BRPI0911667A2 - variante de sintase de isopreno para produção microbiana aprimorada de isopreno - Google Patents
variante de sintase de isopreno para produção microbiana aprimorada de isoprenoInfo
- Publication number
- BRPI0911667A2 BRPI0911667A2 BRPI0911667A BRPI0911667A BRPI0911667A2 BR PI0911667 A2 BRPI0911667 A2 BR PI0911667A2 BR PI0911667 A BRPI0911667 A BR PI0911667A BR PI0911667 A BRPI0911667 A BR PI0911667A BR PI0911667 A2 BRPI0911667 A2 BR PI0911667A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoprene
- production
- present
- synthase variant
- enhanced microbial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03027—Isoprene synthase (4.2.3.27)
Abstract
variante de sintase de isopreno, célula hospedeira, e método de produção de isopreno a presente invenção refere-se a métodos e composições compreendendo pelo menos uma enzima sintase de isopreno com atividade catalítica e/ou solubilidade aprimorada. em particular, a presente invenção proporciona sintases de isopreno de planta variantes para produção aumentada de isopreno em células hospedeiras microbianas. lsopreno biossinteticamente produzido da presente invenção encontra uso na fabricação de borracha e elastômeros.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12533608P | 2008-04-23 | 2008-04-23 | |
PCT/US2009/041581 WO2009132220A2 (en) | 2008-04-23 | 2009-04-23 | Isoprene synthase variants for improved microbial production of isoprene |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0911667A2 true BRPI0911667A2 (pt) | 2019-04-24 |
Family
ID=40810540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0911667A BRPI0911667A2 (pt) | 2008-04-23 | 2009-04-23 | variante de sintase de isopreno para produção microbiana aprimorada de isopreno |
Country Status (14)
Country | Link |
---|---|
US (3) | US8173410B2 (pt) |
EP (1) | EP2279251A2 (pt) |
JP (2) | JP2011518564A (pt) |
KR (1) | KR20110020234A (pt) |
CN (1) | CN102171335A (pt) |
AU (1) | AU2009240505B2 (pt) |
BR (1) | BRPI0911667A2 (pt) |
CA (1) | CA2722440A1 (pt) |
MX (1) | MX2010011706A (pt) |
MY (1) | MY153871A (pt) |
RU (2) | RU2516343C2 (pt) |
SG (2) | SG192545A1 (pt) |
WO (1) | WO2009132220A2 (pt) |
ZA (2) | ZA201007564B (pt) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX344810B (es) * | 2007-06-08 | 2017-01-09 | Danisco Us Inc Genencor Div * | Sistema de expresion de celulasa heterologa y homologa. |
RU2545699C2 (ru) | 2007-12-13 | 2015-04-10 | ДАНИСКО ЮЭс ИНК. | Композиции и способы получения изопрена |
SG192545A1 (en) | 2008-04-23 | 2013-08-30 | Danisco Us Inc | Isoprene synthase variants for improved microbial production of isoprene |
MX2011000072A (es) * | 2008-06-30 | 2011-05-23 | Danisco Inc | Polimeros de isopreno a partir de recursos renovables. |
CA2737223A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
US20100184178A1 (en) * | 2008-09-15 | 2010-07-22 | Zachary Quinn Beck | Increased isoprene production using mevalonate kinase and isoprene synthase |
EP2414311B1 (en) * | 2009-04-02 | 2017-06-07 | Amyris, Inc. | Stabilization and hydrogenation methods for microbial-derived olefins |
US8518686B2 (en) * | 2009-04-23 | 2013-08-27 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
TW201120213A (en) * | 2009-06-17 | 2011-06-16 | Danisco Us Inc | Polymerization of isoprene from renewable resources |
TWI434921B (zh) * | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
TW201412988A (zh) * | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用dxp及mva途徑之改良之異戊二烯製造 |
US20110039323A1 (en) * | 2009-08-14 | 2011-02-17 | Eric Lawrence Singsaas | Isoprene Production |
BR112012015117A2 (pt) * | 2009-12-22 | 2019-09-24 | Danisco Us Inc | "biorreator de membrana para produção aumentada de gás isopreno" |
WO2011079314A2 (en) | 2009-12-23 | 2011-06-30 | Danisco Us Inc. | Compositions and methods of pgl for the increased production of isoprene |
