JP2016508737A5 - - Google Patents
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- JP2016508737A5 JP2016508737A5 JP2015561662A JP2015561662A JP2016508737A5 JP 2016508737 A5 JP2016508737 A5 JP 2016508737A5 JP 2015561662 A JP2015561662 A JP 2015561662A JP 2015561662 A JP2015561662 A JP 2015561662A JP 2016508737 A5 JP2016508737 A5 JP 2016508737A5
- Authority
- JP
- Japan
- Prior art keywords
- methane
- isoprene
- item
- nucleic acid
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims description 90
- 241000894006 Bacteria Species 0.000 claims description 61
- 230000037361 pathway Effects 0.000 claims description 43
- 102000004190 Enzymes Human genes 0.000 claims description 42
- 108090000790 Enzymes Proteins 0.000 claims description 42
- 150000007523 nucleic acids Chemical class 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 40
- 108020004707 nucleic acids Proteins 0.000 claims description 39
- 102000039446 nucleic acids Human genes 0.000 claims description 39
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 22
- 108010075483 isoprene synthase Proteins 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- 150000002430 hydrocarbons Chemical class 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000004215 Carbon black (E152) Substances 0.000 claims description 7
- 241000589344 Methylomonas Species 0.000 claims description 7
- 241000589966 Methylocystis Species 0.000 claims description 6
- 241000124033 Salix Species 0.000 claims description 6
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 6
- 239000003345 natural gas Substances 0.000 claims description 6
- 241000589348 Methylomonas methanica Species 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 5
- 239000000539 dimer Substances 0.000 claims description 5
- 239000013638 trimer Substances 0.000 claims description 5
- 108020004705 Codon Proteins 0.000 claims description 4
- 241000514364 Methylocella Species 0.000 claims description 4
- 241001533203 Methylomicrobium Species 0.000 claims description 4
- 150000001413 amino acids Chemical group 0.000 claims description 4
- 238000000855 fermentation Methods 0.000 claims description 4
- 230000004151 fermentation Effects 0.000 claims description 4
- 101100453077 Botryococcus braunii HDR gene Proteins 0.000 claims description 3
- 102100031515 D-ribitol-5-phosphate cytidylyltransferase Human genes 0.000 claims description 3
- 101710088194 Dehydrogenase Proteins 0.000 claims description 3
- 101000994204 Homo sapiens D-ribitol-5-phosphate cytidylyltransferase Proteins 0.000 claims description 3
- 241000267306 Methylacidiphilum fumariolicum Species 0.000 claims description 3
- 241000672512 Methylacidiphilum infernorum Species 0.000 claims description 3
- 241000922210 Methyloacida Species 0.000 claims description 3
- 241000589350 Methylobacter Species 0.000 claims description 3
- 241000589207 Methylobacter capsulatus Species 0.000 claims description 3
- 241000589339 Methylobacterium organophilum Species 0.000 claims description 3
- 241001085182 Methylocapsa Species 0.000 claims description 3
- 241000566791 Methylocapsa aurea Species 0.000 claims description 3
- 241001609650 Methylocella palustris Species 0.000 claims description 3
- 241001533549 Methylocella silvestris Species 0.000 claims description 3
- 241000589345 Methylococcus Species 0.000 claims description 3
- 241001003008 Methylococcus capsulatus str. Bath Species 0.000 claims description 3
- 241000213422 Methylocystis bryophila Species 0.000 claims description 3
- 241000589964 Methylocystis parvus Species 0.000 claims description 3
- 241001533199 Methylomicrobium album Species 0.000 claims description 3
- 241000589354 Methylosinus Species 0.000 claims description 3
- 241000589349 Methylosinus sporium Species 0.000 claims description 3
- 241000322541 Methylosinus trichosporium OB3b Species 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 3
- 241000220435 Papilionoideae Species 0.000 claims description 3
- 101100397457 Plasmodium falciparum (isolate 3D7) LytB gene Proteins 0.000 claims description 3
- 241000219000 Populus Species 0.000 claims description 3
- 241000168036 Populus alba Species 0.000 claims description 3
- 241000218982 Populus nigra Species 0.000 claims description 3
- 241001600128 Populus tremula x Populus alba Species 0.000 claims description 3
- 240000004923 Populus tremuloides Species 0.000 claims description 3
- 235000011263 Populus tremuloides Nutrition 0.000 claims description 3
- 241000218976 Populus trichocarpa Species 0.000 claims description 3
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 3
- 241000913776 Pueraria montana Species 0.000 claims description 3
- 241000219781 Pueraria montana var. lobata Species 0.000 claims description 3
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 3
- 240000009089 Quercus robur Species 0.000 claims description 3
