JP2017506078A5 - - Google Patents
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- JP2017506078A5 JP2017506078A5 JP2016553501A JP2016553501A JP2017506078A5 JP 2017506078 A5 JP2017506078 A5 JP 2017506078A5 JP 2016553501 A JP2016553501 A JP 2016553501A JP 2016553501 A JP2016553501 A JP 2016553501A JP 2017506078 A5 JP2017506078 A5 JP 2017506078A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant cell
- nucleic acids
- activity
- production
- isoprenoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 51
- 102000039446 nucleic acids Human genes 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 35
- 150000007523 nucleic acids Chemical class 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 20
- 150000003505 terpenes Chemical class 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 230000000694 effects Effects 0.000 claims 17
- 238000004519 manufacturing process Methods 0.000 claims 17
- 108091005646 acetylated proteins Proteins 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 13
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 11
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 11
- 230000014509 gene expression Effects 0.000 claims 11
- 239000002243 precursor Substances 0.000 claims 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- 230000037361 pathway Effects 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
- 230000004108 pentose phosphate pathway Effects 0.000 claims 5
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- CBIDRCWHNCKSTO-UHFFFAOYSA-N prenyl diphosphate Chemical compound CC(C)=CCO[P@](O)(=O)OP(O)(O)=O CBIDRCWHNCKSTO-UHFFFAOYSA-N 0.000 claims 4
- JSNRRGGBADWTMC-UHFFFAOYSA-N alpha-farnesene Natural products CC(C)=CCCC(C)=CCCC(=C)C=C JSNRRGGBADWTMC-UHFFFAOYSA-N 0.000 claims 3
- 239000011436 cob Substances 0.000 claims 3
- 230000001186 cumulative effect Effects 0.000 claims 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 3
- 235000011180 diphosphates Nutrition 0.000 claims 3
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 3
- 108010075483 isoprene synthase Proteins 0.000 claims 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 2
- OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- 101100190555 Dictyostelium discoideum pkgB gene Proteins 0.000 claims 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims 2
- 101100433987 Latilactobacillus sakei subsp. sakei (strain 23K) ackA1 gene Proteins 0.000 claims 2
- 241000219000 Populus Species 0.000 claims 2
- 241000183024 Populus tremula Species 0.000 claims 2
- 241000219780 Pueraria Species 0.000 claims 2
- 101100453320 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) pfkC gene Proteins 0.000 claims 2
- 101100029403 Synechocystis sp. (strain PCC 6803 / Kazusa) pfkA2 gene Proteins 0.000 claims 2
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 2
- 108020002494 acetyltransferase Proteins 0.000 claims 2
- 102000005421 acetyltransferase Human genes 0.000 claims 2
- 101150006213 ackA gene Proteins 0.000 claims 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 2
- 101150038284 pfkA gene Proteins 0.000 claims 2
- 101150004013 pfkA1 gene Proteins 0.000 claims 2
- 101150060387 pfp gene Proteins 0.000 claims 2
- 108010004621 phosphoketolase Proteins 0.000 claims 2
- 229920001550 polyprenyl Polymers 0.000 claims 2
- 125000001185 polyprenyl group Polymers 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 101150003316 rpiA gene Proteins 0.000 claims 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 claims 2
- 101150106193 tal gene Proteins 0.000 claims 2
- 101150040618 talB gene Proteins 0.000 claims 2
- CXENHBSYCFFKJS-UHFFFAOYSA-N α-farnesene Chemical compound CC(C)=CCCC(C)=CCC=C(C)C=C CXENHBSYCFFKJS-UHFFFAOYSA-N 0.000 claims 2
- YKFLAYDHMOASIY-UHFFFAOYSA-N γ-terpinene Chemical compound CC(C)C1=CCC(C)=CC1 YKFLAYDHMOASIY-UHFFFAOYSA-N 0.000 claims 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 claims 1