MX336229B (es) * | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
US20130158106A1 (en) * | 2010-06-02 | 2013-06-20 | The United States Of America As Represented By The Department Of Veteran Affairs | Tocopherol derivatives and methods of use |
WO2011160081A1 (en) | 2010-06-17 | 2011-12-22 | Danisco Us Inc. | Fuel compositions comprising isoprene derivatives |
EP2601300A1 (en) | 2010-08-06 | 2013-06-12 | Danisco US Inc. | Production of isoprene under neutral ph conditions |
EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
US9273298B2 (en) | 2010-10-27 | 2016-03-01 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
EP2655597A1 (en) | 2010-12-22 | 2013-10-30 | Danisco US Inc. | Biological production of pentose sugars using recombinant cells |
CA2822467A1 (en) | 2010-12-22 | 2012-06-28 | Danisco Us Inc. | Compositions and methods for improved isoprene production using two types of ispg enzymes |
KR101420991B1 (ko) | 2011-02-02 | 2014-08-12 | 아미리스 인코퍼레이티드 | 테르펜 합성효소 변이체들을 개발하는 방법들 |
EP2670852A4 (en) | 2011-02-02 | 2017-04-26 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
ES2699747T3 (es) | 2011-04-29 | 2019-02-12 | Danisco Us Inc | Microorganismos recombinantes para la producción potenciada de mevalonato, isopreno e isoprenoides |
EP2702139A1 (en) | 2011-04-29 | 2014-03-05 | Danisco US Inc. | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
WO2013016591A1 (en) * | 2011-07-26 | 2013-01-31 | Zuvachem, Inc. | High efficiency isoprene synthases produced by protein engineering |
SG2014007991A (en) | 2011-08-04 | 2014-03-28 | Danisco Us Inc | Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase |
BR112014002745A8 (pt) | 2011-08-05 | 2017-06-20 | Danisco Us Inc | produção de isoprenoides sob condições de ph neutro |
CN103946383A (zh) | 2011-09-16 | 2014-07-23 | 基因组股份公司 | 用于生产烯烃的微生物和方法 |
MX2014004209A (es) | 2011-10-07 | 2014-08-08 | Danisco Inc | Uso de fosfocetolasa en la produccion de mevalonato, precursores de isoprenoides e isopreno. |
CA2853125A1 (en) * | 2011-10-27 | 2013-05-02 | The Goodyear Tire & Rubber Company | Isoprene synthase variants with improved solubility for production of isoprene |
WO2013096917A1 (en) | 2011-12-23 | 2013-06-27 | Danisco Us Inc. | Production of isoprene under reduced oxygen inlet levels |
WO2013096683A2 (en) * | 2011-12-23 | 2013-06-27 | Danisco Us Inc. | Enhanced production of isoprene using marine bacterial cells |
US8975051B2 (en) | 2011-12-23 | 2015-03-10 | Danisco Us Inc. | Enhanced production of isoprene using host cells having decreased ispA activity |
US20150017696A1 (en) * | 2012-03-02 | 2015-01-15 | Codexis, Inc. a corporation | Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate |
US9315831B2 (en) | 2012-03-30 | 2016-04-19 | Danisco Us Inc. | Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids |
US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
US8895277B2 (en) | 2012-05-02 | 2014-11-25 | Danisco Us Inc. | Legume isoprene synthase for production of isoprene |
US8962296B2 (en) * | 2012-05-30 | 2015-02-24 | Bridgestone Corporation | Isoprene synthase and gene encoding the same, and method for producing isoprene monomer |
BR112014029548B1 (pt) * | 2012-05-30 | 2022-06-07 | Bridgestone Corporation E Ajinomoto Co., Inc | Polinucleotídeo, proteína, vetor de expressão, célula transformada, e, métodos para produzir um monômero de isopreno e um polímero de isopreno |
WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
US9382554B2 (en) | 2012-07-27 | 2016-07-05 | Wisys Technology Foundation, Inc. | Methods for isoprene and pinene production in cyanobacteria |
CN111621453A (zh) | 2012-10-23 | 2020-09-04 | 积水化学工业株式会社 | 重组细胞以及异戊二烯的生产方法 |
WO2014066892A1 (en) * | 2012-10-26 | 2014-05-01 | Coelho Pedro S | De novo metabolic pathways for isoprene biosynthesis |