- 235000011471 Quercus robur Nutrition 0.000 claims description 3
- 241001299688 Salix serpyllifolia Species 0.000 claims description 3
- 108010048916 alcohol dehydrogenase (acceptor) Proteins 0.000 claims description 3
- 108010025743 hexose phosphate synthetase Proteins 0.000 claims description 3
- 101150018742 ispF gene Proteins 0.000 claims description 3
- 239000007011 methylocapsa aurea Substances 0.000 claims description 3
- 210000002706 plastid Anatomy 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims description 2
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 2
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 claims description 2
- 108010033918 Alanine-glyoxylate transaminase Proteins 0.000 claims description 2
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims description 2
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims description 2
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims description 2
- 108090000769 Isomerases Proteins 0.000 claims description 2
- 102000004195 Isomerases Human genes 0.000 claims description 2
- NUHSROFQTUXZQQ-UHFFFAOYSA-N Isopentenyl diphosphate Natural products CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims description 2
- 241001512042 Methylibium petroleiphilum Species 0.000 claims description 2
- 241000314903 Methylocella tundrae Species 0.000 claims description 2
- 108700040132 Mevalonate kinases Proteins 0.000 claims description 2
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims description 2
- 102100024279 Phosphomevalonate kinase Human genes 0.000 claims description 2
- 102000019394 Serine hydroxymethyltransferases Human genes 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000002678 mevalonate kinase Human genes 0.000 claims description 2
- 108091000116 phosphomevalonate kinase Proteins 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 150000003505 terpenes Chemical class 0.000 claims description 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 4
- -1 IspE Proteins 0.000 claims 2
- 108030003618 3,4-dihydroxy-2-butanone-4-phosphate synthases Proteins 0.000 claims 1
- 101100286286 Dictyostelium discoideum ipi gene Proteins 0.000 claims 1
- 102000057412 Diphosphomevalonate decarboxylases Human genes 0.000 claims 1
- 101000908461 Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) Nonribosomal peptide synthetase dtxS1 Proteins 0.000 claims 1
- 101000958834 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Diphosphomevalonate decarboxylase mvd1 Proteins 0.000 claims 1
- 101000958925 Panax ginseng Diphosphomevalonate decarboxylase 1 Proteins 0.000 claims 1
- 241001278077 Salix pentandra Species 0.000 claims 1
- 101150118992 dxr gene Proteins 0.000 claims 1
- 101150014423 fni gene Proteins 0.000 claims 1
- 101150075592 idi gene Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108010007508 Farnesyltranstransferase Proteins 0.000 description 7
- 102000007317 Farnesyltranstransferase Human genes 0.000 description 7
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 description 6
- 230000019612 pigmentation Effects 0.000 description 3
- SEYLPRWNVFCVRQ-UHFFFAOYSA-N 3,4-dihydroxybutan-2-one Chemical compound CC(=O)C(O)CO SEYLPRWNVFCVRQ-UHFFFAOYSA-N 0.000 description 2
- 102100031571 40S ribosomal protein S16 Human genes 0.000 description 2
- 241000409693 Methylomicrobium alcaliphilum Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 101710173432 Phytoene synthase Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003471 mutagenic agent Substances 0.000 description 2
- 231100000707 mutagenic chemical Toxicity 0.000 description 2
- 230000003505 mutagenic effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 108010001545 phytoene dehydrogenase Proteins 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 108010092955 ribosomal protein S16 Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- CNHDIAIOKMXOLK-UHFFFAOYSA-N toluquinol Chemical compound CC1=CC(O)=CC=C1O CNHDIAIOKMXOLK-UHFFFAOYSA-N 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- 108090000489 Carboxy-Lyases Proteins 0.000 description 1
- 241001303121 Methylibium Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361774342P | 2013-03-07 | 2013-03-07 | |
| US61/774,342 | 2013-03-07 | ||
| US201461928333P | 2014-01-16 | 2014-01-16 | |
| US61/928,333 | 2014-01-16 | ||
| PCT/US2014/021258 WO2014138419A1 (en) | 2013-03-07 | 2014-03-06 | Compositions and methods for biological production of isoprene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508737A JP2016508737A (ja) | 2016-03-24 |
| JP2016508737A5 true JP2016508737A5 (enExample) | 2017-04-06 |
Family
ID=51491962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561662A Pending JP2016508737A (ja) | 2013-03-07 | 2014-03-06 | イソプレンの生物学的産生のための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160017374A1 (enExample) |
