BR112014008278A2 - utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno - Google Patents
utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isoprenoInfo
- Publication number
- BR112014008278A2 BR112014008278A2 BR112014008278A BR112014008278A BR112014008278A2 BR 112014008278 A2 BR112014008278 A2 BR 112014008278A2 BR 112014008278 A BR112014008278 A BR 112014008278A BR 112014008278 A BR112014008278 A BR 112014008278A BR 112014008278 A2 BR112014008278 A2 BR 112014008278A2
- Authority
- BR
- Brazil
- Prior art keywords
- mevalonate
- isoprenoid
- production
- isoprene
- phosphocetolase
- Prior art date
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title abstract 10
- 150000003505 terpenes Chemical class 0.000 title abstract 6
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 title abstract 5
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 title abstract 5
- 239000002243 precursor Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 108010004621 phosphoketolase Proteins 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02009—Phosphoketolase (4.1.2.9)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03027—Isoprene synthase (4.2.3.27)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
- C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Botany (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545083P | 2011-10-07 | 2011-10-07 | |
| PCT/US2012/059136 WO2013066568A1 (en) | 2011-10-07 | 2012-10-05 | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014008278A2 true BR112014008278A2 (pt) | 2017-04-18 |
Family
ID=47046886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014008278A BR112014008278A2 (pt) | 2011-10-07 | 2012-10-05 | utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8993305B2 (enExample) |
| EP (2) | EP2764084B2 (enExample) |
| JP (2) | JP6420147B2 (enExample) |
| CN (1) | CN104053765A (enExample) |
| AU (1) | AU2012332996A1 (enExample) |
| BR (1) | BR112014008278A2 (enExample) |
| CA (1) | CA2851265A1 (enExample) |
| DK (2) | DK3339426T3 (enExample) |
| HK (1) | HK1201071A1 (enExample) |
| MX (1) | MX2014004209A (enExample) |
| SG (1) | SG11201401249PA (enExample) |
| WO (1) | WO2013066568A1 (enExample) |
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| SG11201401249PA (en) * | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| US20140128645A1 (en) * | 2011-12-23 | 2014-05-08 | The Goodyear Tire & Rubber Company | Enhanced production of isoprene using marine bacterial cells |
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| WO2014100726A2 (en) | 2012-12-21 | 2014-06-26 | Danisco Us Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
| US9518278B2 (en) | 2013-03-14 | 2016-12-13 | The Regents Of The University Of California | Recombinant microorganisms having a methanol elongation cycle (MEC) |
| EP2984105B1 (en) * | 2013-04-10 | 2019-05-22 | Danisco US Inc. | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
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-
2012
- 2012-10-05 SG SG11201401249PA patent/SG11201401249PA/en unknown
- 2012-10-05 US US13/646,562 patent/US8993305B2/en active Active
- 2012-10-05 CN CN201280059852.7A patent/CN104053765A/zh active Pending
- 2012-10-05 DK DK17206148.3T patent/DK3339426T3/da active
- 2012-10-05 MX MX2014004209A patent/MX2014004209A/es unknown
- 2012-10-05 WO PCT/US2012/059136 patent/WO2013066568A1/en not_active Ceased
- 2012-10-05 CA CA2851265A patent/CA2851265A1/en not_active Abandoned
- 2012-10-05 EP EP12775413.3A patent/EP2764084B2/en active Active
- 2012-10-05 EP EP17206148.3A patent/EP3339426B1/en active Active
- 2012-10-05 BR BR112014008278A patent/BR112014008278A2/pt not_active Application Discontinuation
- 2012-10-05 JP JP2014534810A patent/JP6420147B2/ja active Active
- 2012-10-05 DK DK12775413.3T patent/DK2764084T4/da active
- 2012-10-05 AU AU2012332996A patent/AU2012332996A1/en not_active Abandoned
- 2012-10-05 HK HK15101539.9A patent/HK1201071A1/xx unknown
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2015
- 2015-02-18 US US14/625,487 patent/US9493791B2/en active Active
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2016
- 2016-09-28 US US15/279,184 patent/US10113185B2/en active Active
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2018
- 2018-10-11 JP JP2018192631A patent/JP6639606B2/ja active Active
Also Published As
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|---|---|
| JP6420147B2 (ja) | 2018-11-07 |
| EP2764084B1 (en) | 2018-02-28 |
| US20170198311A1 (en) | 2017-07-13 |
| EP2764084B2 (en) | 2021-11-03 |
| EP3339426B1 (en) | 2022-08-24 |
| WO2013066568A1 (en) | 2013-05-10 |
| US8993305B2 (en) | 2015-03-31 |
| JP6639606B2 (ja) | 2020-02-05 |
| JP2019030315A (ja) | 2019-02-28 |
| US20150225744A1 (en) | 2015-08-13 |
| US9493791B2 (en) | 2016-11-15 |
| HK1201071A1 (en) | 2015-08-21 |
| US10113185B2 (en) | 2018-10-30 |
| DK3339426T3 (da) | 2022-09-12 |
| JP2014531904A (ja) | 2014-12-04 |
| MX2014004209A (es) | 2014-08-08 |
| CA2851265A1 (en) | 2013-05-10 |
| EP3339426A1 (en) | 2018-06-27 |
| AU2012332996A1 (en) | 2014-04-24 |
| SG11201401249PA (en) | 2014-05-29 |
| US20130089906A1 (en) | 2013-04-11 |
| DK2764084T4 (da) | 2021-12-06 |
| CN104053765A (zh) | 2014-09-17 |
| DK2764084T3 (en) | 2018-04-09 |
| EP2764084A1 (en) | 2014-08-13 |
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