US20160002672A1 (en) | 2012-12-21 | 2016-01-07 | Danisco Us Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
KR20150100666A (ko) | 2012-12-27 | 2015-09-02 | 세키스이가가쿠 고교가부시키가이샤 | 재조합 세포, 및 이소프렌의 생산 방법 |
US9175330B2 (en) * | 2013-02-20 | 2015-11-03 | Korea Research Institute Of Bioscience And Biotechnology | Method for screening and quantifying isoprene biosynthesis enzyme activity |
US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY ASSIMILATING FORMAT |
WO2014169144A2 (en) | 2013-04-10 | 2014-10-16 | Danisco Us Inc. | Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids |
CN103215315B (zh) * | 2013-04-15 | 2015-05-20 | 上海工业生物技术研发中心 | 利用蓝藻生产异戊二烯 |
CA2915980A1 (en) | 2013-06-21 | 2014-12-24 | Danisco Us Inc. | Compositions and methods for clostridial transformation |
US10920230B2 (en) | 2013-08-08 | 2021-02-16 | Knipbio, Inc. | Methylotrophs for aquaculture and animal feed |
BR112016005509B1 (pt) | 2013-09-13 | 2021-01-19 | The Board Of Trustees Of The University Of Arkansas | uso de uma composição |
EP3072967B1 (en) | 2013-11-22 | 2020-01-01 | Ajinomoto Co., Inc. | Modified isoprene synthase |
JPWO2015080273A1 (ja) * | 2013-11-28 | 2017-03-16 | 味の素株式会社 | イソプレンモノマーの製造方法 |
SI3077501T1 (sl) | 2013-12-03 | 2022-02-28 | Genomatica, Inc. | Mikroorganizmi in metode za izboljšanje donosa izdelkov z uporabo sinteze acetil-coa |
EP3107993B1 (en) | 2014-02-20 | 2020-08-26 | Danisco US Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
RU2014112066A (ru) | 2014-03-28 | 2015-10-10 | Адзиномото Ко., Инк. | Способ получения мономерного изопрена |
KR101582259B1 (ko) | 2014-07-04 | 2016-01-04 | 명지대학교 산학협력단 | 이소프렌을 생산하는 대장균 균주 fmis2 및 이의 용도 |
WO2016015021A1 (en) | 2014-07-24 | 2016-01-28 | The Regents Of The University Of California | Oxidative starch degradation by a new family of pmos |
KR102330593B1 (ko) * | 2014-07-28 | 2021-11-26 | 에스케이이노베이션 주식회사 | 신규 이소프렌 신타아제 및 이를 이용한 이소프렌의 제조방법 |
RO130063A8 (ro) | 2014-08-28 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea ovotransferinei moderne () |
US20170298363A1 (en) | 2014-09-18 | 2017-10-19 | Genomatica, Inc | Non-natural microbial organisms with improved energetic efficiency |
CN105985975A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
CN105985977B (zh) * | 2015-02-10 | 2020-12-25 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
CN105985973A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
CN105985976A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
CN105985972A (zh) * | 2015-02-10 | 2016-10-05 | 中国科学院微生物研究所 | 异戊二烯合成酶基因及其应用 |
CA2974343A1 (en) * | 2015-02-13 | 2016-08-18 | Sekisui Chemical Co., Ltd. | Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method |
US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
KR102546640B1 (ko) * | 2016-01-26 | 2023-06-22 | 에스케이이노베이션 주식회사 | 재조합 호염성 메탄균주를 이용한 이소프렌의 제조방법 |
CN107991399B (zh) * | 2016-10-27 | 2022-03-08 | 天士力医药集团股份有限公司 | 一种同时测定复方丹参提取物或相关药材中31种成分的方法 |
CA3052635A1 (en) | 2017-02-06 | 2018-11-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of tyramine by fermentation |
US11261450B2 (en) | 2017-02-27 | 2022-03-01 | Sekisui Chemical Co., Ltd. | Recombinant cell, method for producing recombinant cell, and method for producing isoprene or terpene |
WO2018200888A1 (en) | 2017-04-27 | 2018-11-01 | Regents Of The University Of California | Microorganisms and methods for producing cannabinoids and cannabinoid derivatives |
CN111032855A (zh) * | 2017-06-01 | 2020-04-17 | 尼普生物股份有限公司 | 微生物体中异源类胡萝卜素的产生 |
WO2019006257A1 (en) * | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
US11452967B2 (en) | 2017-07-17 | 2022-09-27 | Zymergen Inc. | Metal-organic framework materials |
KR101965210B1 (ko) * | 2017-09-26 | 2019-04-04 | 한국생명공학연구원 | 신규 이소프렌 합성 효소 및 이를 이용한 이소프렌 생산 방법 |