| EP (1) | EP2964748A4 (enExample) |
| JP (1) | JP2016508737A (enExample) |
| KR (1) | KR20150125653A (enExample) |
| CN (1) | CN105008514A (enExample) |
| AU (1) | AU2014225631A1 (enExample) |
| BR (1) | BR112015021003A2 (enExample) |
| CA (1) | CA2901588A1 (enExample) |
| RU (1) | RU2015131480A (enExample) |
| WO (1) | WO2014138419A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9695447B2 (en) * | 2012-12-27 | 2017-07-04 | Sekisui Chemical Co., Ltd. | Recombinant cell and method for producing isoprene |
| ES2757913T3 (es) | 2013-06-18 | 2020-04-30 | Calysta Inc | Composiciones y métodos para la producción biológica de lactato a partir de compuestos de C1 mediante el uso de transformantes de deshidrogenasa láctica |
| WO2015109265A1 (en) | 2014-01-16 | 2015-07-23 | Calysta, Inc. | Microorganisms for the enhanced production of amino acids and related methods |
| US10443060B2 (en) | 2014-06-18 | 2019-10-15 | Calysta, Inc. | Nucleic acids and vectors for use with methanotrophic bacteria |
| JP2016059313A (ja) * | 2014-09-17 | 2016-04-25 | 積水化学工業株式会社 | 組換え細胞、並びに、イソプレン又は環式イソプレノイドの生産方法 |
| DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
| JP2018516552A (ja) | 2015-05-06 | 2018-06-28 | トレリス， インコーポレイテッド | メチオニンの生物学的産生のための組成物及び方法 |
| CA2984135A1 (en) | 2015-05-13 | 2016-11-17 | Calysta, Inc. | Proline auxotrophs |
| US20180291401A1 (en) * | 2015-08-17 | 2018-10-11 | Invista North America S.A.R.L. | Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof |
| US10533192B2 (en) | 2015-12-22 | 2020-01-14 | Nutech Ventures | Production of isoprene by methane-producing archaea |
| KR102546640B1 (ko) | 2016-01-26 | 2023-06-22 | 에스케이이노베이션 주식회사 | 재조합 호염성 메탄균주를 이용한 이소프렌의 제조방법 |
| JP2018014960A (ja) * | 2016-07-29 | 2018-02-01 | 横浜ゴム株式会社 | 発現ベクター、形質転換された藻類、形質転換された珪藻、及び、ポリヌクレオチド |
| JPWO2018079619A1 (ja) * | 2016-10-28 | 2019-09-19 | 積水化学工業株式会社 | 組換え細胞、並びに、イソプレン又はテルペンの生産方法 |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| US11180707B2 (en) * | 2018-08-03 | 2021-11-23 | Faramaz Fred Faramarzi | System and method for duplicating flammable gas |
| CN109943493B (zh) * | 2019-04-17 | 2021-05-18 | 天津大学 | 实现通用酶催化功能多样性的突变体菌株及其构建方法 |
| JP7754406B2 (ja) * | 2021-03-26 | 2025-10-15 | 三菱ケミカル株式会社 | イソプレン産生能を有する遺伝子改変微生物およびこれを用いたイソプレン製造方法 |
| CN119736218A (zh) * | 2023-09-19 | 2025-04-01 | 西安卓虹超源生物科技有限公司 | 一种萜类化合物的生产及菌株 |
| WO2025155137A1 (ko) * | 2024-01-18 | 2025-07-24 | 한국생명공학연구원 | 메탄으로부터 이소프렌 생산능을 갖는 형질전환체 |
| WO2026010860A1 (en) | 2024-07-02 | 2026-01-08 | Bp Corporation North America Inc. | Recombinant microorganisms for isoprene production |
| US20260055330A1 (en) * | 2024-07-26 | 2026-02-26 | Visolis, Inc. | High energy density rocket fuel compositions |
| WO2026122827A2 (en) | 2024-12-05 | 2026-06-11 | Bp Corporation North America Inc. | Ppi-dependent kdg kinases and uses thereof |
| WO2026122843A2 (en) | 2024-12-05 | 2026-06-11 | Bp Corporation North America Inc. | Recombinant microorganisms for βeta-myrcene and nerol production |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818424B2 (en) * | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
| US20030219798A1 (en) * | 2000-09-29 | 2003-11-27 | Gokarn Ravi R. | Isoprenoid production |
| US7947478B2 (en) * | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| EP3354740A1 (en) * | 2007-12-13 | 2018-08-01 | Danisco US Inc. | Compositions and methods for producing isoprene |
| SG169652A1 (en) * | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Reduction of carbon dioxide emission during isoprene production by fermentation |
| TW201412988A (zh) * | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| DE102012012913A1 (de) * | 2012-06-27 | 2014-01-02 | Beatrice Saier | Vorrichtung und Verfahren zur schaltbaren Förderung wenigstens eines Mediums |
| EP2935364A2 (en) * | 2012-12-21 | 2015-10-28 | Danisco US Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
| US9695447B2 (en) * | 2012-12-27 | 2017-07-04 | Sekisui Chemical Co., Ltd. | Recombinant cell and method for producing isoprene |
-
2014
- 2014-03-06 JP JP2015561662A patent/JP2016508737A/ja active Pending
- 2014-03-06 CA CA2901588A patent/CA2901588A1/en not_active Abandoned
- 2014-03-06 KR KR1020157023131A patent/KR20150125653A/ko not_active Withdrawn
- 2014-03-06 CN CN201480012326.4A patent/CN105008514A/zh active Pending
- 2014-03-06 BR BR112015021003A patent/BR112015021003A2/pt not_active IP Right Cessation
- 2014-03-06 US US14/773,118 patent/US20160017374A1/en not_active Abandoned
- 2014-03-06 WO PCT/US2014/021258 patent/WO2014138419A1/en not_active Ceased
- 2014-03-06 RU RU2015131480A patent/RU2015131480A/ru not_active Application Discontinuation
- 2014-03-06 AU AU2014225631A patent/AU2014225631A1/en not_active Abandoned
- 2014-03-06 EP EP14760094.4A patent/EP2964748A4/en not_active Withdrawn
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