
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
EP2702139A1 (en) 2011-04-29 2014-03-05 Danisco US Inc. Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
WO2012149491A2 (en) 2011-04-29 2012-11-01 Danisco Us Inc. Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
US20130122562A1 (en) 2011-08-04 2013-05-16 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
US8951764B2 (en) 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
EP2764084B2 (en) 2011-10-07 2021-11-03 Danisco US Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
WO2013053824A1 (en) 2011-10-11 2013-04-18 Metabolic Explorer New biosynthesis pathway for prenol in a recombinant microorganism
US8735134B2 (en) 2011-10-27 2014-05-27 Danisco Us Inc. Isoprene synthase variants with improved solubility for production of isoprene
AU2012358149A1 (en) 2011-12-23 2014-07-03 Danisco Us Inc. Enhanced production of isoprene using host cells having decreased ispA activity
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US20130295627A1 (en) * 2012-04-09 2013-11-07 Robert J. Hanchar Process for producing methyl butenol (2-methyl-3-buten-2-ol)
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
KR20150014941A (ko) 2012-05-16 2015-02-09 글리코스 바이오테크놀로지스, 인코포레이티드 아이소프렌의 생산을 위한 미생물유기체 및 방법
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
EP2935364A2 (en) 2012-12-21 2015-10-28 Danisco US Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
EP2984105B1 (en) 2013-04-10 2019-05-22 Danisco US Inc. Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
ES2728307T3 (es) 2013-06-21 2019-10-23 Danisco Us Inc Composiciones y métodos para la transformación clostridial
EP3075843B1 (en) 2013-11-28 2019-07-03 Ajinomoto Co., Inc. Method for producing isoprene monomer
JP6744819B2 (ja) 2014-02-20 2020-08-19 ダニスコ・ユーエス・インク メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルCoA由来産物の生産向上のための組換え微生物
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
WO2016015021A1 (en) 2014-07-24 2016-01-28 The Regents Of The University Of California Oxidative starch degradation by a new family of pmos
US10113186B2 (en) 2014-11-13 2018-10-30 Global Bioenergies Alkenol dehydratase variants
WO2016085987A1 (en) * 2014-11-26 2016-06-02 Visolis, Inc. Processes for conversion of biologically derived mevalonic acid
CN104910448B (zh) * 2015-06-03 2017-06-06 华南理工大学 一种医用套扎器环形弹性圈的制备方法
US20180237359A1 (en) * 2015-08-19 2018-08-23 Technology Holding, Llc Hybrid chem-bio method to produce diene molecules
RU2734778C2 (ru) * 2016-05-06 2020-10-23 Курарей Ко., Лтд. Способ получения сопряженного диена
US20190241913A1 (en) * 2016-10-12 2019-08-08 Reliance Industries Limited Method for production of isoprene recombinant microorganism, gene construct, vector and application thereof
CA3062645A1 (en) 2017-05-10 2018-11-15 Baymedica, Inc. Recombinant production systems for prenylated polyketides of the cannabinoid family
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
CN111868047A (zh) 2017-12-21 2020-10-30 齐默尔根公司 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
CN110241103B (zh) * 2019-07-04 2021-01-19 江西邦泰绿色生物合成生态产业园发展有限公司 一种生物酶法生产异戊二烯的方法
EP4347800A1 (en) 2021-05-26 2024-04-10 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability
WO2023077017A1 (en) * 2021-10-27 2023-05-04 The Regents Of The University Of California Methods and compositions useful for the production of olefinic ester