US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
EP3720944A1 (en) | 2017-12-07 | 2020-10-14 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
WO2020069142A1 (en) | 2018-09-26 | 2020-04-02 | Demetrix, Inc. | Optimized expression systems for expressing berberine bridge enzyme and berberine bridge enzyme-like polypeptides |
WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
CN114729337A (zh) | 2019-05-22 | 2022-07-08 | 德美崔克斯公司 | 优化的大麻素合酶多肽 |
CN110241103B (zh) * | 2019-07-04 | 2021-01-19 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种生物酶法生产异戊二烯的方法 |
CN115038786A (zh) | 2019-09-18 | 2022-09-09 | 德美崔克斯公司 | 优化的四氢大麻酚酸(thca)合酶多肽 |
WO2021183448A1 (en) | 2020-03-09 | 2021-09-16 | Demetrix, Inc. | Optimized olivetolic acid cyclase polypeptides |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1344713A (en) * | 1915-12-02 | 1920-06-29 | Westinghouse Electric & Mfg Co | Reactance-coil |
DE1793254A1 (de) * | 1968-08-23 | 1971-12-16 | Bayer Ag | Verfahren zur Gewinnung von Cyclopenten,Isopren und einem Diolefinstrom aus C?-Crackbenzinschnitten |
US5380831A (en) * | 1986-04-04 | 1995-01-10 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene |
DE3338269A1 (de) * | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur gewinnung von isopren aus einem c(pfeil abwaerts)5(pfeil abwaerts)-kohlenwasserstoffgemisch |
GB8407828D0 (en) * | 1984-03-27 | 1984-05-02 | Ontario Research Foundation | In situ preparation |
US4570029A (en) * | 1985-03-04 | 1986-02-11 | Uop Inc. | Process for separating isoprene |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
EP0215594B2 (en) | 1985-08-29 | 2003-10-15 | Genencor International, Inc. | Heterologous polypeptide expressed in filamentous fungi, processes for their preparation, and vectors for their preparation |
DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US4846872A (en) * | 1986-08-11 | 1989-07-11 | Fujisawa Pharmaceutical Co., Ltd. | Herbicide |
US5322770A (en) * | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
US5545816A (en) * | 1990-03-02 | 1996-08-13 | Amoco Corporation | Phytoene biosynthesis in genetically engineered hosts |
US5306862A (en) * | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
ES2322032T3 (es) * | 1990-12-10 | 2009-06-16 | Genencor Int | Sacrificacion mejorada de celulosa por clonacion y amplificacion del gen de beta-glucosidasa de trichoderma reesei. |
TW261517B (pt) * | 1991-11-29 | 1995-11-01 | Mitsubishi Shozi Kk | |
WO1995004134A1 (en) | 1993-08-02 | 1995-02-09 | Genencor International, Inc. | Method of reducing complex carbohydrates in fermentation products |
CA2118071C (en) | 1993-10-28 | 2004-09-14 | Rodney B. Croteau | Dna encoding limonene synthase from mentha spicata |
US5861271A (en) * | 1993-12-17 | 1999-01-19 | Fowler; Timothy | Cellulase enzymes and systems for their expressions |
US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
US5849970A (en) * | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
US8106260B2 (en) * | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
DE19629568C1 (de) * | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
CA2278523C (en) * | 1997-01-17 | 2013-06-18 | The Scripps Research Institute | Rna binding protein and binding site useful for expression of recombinant molecules |
CA2736981A1 (en) * | 1998-04-14 | 1999-10-21 | Kyowa Hakko Bio Co., Ltd. | Process for producing isoprenoid compounds by microorganisms |
US6176176B1 (en) * | 1998-04-30 | 2001-01-23 | Board Of Trustees Operating Michigan State University | Apparatus for treating cellulosic materials |
AR022383A1 (es) | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
US6268328B1 (en) * | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
US6442536B1 (en) | 2000-01-18 | 2002-08-27 | Praxair Technology, Inc. | Method for predicting flammability limits of complex mixtures |