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 claims 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-CMKODMSKSA-N (-)-Abietadiene Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CCC(C(C)C)=C3)C3=CC[C@H]21 BBPXZLJCPUPNGH-CMKODMSKSA-N 0.000 claims 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 claims 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 1
- JSNRRGGBADWTMC-QINSGFPZSA-N (E)-beta-Farnesene Natural products CC(C)=CCC\C(C)=C/CCC(=C)C=C JSNRRGGBADWTMC-QINSGFPZSA-N 0.000 claims 1
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 claims 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 1
- JXBSHSBNOVLGHF-UHFFFAOYSA-N 10-cis-Dihydrofarnesen Natural products CC=C(C)CCC=C(C)CCC=C(C)C JXBSHSBNOVLGHF-UHFFFAOYSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-UHFFFAOYSA-N Abietadien Natural products CC1(C)CCCC2(C)C(CCC(C(C)C)=C3)C3=CCC21 BBPXZLJCPUPNGH-UHFFFAOYSA-N 0.000 claims 1
- 108010092060 Acetate kinase Proteins 0.000 claims 1
- 102000008146 Acetate-CoA ligase Human genes 0.000 claims 1
- 108010049926 Acetate-CoA ligase Proteins 0.000 claims 1
- 101100182965 Escherichia coli (strain K12) maeA gene Proteins 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 239000005792 Geraniol Substances 0.000 claims 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims 1
- 101000729289 Homo sapiens Ribose-5-phosphate isomerase Proteins 0.000 claims 1
- 229930184510 Mallotus Natural products 0.000 claims 1
- 241001060384 Mallotus <angiosperm> Species 0.000 claims 1
- 101000689035 Mus musculus Ribulose-phosphate 3-epimerase Proteins 0.000 claims 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 claims 1
- 101000729343 Oryza sativa subsp. japonica Ribulose-phosphate 3-epimerase, cytoplasmic isoform Proteins 0.000 claims 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 1
- 102000001105 Phosphofructokinases Human genes 0.000 claims 1
- 108010069341 Phosphofructokinases Proteins 0.000 claims 1
- 241000168036 Populus alba Species 0.000 claims 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 claims 1
- 101100217493 Rhizobium meliloti (strain 1021) actP1 gene Proteins 0.000 claims 1
- 102100031139 Ribose-5-phosphate isomerase Human genes 0.000 claims 1
- 101150024271 TKT gene Proteins 0.000 claims 1
- 108020004530 Transaldolase Proteins 0.000 claims 1
- 102100028601 Transaldolase Human genes 0.000 claims 1
- 102000014701 Transketolase Human genes 0.000 claims 1
- 108010043652 Transketolase Proteins 0.000 claims 1
- 229930014549 abietadiene Natural products 0.000 claims 1
- 101150015189 aceE gene Proteins 0.000 claims 1
- 101150077561 aceF gene Proteins 0.000 claims 1
- 101150094483 actP gene Proteins 0.000 claims 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 claims 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 claims 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-CBBWQLFWSA-N amorpha-4,11-diene Chemical compound C1=C(C)CC[C@H]2[C@H](C)CC[C@@H](C(C)=C)[C@H]21 HMTAHNDPLDKYJT-CBBWQLFWSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-UHFFFAOYSA-N amorphadiene Natural products C1=C(C)CCC2C(C)CCC(C(C)=C)C21 HMTAHNDPLDKYJT-UHFFFAOYSA-N 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- YSNRTFFURISHOU-UHFFFAOYSA-N beta-farnesene Natural products C=CC(C)CCC=C(C)CCC=C(C)C YSNRTFFURISHOU-UHFFFAOYSA-N 0.000 claims 1
- 229930006722 beta-pinene Natural products 0.000 claims 1
- 229930006737 car-3-ene Natural products 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- BQOFWKZOCNGFEC-UHFFFAOYSA-N carene Chemical compound C1C(C)=CCC2C(C)(C)C12 BQOFWKZOCNGFEC-UHFFFAOYSA-N 0.000 claims 1
- 229930007796 carene Natural products 0.000 claims 1
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 claims 1
- 229940113087 geraniol Drugs 0.000 claims 1
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 claims 1
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 229930007744 linalool Natural products 0.000 claims 1
- 101150003321 lpdA gene Proteins 0.000 claims 1