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3792104A (en) * 1970-06-27 1974-02-12 Basf Ag Manufacture of isoprene
JPS5242763B2 (pt) * 1971-01-12 1977-10-26
CA1338400C (en) 1983-08-31 1996-06-18 David H. Gelfand Recombinant fungal cellulases
GB8407828D0 (en) * 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) * 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0215594B2 (en) 1985-08-29 2003-10-15 Genencor International, Inc. Heterologous polypeptide expressed in filamentous fungi, processes for their preparation, and vectors for their preparation
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4734538A (en) * 1986-12-24 1988-03-29 Union Carbide Corporation Process for the production of dienes
DK1225227T3 (da) * 1990-12-10 2009-06-22 Genencor Int Forbedret forsukring af cellulose ved kloning og amplifikation af beta-glucosidase genet af trichoderma
WO1995004134A1 (en) 1993-08-02 1995-02-09 Genencor International, Inc. Method of reducing complex carbohydrates in fermentation products
US5861271A (en) * 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) * 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US6176176B1 (en) * 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
EP2305825B1 (en) * 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
EP1947189B1 (en) 1998-07-06 2010-12-01 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
US6268328B1 (en) * 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
EP1354956A4 (en) 2000-12-28 2004-10-27 Toyota Motor Co Ltd PROCESS FOR PRODUCING PRENYL ALCOHOL
WO2002053751A1 (fr) * 2000-12-28 2002-07-11 Kabushiki Kaisha Toyota Chuo Kenkyusho Polypeptides, polynucleotides, acides nucleiques de recombinaison, produits de recombinaison et procede de production d'alcool prenylique
JP4430869B2 (ja) * 2001-04-04 2010-03-10 ジェネンコー・インターナショナル・インク 宿主細胞の分離した生産及び異化経路
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
EP1499709B1 (en) * 2002-04-22 2012-01-04 E.I. Du Pont De Nemours And Company Promoter and plasmid system for genetic engineering
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
DK1627049T3 (da) 2003-05-29 2010-05-31 Genencor Int Nye Trichoderma-gener
JP5091484B2 (ja) * 2003-11-21 2012-12-05 ジェネンコー・インターナショナル・インク トリコデルマにおける顆粒デンプン加水分解酵素の発現及び顆粒デンプン基質からグルコースシロップを製造する方法
CA2652732C (en) * 2006-05-26 2015-04-28 Amyris Biotechnologies, Inc. Fuel components, fuel compositions and methods of making and using same
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
WO2009006429A1 (en) * 2007-06-29 2009-01-08 Regents Of The University Of California Host cells and methods for producing 3-methyl-2-buten-1-ol, 3-methyl-3-buten-1-ol, and 3-methyl-butan-1-ol
CN102791848B (zh) * 2008-07-02 2017-11-10 丹尼斯科美国公司 用于在去偶联条件和/或安全操作范围下产生不含c5烃的异戊二烯的方法和组合物
SG169614A1 (en) 2008-09-15 2011-04-29 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene

Also Published As

Publication number Publication date
EP2340312A2 (en) 2011-07-06
US20130309743A1 (en) 2013-11-21
CA2737195A1 (en) 2010-03-18
US8476049B2 (en) 2013-07-02
US8945893B2 (en) 2015-02-03
SG169614A1 (en) 2011-04-29
ZA201102109B (en) 2013-10-30
WO2010031076A3 (en) 2010-11-11
US20150191746A1 (en) 2015-07-09
WO2010031076A2 (en) 2010-03-18
US20100113846A1 (en) 2010-05-06

Similar Documents

Publication Publication Date Title
BRPI0918936A2 (pt) conversão de derivados de prenila em isopreno
BR112012000769A2 (pt) lupeol -tipo de derivados triterpenos como antivirais
BRPI1008287A2 (pt) métodos de preparação de butadieno e isopreno renováveis
BRPI1013246A2 (pt) derivados de benzofuralina
BR112012002828A2 (pt) derivados de 5-fluorpirimidinona
DOP2011000086A (es) Derivados de acido 1-amino-2-ciclobutiletilboronico
ECSP12011999A (es) Derivados benzamida sustituidos
BRPI0906980A2 (pt) Composição de derivados e maleatados
BR112012015868A2 (pt) derivados de imidazolidinadiona
BRPI1012770A2 (pt) derivados de tiofeno
BRPI1013844A2 (pt) derivados de piridina-isoxazol
BRPI1011468A2 (pt) derivados condensados de pirrolipiridino
DK2397480T3 (da) Diazepindionderivat
BRPI1013853A2 (pt) composições tópicas estáveis de derivados de 1,2,4-tiadiazol
BR112013013445A2 (pt) composição tópica promotora de melanina
BRPI0816161A2 (pt) Transformante capaz de produzir isopropanol
BRPI1014454A2 (pt) derivados de isoxazol-pirazol
DK2387580T3 (da) Deoxyactagardinderivater
BRPI1014688A2 (pt) aplicações terapêuticas de derivados de quinazolinadiona
DK2391349T3 (da) Farmaceutisk sammensætning omfattende 2-oco-1-pyrrolidin-derivater
BRPI1011416A2 (pt) derivados de antraquinova novos
BR112012002810A2 (pt) derivados de n1-acil-5-fluoropirimidinona
BR112012002807A2 (pt) derivados de 5-flúor-2-oxopirimidina-1(2h)-caboxilato
BR112012014770A2 (pt) derivados de etinila
BR112012002971A2 (pt) preparação regioseletiva de derivados 2-amino-5-trifluorometil-pirmidinas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.