WO2001058839A1 (en) | 2000-02-07 | 2001-08-16 | Eastman Chemical Company | Process to recover condensable gases from oxygen containing mixtures |
KR20010084864A (ko) | 2000-02-29 | 2001-09-06 | 김수언 | 개똥쑥의 아모파-4,11-디엔 합성효소, 이를 코딩하는유전자, 이 유전자를 포함하는 발현벡터 및, 이발현벡터로 형질전환된 대장균 및 식물체 |
US6270739B1 (en) * | 2000-06-16 | 2001-08-07 | Eastman Chemical Company | Process for the removal of carbon dioxide from 3,4-epoxy-1-butene process recycle streams |
AU2001278098A1 (en) * | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
WO2002016642A1 (en) * | 2000-08-18 | 2002-02-28 | Integrigen, Inc. | Methods and compositions for directed molecular evolution using dna-end modification |
US6553689B2 (en) * | 2000-09-24 | 2003-04-29 | 3M Innovative Properties Company | Vapor collection method and apparatus |
US6582914B1 (en) * | 2000-10-26 | 2003-06-24 | Genencor International, Inc. | Method for generating a library of oligonucleotides comprising a controlled distribution of mutations |
AU2002233614B2 (en) | 2001-03-22 | 2007-05-24 | Scentgene Pollination Ltd. | Method of enhancing entomophilous |
US7241587B2 (en) * | 2001-04-04 | 2007-07-10 | Genencor International, Inc. | Method of uncoupling the catabolic pathway of glycolysis from the oxidative membrane bound pathway of glucose conversion |
RU2197461C2 (ru) * | 2001-04-05 | 2003-01-27 | Общество с ограниченной ответственностью "Еврохим-СПб-Трейдинг" | Способ получения изопрена |
AU2002316966B2 (en) * | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
US6998471B2 (en) | 2001-07-25 | 2006-02-14 | E.I. Du Pont De Nemours And Company | Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods |
US7192751B2 (en) * | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
EP2374879A3 (en) | 2002-04-22 | 2012-01-11 | E. I. du Pont de Nemours and Company | Promoter and plasmid system for genetic engineering |
US20050287655A1 (en) * | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
EP1576123B1 (en) | 2002-10-04 | 2010-12-29 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
US20040219629A1 (en) * | 2002-12-19 | 2004-11-04 | Qiong Cheng | Increasing carotenoid production in bacteria via chromosomal integration |
FR2850101B1 (fr) * | 2003-01-22 | 2007-03-02 | Michelin Soc Tech | Procede d'obtention d'une coupe c5 "fcc" enrichie en isoprene et polymerisation selective de l'isoprene a partir de cette coupe |
ATE524491T1 (de) | 2003-05-29 | 2011-09-15 | Genencor Int | Neue trichoderma-gene |
KR101190897B1 (ko) | 2003-06-12 | 2012-10-12 | 디에스엠 아이피 어셋츠 비.브이. | 피드백 내성 메발로네이트 키나아제 |
PL202927B1 (pl) | 2003-07-20 | 2009-08-31 | Carr Daniel R | Peptyd i kompozycja farmaceutyczna oraz ich zastosowania medyczne |
AU2004293789B2 (en) * | 2003-11-21 | 2009-07-23 | Genencor International, Inc. | Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates |
EP2325318A1 (en) | 2004-02-13 | 2011-05-25 | Novozymes A/S | Protease variants |
BRPI0510115B1 (pt) * | 2004-05-21 | 2022-09-27 | The Regents Of The University Of California | Método para produzir um isoprenóide ou precursor de isoprenóide através de uma via de mevalonato em escherichia coli e célula hospedeira geneticamente modificada que os produz |
ATE554080T1 (de) * | 2004-06-18 | 2012-05-15 | Shell Int Research | Verfahren zur herstellung eines olefinoxids, 1,2- diols, a 1,2-diolethers oder alkanolamins |
WO2006063752A1 (en) | 2004-12-14 | 2006-06-22 | Dsm Ip Assets B.V. | Improved mevalonate kinase |
JP4117350B2 (ja) * | 2005-03-03 | 2008-07-16 | 富山県 | 機能改変フェニルアラニン脱水素酵素、およびこの酵素を用いた生体試料中のアミノ酸の分析方法 |
JP4446482B2 (ja) * | 2005-08-10 | 2010-04-07 | 独立行政法人産業技術総合研究所 | ユーカリ・モノテルペン合成酵素遺伝子 |
WO2007093962A2 (en) * | 2006-02-14 | 2007-08-23 | Firmenich Sa | Method for producing terpenes and mep-transformed microorganisms therefore |