- 101150108859 maeB gene Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 claims 1
- 101150038927 pdhR gene Proteins 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 101150108780 pta gene Proteins 0.000 claims 1
- 101150018078 rpe gene Proteins 0.000 claims 1
- 229930006696 sabinene Natural products 0.000 claims 1
- 229930006978 terpinene Natural products 0.000 claims 1
- 150000003507 terpinene derivatives Chemical class 0.000 claims 1
- 101150014795 tktA gene Proteins 0.000 claims 1
- -1 tkta Proteins 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461942546P | 2014-02-20 | 2014-02-20 | |
| US61/942,546 | 2014-02-20 | ||
| PCT/US2015/016954 WO2015127305A2 (en) | 2014-02-20 | 2015-02-20 | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506078A JP2017506078A (ja) | 2017-03-02 |
| JP2017506078A5 true JP2017506078A5 (enExample) | 2018-04-05 |
| JP6744819B2 JP6744819B2 (ja) | 2020-08-19 |
Family
ID=52633654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553501A Active JP6744819B2 (ja) | 2014-02-20 | 2015-02-20 | メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルＣｏＡ由来産物の生産向上のための組換え微生物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10648004B2 (enExample) |
| EP (1) | EP3107993B1 (enExample) |
| JP (1) | JP6744819B2 (enExample) |
| BR (1) | BR112016018774A2 (enExample) |
| DK (1) | DK3107993T3 (enExample) |
| WO (1) | WO2015127305A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10648004B2 (en) | 2014-02-20 | 2020-05-12 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products |
| CA3047268A1 (en) * | 2016-12-16 | 2018-06-21 | Danisco Us Inc. | Bifunctional phosphoketolase-phosphotransacetylase fusion polypeptides |
| WO2018136425A1 (en) * | 2017-01-17 | 2018-07-26 | White Dog Labs, Inc. | Proteinic biomass preparation comprising a non-native organism of the clostridia class |
| CA3084263A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| US20210087571A1 (en) * | 2018-02-26 | 2021-03-25 | William Marsh Rice University | Acetyl-coa-derived biosynthesis |
| WO2019208747A1 (ja) * | 2018-04-27 | 2019-10-31 | 長瀬産業株式会社 | セドヘプツロースの製造方法 |
| CN109486720B (zh) * | 2018-12-18 | 2020-08-04 | 江南大学 | 一种产l-木酮糖的枯草芽孢杆菌及其应用 |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| CN111607546B (zh) * | 2020-04-30 | 2022-08-09 | 中国科学院青岛生物能源与过程研究所 | 一种高产法尼烯的基因工程菌及其构建方法与应用 |
| MX2024000606A (es) * | 2021-07-12 | 2024-01-30 | Danisco Us Inc | Celula de levadura recombinante. |
| KR102572850B1 (ko) * | 2022-07-11 | 2023-08-31 | 대상 주식회사 | L-글루탐산을 생산하는 코리네박테리움 속 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| AU2003238899A1 (en) * | 2002-06-07 | 2003-12-22 | Wisconsin Alumni Research Foundation | Method of controling acetylation of metabolic enzymes |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| BRPI0614990A2 (pt) | 2005-08-19 | 2011-04-26 | Univ California | células hospedeiras geneticamente modificadas e uso das mesmas para produção de compostos isoprenóides |
| CA2651747C (en) | 2006-05-26 | 2017-10-24 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| BRPI0823506A8 (pt) | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| WO2009100231A2 (en) | 2008-02-06 | 2009-08-13 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| WO2009126623A2 (en) * | 2008-04-08 | 2009-10-15 | Amyris Biotechnologies, Inc. | Expression of heterologous sequences |
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-
2015
- 2015-02-20 US US15/120,037 patent/US10648004B2/en active Active
- 2015-02-20 BR BR112016018774A patent/BR112016018774A2/pt not_active Application Discontinuation
- 2015-02-20 JP JP2016553501A patent/JP6744819B2/ja active Active
- 2015-02-20 WO PCT/US2015/016954 patent/WO2015127305A2/en not_active Ceased
- 2015-02-20 DK DK15708996.2T patent/DK3107993T3/da active
- 2015-02-20 EP EP15708996.2A patent/EP3107993B1/en active Active
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2020
- 2020-05-11 US US16/872,329 patent/US11685937B2/en active Active
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