WO2007136847A2 (en) | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
AU2007267033B2 (en) | 2006-05-26 | 2012-05-24 | Amyris, Inc. | Production of isoprenoids |
WO2008002472A2 (en) | 2006-06-23 | 2008-01-03 | Danisco Us Inc., Genencor Division | Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties |
US7947478B2 (en) | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
JP2008035831A (ja) | 2006-08-09 | 2008-02-21 | Nitta Ind Corp | 有用部分の生産性が高められた植物及びその作製方法 |
JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Adeka | 新規なアセトアセチルCoA合成酵素、それをコードするDNA配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
JP2008182950A (ja) | 2007-01-30 | 2008-08-14 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 柑橘類酵素遺伝子調製方法 |
US8609385B2 (en) * | 2007-05-01 | 2013-12-17 | Zuvachem, Inc. | Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism |
JP5548613B2 (ja) | 2007-06-06 | 2014-07-16 | ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン | 複数のタンパク質の性質を改良する方法 |
NZ583701A (en) | 2007-09-11 | 2012-03-30 | Sapphire Energy Inc | Molecule production by photosynthetic organisms |
RU2545699C2 (ru) | 2007-12-13 | 2015-04-10 | ДАНИСКО ЮЭс ИНК. | Композиции и способы получения изопрена |
US20110045563A1 (en) * | 2008-02-06 | 2011-02-24 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
JP2009207402A (ja) | 2008-03-04 | 2009-09-17 | Shizuokaken Koritsu Daigaku Hojin | 組換えサビネン合成酵素及びその利用 |
SG192545A1 (en) * | 2008-04-23 | 2013-08-30 | Danisco Us Inc | Isoprene synthase variants for improved microbial production of isoprene |
MX2011000072A (es) | 2008-06-30 | 2011-05-23 | Danisco Inc | Polimeros de isopreno a partir de recursos renovables. |
US8420360B2 (en) | 2008-07-02 | 2013-04-16 | Danisco Us Inc. | Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges |
BRPI0918936A2 (pt) * | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
US20100184178A1 (en) | 2008-09-15 | 2010-07-22 | Zachary Quinn Beck | Increased isoprene production using mevalonate kinase and isoprene synthase |
CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
CA2737236A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
BRPI0923828A2 (pt) | 2008-12-30 | 2019-09-24 | Danisco Us Inc | método de produção de isopreno e um co-produto. |
US8518686B2 (en) | 2009-04-23 | 2013-08-27 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用dxp及mva途徑之改良之異戊二烯製造 |
EP2449107B1 (en) | 2009-06-29 | 2015-04-08 | The University Of Western Australia | Terpene synthases from santalum |
US9273298B2 (en) | 2010-10-27 | 2016-03-01 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
-
2009
- 2009-04-23 SG SG2013055827A patent/SG192545A1/en unknown
- 2009-04-23 KR KR1020107026164A patent/KR20110020234A/ko not_active Application Discontinuation
- 2009-04-23 MX MX2010011706A patent/MX2010011706A/es unknown
- 2009-04-23 AU AU2009240505A patent/AU2009240505B2/en not_active Ceased
- 2009-04-23 MY MYPI2010004990A patent/MY153871A/en unknown
- 2009-04-23 CA CA2722440A patent/CA2722440A1/en not_active Abandoned
- 2009-04-23 EP EP09735440A patent/EP2279251A2/en not_active Withdrawn
- 2009-04-23 CN CN2009801234600A patent/CN102171335A/zh active Pending
- 2009-04-23 ZA ZA201007564A patent/ZA201007564B/xx unknown
- 2009-04-23 WO PCT/US2009/041581 patent/WO2009132220A2/en active Application Filing
- 2009-04-23 JP JP2011506460A patent/JP2011518564A/ja active Pending
- 2009-04-23 US US12/429,143 patent/US8173410B2/en not_active Expired - Fee Related
- 2009-04-23 RU RU2010147659/10A patent/RU2516343C2/ru not_active IP Right Cessation
- 2009-04-23 SG SG201007802A patent/SG165884A1/en unknown
- 2009-04-23 BR BRPI0911667A patent/BRPI0911667A2/pt not_active IP Right Cessation
-
2011
- 2011-10-22 ZA ZA2011/08569A patent/ZA201108569B/en unknown
-
2012
- 2012-03-30 US US13/436,612 patent/US8916370B2/en not_active Expired - Fee Related
-
2014
- 2014-03-06 RU RU2014108776/10A patent/RU2014108776A/ru not_active Application Discontinuation
- 2014-04-17 JP JP2014085377A patent/JP2014158489A/ja active Pending
- 2014-11-17 US US14/543,628 patent/US20150191712A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8916370B2 (en) | 2014-12-23 |
MY153871A (en) | 2015-03-31 |
US20150191712A1 (en) | 2015-07-09 |
US8173410B2 (en) | 2012-05-08 |
CN102171335A (zh) | 2011-08-31 |
EP2279251A2 (en) | 2011-02-02 |
US20100003716A1 (en) | 2010-01-07 |
AU2009240505A2 (en) | 2010-11-25 |
SG192545A1 (en) | 2013-08-30 |
RU2010147659A (ru) | 2012-05-27 |
RU2516343C2 (ru) | 2014-05-20 |
RU2014108776A (ru) | 2015-09-20 |
MX2010011706A (es) | 2011-03-15 |
SG165884A1 (en) | 2010-11-29 |
JP2014158489A (ja) | 2014-09-04 |
WO2009132220A9 (en) | 2010-05-06 |
US20130260432A1 (en) | 2013-10-03 |
ZA201007564B (en) | 2012-01-25 |
CA2722440A1 (en) | 2009-10-29 |
AU2009240505B2 (en) | 2013-09-05 |
AU2009240505A1 (en) | 2009-10-29 |
KR20110020234A (ko) | 2011-03-02 |
WO2009132220A3 (en) | 2010-01-21 |
JP2011518564A (ja) | 2011-06-30 |
ZA201108569B (en) | 2014-10-29 |
WO2009132220A2 (en) | 2009-10-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0911667A2 (pt) | variante de sintase de isopreno para produção microbiana aprimorada de isopreno | |
BR112013010551A8 (pt) | variantes de isopreno sintase para produção aprimorada de isopreno | |
WO2010124146A3 (en) | Three-dimensional structure of isoprene synthase and its use thereof for generating variants | |
BR112012014062A2 (pt) | organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo | |
WO2010030711A3 (en) | Microorganisms for the production of 1,4-butanediol | |
MX2012004291A (es) | Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos. | |
WO2009023525A3 (en) | Methods of modulating mesenchymal stem cell differentiation | |
MY187676A (en) | Microorganisms for the production of 1,4-butanediol and related methods | |
BR112014006244A2 (pt) | microrganismos e métodos para produzir alcenos | |
WO2013022881A8 (en) | Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside | |
WO2006125000A3 (en) | Method for the production of resveratrol in a recombinant oleaginous microorganism | |
WO2009135074A3 (en) | Microorganisms for the production of methacrylic acid | |
BR112012009332A2 (pt) | micro-organismo para a produção de anilina | |
BR112014027488A2 (pt) | isopreno sintase de legumes para produção de isopreno | |
WO2008142036A8 (en) | Plant cells and plants with increased tolerance and/or resistance to environmental stress and increased biomass production-ko | |
AU2011372711B2 (en) | Method for processing mesenchymal stem cells and the use thereof in the treatment of diseases associated with oxidative stress | |
BR112014014652A2 (pt) | microrganismos modificados e métodos de fazer butadieno usando os mesmos | |
UY32587A (es) | Manipulación de la biosíntesis de fructano y aumento de biomasa | |
BRPI0823256B8 (pt) | uso de sacarose como substrato para produção fermentativa de 1,2-propanodiol | |
BRPI0815474A8 (pt) | Método para produzir um alimento ou bebida à base de malte apropriado para consumo por um indivíduo com doença celíaca | |
AR061366A1 (es) | Epsp sintasas mejoradas: composiciones y metodos de uso de las mismas | |
BR112014010448A2 (pt) | microorganismos e métodos para a produção de caprolactona | |
BR112013030936A2 (pt) | metabolismo microbiano de oxiânios de cloro como um controle de produção de sulfeto de hidrogênio biogênico | |
BR112014006009A8 (pt) | Variantes de enzimas com propriedades aperfeiçoadas | |
MY182946A (en) | Production of organic acids by fermentation at low ph |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A E 10A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2521 DE 30/04/2019. |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] |